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M.S.W.)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Long non-coding RNAs (lncRNAs) are a class of non-coding RNA molecules with transcripts longer than 200 bp, which were initially thought to be noise from genomic transcription without biological function. However, since the discovery of H19 in 1980 and Xist in 1990, increasing evidence has shown that lncRNAs regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels through specific regulatory actions and are involved in the development of cancer and other diseases. Despite many lncRNAs being expressed at lower levels than those of protein-coding genes with less sequence conservation across species, lncRNAs have become an intense area of RNA research. They exert diverse biological functions such as inducing chromatin remodeling, recruiting transcriptional machinery, acting as competitive endogenous RNAs for microRNAs, and modulating protein\u2013protein interactions. Epithelial\u2013mesenchymal transition (EMT) is a developmental process, associated with embryonic development, wound healing, and cancer progression. In the context of oncogenesis, the EMT program is transiently activated and confers migratory\/invasive and cancer stem cell (CSC) properties to tumor cells, which are crucial for malignant progression, metastasis, and therapeutic resistance. Accumulating evidence has revealed that lncRNAs play crucial roles in the regulation of tumor epithelial\/mesenchymal plasticity (EMP) and cancer stemness. Here, we summarize the emerging roles and molecular mechanisms of lncRNAs in regulating tumor cell EMP and their effects on tumor initiation and progression through regulation of CSCs. We also discuss the potential of lncRNAs as diagnostic and prognostic biomarkers and therapeutic targets.<\/jats:p>","DOI":"10.3390\/cells14030227","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T10:09:52Z","timestamp":1738750192000},"page":"227","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Long Non-Coding RNAs: Key Regulators of Tumor Epithelial\/Mesenchymal Plasticity and Cancer Stemness"],"prefix":"10.3390","volume":"14","author":[{"given":"Yuan","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3619-2634","authenticated-orcid":false,"given":"Yun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2297-4346","authenticated-orcid":false,"given":"Jian","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, The Fourth Affiliated Hospital of China Medical University, Shengyang 110032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max S.","family":"Wicha","sequence":"additional","affiliation":[{"name":"Division of Hematology & Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Division of Hematology & Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.3192","article-title":"The landscape of long noncoding RNAs in the human transcriptome","volume":"47","author":"Iyer","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/j.molcel.2022.05.027","article-title":"Integrated lncRNA function upon genomic and epigenomic regulation","volume":"82","author":"Herman","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1158\/0008-5472.CAN-23-0544","article-title":"Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis","volume":"83","author":"Su","year":"2023","journal-title":"Cancer Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41419-021-03708-6","article-title":"A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear beta-catenin levels","volume":"12","author":"Wen","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1158\/0008-5472.CAN-20-2612","article-title":"SCIRT lncRNA Restrains Tumorigenesis by Opposing Transcriptional Programs of Tumor-Initiating Cells","volume":"81","author":"Zagorac","year":"2021","journal-title":"Cancer Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12943-022-01638-1","article-title":"Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt\/\u03b2-catenin signaling to promote colorectal cancer progression by preventing m6A-mediated degradation of STEAP3 mRNA","volume":"21","author":"Zhou","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Xiao, B., Liu, M., Chen, M., Xia, N., Guo, H., Huang, J., Liu, Z., and Wang, F. (2023). N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2\u2032-O methylation. Cell. Mol. Biol. Lett., 28.","DOI":"10.1186\/s11658-023-00493-2"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.1038\/s41467-023-43113-5","article-title":"LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2\u2032-O-methylation","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"11911","DOI":"10.1093\/nar\/gkad899","article-title":"Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response","volume":"51","author":"Murphy","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1038\/s41418-023-01225-x","article-title":"LncRNA BCAN-AS1 stabilizes c-Myc via N(6)-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer","volume":"30","author":"Wu","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.7150\/ijbs.80873","article-title":"LncRNA GSCAR promotes glioma stem cell maintenance via stabilizing SOX2 expression","volume":"19","author":"Jiang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10733","DOI":"10.1093\/nar\/gkac854","article-title":"Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5\/p300 complex","volume":"50","author":"Lv","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41413-023-00289-2","article-title":"HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation","volume":"11","author":"Li","year":"2023","journal-title":"Bone Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ymthe.2020.09.024","article-title":"A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis","volume":"29","author":"Wang","year":"2021","journal-title":"Mol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/15548627.2019.1598750","article-title":"Long noncoding RNA CA7-4 promotes autophagy and apoptosis via sponging MIR877-3P and MIR5680 in high glucose-induced vascular endothelial cells","volume":"16","author":"Zhao","year":"2020","journal-title":"Autophagy"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.cell.2018.03.064","article-title":"Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response","volume":"173","author":"Jiang","year":"2018","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1126\/science.ade0522","article-title":"The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9","volume":"381","author":"Wang","year":"2023","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/CIRCULATIONAHA.120.052023","article-title":"Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization","volume":"144","author":"Fasolo","year":"2021","journal-title":"Circulation"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Shen, P., Gao, J., Huang, S., You, C., Wang, H., Chen, P., Yao, T., Gao, T., Zhou, B., and Shen, S. (2023). LncRNA AC006064.4-201 serves as a novel molecular marker in alleviating cartilage senescence and protecting against osteoarthritis by destabilizing CDKN1B mRNA via interacting with PTBP1. Biomark. Res., 11.","DOI":"10.1186\/s40364-023-00477-6"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12943-019-1044-9","article-title":"The molecular mechanism of LncRNA34a-mediated regulation of bone metastasis in hepatocellular carcinoma","volume":"18","author":"Zhang","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.semcancer.2020.12.012","article-title":"lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions","volume":"75","author":"McCabe","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gutierrez-Cruz, J.A., Maldonado, V., and Melendez-Zajgla, J. (2022). Regulation of the Cancer Stem Phenotype by Long Non-Coding RNAs. Cells, 11.","DOI":"10.3390\/cells11152352"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Sonawala, K., Ramalingam, S., and Sellamuthu, I. (2022). Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways. Cells, 11.","DOI":"10.3390\/cells11213492"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1073\/pnas.0530291100","article-title":"Prospective identification of tumorigenic breast cancer cells","volume":"100","author":"Wicha","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/stem.30","article-title":"Identification of gastric cancer stem cells using the cell surface marker CD44","volume":"27","author":"Takaishi","year":"2009","journal-title":"Stem Cells"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"16281","DOI":"10.1073\/pnas.0905653106","article-title":"Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment","volume":"106","author":"Bertolini","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1158\/0008-5472.CAN-06-2030","article-title":"Identification of pancreatic cancer stem cells","volume":"67","author":"Li","year":"2007","journal-title":"Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10158","DOI":"10.1073\/pnas.0703478104","article-title":"Phenotypic characterization of human colorectal cancer stem cells","volume":"104","author":"Dalerba","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1158\/0008-5472.CAN-15-1824","article-title":"RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells","volume":"76","author":"Zhang","year":"2016","journal-title":"Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nsmb.3235","article-title":"lnc-beta-Catm elicits EZH2-dependent beta-catenin stabilization and sustains liver CSC self-renewal","volume":"23","author":"Zhu","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/j.cell.2022.04.034","article-title":"XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation","volume":"185","author":"Richart","year":"2022","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"106462","DOI":"10.1016\/j.phrs.2022.106462","article-title":"Transcriptome analysis identifies TODL as a novel lncRNA associated with proliferation, differentiation, and tumorigenesis in liposarcoma through FOXM1","volume":"185","author":"Kanojia","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/nar\/gkad1095","article-title":"Epigenetic regulation of asymmetric cell division by the LIBR-BRD4 axis","volume":"52","author":"Chen","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41568-021-00332-6","article-title":"Linking EMT programmes to normal and neoplastic epithelial stem cells","volume":"21","author":"Lambert","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","article-title":"The epithelial-mesenchymal transition generates cells with properties of stem cells","volume":"133","author":"Mani","year":"2008","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.stem.2014.02.002","article-title":"Metastatic stem cells: Sources, niches, and vital pathways","volume":"14","author":"Oskarsson","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1101\/gad.277681.116","article-title":"Distinctive properties of metastasis-initiating cells","volume":"30","author":"Kang","year":"2016","journal-title":"Genes Dev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-3-319-55947-6_12","article-title":"Mesenchymal-Epithelial Transition and Circulating Tumor Cells in Small Cell Lung Cancer","volume":"994","author":"Hamilton","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ccr.2012.10.012","article-title":"Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1","volume":"22","author":"Ocana","year":"2012","journal-title":"Cancer Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"11271","DOI":"10.1158\/0008-5472.CAN-06-2044","article-title":"Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2","volume":"66","author":"Chaffer","year":"2006","journal-title":"Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.semcancer.2023.10.001","article-title":"Transcriptional regulation of EMT transcription factors in cancer","volume":"97","author":"Saitoh","year":"2023","journal-title":"Semin. Cancer Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41418-020-0596-y","article-title":"LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-\u03b2\/SMAD2\/3 signaling pathway","volume":"28","author":"Wu","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12943-020-1133-9","article-title":"lncRNA JPX\/miR-33a-5p\/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt\/\u03b2-catenin signaling","volume":"19","author":"Pan","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12964-020-00602-0","article-title":"lncRNA HOTAIR overexpression induced downregulation of c-Met signaling promotes hybrid epithelial\/mesenchymal phenotype in hepatocellular carcinoma cells","volume":"18","author":"Topel","year":"2020","journal-title":"Cell Commun. Signal."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e2206694120","DOI":"10.1073\/pnas.2206694120","article-title":"lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1","volume":"120","author":"Zhang","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13045-022-01306-3","article-title":"Long noncoding RNA Smyca coactivates TGF-beta\/Smad and Myc pathways to drive tumor progression","volume":"15","author":"Chen","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/s41388-023-02652-3","article-title":"LncRNA XIST regulates breast cancer stem cells by activating proinflammatory IL-6\/STAT3 signaling","volume":"42","author":"Ma","year":"2023","journal-title":"Oncogene"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s41419-020-03141-1","article-title":"LncRNA LHFPL3-AS1 contributes to tumorigenesis of melanoma stem cells via the miR-181a-5p\/BCL2 pathway","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41419-019-1740-9","article-title":"LINC81507 act as a competing endogenous RNA of miR-199b-5p to facilitate NSCLC proliferation and metastasis via regulating the CAV1\/STAT3 pathway","volume":"10","author":"Peng","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s13046-020-01783-9","article-title":"HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer","volume":"39","author":"Hu","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7349","DOI":"10.1038\/s41467-021-26901-9","article-title":"The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer","volume":"12","author":"Singh","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/s41418-023-01160-x","article-title":"Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung cancer","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Chen, Y.L., Liu, Y.N., Lin, Y.T., Tsai, M.F., Wu, S.G., Chang, T.H., Hsu, C.L., Wu, H.D., and Shih, J.Y. (2023). LncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis. J. Biomed. Sci., 30.","DOI":"10.1186\/s12929-023-00973-9"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/379131a0","article-title":"Requirement for Xist in X chromosome inactivation","volume":"379","author":"Penny","year":"1996","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/349038a0","article-title":"A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome","volume":"349","author":"Brown","year":"1991","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/7734","article-title":"Tsix, a gene antisense to Xist at the X-inactivation centre","volume":"21","author":"Lee","year":"1999","journal-title":"Nat. Genet."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.1038\/s41467-021-27294-5","article-title":"SPEN is required for Xist upregulation during initiation of X chromosome inactivation","volume":"12","author":"Tan","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Cerase, A., Pintacuda, G., Tattermusch, A., and Avner, P. (2015). Xist localization and function: New insights from multiple levels. Genome Biol., 16.","DOI":"10.1186\/s13059-015-0733-y"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41586-020-1974-9","article-title":"SPEN integrates transcriptional and epigenetic control of X-inactivation","volume":"578","author":"Dossin","year":"2020","journal-title":"Nature"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6520","DOI":"10.1158\/1078-0432.CCR-13-0877","article-title":"The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression","volume":"19","author":"Salvador","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/s41580-021-00398-y","article-title":"The molecular principles of gene regulation by Polycomb repressive complexes","volume":"22","author":"Blackledge","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molcel.2019.03.011","article-title":"Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation","volume":"74","author":"Laugesen","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.tig.2020.12.006","article-title":"Polycomb Gene Silencing Mechanisms: PRC2 Chromatin Targeting, H3K27me3 \u2018Readout\u2019, and Phase Separation-Based Compaction","volume":"37","author":"Guo","year":"2021","journal-title":"Trends Genet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.7150\/thno.54549","article-title":"LncRNA PRADX-mediated recruitment of PRC2\/DDX5 complex suppresses UBXN1 expression and activates NF-kappaB activity, promoting tumorigenesis","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/s41419-021-04082-z","article-title":"Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.molcel.2017.11.013","article-title":"hnRNPK Recruits PCGF3\/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing","volume":"68","author":"Pintacuda","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1163045","article-title":"Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome","volume":"322","author":"Zhao","year":"2008","journal-title":"Science"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1186\/s12967-023-04394-y","article-title":"JMJD6-BRD4 complex stimulates lncRNA HOTAIR transcription by binding to the promoter region of HOTAIR and induces radioresistance in liver cancer stem cells","volume":"21","author":"Pei","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/s41375-023-01923-y","article-title":"A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development","volume":"37","author":"Liu","year":"2023","journal-title":"Leukemia"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"353","DOI":"10.7150\/thno.39093","article-title":"Genome-wide interaction target profiling reveals a novel Peblr20-eRNA activation pathway to control stem cell pluripotency","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1038\/s41380-020-0662-3","article-title":"LncRNA-AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia","volume":"26","author":"Ni","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/s12276-021-00647-2","article-title":"LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3","volume":"53","author":"Yuan","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/s41388-020-01638-9","article-title":"A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability","volume":"40","author":"Zhu","year":"2021","journal-title":"Oncogene"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ccell.2017.02.013","article-title":"m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program","volume":"31","author":"Zhang","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6327","DOI":"10.1038\/s41467-023-42135-3","article-title":"NAT10-dependent N4-acetylcytidine modification mediates PAN RNA stability, KSHV reactivation, and IFI16-related inflammasome activation","volume":"14","author":"Yan","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"7160","DOI":"10.1038\/s41467-022-34702-x","article-title":"Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer","volume":"13","author":"Chen","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/s41388-023-02628-3","article-title":"N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing","volume":"42","author":"Yu","year":"2023","journal-title":"Oncogene"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12943-020-01299-y","article-title":"LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM","volume":"20","author":"Zhang","year":"2021","journal-title":"Mol Cancer"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12943-021-01469-6","article-title":"LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway","volume":"20","author":"He","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Xie, X., Macknight, H.P., Lu, A.L., and Chalfant, C.E. (2024). RNA splicing variants of the novel long non-coding RNA, CyKILR, possess divergent biological functions in non-small cell lung cancer. bioRxiv.","DOI":"10.1101\/2024.07.08.602494"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12943-017-0738-0","article-title":"Long noncoding RNA NORAD, a novel competing endogenous RNA, enhances the hypoxia-induced epithelial-mesenchymal transition to promote metastasis in pancreatic cancer","volume":"16","author":"Li","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.omtn.2018.09.026","article-title":"lncRNA GAS5 Reverses EMT and Tumor Stem Cell-Mediated Gemcitabine Resistance and Metastasis by Targeting miR-221\/SOCS3 in Pancreatic Cancer","volume":"13","author":"Liu","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"13616","DOI":"10.1038\/ncomms13616","article-title":"Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment","volume":"7","author":"Katsushima","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13045-021-01194-z","article-title":"A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties","volume":"14","author":"Liu","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.biopha.2018.09.057","article-title":"LncRNA THOR increases the stemness of gastric cancer cells via enhancing SOX9 mRNA stability","volume":"108","author":"Song","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12943-020-01201-w","article-title":"Long noncoding RNA ZFAS1 promoting small nucleolar RNA-mediated 2\u2032-O-methylation via NOP58 recruitment in colorectal cancer","volume":"19","author":"Wu","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Monaco, P.L., Marcel, V., Diaz, J.-J., and Catez, F. (2018). 2\u2032-O-Methylation of Ribosomal RNA: Towards an Epitranscriptomic Control of Translation?. Biomolecules, 8.","DOI":"10.3390\/biom8040106"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41374-021-00664-9","article-title":"Induction of cancer cell stemness in glioma through glycolysis and the long noncoding RNA HULC-activated FOXM1\/AGR2\/HIF-1alpha axis","volume":"102","author":"Li","year":"2022","journal-title":"Lab. Investig."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1038\/s41388-022-02538-w","article-title":"LncRNA PVT-1 promotes osteosarcoma cancer stem-like properties through direct interaction with TRIM28 and TSC2 ubiquitination","volume":"41","author":"Tsang","year":"2022","journal-title":"Oncogene"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e112414","DOI":"10.15252\/embj.2022112414","article-title":"LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates","volume":"42","author":"Guo","year":"2023","journal-title":"EMBO J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"22240","DOI":"10.1021\/acsnano.3c01199","article-title":"Long Noncoding RNA URB1-Antisense RNA 1 (AS1) Suppresses Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma by Driving Ferritin Phase Separation","volume":"17","author":"Gao","year":"2023","journal-title":"ACS Nano"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"eadf3984","DOI":"10.1126\/sciadv.adf3984","article-title":"Multiomics analyses reveal DARS1-AS1\/YBX1-controlled posttranscriptional circuits promoting glioblastoma tumorigenesis\/radioresistance","volume":"9","author":"Zheng","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"13608","DOI":"10.1038\/ncomms13608","article-title":"LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells","volume":"7","author":"Zhu","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e2407493","DOI":"10.1002\/advs.202407493","article-title":"LncRNA FAISL Inhibits Calpain 2-Mediated Proteolysis of FAK to Promote Progression and Metastasis of Triple Negative Breast Cancer","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer","volume":"20","author":"Dongre","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.celrep.2014.12.032","article-title":"Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation","volume":"10","author":"Schmidt","year":"2015","journal-title":"Cell Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1172\/JCI59218","article-title":"Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells","volume":"122","author":"Mateo","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1073\/pnas.1812876116","article-title":"Acquisition of a hybrid E\/M state is essential for tumorigenicity of basal breast cancer cells","volume":"116","author":"Kroger","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1158\/0008-5472.CAN-14-3476","article-title":"Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis","volume":"75","author":"Ruscetti","year":"2015","journal-title":"Cancer Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"eaak9557","DOI":"10.1126\/scisignal.aak9557","article-title":"The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b\/c and let-7b","volume":"10","author":"Zhou","year":"2017","journal-title":"Sci. Signal."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1684\/ecn.2024.0495","article-title":"MALAT1 promotes epithelial-mesenchymal transition of pancreatic cancer cells through the miR-141-5p-TGF-ss-TGFBR1\/TGFBR2 axis","volume":"35","author":"Li","year":"2024","journal-title":"Eur Cytokine Netw"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12967-015-0442-z","article-title":"The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer","volume":"13","author":"Li","year":"2015","journal-title":"J. Transl. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.canlet.2017.09.019","article-title":"LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9","volume":"410","author":"Fu","year":"2017","journal-title":"Cancer Lett."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1158\/0008-5472.CAN-12-1033","article-title":"TWIST1 is an ERK1\/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells","volume":"72","author":"Weiss","year":"2012","journal-title":"Cancer Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12943-017-0729-1","article-title":"A long non-coding RNA HOTTIP expression is associated with disease progression and predicts outcome in small cell lung cancer patients","volume":"16","author":"Sun","year":"2017","journal-title":"Mol Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1038\/onc.2010.102","article-title":"ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI\/SNF chromatin-remodeling protein BRG1","volume":"29","author":"Lazaro","year":"2010","journal-title":"Oncogene"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/sj.bjc.6602266","article-title":"Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma","volume":"92","author":"Miyoshi","year":"2005","journal-title":"Br. J. Cancer"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12943-020-1143-7","article-title":"Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2","volume":"19","author":"Zhan","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"8141","DOI":"10.1038\/s41467-023-43974-w","article-title":"LncRNA MIR200CHG inhibits EMT in gastric cancer by stabilizing miR-200c from target-directed miRNA degradation","volume":"14","author":"Zhu","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e1432","DOI":"10.1002\/ctm2.1432","article-title":"Upregulation of LINC00501 by H3K27 acetylation facilitates gastric cancer metastasis through activating epithelial-mesenchymal transition and angiogenesis","volume":"13","author":"Dou","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1007\/s11427-020-1895-2","article-title":"Loss of lncRNA SNHG8 promotes epithelial-mesenchymal transition by destabilizing CDH1 mRNA","volume":"64","author":"He","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e112806","DOI":"10.15252\/embj.2022112806","article-title":"LncRNA LITATS1 suppresses TGF-beta-induced EMT and cancer cell plasticity by potentiating TbetaRI degradation","volume":"42","author":"Fan","year":"2023","journal-title":"EMBO J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"eadf1947","DOI":"10.1126\/scisignal.adf1947","article-title":"The lncRNA LETS1 promotes TGF-beta-induced EMT and cancer cell migration by transcriptionally activating a TbetaR1-stabilizing mechanism","volume":"16","author":"Fan","year":"2023","journal-title":"Sci. Signal."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.7150\/ijbs.27197","article-title":"TGF-beta\/SMAD4-Regulated LncRNA-LINP1 Inhibits Epithelial-Mesenchymal Transition in Lung Cancer","volume":"14","author":"Zhang","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41419-022-04540-2","article-title":"The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p\/VAMP7 axis","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41419-019-1948-8","article-title":"Long non-coding RNA linc00645 promotes TGF-beta-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S1097-2765(00)00134-9","article-title":"Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation","volume":"6","author":"Kavsak","year":"2000","journal-title":"Mol. Cell"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s13046-021-02140-0","article-title":"Long noncoding RNA SGO1-AS1 inactivates TGFbeta signaling by facilitating TGFB1\/2 mRNA decay and inhibits gastric carcinoma metastasis","volume":"40","author":"Huang","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1016\/j.celrep.2016.11.034","article-title":"PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing","volume":"17","author":"Vuong","year":"2016","journal-title":"Cell Rep."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e2117988119","DOI":"10.1073\/pnas.2117988119","article-title":"TGFB2-AS1 inhibits triple-negative breast cancer progression via interaction with SMARCA4 and regulating its targets TGFB2 and SOX2","volume":"119","author":"Zhou","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1038\/s41388-021-01760-2","article-title":"Long non-coding RNA SMASR inhibits the EMT by negatively regulating TGF-beta\/Smad signaling pathway in lung cancer","volume":"40","author":"Xu","year":"2021","journal-title":"Oncogene"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"106311","DOI":"10.1016\/j.phrs.2022.106311","article-title":"STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response","volume":"182","author":"Sadrkhanloo","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-023-05099-7","article-title":"Wnt\/beta-catenin-driven EMT regulation in human cancers","volume":"81","author":"Xue","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13046-018-0831-2","article-title":"LINC01287\/miR-298\/STAT3 feedback loop regulates growth and the epithelial-to-mesenchymal transition phenotype in hepatocellular carcinoma cells","volume":"37","author":"Mo","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41419-019-2188-7","article-title":"Long non-coding RNA DLGAP1-AS1 facilitates tumorigenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via the feedback loop of miR-26a\/b-5p\/IL-6\/JAK2\/STAT3 and Wnt\/beta-catenin pathway","volume":"11","author":"Lin","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/s12276-023-00972-8","article-title":"LncRNA KIAA0087 suppresses the progression of osteosarcoma by mediating the SOCS1\/JAK2\/STAT3 signaling pathway","volume":"55","author":"Gong","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s13402-020-00532-6","article-title":"LncRNA PVT1 induces aggressive vasculogenic mimicry formation through activating the STAT3\/Slug axis and epithelial-to-mesenchymal transition in gastric cancer","volume":"43","author":"Zhao","year":"2020","journal-title":"Cell. Oncol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12935-021-01780-8","article-title":"The lncRNA NEAT1 promotes the epithelial-mesenchymal transition and metastasis of osteosarcoma cells by sponging miR-483 to upregulate STAT3 expression","volume":"21","author":"Chen","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.omtn.2020.10.010","article-title":"lncRNA SNHG10 Promotes the Proliferation and Invasion of Osteosarcoma via Wnt\/beta-Catenin Signaling","volume":"22","author":"Zhu","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41419-020-02827-w","article-title":"Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt\/beta-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma","volume":"11","author":"Dai","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s13046-022-02544-6","article-title":"LncRNA CEBPA-DT promotes liver cancer metastasis through DDR2\/beta-catenin activation via interacting with hnRNPC","volume":"41","author":"Cai","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12943-022-01555-3","article-title":"Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m(6)A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression","volume":"21","author":"Liu","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41419-023-05862-5","article-title":"The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1\/PAK1 modulation","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41422-018-0134-3","article-title":"LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition","volume":"29","author":"Hu","year":"2019","journal-title":"Cell Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41419-021-03435-y","article-title":"Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1158\/0008-5472.CAN-20-0832","article-title":"A lncRNA TCL6-miR-155 Interaction Regulates the Src-Akt-EMT Network to Mediate Kidney Cancer Progression and Metastasis","volume":"81","author":"Kulkarni","year":"2021","journal-title":"Cancer Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"28340","DOI":"10.18632\/oncotarget.8634","article-title":"c-Src activation promotes nasopharyngeal carcinoma metastasis by inducing the epithelial-mesenchymal transition via PI3K\/Akt signaling pathway: A new and promising target for NPC","volume":"7","author":"Ke","year":"2016","journal-title":"Oncotarget"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1038\/s41467-021-25552-0","article-title":"Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and DeltaNp63","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41419-020-03346-4","article-title":"Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p\/BCL9L axis","volume":"12","author":"Lu","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7150\/ijbs.39461","article-title":"LncARSR sponges miR-129-5p to promote proliferation and metastasis of bladder cancer cells through increasing SOX4 expression","volume":"16","author":"Liao","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Xiao, Q., Lin, C., Peng, M., Ren, J., Jing, Y., Lei, L., Tao, Y., Huang, J., Yang, J., and Sun, M. (2022). Circulating plasma exosomal long non-coding RNAs LINC00265, LINC00467, UCA1, and SNHG1 as biomarkers for diagnosis and treatment monitoring of acute myeloid leukemia. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1033143"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1016\/j.ymthe.2022.01.046","article-title":"Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment","volume":"30","author":"Xu","year":"2022","journal-title":"Mol. Ther."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"7602","DOI":"10.1111\/jcmm.16009","article-title":"Serum exosomal lncRNA XIST is a potential non-invasive biomarker to diagnose recurrence of triple-negative breast cancer","volume":"25","author":"Lan","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s13046-023-02859-y","article-title":"Exosomal long noncoding RNA MLETA1 promotes tumor progression and metastasis by regulating the miR-186-5p\/EGFR and miR-497-5p\/IGF1R axes in non-small cell lung cancer","volume":"42","author":"Hsu","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4103\/1008-682X.167715","article-title":"Prostate cancer antigen 3 moderately improves diagnostic accuracy in Chinese patients undergoing first prostate biopsy","volume":"19","author":"Sun","year":"2017","journal-title":"Asian J. Androl."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"11091","DOI":"10.18632\/oncotarget.2691","article-title":"Development and prospective multicenter evaluation of the long noncoding RNA MALAT-1 as a diagnostic urinary biomarker for prostate cancer","volume":"5","author":"Wang","year":"2014","journal-title":"Oncotarget"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Li, Y., Ji, J., Lyu, J., Jin, X., He, X., Mo, S., Xu, H., He, J., Cao, Z., and Chen, X. (2021). A Novel Urine Exosomal lncRNA Assay to Improve the Detection of Prostate Cancer at Initial Biopsy: A Retrospective Multicenter Diagnostic Feasibility Study. Cancers, 13.","DOI":"10.3390\/cancers13164075"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41418-019-0381-y","article-title":"The lncRNA PVT1 regulates nasopharyngeal carcinoma cell proliferation via activating the KAT2A acetyltransferase and stabilizing HIF-1alpha","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"12692","DOI":"10.1038\/ncomms12692","article-title":"A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells","volume":"7","author":"Qu","year":"2016","journal-title":"Nat. Commun."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/3\/227\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:27:21Z","timestamp":1760027241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/3\/227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":152,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["cells14030227"],"URL":"https:\/\/doi.org\/10.3390\/cells14030227","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]}}}