{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:54:16Z","timestamp":1789631656495,"version":"build-2803163510"},"reference-count":97,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Imam Abdulrahman Bin Faisal University, Dammam","award":["IF-2020-012-Med"],"award-info":[{"award-number":["IF-2020-012-Med"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>\u03b2-globin gene cluster regulation involves complex mechanisms to ensure proper expression and function in RBCs. During development, switching occurs as \u03b3-globin is replaced by \u03b2-globin. Key regulators, like BCL11A and ZBTB7A, repress \u03b3-globin expression to facilitate this transition with other factors, like KLF1, LSD1, and PGC-1\u03b1; these regulators ensure an orchestrated transition from \u03b3- to \u03b2-globin during development. While these mechanisms have been extensively studied, circRNAs have recently emerged as key contributors to gene regulation, but their role in \u03b2-globin gene cluster regulation remains largely unexplored. Although discovered in the 1970s, circRNAs have only recently been recognized for their functional roles, particularly in interactions with RNA-binding proteins. Understanding how circRNAs contribute to switching from \u03b3- to \u03b2-globin could lead to new therapeutic strategies for hemoglobinopathies, such as sickle cell disease and \u03b2-thalassemia. This review uses the circAtlas 3.0 database to explore circRNA expressions in genes related to switching from \u03b3- to \u03b2-globin expression, focusing on blood, bone marrow, liver, and spleen. It emphasizes the exploration of the potential interactions between circRNAs and RNA-binding proteins involved in \u03b2-globin gene cluster regulatory mechanisms, further enhancing our understanding of \u03b2-globin gene cluster expression.<\/jats:p>","DOI":"10.3390\/cells14040312","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T08:36:46Z","timestamp":1739954206000},"page":"312","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in \u03b3-Globin to \u03b2-Globin Switching"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-8764","authenticated-orcid":false,"given":"Alawi","family":"Habara","sequence":"first","affiliation":[{"name":"Department of Biochemistry, College of Medicine, Imam Abdulrahman Bin Faisal University, P.O. 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