{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:16:51Z","timestamp":1790957811055,"version":"4.1.0"},"reference-count":113,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["DK 116591"],"award-info":[{"award-number":["DK 116591"]}]},{"name":"NIH","award":["FG-1300157"],"award-info":[{"award-number":["FG-1300157"]}]},{"name":"Saudi Arabian Cultural Mission to the USA","award":["DK 116591"],"award-info":[{"award-number":["DK 116591"]}]},{"name":"Saudi Arabian Cultural Mission to the USA","award":["FG-1300157"],"award-info":[{"award-number":["FG-1300157"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) in the aging population. Gender studies show that aging is associated with loss of protection from AKI in the female population. While ER stress contributes to IRI-induced AKI in the young, ER regulation during IR in the aged kidney is unclear. Because current evidence suggests hydrogen sulfide (H2S) modulates ER stress, we investigated whether exogenous supplementation of diallyl trisulfide (DATS), an H2S donor, mitigates AKI in aged female kidneys. Wild-type (WT, C57BL\/6J) mice aged 75\u201378 weeks were treated with or without DATS before and after renal IRI. IRI increased ER stress proteins, inflammation, and fibrosis markers in the IRI kidney compared to the control. DATS mitigated ER stress, and reduced inflammation and fibrosis markers in the IRI kidney. Further, IRI kidneys demonstrated reduced blood flow, vascularity, angiogenesis, increased resistive index (RI), and reduced function. DATS treatment upregulated PI3K, AKT, p-mTOR, and pMAPK signaling to stimulate angiogenesis, which improved vascular density, blood flow, and renal function. Together, our results suggest that DATS rescues the aged female kidney IRI by modulating ER stress and upregulation of angiogenesis.<\/jats:p>","DOI":"10.3390\/cells14060420","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T10:45:06Z","timestamp":1741776306000},"page":"420","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diallyl Trisulfide Attenuates Ischemia-Reperfusion-Induced ER Stress and Kidney Dysfunction in Aged Female Mice"],"prefix":"10.3390","volume":"14","author":[{"given":"Sathnur","family":"Pushpakumar","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subir Kumar","family":"Juin","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebah","family":"Almarshood","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibson Dibe","family":"Gondim","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Louisville School of Medicine, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Ouseph","sequence":"additional","affiliation":[{"name":"Division of Nephrology & Hypertension, University of Louisville School of Medicine, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-3443","authenticated-orcid":false,"given":"Utpal","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nieuwenhuijs-Moeke, G.J., Pischke, S.E., Berger, S.P., Sanders, J.S.F., Pol, R.A., Struys, M., Ploeg, R.J., and Leuvenink, H.G.D. (2020). Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair. J. Clin. Med., 9.","DOI":"10.3390\/jcm9010253"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Tammaro, A., Kers, J., Scantlebery, A.M.L., and Florquin, S. (2020). Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01346"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1056\/NEJM199605303342207","article-title":"Acute renal failure","volume":"334","author":"Thadhani","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/07853890.2018.1489142","article-title":"Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury","volume":"50","author":"Yan","year":"2018","journal-title":"Ann. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/MNH.0000000000000141","article-title":"Endoplasmic reticulum stress in kidney function and disease","volume":"24","author":"Taniguchi","year":"2015","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.bbadis.2015.06.004","article-title":"C\/EBP homologous protein (CHOP) gene deficiency attenuates renal ischemia\/reperfusion injury in mice","volume":"1852","author":"Noh","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"H355","DOI":"10.1152\/ajpheart.00437.2016","article-title":"Endoplasmic reticulum stress and the development of endothelial dysfunction","volume":"312","author":"Battson","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tam, A.B., Mercado, E.L., Hoffmann, A., and Niwa, M. (2012). ER stress activates NF-kappaB by integrating functions of basal IKK activity, IRE1 and PERK. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045078"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ebiom.2018.10.006","article-title":"Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease","volume":"37","author":"Shu","year":"2018","journal-title":"Ebiomedicine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"C1697","DOI":"10.1152\/ajpcell.00370.2022","article-title":"Emerging links between endoplasmic reticulum stress responses and acute kidney injury","volume":"323","author":"Porter","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41419-023-05905-x","article-title":"Research progress on endoplasmic reticulum homeostasis in kidney diseases","volume":"14","author":"Wu","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/cphy.c110041","article-title":"Pathophysiology of acute kidney injury","volume":"2","author":"Basile","year":"2012","journal-title":"Compr. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"F688","DOI":"10.1152\/ajprenal.00452.2006","article-title":"Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury","volume":"293","author":"Horbelt","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"F928","DOI":"10.1152\/ajprenal.00596.2007","article-title":"Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor","volume":"294","author":"Basile","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"F351","DOI":"10.1152\/ajprenal.90276.2008","article-title":"Preservation of peritubular capillary endothelial integrity and increasing pericytes may be critical to recovery from postischemic acute kidney injury","volume":"295","author":"Kwon","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kwiatkowska, E., Kwiatkowski, S., Dziedziejko, V., Tomasiewicz, I., and Domanski, L. (2023). Renal Microcirculation Injury as the Main Cause of Ischemic Acute Kidney Injury Development. Biology, 12.","DOI":"10.3390\/biology12020327"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1172\/JCI45161","article-title":"Cellular pathophysiology of ischemic acute kidney injury","volume":"121","author":"Bonventre","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/sj.ki.5002312","article-title":"The endothelial cell in ischemic acute kidney injury: Implications for acute and chronic function","volume":"72","author":"Basile","year":"2007","journal-title":"Kidney Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s00467-015-3231-2","article-title":"The multifaceted role of the renal microvasculature during acute kidney injury","volume":"31","author":"Maringer","year":"2016","journal-title":"Pediatr. Nephrol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1681\/ASN.2014010060","article-title":"Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney","volume":"26","author":"Dimke","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/1479164116666762","article-title":"Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis","volume":"14","author":"Dong","year":"2017","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1161\/ATVBAHA.112.249318","article-title":"Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice","volume":"32","author":"Kassan","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"35867","DOI":"10.1074\/jbc.M100747200","article-title":"Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/CIRCRESAHA.108.183749","article-title":"Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: Prevention by oxygen-regulated protein 150 expression","volume":"104","author":"Sanson","year":"2009","journal-title":"Circ. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/iub.1292","article-title":"Endoplasmic reticulum stress and endothelial dysfunction","volume":"66","author":"Lenna","year":"2014","journal-title":"IUBMB Life"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s11357-020-00299-6","article-title":"Exogenous hydrogen sulfide and miR-21 antagonism attenuates macrophage-mediated inflammation in ischemia reperfusion injury of the aged kidney","volume":"43","author":"Pushpakumar","year":"2021","journal-title":"Geroscience"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3892\/mmr.2016.5289","article-title":"Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model","volume":"14","author":"Li","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_28","first-page":"7740","article-title":"Hydrogen sulfide preconditioning protects against myocardial ischemia\/reperfusion injury in rats through inhibition of endo\/sarcoplasmic reticulum stress","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zhong, H., Yu, H., Chen, J., Sun, J., Guo, L., Huang, P., and Zhong, Y. (2020). Hydrogen Sulfide and Endoplasmic Reticulum Stress: A Potential Therapeutic Target for Central Nervous System Degeneration Diseases. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00702"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"64203","DOI":"10.18632\/oncotarget.19448","article-title":"Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: Involving suppression in hippocampal endoplasmic reticulum stress","volume":"8","author":"Zou","year":"2017","journal-title":"Oncotarget"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9095242","DOI":"10.1155\/2016\/9095242","article-title":"Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress","volume":"2016","author":"Yang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wang, M., Wang, Z., Miao, Y., Wei, H., Peng, J., and Zhou, Y. (2022). Diallyl Trisulfide Promotes Placental Angiogenesis by Regulating Lipid Metabolism and Alleviating Inflammatory Responses in Obese Pregnant Mice. Nutrients, 14.","DOI":"10.3390\/nu14112230"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Puccinelli, M.T., and Stan, S.D. (2017). Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081645"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/alz.12305","article-title":"Plasma hydrogen sulfide: A biomarker of Alzheimer\u2019s disease and related dementias","volume":"17","author":"Disbrow","year":"2021","journal-title":"Alzheimers Dement."},{"key":"ref_35","first-page":"126","article-title":"The effect of gender on acute kidney injury developing in the intensive care unit","volume":"23","author":"Guzel","year":"2019","journal-title":"Hippokratia"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.kint.2022.02.033","article-title":"Harmonization of epidemiology of acute kidney injury and acute kidney disease produces comparable findings across four geographic populations","volume":"101","author":"Sawhney","year":"2022","journal-title":"Kidney Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"74","DOI":"10.30802\/AALAS-JAALAS-22-000064","article-title":"High-dose Meloxicam Provides Improved Analgesia in Female CD1 Mice: A Pharmacokinetic and Efficacy Study","volume":"62","author":"Kim","year":"2023","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.30802\/AALAS-JAALAS-21-000071","article-title":"Toxic Effects of High-dose Meloxicam and Carprofen on Female CD1 Mice","volume":"61","author":"Kendall","year":"2022","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.niox.2015.02.003","article-title":"MMP-9- and NMDA receptor-mediated mechanism of diabetic renovascular remodeling and kidney dysfunction: Hydrogen sulfide is a key modulator","volume":"46","author":"Kundu","year":"2015","journal-title":"Nitric Oxide Biol. Chem. Off. J. Nitric Oxide Soc."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Pushpakumar, S., Ren, L., Juin, S.K., Majumder, S., Kulkarni, R., and Sen, U. (2020). Methylation-dependent antioxidant-redox imbalance regulates hypertensive kidney injury in aging. Redox Biol., 37.","DOI":"10.1016\/j.redox.2020.101754"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1097\/HJH.0b013e3283649b33","article-title":"Angiotensin-II induced hypertension and renovascular remodelling in tissue inhibitor of metalloproteinase 2 knockout mice","volume":"31","author":"Pushpakumar","year":"2013","journal-title":"J. Hypertens."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Pushpakumar, S., Ren, L., Kundu, S., Gamon, A., Tyagi, S.C., and Sen, U. (2017). Toll-like Receptor 4 Deficiency Reduces Oxidative Stress and Macrophage Mediated Inflammation in Hypertensive Kidney. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-06484-6"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1093\/ndt\/gfp225","article-title":"Transcutaneous measurement of glomerular filtration rate using FITC-sinistrin in rats","volume":"24","author":"Sadick","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1111\/j.1523-1755.2004.00621.x","article-title":"The role of vascular endothelial growth factor (VEGF) in renal pathophysiology","volume":"65","author":"Schrijvers","year":"2004","journal-title":"Kidney Int."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Karar, J., and Maity, A. (2011). PI3K\/AKT\/mTOR Pathway in Angiogenesis. Front. Mol. Neurosci., 4.","DOI":"10.3389\/fnmol.2011.00051"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Song, Y.Y., Liang, D., Liu, D.K., Lin, L., Zhang, L., and Yang, W.Q. (2023). The role of the ERK signaling pathway in promoting angiogenesis for treating ischemic diseases. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1164166"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"F149","DOI":"10.1152\/ajprenal.00099.2020","article-title":"Sex differences in renal ischemia-reperfusion injury","volume":"319","author":"Hosszu","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.3892\/mmr.2014.2089","article-title":"Effect of gender differences on the regulation of renal ischemia-reperfusion-induced inflammation in mice","volume":"9","author":"Kang","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000500093","article-title":"Transforming Growth Factor-beta in the Acute Kidney Injury to Chronic Kidney Disease Transition","volume":"143","author":"Gewin","year":"2019","journal-title":"Nephron"},{"key":"ref_50","first-page":"51","article-title":"A cardioprotective insight of the cystathionine gamma-lyase\/hydrogen sulfide pathway","volume":"7","author":"Huang","year":"2015","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"101579","DOI":"10.1016\/j.arr.2022.101579","article-title":"Protein S-sulfhydration: Unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations","volume":"76","author":"Gupta","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1111\/jcmm.16423","article-title":"Hydrogen sulphide reduces hyperhomocysteinaemia-induced endothelial ER stress by sulfhydrating protein disulphide isomerase to attenuate atherosclerosis","volume":"25","author":"Jiang","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Fu, X., Zhang, Q., Chen, Y., Li, Y., and Wang, H. (2025). Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress\/NLRP3 inflammasome pathway. Mol. Cell Biochem.","DOI":"10.1007\/s11010-025-05220-3"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Wang, Q., Xue, X., Wang, P., Yu, Y., Wang, J., Jiang, Q., and Xiao, J. (2024). Angiotensin 1 peptide-conjugated CdSe\/ZnS quantum dots for cardiac-specific hydrogen sulfide targeted therapy in myocardial ischemia-reperfusion injury. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1435282"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1871529X1401140724093505","article-title":"Renal endothelial dysfunction in acute kidney ischemia reperfusion injury","volume":"14","author":"Basile","year":"2014","journal-title":"Cardiovasc. Hematol. Disord. Drug Targets"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000526050","article-title":"Targeting Endoplasmic Reticulum for Novel Therapeutics and Monitoring in Acute Kidney Injury","volume":"147","author":"Li","year":"2023","journal-title":"Nephron"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/boc.201800019","article-title":"Endoplasmic reticulum stress and kidney dysfunction","volume":"110","author":"Gallazzini","year":"2018","journal-title":"Biol. Cell"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"12910","DOI":"10.1111\/jcmm.15999","article-title":"The endoplasmic reticulum stress and the unfolded protein response in kidney disease: Implications for vascular growth factors","volume":"24","author":"Ricciardi","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"F875","DOI":"10.1152\/ajprenal.00590.2012","article-title":"Gender differences control the susceptibility to ER stress-induced acute kidney injury","volume":"304","author":"Hodeify","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1021\/acs.jpcb.7b03683","article-title":"Computational Study of H(2)S Release in Reactions of Diallyl Polysulfides with Thiols","volume":"121","author":"Cai","year":"2017","journal-title":"J. Phys. Chem. B"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1021\/acs.orglett.5b01962","article-title":"Diallyl Trisulfide Is a Fast H2S Donor, but Diallyl Disulfide Is a Slow One: The Reaction Pathways and Intermediates of Glutathione with Polysulfides","volume":"17","author":"Liang","year":"2015","journal-title":"Org. Lett."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"14557","DOI":"10.1074\/jbc.M112.340570","article-title":"The unfolded protein response regulates an angiogenic response by the kidney epithelium during ischemic stress","volume":"287","author":"Bouvier","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"492","DOI":"10.2337\/db11-0315","article-title":"Activation of endoplasmic reticulum stress by hyperglycemia is essential for Muller cell-derived inflammatory cytokine production in diabetes","volume":"61","author":"Zhong","year":"2012","journal-title":"Diabetes"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cmet.2013.02.003","article-title":"Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1alpha degradation of netrin-1","volume":"17","author":"Binet","year":"2013","journal-title":"Cell Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/CIRCULATIONAHA.111.041830","article-title":"C\/EBP homologous protein-10 (CHOP-10) limits postnatal neovascularization through control of endothelial nitric oxide synthase gene expression","volume":"125","author":"Loinard","year":"2012","journal-title":"Circulation"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1128\/MCB.00959-13","article-title":"CREB3L1 is a metastasis suppressor that represses expression of genes regulating metastasis, invasion, and angiogenesis","volume":"33","author":"Mellor","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nri2359","article-title":"The endoplasmic reticulum stress response in immunity and autoimmunity","volume":"8","author":"Todd","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7150\/ijbs.38143","article-title":"Hydrogen Sulfide Plays an Important Protective Role through Influencing Endoplasmic Reticulum Stress in Diseases","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1476-5381.2010.01191.x","article-title":"Hydrogen sulphide and angiogenesis: Mechanisms and applications","volume":"164","author":"Szabo","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e13374","DOI":"10.1111\/cpr.13374","article-title":"Role of hydrogen sulphide in physiological and pathological angiogenesis","volume":"56","author":"Zhang","year":"2023","journal-title":"Cell Prolif."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/ars.2013.5309","article-title":"Production and physiological effects of hydrogen sulfide","volume":"20","author":"Kimura","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical Biology of H(2)S Signaling through Persulfidation","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1080\/0886022X.2022.2107936","article-title":"The roles of hydrogen sulfide in renal physiology and disease states","volume":"44","author":"Feng","year":"2022","journal-title":"Ren. Fail."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00395-005-0569-9","article-title":"Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels","volume":"101","author":"Johansen","year":"2006","journal-title":"Basic Res. Cardiol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Lobb, I., Zhu, J., Liu, W., Haig, A., Lan, Z., and Sener, A. (2014). Hydrogen sulfide treatment ameliorates long-term renal dysfunction resulting from prolonged warm renal ischemia-reperfusion injury. Can. Urol. Assoc. J., 8.","DOI":"10.5489\/cuaj.1694"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jss.2017.05.123","article-title":"Hydrogen sulfide prevents renal ischemia-reperfusion injury in CLAWN miniature swine","volume":"219","author":"Sekijima","year":"2017","journal-title":"J. Surg. Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Andrey, M.n., Natalia, Z., Alexandr, O., and Iryna, P. (2014). P1 Gender dimorphism of hydrogen sulfide production and physiological effects in cardiovascular system. Nitric Oxide Biol. Chem. Off. J. Nitric Oxide Soc., 39.","DOI":"10.1016\/j.niox.2014.03.051"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.redox.2018.01.007","article-title":"Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease","volume":"15","author":"Rajpal","year":"2018","journal-title":"Redox Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ejphar.2013.07.008","article-title":"Sex differences in ischemia\/reperfusion-induced acute kidney injury are dependent on the renal sympathetic nervous system","volume":"714","author":"Tanaka","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/ALN.0000000000004436","article-title":"Postoperative Acute Kidney Injury by Age and Sex: A Retrospective Cohort Association Study","volume":"138","author":"Privratsky","year":"2023","journal-title":"Anesthesiology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e51462","DOI":"10.15252\/embr.202051462","article-title":"Inositol-requiring enzyme-1 regulates phosphoinositide signaling lipids and macrophage growth","volume":"21","author":"Hamid","year":"2020","journal-title":"EMBO Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.molmed.2012.06.010","article-title":"ER stress-induced inflammation: Does it aid or impede disease progression?","volume":"18","author":"Garg","year":"2012","journal-title":"Trends Mol. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.ijcard.2016.06.200","article-title":"Involvement of exogenous H2S in recovery of cardioprotection from ischemic post-conditioning via increase of autophagy in the aged hearts","volume":"220","author":"Chen","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/1566524016666160523143937","article-title":"The Role of the PERK\/eIF2alpha\/ATF4\/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress","volume":"16","author":"Rozpedek","year":"2016","journal-title":"Curr. Mol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Shu, S., Wang, Y., Zheng, M., Liu, Z., Cai, J., Tang, C., and Dong, Z. (2019). Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair. Cells, 8.","DOI":"10.3390\/cells8030207"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.clinbiochem.2009.09.022","article-title":"Expression of HIF-1 alpha, VEGF and EPO in peripheral blood from patients with two cardiac abnormalities associated with hypoxia","volume":"43","year":"2010","journal-title":"Clin. Biochem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1152\/japplphysiol.00780.2014","article-title":"Hypoxia-inducible factor-1 modulates the expression of vascular endothelial growth factor and endothelial nitric oxide synthase induced by eccentric exercise","volume":"118","author":"Almar","year":"2015","journal-title":"J Appl Physiol (1985)"},{"key":"ref_88","first-page":"939","article-title":"Ginsenoside protects against AKI via activation of HIF-1alpha and VEGF-A in the kidney-brain axis","volume":"45","author":"Mao","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1759091419871420","article-title":"Erythropoietin as a Neuroprotective Molecule: An Overview of Its Therapeutic Potential in Neurodegenerative Diseases","volume":"11","author":"Rey","year":"2019","journal-title":"ASN Neuro"},{"key":"ref_90","first-page":"E2302","article-title":"Carbon monoxide protects the kidney through the central circadian clock and CD39","volume":"115","author":"Gallo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/ddr.21764","article-title":"Fenofibrate attenuates ischemia reperfusion-induced acute kidney injury and associated liver dysfunction in rats","volume":"82","author":"Kaur","year":"2021","journal-title":"Drug Dev. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrneph.2013.35","article-title":"Angiogenesis and hypoxia in the kidney","volume":"9","author":"Tanaka","year":"2013","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.3390\/cancers3033242","article-title":"Aberrant signaling pathways in glioma","volume":"3","author":"Nakada","year":"2011","journal-title":"Cancers"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"119119","DOI":"10.1016\/j.lfs.2021.119119","article-title":"PI3K\/AKT activation attenuates acute kidney injury following liver transplantation by inducing FoxO3a nuclear export and deacetylation","volume":"272","author":"Meng","year":"2021","journal-title":"Life Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3892\/mmr.2021.12322","article-title":"miR-214 ameliorates sepsis-induced acute kidney injury via PTEN\/AKT\/mTOR-regulated autophagy","volume":"24","author":"Sang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e2688","DOI":"10.1038\/cddis.2017.18","article-title":"Hydrogen sulfide promotes autophagy of hepatocellular carcinoma cells through the PI3K\/Akt\/mTOR signaling pathway","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen sulfide mediates the vasoactivity of garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Chiba, T., Oda, A., Zhang, Y., Pfister, K.E., Bons, J., Bharathi, S.S., Kinoshita, A., Zhang, B.B., Richert, A.C., and Schilling, B. Loss of long-chain acyl-CoA dehydrogenase protects against acute kidney injury. JCI Insight, 2025. in press\u00a0.","DOI":"10.1172\/jci.insight.186073"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Piko, N., Bevc, S., Hojs, R., and Ekart, R. (2023). The Role of Oxidative Stress in Kidney Injury. Antioxidants, 12.","DOI":"10.3390\/antiox12091772"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Xie, C., Zhou, X., Chen, W., Ren, D., Li, X., Jiang, R., Zhong, C., and Zhu, J. (2024). Diallyl trisulfide induces pyroptosis and impairs lung CSC-like properties by activating the ROS\/Caspase 1 signaling pathway. Chem. Biol. Interact., 397.","DOI":"10.1016\/j.cbi.2024.111083"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.1039\/C9FO00646J","article-title":"Diallyl trisulfide induces G2\/M cell-cycle arrest and apoptosis in anaplastic thyroid carcinoma 8505C cells","volume":"10","author":"Zheng","year":"2019","journal-title":"Food Funct"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"106030","DOI":"10.1016\/j.phrs.2021.106030","article-title":"Toll-like receptor 4 mutation protects the kidney from Ang-II-induced hypertensive injury","volume":"175","author":"Majumder","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10157-014-0952-7","article-title":"An AKI biomarker lipocalin 2 in the blood derives from the kidney in renal injury but from neutrophils in normal and infected conditions","volume":"19","author":"Kanda","year":"2015","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1681\/ASN.2015060683","article-title":"Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI","volume":"27","author":"Zhang","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"110307","DOI":"10.1016\/j.intimp.2023.110307","article-title":"The role of IL-17 in acute kidney injury","volume":"119","author":"Wang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1681\/ASN.2016020177","article-title":"Of Inflammasomes and Alarmins: IL-1beta and IL-1alpha in Kidney Disease","volume":"27","author":"Anders","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1681\/ASN.2012101024","article-title":"Epithelial cell TGFbeta signaling induces acute tubular injury and interstitial inflammation","volume":"24","author":"Gentle","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2149412","DOI":"10.1080\/0886022X.2022.2149412","article-title":"Depletion of macrophages with clodronate liposomes partially attenuates renal fibrosis on AKI-CKD transition","volume":"45","author":"Hu","year":"2023","journal-title":"Ren. Fail."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e005092","DOI":"10.1161\/JAHA.116.005092","article-title":"Inhibition of IkappaB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis","volume":"6","author":"Johnson","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1186\/s12967-023-04407-w","article-title":"Influence of arterial blood gases on the renal arterial resistive index in intensive care unit","volume":"21","author":"Ruiz","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Iciek, M., Bilska-Wilkosz, A., Gorny, M., Sokolowska-Jezewicz, M., and Kowalczyk-Pachel, D. (2016). The Effects of Different Garlic-Derived Allyl Sulfides on Anaerobic Sulfur Metabolism in the Mouse Kidney. Antioxidants, 5.","DOI":"10.3390\/antiox5040046"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/cbf.1835","article-title":"The effects of garlic-derived sulfur compounds on cell proliferation, caspase 3 activity, thiol levels and anaerobic sulfur metabolism in human hepatoblastoma HepG2 cells","volume":"30","author":"Iciek","year":"2012","journal-title":"Cell Biochem. Funct."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/6\/420\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:51:29Z","timestamp":1760028689000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/6\/420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":113,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["cells14060420"],"URL":"https:\/\/doi.org\/10.3390\/cells14060420","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,12]]}}}