{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:21:47Z","timestamp":1791429707096,"version":"4.3.3"},"reference-count":50,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["2022R1I1A1A01073599"],"award-info":[{"award-number":["2022R1I1A1A01073599"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["RS-2022-NR075558"],"award-info":[{"award-number":["RS-2022-NR075558"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Wound-induced hair-follicle neogenesis (WIHN) is the phenomenon of regenerating new hair follicles from wounds in mammals. The WIHN involves both developmental and adult wound-healing processes. Moreover, the WIHN is regulated by a variety of factors, particularly multiple molecular signaling pathways produced in several types of cells. Here, the role of multiple signaling in different types of cells in WIHN is comprehensively described. Furthermore, the lack of dermal \u03b3\u03b4 T cells in the human scalp has hindered the clinical application of WIHN, but the development of drugs such as Wnt signaling activators is increasing the effectiveness of WIHN in humans. Overall, understanding the underlying mechanisms that regulate WIHN may help treat skin diseases, including alopecia.<\/jats:p>","DOI":"10.3390\/cells14060440","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T08:57:02Z","timestamp":1742201822000},"page":"440","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Molecular Signaling Pathways in Wound-Induced Hair-Follicle Neogenesis"],"prefix":"10.3390","volume":"14","author":[{"given":"Soung-Hoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anatomy, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41586-018-0073-7","article-title":"Diverse mechanisms for endogenous regeneration and repair in mammalian organs","volume":"557","author":"Wells","year":"2018","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature24487","article-title":"Regeneration of the entire human epidermis using transgenic stem cells","volume":"551","author":"Hirsch","year":"2017","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature05766","article-title":"Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding","volume":"447","author":"Ito","year":"2007","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/177791b0","article-title":"Incomplete wound contracture and the phenomenon of hair neogenesis in rabbits\u2019 skin","volume":"177","author":"Billingham","year":"1956","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/185051a0","article-title":"Formation of new wool follicles in the adult sheep","volume":"185","author":"Brook","year":"1960","journal-title":"Nature"},{"key":"ref_6","first-page":"1","article-title":"The Healing of Untreated Experimental Wounds","volume":"22","author":"Dann","year":"1941","journal-title":"Br. 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