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These include hyperproliferative states in psoriasis and dermatitis as well as hypoproliferative states in chronic wounds. This emphasises the importance of investigating the proliferation kinetics under conditions of healthy skin and identifying the key regulators of epidermal homeostasis, maintenance, and recovery following wound healing. Animal models contribute to our understanding of human epidermal self-renewal. Human skin xenografting overcomes the ethical limitations of studying human skin during regeneration. The application of this approach has allowed for the identification of a single population of stem cells and both slowly and rapidly cycling progenitors within the epidermal basal layer and the mapping of their location in relation to rete ridges and hair follicles. Furthermore, we have traced the dynamics of the proliferation pattern reorganization that occurs during epidermal regeneration, underlining the role of YAP activity in epidermal relief formation.<\/jats:p>","DOI":"10.3390\/cells14060448","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T11:04:22Z","timestamp":1742209462000},"page":"448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Recovery of Epidermal Proliferation Pattern in Human Skin Xenograft"],"prefix":"10.3390","volume":"14","author":[{"given":"Olga","family":"Cherkashina","sequence":"first","affiliation":[{"name":"Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2827-9993","authenticated-orcid":false,"given":"Alexandra","family":"Tsitrina","sequence":"additional","affiliation":[{"name":"Ilse Katz Institute of Nanoscale Science, Ben Gurion University of the Negev, Beer Sheva 8410501, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danila","family":"Abolin","sequence":"additional","affiliation":[{"name":"Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Morgun","sequence":"additional","affiliation":[{"name":"Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia"},{"name":"Research Institute of Molecular and Cellular Medicine, Peoples\u2019 Friendship University of Russia (RUDN University), 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2908-6499","authenticated-orcid":false,"given":"Anastasiya","family":"Kosykh","sequence":"additional","affiliation":[{"name":"Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, 117997 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7250-4852","authenticated-orcid":false,"given":"Marat","family":"Sabirov","sequence":"additional","affiliation":[{"name":"Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5405-0212","authenticated-orcid":false,"given":"Ekaterina","family":"Vorotelyak","sequence":"additional","affiliation":[{"name":"Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6987-0683","authenticated-orcid":false,"given":"Ekaterina","family":"Kalabusheva","sequence":"additional","affiliation":[{"name":"Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"ref_1","first-page":"77","article-title":"The Epidermal Proliferative Unit: The Possible Role of the Central Basal Cell","volume":"7","author":"Potten","year":"1974","journal-title":"Cell Tissue Kinet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/0092-8674(90)90696-C","article-title":"Label-Retaining Cells Reside in the Bulge Area of Pilosebaceous Unit: Implications for Follicular Stem Cells, Hair Cycle, and Skin Carcinogenesis","volume":"61","author":"Cotsarelis","year":"1990","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature05574","article-title":"A Single Type of Progenitor Cell Maintains Normal Epidermis","volume":"446","author":"Clayton","year":"2007","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.devcel.2009.12.016","article-title":"The Ordered Architecture of Murine Ear Epidermis Is Maintained by Progenitor Cells with Random Fate","volume":"18","author":"Klein","year":"2010","journal-title":"Dev. 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