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However, SC transplants face significant oxidative stress facilitated by ROS in the lesion, leading to poor survival. deferoxamine mesylate (DFO) is a neuroprotective agent shown to reduce H2O2-induced cell death in serum-containing conditions. Here we show that DFO is not necessary to induce neuroprotection under serum-free conditions by cell survival quantification and phenotypic analysis via immunohistochemistry, Hif1\u03b1 and collagen IV quantification via whole cell corrected total cell fluorescence, and cell death transcript changes via RT-qPCR. Our results indicate survival of SC regardless of DFO pretreatment in serum-free conditions and an increased survival facilitated by DFO in serum-containing conditions. Furthermore, our results showed strong nuclear expression of Hif1\u03b1 in serum-free conditions regardless of DFO pre-treatment and a nuclear expression of Hif1\u03b1 in DFO-treated SCs in serum conditions. Transcriptomic analysis reveals upregulation of autophagy transcripts in SCs grown in serum-free media relative to SCs in serum conditions, with and without DFO and H2O2. Thus, indicating a pro-repair and regenerative state of the SCs in serum-free conditions. Overall, results indicate the protectiveness of CDM in enhancing SC survival against ROS-induced cell death in vitro.<\/jats:p>","DOI":"10.3390\/cells14060461","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T07:59:54Z","timestamp":1742457594000},"page":"461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Deferoxamine Mesylate in Serum and Serum-Free Media: Adult Ventral Root Schwann Cell Survival Following Hydrogen Peroxide-Induced Cell Death"],"prefix":"10.3390","volume":"14","author":[{"given":"Yee Hang Ethan","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Chronic Brain Injury Program, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinay R.","family":"Putta","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrus H. H.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7281-7959","authenticated-orcid":false,"given":"Stephen R.","family":"Vidman","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Neuroscience Graduate Program, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5274-9238","authenticated-orcid":false,"given":"Paula","family":"Monje","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Kentucky, Lexington, KY 40506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7366-652X","authenticated-orcid":false,"given":"Giles W.","family":"Plant","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Chronic Brain Injury Program, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"ref_1","unstructured":"Bennett, J., Das, J.M., and Emmady, P.D. 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