{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:58:49Z","timestamp":1791575929315,"version":"4.3.4"},"reference-count":283,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Metabolic dysfunction leading to non-alcoholic fatty liver disease (NAFLD) exhibits distinct molecular and immune signatures that are influenced by factors like gut microbiota. The gut microbiome interacts with the liver via a bidirectional relationship with the gut\u2013liver axis. Microbial metabolites, sirtuins, and immune responses are pivotal in different metabolic diseases. This extensive review explores the complex and multifaceted interrelationship between sirtuins and gut microbiota, highlighting their importance in health and disease, particularly metabolic dysfunction and hepatocellular carcinoma (HCC). Sirtuins (SIRTs), classified as a group of NAD+-dependent deacetylases, serve as crucial modulators of a wide spectrum of cellular functions, including metabolic pathways, the inflammatory response, and the process of senescence. Their subcellular localization and diverse functions link them to various health conditions, including NAFLD and cancer. Concurrently, the gut microbiota, comprising diverse microorganisms, significantly influences host metabolism and immune responses. Recent findings indicate that sirtuins modulate gut microbiota composition and function, while the microbiota can affect sirtuin activity. This bidirectional relationship is particularly relevant in metabolic disorders, where dysbiosis contributes to disease progression. The review highlights recent findings on the roles of specific sirtuins in maintaining gut health and their implications in metabolic dysfunction and HCC development. Understanding these interactions offers potential therapeutic avenues for managing diseases linked to metabolic dysregulation and liver pathology.<\/jats:p>","DOI":"10.3390\/cells14060466","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T07:25:00Z","timestamp":1742541900000},"page":"466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sirtuins and Gut Microbiota: Dynamics in Health and a Journey from Metabolic Dysfunction to Hepatocellular Carcinoma"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5067-4984","authenticated-orcid":false,"given":"Mahmoud","family":"Zhra","sequence":"first","affiliation":[{"name":"Department of Anatomy and Genetics, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-0143","authenticated-orcid":false,"given":"Muhammad Affan","family":"Elahi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-3320","authenticated-orcid":false,"given":"Aamira","family":"Tariq","sequence":"additional","affiliation":[{"name":"Department of Biosciences, COMSATS University Islamabad, Islamabad Campus, Islamabad 45550, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abu-Zaid","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-910X","authenticated-orcid":false,"given":"Ahmed","family":"Yaqinuddin","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Genetics, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wu, Q., Zhang, T.-N., Chen, H.-h., Yu, X.-F., Lv, J., Liu, Y.-Y., Liu, Y., Zheng, G., Zhao, J., and Wei, Y.-F. (2022). The sirtuin family in health and disease. Signal Transduct. Target. Ther., 7.","DOI":"10.1038\/s41392-022-01257-8"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1080\/00207454.2022.2057849","article-title":"Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases","volume":"133","author":"Bhatt","year":"2022","journal-title":"Int. J. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ceballos, M.P., Quiroga, A.D., and Palma, N.F. (2023). Role of sirtuins in hepatocellular carcinoma progression and multidrug resistance: Mechanistical and pharmacological perspectives. Biochem. Pharmacol., 212.","DOI":"10.1016\/j.bcp.2023.115573"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Afzaal, M., Saeed, F., Shah, Y.A., Hussain, M., Rabail, R., Socol, C.T., Hassoun, A., Pateiro, M., Lorenzo, J.M., and Rusu, A.V. (2022). Human gut microbiota in health and disease: Unveiling the relationship. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.999001"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00281-024-01012-x","article-title":"Gut microbiota-derived metabolites tune host homeostasis fate","volume":"46","author":"Kim","year":"2024","journal-title":"Semin. Immunopathol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Li, X., Du, Y., Xue, C., Kang, X., Sun, C., Peng, H., Fang, L., Han, Y., Xu, X., and Zhao, C. (2023). SIRT2 Deficiency Aggravates Diet-Induced Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108970"},{"key":"ref_7","first-page":"1","article-title":"Shedding light on structure, function and regulation of human sirtuins: A comprehensive review","volume":"13","author":"Sharma","year":"2022","journal-title":"3 Biotech"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Afzaal, A., Rehman, K., Kamal, S., and Akash, M.S.H. (2022). Versatile role of sirtuins in metabolic disorders: From modulation of mitochondrial function to therapeutic interventions. J. Biochem. Mol. Toxicol., 36.","DOI":"10.1002\/jbt.23047"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"D\u2019Angelo, S., Mele, E., Di Filippo, F., Viggiano, A., and Meccariello, R. (2021). Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18031243"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41421-021-00326-6","article-title":"SIRT2-mediated deacetylation and deubiquitination of C\/EBP\u03b2 prevents ethanol-induced liver injury","volume":"7","author":"Zhang","year":"2021","journal-title":"Cell Discov."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1021\/acs.jmedchem.3c01979","article-title":"SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process","volume":"67","author":"Lambona","year":"2024","journal-title":"J. Med. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Tao, Z., Jin, Z., Wu, J., Cai, G., and Yu, X. (2023). Sirtuin family in autoimmune diseases. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1186231"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/php.13254","article-title":"Mitochondrial Sirtuins in Skin and Skin Cancers","volume":"96","author":"Su","year":"2020","journal-title":"Photochem. Photobiol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Polj\u0161ak, B., Kova\u010d, V., \u0160palj, S., and Milisav, I. (2023). The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032959"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbpa.2019.01.023","article-title":"Updates on the epigenetic roles of sirtuins","volume":"51","author":"Kosciuk","year":"2019","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zulkifli, N.D., and Zulkifle, N. (2023). Insight from sirtuins interactome: Topological prominence and multifaceted roles of SIRT1 in modulating immunity, aging and cancer. Genom. Inform., 21.","DOI":"10.5808\/gi.23003"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.dnarep.2019.06.009","article-title":"Current role of mammalian sirtuins in DNA repair","volume":"80","year":"2019","journal-title":"DNA Repair"},{"key":"ref_18","first-page":"10017","article-title":"The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair","volume":"44","author":"Roos","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/physrev.00030.2018","article-title":"SIRT6, a Mammalian Deacylase with Multitasking Abilities","volume":"100","author":"Chang","year":"2020","journal-title":"Physiol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1128\/MCB.00030-16","article-title":"Base Excision Repair, a Pathway Regulated by Posttranslational Modifications","volume":"36","author":"Carter","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Alves-Fernandes, D.K., and Jasiulionis, M.G. (2019). The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133153"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1089\/dna.2016.3280","article-title":"Role of Sirtuins in Maintenance of Genomic Stability: Relevance to Cancer and Healthy Aging","volume":"35","author":"Wu","year":"2016","journal-title":"DNA Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/acel.12685","article-title":"Sirtuins at the crossroads of stemness, aging, and cancer","volume":"16","author":"Vassilopoulos","year":"2017","journal-title":"Aging Cell"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Goes, J., Viana, M., Sampaio, L., Dias, R., Oliveira, R., Cavalcante, C., Borges, D., Magalh\u00e3es, S., Pinheiro, R., and Junior, H. (2023). Differential Gene Expression of Sirtuins (Sirt1 to Sirt7) Reveals Potential Roles In Myelodysplastic Neoplasm Pathobiology. Hematol. Transfus. Cell Ther., 45.","DOI":"10.1016\/j.htct.2023.09.809"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chojdak-\u0141ukasiewicz, J., Bizo\u0144, A., Waliszewska-Pros\u00f3\u0142, M., Piwowar, A., Budrewicz, S., and Pokryszko-Dragan, A. (2022). Role of Sirtuins in Physiology and Diseases of the Central Nervous System. Biomedicines, 10.","DOI":"10.3390\/biomedicines10102434"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Hong, Y.A., Kim, J.E., Jo, M.J., and Ko, G.J. (2020). The Role of Sirtuins in Kidney Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186686"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1161\/CIRCRESAHA.124.325440","article-title":"Roles of Sirtuins in Cardiovascular Diseases: Mechanisms and Therapeutics","volume":"136","author":"Ding","year":"2025","journal-title":"Circ. Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kumari, P., Tarighi, S., Braun, T., and Ianni, A. (2021). SIRT7 Acts as a Guardian of Cellular Integrity by Controlling Nucleolar and Extra-Nucleolar Functions. Genes, 12.","DOI":"10.3390\/genes12091361"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Maissan, P., Mooij, E.J., and Barberis, M. (2021). Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic Review. Biology, 10.","DOI":"10.3390\/biology10030194"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/mrd.23437","article-title":"Sirtuins in female meiosis and in reproductive longevity","volume":"87","author":"Vazquez","year":"2020","journal-title":"Mol. Reprod. Dev."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kratz, E.M., Kokot, I., Dymicka-Piekarska, V., and Piwowar, A. (2021). Sirtuins\u2014The New Important Players in Women\u2019s Gynecological Health. Antioxidants, 10.","DOI":"10.3390\/antiox10010084"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s12276-022-00739-7","article-title":"Sirtuins are crucial regulators of T cell metabolism and functions","volume":"54","author":"Hamaidi","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Watroba, M., and Szukiewicz, D. (2021). Sirtuins at the Service of Healthy Longevity. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.724506"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zhao, E., Hou, J., Ke, X., Abbas, M.N., Kausar, S., Zhang, L., and Cui, H. (2019). The Roles of Sirtuin Family Proteins in Cancer Progression. Cancers, 11.","DOI":"10.3390\/cancers11121949"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Carafa, V., Altucci, L., and Nebbioso, A. (2019). Dual Tumor Suppressor and Tumor Promoter Action of Sirtuins in Determining Malignant Phenotype. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00038"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.semcancer.2018.11.003","article-title":"The roles of sirtuins family in cell metabolism during tumor development","volume":"57","author":"Zhu","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Yin, J.-Y., Lu, X.-T., Hou, M.-L., Cao, T., and Tian, Z. (2023). Sirtuin1-p53: A potential axis for cancer therapy. Biochem. Pharmacol., 212.","DOI":"10.1016\/j.bcp.2023.115543"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1002\/ijc.33118","article-title":"The role of SIRT2 in cancer: A novel therapeutic target","volume":"147","author":"Chen","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Onyiba, C.I., Scarlett, C.J., and Weidenhofer, J. (2022). The Mechanistic Roles of Sirtuins in Breast and Prostate Cancer. Cancers, 14.","DOI":"10.3390\/cancers14205118"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1158\/0008-5472.CAN-15-2733","article-title":"Mitochondrial Sirtuins in Cancer: Emerging Roles and Therapeutic Potential","volume":"76","author":"George","year":"2016","journal-title":"Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Fiorentino, F., Carafa, V., Favale, G., Altucci, L., Mai, A., and Rotili, D. (2021). The Two-Faced Role of SIRT6 in Cancer. Cancers, 13.","DOI":"10.3390\/cancers13051156"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1080\/15384101.2020.1843813","article-title":"The possible role of Sirtuins and microRNAs in hepatocellular carcinoma therapy","volume":"19","author":"Karbasforooshan","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Farcas, M., Gavrea, A.-A., Gulei, D., Ionescu, C., Irimie, A., Catana, C.S., and Berindan-Neagoe, I. (2019). SIRT1 in the Development and Treatment of Hepatocellular Carcinoma. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00148"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.abb.2010.05.003","article-title":"Regulation of SIRT1 in cellular functions: Role of polyphenols","volume":"501","author":"Chung","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/abbs\/gms108","article-title":"SIRT1 and energy metabolism","volume":"45","author":"Li","year":"2013","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Zhang, L., Kim, S., and Ren, X. (2020). The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.01721"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Hong, J.Y., and Lin, H. (2021). Sirtuin Modulators in Cellular and Animal Models of Human Diseases. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.735044"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"37382","DOI":"10.1039\/D0RA06316A","article-title":"Recent advances in the development of histone deacylase SIRT2 inhibitors","volume":"10","author":"Yang","year":"2020","journal-title":"RSC Adv."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/9282484","article-title":"Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction","volume":"2022","author":"Zhu","year":"2022","journal-title":"Genet. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"33837","DOI":"10.1074\/jbc.M113.510354","article-title":"Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site","volume":"288","author":"Bharathi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Shen, Y., Wu, Q., Shi, J., and Zhou, S. (2020). Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson\u2019s disease. Biomed. Pharmacother., 132.","DOI":"10.1016\/j.biopha.2020.110928"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.molmet.2019.04.008","article-title":"SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1","volume":"25","author":"Sebaa","year":"2019","journal-title":"Mol. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Kincaid, B., and Bossy-Wetzel, E. (2013). Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front. Aging Neurosci., 5.","DOI":"10.3389\/fnagi.2013.00048"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.molcel.2011.01.002","article-title":"Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction","volume":"41","author":"Hallows","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Yan, Y., Principe, D.R., Zou, X., Vassilopoulos, A., and Gius, D. (2014). SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis. Cancer Metab., 2.","DOI":"10.1186\/2049-3002-2-15"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Wang, C., Liu, Y., Zhu, Y., and Kong, C. (2020). Functions of mammalian SIRT4 in cellular metabolism and research progress in human cancer (Review). Oncol. Lett., 20.","DOI":"10.3892\/ol.2020.11872"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.cell.2014.11.046","article-title":"Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity","volume":"159","author":"Mathias","year":"2014","journal-title":"Cell"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Tomaselli, D., Steegborn, C., Mai, A., and Rotili, D. (2020). Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00474"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1007\/s11427-015-4902-8","article-title":"SIRT5, functions in cellular metabolism with a multiple enzymatic activities","volume":"58","author":"Yang","year":"2015","journal-title":"Sci. China Life Sci."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Fabbrizi, E., Fiorentino, F., Carafa, V., Altucci, L., Mai, A., and Rotili, D. (2023). Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection. Cells, 12.","DOI":"10.3390\/cells12060852"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/15548627.2015.1009778","article-title":"SIRT5 regulation of ammonia-induced autophagy and mitophagy","volume":"11","author":"Polletta","year":"2015","journal-title":"Autophagy"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Nah\u00e1lkov\u00e1, J. (2023). A new view on functions of the lysine demalonylase activity of SIRT5. Life Sci., 320.","DOI":"10.1016\/j.lfs.2023.121572"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Pederson, N.J., and Diehl, K.L. (2024). DNA stimulates SIRT6 to mono-ADP-ribosylate proteins within histidine repeats. bioRxiv.","DOI":"10.1101\/2024.07.31.606047"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cell.2009.12.041","article-title":"The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1\u03b1","volume":"140","author":"Zhong","year":"2010","journal-title":"Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"9732","DOI":"10.1021\/acs.jmedchem.1c00601","article-title":"Emerging Therapeutic Potential of SIRT6 Modulators","volume":"64","author":"Fiorentino","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/21541264.2016.1276658","article-title":"The seven faces of SIRT7","volume":"8","author":"Blank","year":"2017","journal-title":"Transcription"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cellsig.2014.11.026","article-title":"Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin!","volume":"27","author":"Kiran","year":"2015","journal-title":"Cell. Signal."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Lagunas-Rangel, F.A. (2022). SIRT7 in the aging process. Cell. Mol. Life Sci., 79.","DOI":"10.1007\/s00018-022-04342-x"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Matija\u0161i\u0107, M., Me\u0161trovi\u0107, T., \u010cip\u010di\u0107 Paljetak, H., Peri\u0107, M., Bare\u0161i\u0107, A., and Verbanac, D. (2020). Gut Microbiota beyond Bacteria\u2014Mycobiome, Virome, Archaeome, and Eukaryotic Parasites in IBD. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082668"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Vemuri, R., Shankar, E.M., Chieppa, M., Eri, R., and Kavanagh, K. (2020). Beyond Just Bacteria: Functional Biomes in the Gut Ecosystem Including Virome, Mycobiome, Archaeome and Helminths. Microorganisms, 8.","DOI":"10.3390\/microorganisms8040483"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Garcia-Bonete, M.J., Rajan, A., Suriano, F., and Layunta, E. (2023). The Underrated Gut Microbiota Helminths, Bacteriophages, Fungi, and Archaea. Life, 13.","DOI":"10.3390\/life13081765"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1021\/acschemneuro.3c00127","article-title":"Gut Microbiome\u2013Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders","volume":"14","author":"Sasso","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Abenavoli, L., Giubilei, L., Procopio, A.C., Spagnuolo, R., Luzza, F., Boccuto, L., and Scarpellini, E. (2022). Gut Microbiota in Non-Alcoholic Fatty Liver Disease Patients with Inflammatory Bowel Diseases: A Complex Interplay. Nutrients, 14.","DOI":"10.3390\/nu14245323"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/jvim.14875","article-title":"The Gastrointestinal Microbiome: A Review","volume":"32","author":"Barko","year":"2017","journal-title":"J. Vet. Intern. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/imr.12567","article-title":"Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease","volume":"279","author":"Pickard","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s43393-021-00052-w","article-title":"Influence of gut microbiome on the human physiology","volume":"2","author":"Srivastava","year":"2021","journal-title":"Syst. Microbiol. Biomanufacturing"},{"key":"ref_77","first-page":"1","article-title":"Gut microbiota as a source of novel antimicrobials","volume":"10","author":"Mayer","year":"2018","journal-title":"Gut Microbes"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: Metabolism of nutrients and other food components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mib.2016.10.003","article-title":"Microbiome, metabolites and host immunity","volume":"35","author":"Levy","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.4476","article-title":"Interactions between the microbiota, immune and nervous systems in health and disease","volume":"20","author":"Fung","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Gasaly, N., de Vos, P., and Hermoso, M.A. (2021). Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.658354"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmet.2017.05.008","article-title":"Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System","volume":"26","author":"Postler","year":"2017","journal-title":"Cell Metab."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ. Microbiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3920\/BM2020.0057","article-title":"Short chain fatty acids in human gut and metabolic health","volume":"11","author":"Blaak","year":"2020","journal-title":"Benef. Microbes"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Parada Venegas, D., De La Fuente, M.K., Landskron, G., Gonz\u00e1lez, M.J., Quera, R., Dijkstra, G., Harmsen, H.J.M., Faber, K.N., and Hermoso, M.A. (2019). Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00277"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0029665120006916","article-title":"SCFA: Mechanisms and functional importance in the gut","volume":"80","author":"Marinelli","year":"2021","journal-title":"Proc. Nutr. Soc."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"He, J., Zhang, P., Shen, L., Niu, L., Tan, Y., Chen, L., Zhao, Y., Bai, L., Hao, X., and Li, X. (2020). Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176356"},{"key":"ref_88","first-page":"s15","article-title":"The Role of the Gut Microbiota in Bile Acid Metabolism","volume":"16","year":"2017","journal-title":"Ann. Hepatol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Oliphant, K., and Allen-Vercoe, E. (2019). Macronutrient metabolism by the human gut microbiome: Major fermentation by-products and their impact on host health. Microbiome, 7.","DOI":"10.1186\/s40168-019-0704-8"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Moszak, M., Szuli\u0144ska, M., and Bogda\u0144ski, P. (2020). You Are What You Eat\u2014The Relationship between Diet, Microbiota, and Metabolic Disorders\u2014A Review. Nutrients, 12.","DOI":"10.3390\/nu12041096"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Anwar, H., Iftikhar, A., Muzaffar, H., Almatroudi, A., Allemailem, K.S., Navaid, S., Saleem, S., and Khurshid, M. (2021). Biodiversity of Gut Microbiota: Impact of Various Host and Environmental Factors. BioMed Res. Int., 2021.","DOI":"10.1155\/2021\/5575245"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G.A.D., Gasbarrini, A., and Mele, M.C. (2019). What Is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms, 7.","DOI":"10.3390\/microorganisms7010014"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Wang, Y., Xu, B., Chen, H., Yang, F., Huang, J., Jiao, X., and Zhang, Y. (2023). Environmental factors and gut microbiota: Toward better conservation of deer species. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1136413"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nature25973","article-title":"Environment dominates over host genetics in shaping human gut microbiota","volume":"555","author":"Rothschild","year":"2018","journal-title":"Nature"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.it.2017.06.003","article-title":"Host Genetics and Gut Microbiome: Challenges and Perspectives","volume":"38","author":"Kurilshikov","year":"2017","journal-title":"Trends Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3345\/cep.2021.00955","article-title":"Factors influencing development of the infant microbiota: From prenatal period to early infancy","volume":"65","author":"Jeong","year":"2021","journal-title":"Clin. Exp. Pediatr."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Hasan, N., and Yang, H. (2019). Factors affecting the composition of the gut microbiota, and its modulation. PeerJ, 7.","DOI":"10.7717\/peerj.7502"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mib.2018.07.003","article-title":"Low diversity gut microbiota dysbiosis: Drivers, functional implications and recovery","volume":"44","author":"Kriss","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s40588-023-00213-6","article-title":"Gut Microbiota and Autoimmune Diseases: Mechanisms, Treatment, Challenges, and Future Recommendations","volume":"11","author":"Heravi","year":"2024","journal-title":"Curr. Clin. Microbiol. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1007\/s00018-017-2509-x","article-title":"Mechanisms and consequences of intestinal dysbiosis","volume":"74","author":"Weiss","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_101","first-page":"1","article-title":"Defining Dysbiosis for a Cluster of Chronic Diseases","volume":"9","author":"Willighagen","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Jalandra, R., Dhar, R., Pethusamy, K., Sharma, M., and Karmakar, S. (2022). Dysbiosis: Gut feeling. F1000Research, 11.","DOI":"10.12688\/f1000research.122429.1"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Hou, K., Wu, Z., Chen, X.-Y., Wang, J.-Q., Zhang, D., Xiao, C., Zhu, D., Koya, J.B., Wei, L., and Li, J. (2022). Microbiota in health and diseases. Signal Transduct. Target. Ther., 7.","DOI":"10.1038\/s41392-022-00974-4"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Kho, Z.Y., and Lal, S.K. (2018). The Human Gut Microbiome\u2014A Potential Controller of Wellness and Disease. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01835"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/jam.14661","article-title":"Gut dysbacteriosis and intestinal disease: Mechanism and treatment","volume":"129","author":"Meng","year":"2020","journal-title":"J. Appl. Microbiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-017-0002-0","article-title":"Crosstalk between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis","volume":"50","author":"Zhang","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1096\/fj.13-243568","article-title":"The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome","volume":"28","author":"Caron","year":"2013","journal-title":"FASEB J."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Vikram, A., Kim, Y.-R., Kumar, S., Li, Q., Kassan, M., Jacobs, J.S., and Irani, K. (2016). Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1. Nat. Commun., 7.","DOI":"10.1038\/ncomms12565"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1053\/j.gastro.2017.05.022","article-title":"Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota","volume":"153","author":"Wellman","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Munteanu, C., Onose, G., Po\u0219taru, M., Turnea, M., Rotariu, M., and Galaction, A.I. (2024). Hydrogen Sulfide and Gut Microbiota: Their Synergistic Role in Modulating Sirtuin Activity and Potential Therapeutic Implications for Neurodegenerative Diseases. Pharmaceuticals, 17.","DOI":"10.3390\/ph17111480"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Hou, D., Yu, T., Lu, X., Hong, J.Y., Yang, M., Zi, Y., Ho, T.T., and Lin, H. (2024). Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis. Proc. Natl. Acad. Sci. USA, 121.","DOI":"10.1073\/pnas.2319833121"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/bph.15980","article-title":"Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling","volume":"180","author":"Liu","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Chen, M., Hui, S., Lang, H., Zhou, M., Zhang, Y., Kang, C., Zeng, X., Zhang, Q., Yi, L., and Mi, M. (2018). SIRT3 Deficiency Promotes High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Correlation with Impaired Intestinal Permeability through Gut Microbial Dysbiosis. Mol. Nutr. Food Res., 63.","DOI":"10.1002\/mnfr.201800612"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Knop, M., Treitz, C., Bettendorf, S., Bossen, J., von Frieling, J., Doms, S., Bruchhaus, I., K\u00fchnlein, R.P., Baines, J.F., and Tholey, A. (2023). A mitochondrial sirtuin shapes the intestinal microbiota by controlling lysozyme expression. bioRxiv.","DOI":"10.1101\/2023.06.02.543385"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Tucker, S.A., Hu, S.-H., Vyas, S., Park, A., Joshi, S., Inal, A., Lam, T., Tan, E., Haigis, K.M., and Haigis, M.C. (2024). SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis. Cell Rep., 43.","DOI":"10.1016\/j.celrep.2024.113975"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jhep.2022.02.030","article-title":"Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis","volume":"77","author":"Sun","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Xu, K., Guo, Y., Wang, Y., Ren, Y., Low, V., Cho, S., Ping, L., Peng, K., Li, X., and Qiu, Y. (2022). Decreased Enterobacteriaceae translocation due to gut microbiota remodeling mediates the alleviation of premature aging by a high-fat diet. Aging Cell, 22.","DOI":"10.1111\/acel.13760"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Kim, S., Byun, J., Jung, S., Kim, B., Lee, K., Jeon, H., Lee, J., Choi, H., Kim, E., and Jeen, Y. (2022). Sirtuin 7 Inhibitor Attenuates Colonic Mucosal Immune Activation in Mice\u2014Potential Therapeutic Target in Inflammatory Bowel Disease. Biomedicines, 10.","DOI":"10.3390\/biomedicines10112693"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/mi.2014.35","article-title":"Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut","volume":"7","author":"Caruso","year":"2014","journal-title":"Mucosal Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.15407\/fz66.06.097","article-title":"SIRT1 Is A Regulator Of Autophagy In Intestinal Cells","volume":"66","author":"Lytvynenko","year":"2020","journal-title":"Fiziolohichny\u012d zhurnal"},{"key":"ref_121","first-page":"602","article-title":"Role of SIRT1 in the protection of intestinal epithelial barrier under hypoxia and its mechanism","volume":"17","author":"Ma","year":"2014","journal-title":"Chin. J. Gastrointest. Surg."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Markandey, M., Aditya, B., Edward, I.N., Saurabh, K., Simon, T., Fiona, P., and Ahuja, V. (2021). Gut microbiota: Sculptors of the intestinal stem cell niche in health and inflammatory bowel disease. Gut Microbes, 13.","DOI":"10.1080\/19490976.2021.1990827"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jcmgh.2020.01.004","article-title":"SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and Differentiation","volume":"10","author":"Li","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.molcel.2019.06.008","article-title":"SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism","volume":"75","author":"Wang","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"31995","DOI":"10.1074\/jbc.M110.124164","article-title":"SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells","volume":"285","author":"Nasrin","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1089\/ars.2017.7264","article-title":"Emerging Roles for SIRT5 in Metabolism and Cancer","volume":"28","author":"Guo","year":"2018","journal-title":"Antioxidants Redox Signal."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-32846-4","article-title":"Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity","volume":"13","author":"Xiong","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Xu, K., Guo, Y., Ping, L., Qiu, Y., Liu, Q., Li, Z., and Wang, Z. (2020). Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice. Cells, 9.","DOI":"10.3390\/cells9061513"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/carcin\/bgv167","article-title":"The complex role of SIRT6 in carcinogenesis","volume":"37","author":"Lerrer","year":"2015","journal-title":"Carcinog."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Liu, X., Li, C., Li, Q., Chang, H.-C., and Tang, Y.-C. (2020). SIRT7 Facilitates CENP-A Nucleosome Assembly and Suppresses Intestinal Tumorigenesis. iScience, 23.","DOI":"10.1016\/j.isci.2020.101461"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Haslberger, A., Lilja, S., B\u00e4ck, H., Stoll, C., Mayer, A., Pointner, A., Hippe, B., and Krammer, U. (2021). Increased Sirtuin expression, senescence regulating miRNAs, mtDNA, and Bifidobateria correlate with wellbeing and skin appearance after Sirtuin- activating drink. Bioact. Compd. Health Dis., 4.","DOI":"10.31989\/bchd.v4i4.801"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Salazar, J., Dur\u00e1n, P., D\u00edaz, M.P., Chac\u00edn, M., Santeliz, R., Mengual, E., Guti\u00e9rrez, E., Le\u00f3n, X., D\u00edaz, A., and Bernal, M. (2023). Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20105845"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Clark, A., and Mach, N. (2017). The Crosstalk between the Gut Microbiota and Mitochondria during Exercise. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00319"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-021-02814-5","article-title":"Gut microbiota accelerates cisplatin-induced acute liver injury associated with robust inflammation and oxidative stress in mice","volume":"19","author":"Gong","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-07859-7","article-title":"Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway","volume":"10","author":"Singh","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Yang, M., Massad, K., Kimchi, E.T., Staveley-O\u2019carroll, K.F., and Li, G. (2024). Gut microbiota and metabolite interface-mediated hepatic inflammation. Immunometabolism, 6.","DOI":"10.1097\/IN9.0000000000000037"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3892\/mmr.2020.11138","article-title":"Saccharomyces Boulardii Modulates Necrotizing Enterocolitis in Neonatal Mice by Regulating the Sirtuin 1\/NF-\u03baB Pathway and the Intestinal Microbiota","volume":"22","author":"Zhang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/hep.29466","article-title":"Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease","volume":"67","author":"Estes","year":"2018","journal-title":"Hepatology"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"(2016). EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J. Hepatol., 64, 1388\u20131402.","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-pathol-121808-102132","article-title":"Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis","volume":"5","author":"Tiniakos","year":"2010","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000448940","article-title":"Non-Alcoholic Fatty Liver Disease: Cause or Effect of Metabolic Syndrome","volume":"32","author":"Grander","year":"2016","journal-title":"Visc. Med."},{"key":"ref_142","unstructured":"Paschos, P., and Paletas, K. (2009). Non alcoholic fatty liver disease two-hit process: Multifactorial character of the second hit. Hippokratia, 13."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4239\/wjd.v12.i6.730","article-title":"Mechanisms linking gut microbial metabolites to insulin resistance","volume":"12","author":"Jang","year":"2021","journal-title":"World J. Diabetes"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Zhou, S., Tang, X., and Chen, H.-Z. (2018). Sirtuins and Insulin Resistance. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00748"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Wang, Y.-J., Paneni, F., Stein, S., and Matter, C.M. (2021). Modulating Sirtuin Biology and Nicotinamide Adenine Diphosphate Metabolism in Cardiovascular Disease\u2014From Bench to Bedside. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.755060"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Chandramowlishwaran, P., Vijay, A., Abraham, D., Li, G., Mwangi, S.M., and Srinivasan, S. (2020). Role of Sirtuins in Modulating Neurodegeneration of the Enteric Nervous System and Central Nervous System. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.614331"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Ghosh-Swaby, O.R., Reichelt, A.C., Sheppard, P.A., Davies, J., Bussey, T.J., and Saksida, L.M. (2022). Metabolic hormones mediate cognition. Front. Neuroendocr., 66.","DOI":"10.1016\/j.yfrne.2022.101009"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuroscience.2023.10.005","article-title":"Melatonin Improves Mitochondrial Dysfunction and Attenuates Neuropathic Pain by Regulating SIRT1 in Dorsal Root Ganglions","volume":"534","author":"Zeng","year":"2023","journal-title":"Neuroscience"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Naaz, S., Mishra, S., Pal, P.K., Chattopadhyay, A., Das, A.R., and Bandyopadhyay, D. (2020). Activation of SIRT1\/PGC 1\u03b1\/SIRT3 pathway by melatonin provides protection against mitochondrial dysfunction in isoproterenol induced myocardial injury. Heliyon, 6.","DOI":"10.1016\/j.heliyon.2020.e05159"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/mp.2015.220","article-title":"Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1","volume":"21","author":"Fujitsuka","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bcp.2018.02.001","article-title":"Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis","volume":"153","author":"Song","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.bbadis.2014.05.015","article-title":"RETRACTED: Leptin attenuates BACE1 expression and amyloid-\u03b2 genesis via the activation of SIRT1 signaling pathway","volume":"1842","author":"Marwarha","year":"2014","journal-title":"Biochim. Biophys. Acta BBA Mol. Basis Dis."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Sasaki, T. (2015). Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity. Front. Endocrinol., 6.","DOI":"10.3389\/fendo.2015.00109"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Chaudhry, T.S., Senapati, S.G., Gadam, S., Mannam, H.P.S.S., Voruganti, H.V., Abbasi, Z., Abhinav, T., Challa, A.B., Pallipamu, N., and Bheemisetty, N. (2023). The Impact of Microbiota on the Gut\u2013Brain Axis: Examining the Complex Interplay and Implications. J. Clin. Med., 12.","DOI":"10.3390\/jcm12165231"},{"key":"ref_155","first-page":"410","article-title":"Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients","volume":"44","author":"Wu","year":"2014","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_156","first-page":"584","article-title":"Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH","volume":"1861","author":"Bruce","year":"2016","journal-title":"Biochim. Biophys. Acta BBA Mol. Cell Biol. Lipids"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41574-019-0156-z","article-title":"Gut microbial metabolites in obesity, NAFLD and T2DM","volume":"15","author":"Canfora","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41575-020-0269-9","article-title":"Gut microbiota and human NAFLD: Disentangling microbial signatures from metabolic disorders","volume":"17","author":"Vigliotti","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1158\/2159-8290.CD-16-0932","article-title":"Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity","volume":"7","author":"Loo","year":"2017","journal-title":"Cancer Discov."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Bo, T., Shao, S., Wu, D., Niu, S., Zhao, J., and Gao, L. (2017). Relative variations of gut microbiota in disordered cholesterol metabolism caused by high-cholesterol diet and host genetics. Microbiologyopen, 6.","DOI":"10.1002\/mbo3.491"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/gutjnl-2019-319664","article-title":"Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites","volume":"70","author":"Zhang","year":"2020","journal-title":"Gut"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"20704","DOI":"10.3390\/ijms141020704","article-title":"Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)","volume":"14","author":"Takaki","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Elinav","year":"2012","journal-title":"Nature"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.jhep.2017.05.007","article-title":"Targeting the gut-liver axis in liver disease","volume":"67","author":"Wiest","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3748\/wjg.v23.i1.60","article-title":"Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier","volume":"23","author":"Zhou","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Kang, C., Wang, B., Kaliannan, K., Wang, X., Lang, H., Hui, S., Huang, L., Zhang, Y., Zhou, M., and Chen, M. (2017). Gut Microbiota Mediates the Protective Effects of Dietary Capsaicin against Chronic Low-Grade Inflammation and Associated Obesity Induced by High-Fat Diet. mBio, 8.","DOI":"10.1128\/mBio.00900-17"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Muccioli, G.G., Naslain, D., B\u00e4ckhed, F., Reigstad, C.S., Lambert, D.M., Delzenne, N.M., and Cani, P.D. (2010). The endocannabinoid system links gut microbiota to adipogenesis. Mol. Syst. Biol., 6.","DOI":"10.1038\/msb.2010.46"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Lam, Y.Y., Ha, C.W.Y., Campbell, C.R., Mitchell, A.J., Dinudom, A., Oscarsson, J., Cook, D.I., Hunt, N.H., Caterson, I.D., and Holmes, A.J. (2012). Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034233"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1038\/ismej.2014.45","article-title":"Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity","volume":"8","author":"Everard","year":"2014","journal-title":"ISME J."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMra1713263","article-title":"Hepatocellular Carcinoma","volume":"380","author":"Villanueva","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jamaoncol.2017.3055","article-title":"The Burden of Primary Liver Cancer and Underlying Etiologies from 1990 to 2015 at the Global, Regional, and National Level: Results from the Global Burden of Disease Study 2015","volume":"3","author":"Akinyemiju","year":"2017","journal-title":"JAMA Oncol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jceh.2019.01.004","article-title":"Hepatocellular Carcinoma: Etiology and Current and Future Drugs","volume":"9","author":"Jindal","year":"2019","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/hep.26986","article-title":"Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.","volume":"59","author":"Wong","year":"2014","journal-title":"Hepatology"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"An, L., Wirth, U., Koch, D., Schirren, M., Drefs, M., Koliogiannis, D., Niess, H., Andrassy, J., Guba, M., and Bazhin, A.V. (2023). Metabolic Role of Autophagy in the Pathogenesis and Development of NAFLD. Metabolites, 13.","DOI":"10.3390\/metabo13010101"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1016\/j.ajpath.2011.07.014","article-title":"Melanocortin 4 Receptor\u2013Deficient Mice as a Novel Mouse Model of Nonalcoholic Steatohepatitis","volume":"179","author":"Itoh","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_176","first-page":"111","article-title":"Bile Acid\u2013microbiota Crosstalk in Gastrointestinal Inflammation and Carcinogenesis","volume":"15","author":"Wang","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Milosevic, I., Vujovic, A., Barac, A., Djelic, M., Korac, M., Radovanovic Spurnic, A., Gmizic, I., Stevanovic, O., Djordjevic, V., and Lekic, N. (2019). Gut-Liver Axis, Gut Microbiota, and Its Modulation in the Management of Liver Diseases: A Review of the Literature. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020395"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Yu, L., Li, Y., Song, S., Zhang, Y., Wang, Y., Wang, H., Yang, Z., and Wang, Y. (2024). The dual role of sirtuins in cancer: Biological functions and implications. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1384928"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/1878-0261.12067","article-title":"USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1\/AKT\/MRP1 signaling pathway","volume":"11","author":"Ling","year":"2017","journal-title":"Mol. Oncol."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Hao, C., Zhu, P.-X., Yang, X., Han, Z.-P., Jiang, J.-H., Zong, C., Zhang, X.-G., Liu, W.-T., Zhao, Q.-D., and Fan, T.-T. (2014). Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-978"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1136\/gutjnl-2017-315084","article-title":"Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma","volume":"68","author":"Ren","year":"2018","journal-title":"Gut"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.redox.2017.03.006","article-title":"Butyrate induces ROS-mediated apoptosis by modulating miR-22\/SIRT-1 pathway in hepatic cancer cells","volume":"12","author":"Pant","year":"2017","journal-title":"Redox Biol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/sj.bjc.6605895","article-title":"microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity","volume":"103","author":"Zhang","year":"2010","journal-title":"Br. J. Cancer"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Qian, L., Zhang, Y., Wang, G., Li, B., Zhou, H., Qiu, J., and Qin, L. (2023). MicroRNA-29 Regulates Tumor Progression and Survival Through miR-29a-SIRT1-Wnt\/\u03b2-catenin Pathway in Hepatocellular Carcinoma. Biochem. Genet., preprint.","DOI":"10.21203\/rs.3.rs-2773899\/v1"},{"key":"ref_185","first-page":"1064","article-title":"Ubiquitin-Specific Protease 22\/Silent Information Regulator 1 Axis Plays a Pivotal Role in the Prognosis and 5-Fluorouracil Resistance in Hepatocellular Carcinoma","volume":"65","author":"Wang","year":"2019","journal-title":"Dig. Dis. Sci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1038\/onc.2016.521","article-title":"LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells","volume":"36","author":"Xiong","year":"2017","journal-title":"Oncogene"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Zhou, Z.-Q., Guan, J., Chen, S., Sun, J., and Zhang, Z. (2022). Sirtuin 1 Protects the Mitochondria in Hepatocellular Carcinoma Cells via Suppressing Hypoxia-Induced Factor-1 Alpha Expression. Mol. Cell. Biochem., preprint.","DOI":"10.21203\/rs.3.rs-1186638\/v1"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"29255","DOI":"10.18632\/oncotarget.8711","article-title":"SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1\u03b1-mediated mitochondrial biogenesis","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms1001","article-title":"Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer","volume":"1","author":"Herranz","year":"2010","journal-title":"Nat. Commun."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1245\/s10434-011-2159-4","article-title":"SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis","volume":"19","author":"Chen","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1158\/0008-5472.CAN-10-4274","article-title":"Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth","volume":"71","author":"Chen","year":"2011","journal-title":"Cancer Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1038\/onc.2008.345","article-title":"The epithelial polarity program: Machineries involved and their hijacking by cancer","volume":"27","author":"Tanos","year":"2008","journal-title":"Oncogene"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1158\/1535-7163.MCT-12-0700","article-title":"Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo","volume":"12","author":"Portmann","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/hep.26278","article-title":"SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B\/glycogen synthase kinase-3\u03b2\/\u03b2-catenin signaling","volume":"57","author":"Chen","year":"2013","journal-title":"Hepatology"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.tranon.2017.09.006","article-title":"Downregulation of SIRT2 Inhibits Invasion of Hepatocellular Carcinoma by Inhibiting Energy Metabolism","volume":"10","author":"Huang","year":"2017","journal-title":"Transl. Oncol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/onc.2015.121","article-title":"Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3\u03b2\/BCL2-associated X protein-dependent apoptotic pathway","volume":"35","author":"Song","year":"2015","journal-title":"Oncogene"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Zeng, X., Wang, N., Zhai, H., Wang, R., Wu, J., and Pu, W. (2017). SIRT3 functions as a tumor suppressor in hepatocellular carcinoma. Tumor Biol., 39.","DOI":"10.1177\/1010428317691178"},{"key":"ref_198","first-page":"978","article-title":"The expression of SIRT3 in primary hepatocellular carcinoma and the mechanism of its tumor suppressing effects","volume":"21","author":"Liu","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbrc.2012.05.053","article-title":"Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation","volume":"423","author":"Zhang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"50117","DOI":"10.18632\/oncotarget.10319","article-title":"Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1\/JNK signaling pathway","volume":"7","author":"Tao","year":"2016","journal-title":"Oncotarget"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/hep.30421","article-title":"Sirtuin 4 Depletion Promotes Hepatocellular Carcinoma Tumorigenesis Through Regulating Adenosine-Monophosphate\u2013Activated Protein Kinase Alpha\/Mammalian Target of Rapamycin Axis in Mice","volume":"69","author":"Wang","year":"2019","journal-title":"Hepatology"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Huang, F.-Y., Wong, D.K.-H., Seto, W.-K., Mak, L.-Y., Cheung, T.-T., and Yuen, M.-F. (2021). Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2\/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma. Cell Death Discov., 7.","DOI":"10.1038\/s41420-021-00470-8"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.7150\/jca.31266","article-title":"SIRT5 Promotes Hepatocellular Carcinoma Progression by Regulating Mitochondrial Apoptosis","volume":"10","author":"Zhang","year":"2019","journal-title":"J. Cancer"},{"key":"ref_204","first-page":"342","article-title":"SIRT5 promotes cell proliferation and invasion in hepatocellular carcinoma by targeting E2F1","volume":"17","author":"Chang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Lee, N., Ryu, H.G., Kwon, J.-H., Kim, D.-K., Kim, S.R., Wang, H.J., Kim, K.-T., and Choi, K.Y. (2016). SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165835"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"882","DOI":"10.3892\/mmr.2013.1879","article-title":"Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal-regulated kinase signaling pathway","volume":"9","author":"Zhang","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"ref_207","first-page":"1575","article-title":"SIRT6 regulates the proliferation and apoptosis of hepatocellular carcinoma via the ERK1\/2 signaling pathway","volume":"20","author":"Zhang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1158\/1078-0432.CCR-15-1638","article-title":"SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein\u2013Dependent Apoptotic Pathway","volume":"22","author":"Ran","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.gendis.2020.08.007","article-title":"Hepatic SIRT6 deficit promotes liver tumorigenesis in the mice models","volume":"9","author":"Wang","year":"2020","journal-title":"Genes Dis."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/hep.26101","article-title":"Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b","volume":"57","author":"Kim","year":"2013","journal-title":"Hepatology"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Kim, Y., Jung, K.-Y., Kim, Y.H., Xu, P., Kang, B.E., Jo, Y., Pandit, N., Kwon, J., Gariani, K., and Gariani, J. (2024). Inhibition of SIRT7 Overcomes Sorafenib Acquired Resistance by Suppressing ERK1\/2 Phosphorylation via the DDX3X-mediated NLRP3 Inflammasome in Hepatocellular Carcinoma. Drug Resist. Updates, 73.","DOI":"10.1016\/j.drup.2024.101054"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/cas.16091","article-title":"SIRT7 Promotes Hippo\/YAP Activation and Cancer Cell Proliferation in Hepatocellular Carcinoma via Suppressing MST1","volume":"115","author":"Gu","year":"2024","journal-title":"Cancer Sci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2174\/0929867324666171009121702","article-title":"Gut Microbiota as a Therapeutic Target for Metabolic Disorders","volume":"25","author":"Okubo","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Cani, P.D., Moens de Hase, E., and Van Hul, M. (2021). Gut Microbiota and Host Metabolism: From Proof of Concept to Therapeutic Intervention. Microorganisms, 9.","DOI":"10.3390\/microorganisms9061302"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/hep.29892","article-title":"Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD","volume":"68","author":"Caussy","year":"2018","journal-title":"Hepatology"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Zeybel, M., Arif, M., Li, X., Altay, O., Yang, H., Shi, M., Akyildiz, M., Saglam, B., Gonenli, M.G., and Yigit, B. (2022). Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis. Adv. Sci., 9.","DOI":"10.1002\/advs.202104373"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Liu, L., Fu, Q., Li, T., Shao, K., Zhu, X., Cong, Y., and Zhao, X. (2022). Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0262855"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.transproceed.2016.01.077","article-title":"Profile of Gut Microbiota Associated with the Presence of Hepatocellular Cancer in Patients with Liver Cirrhosis","volume":"48","author":"Wronka","year":"2016","journal-title":"Transplant. Proc."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Ni, J., Huang, R., Zhou, H., Xu, X., Li, Y., Cao, P., Zhong, K., Ge, M., Chen, X., and Hou, B. (2019). Analysis of the Relationship Between the Degree of Dysbiosis in Gut Microbiota and Prognosis at Different Stages of Primary Hepatocellular Carcinoma. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.01458"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/hep.30036","article-title":"Hepatocellular Carcinoma Is Associated with Gut Microbiota Profile and Inflammation in Nonalcoholic Fatty Liver Disease","volume":"69","author":"Ponziani","year":"2019","journal-title":"Hepatology"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1002\/cam4.3045","article-title":"Liver cirrhosis contributes to the disorder of gut microbiota in patients with hepatocellular carcinoma","volume":"9","author":"Zheng","year":"2020","journal-title":"Cancer Med."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-20422-7","article-title":"Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma","volume":"12","author":"Behary","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pharmthera.2018.03.004","article-title":"Sirtuin activators and inhibitors: Promises, achievements, and challenges","volume":"188","author":"Dai","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Manjula, R., Anuja, K., and Alcain, F.J. (2021). SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.585821"},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Tian, C., Huang, R., and Xiang, M. (2024). SIRT1: Harnessing multiple pathways to hinder NAFLD. Pharmacol. Res., 203.","DOI":"10.1016\/j.phrs.2024.107155"},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Lakhan, S.E., and Kirchgessner, A. (2011). Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction. J. Transl. Med., 9.","DOI":"10.1186\/1479-5876-9-202"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnesp.2021.06.026","article-title":"Polyphenols in the prevention and treatment of non-alcoholic fatty liver disease: An update of preclinical and clinical studies","volume":"44","author":"Bayram","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Wang, P., Wang, J., Li, D., Ke, W., Chen, F., and Hu, X. (2020). Targeting the gut microbiota with resveratrol: A demonstration of novel evidence for the management of hepatic steatosis. J. Nutr. Biochem., 81.","DOI":"10.1016\/j.jnutbio.2020.108363"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Du, F., Huang, R., Lin, D., Wang, Y., Yang, X., Huang, X., Zheng, B., Chen, Z., Huang, Y., and Wang, X. (2021). Resveratrol Improves Liver Steatosis and Insulin Resistance in Non-alcoholic Fatty Liver Disease in Association with the Gut Microbiota. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.611323"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Prakash, V., Bose, C., Sunilkumar, D., Cherian, R.M., Thomas, S.S., and Nair, B.G. (2024). Resveratrol as a Promising Nutraceutical: Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25063370"},{"key":"ref_231","first-page":"71","article-title":"Possible protective effects of resveratrol in hepatocellular carcinoma","volume":"23","author":"Karabekir","year":"2020","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"He, X., Li, Y., Deng, X., Xiao, X., and Zeng, J. (2023). Integrative evidence construction for resveratrol treatment of nonalcoholic fatty liver disease: Preclinical and clinical meta-analyses. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1230783"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11010-016-2807-x","article-title":"Resveratrol supplement inhibited the NF-\u03baB inflammation pathway through activating AMPK\u03b1-SIRT1 pathway in mice with fatty liver","volume":"422","author":"Tian","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1021\/acs.jafc.9b04259","article-title":"Pterostilbene improves hepatic lipid accumulation via the MiR-34a\/Sirt1\/SREBP-1 pathway in fructose-fed rats","volume":"68","author":"Wu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/10408363.2013.805182","article-title":"Pterostilbene: Biomedical applications","volume":"50","author":"Estrela","year":"2013","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"8371","DOI":"10.1021\/jf501318b","article-title":"Pterostilbene, a Dimethyl Ether Derivative of Resveratrol, Reduces Fat Accumulation in Rats Fed an Obesogenic Diet","volume":"62","author":"Lasa","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/biof.1410","article-title":"Metabolism and pharmacokinetics of resveratrol and pterostilbene","volume":"44","author":"Wang","year":"2018","journal-title":"BioFactors"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.3390\/cimb45060321","article-title":"SIRT1 Activator E1231 Alleviates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism","volume":"45","author":"Han","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.tiv.2013.01.014","article-title":"Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells","volume":"27","author":"Vidyashankar","year":"2013","journal-title":"Toxicol. Vitr."},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Cao, P., Wang, Y., Zhang, C., Sullivan, M.A., Chen, W., Jing, X., Yu, H., Li, F., Wang, Q., and Zhou, Z. (2023). Quercetin ameliorates nonalcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy. J. Nutr. Biochem., 120.","DOI":"10.1016\/j.jnutbio.2023.109414"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.fct.2012.10.030","article-title":"Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils","volume":"52","author":"Ying","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Chen, L., Liu, J., Mei, G., Chen, H., Peng, S., Zhao, Y., Yao, P., and Tang, Y. (2021). Quercetin and non-alcoholic fatty liver disease: A review based on experimental data and bioinformatic analysis. Food Chem. Toxicol., 154.","DOI":"10.1016\/j.fct.2021.112314"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.bbadis.2019.06.009","article-title":"Nicotinamide riboside, an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis","volume":"1865","author":"Pham","year":"2019","journal-title":"Biochim. Biophys. Acta BBA Mol. Basis Dis."},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Longo, L., de Castro, J.M., Keingeski, M.B., Rampelotto, P.H., Stein, D.J., Guerreiro, G.T.S., de Souza, V.E.G., Cerski, C.T.S., Uribe-Cruz, C., and Torres, I.L. (2023). Nicotinamide riboside and dietary restriction effects on gut microbiota and liver inflammatory and morphologic markers in cafeteria diet\u2013induced obesity in rats. Nutrition, 110.","DOI":"10.1016\/j.nut.2023.112019"},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Han, X., Bao, X., Lou, Q., Xie, X., Zhang, M., Zhou, S., Guo, H., Jiang, G., and Shi, Q. (2019). Nicotinamide riboside exerts protective effect against aging-induced NAFLD-like hepatic dysfunction in mice. PeerJ, 7.","DOI":"10.7717\/peerj.7568"},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Zhang, H., Zhao, X., Zhang, L., Sun, D., Ma, Y., Bai, Y., Bai, X., Liang, X., and Liang, H. (2024). Nicotinamide Riboside Ameliorates Fructose-Induced Lipid Metabolism Disorders in Mice by Activating Browning of WAT, and May Be Also Related to the Regulation of Gut Microbiota. Nutrients, 16.","DOI":"10.3390\/nu16223920"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Pang, N., Hu, Q., Zhou, Y., Xiao, Y., Li, W., Ding, Y., Chen, Y., Ye, M., Pei, L., and Li, Q. (2023). Nicotinamide Adenine Dinucleotide Precursor Suppresses Hepatocellular Cancer Progression in Mice. Nutrients, 15.","DOI":"10.3390\/nu15061447"},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Lin, X., Zhang, J., Chu, Y., Nie, Q., and Zhang, J. (2024). Berberine prevents NAFLD and HCC by modulating metabolic disorders. Pharmacol. Ther., 254.","DOI":"10.1016\/j.pharmthera.2024.108593"},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Dai, Y., Zhu, W., Zhou, J., and Shen, T. (2022). The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in rats. Braz. J. Med. Biol. Res., 55.","DOI":"10.1590\/1414-431x2022e12096"},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Shu, X., Li, M., Cao, Y., Li, C., Zhou, W., Ji, G., and Zhang, L. (2021). Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.750826"},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Ionita-Radu, F., Patoni, C., Nancoff, A.S., Marin, F.-S., Gaman, L., Bucurica, A., Socol, C., Jinga, M., Dutu, M., and Bucurica, S. (2024). Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease\u2014Clinical and Pre-Clinical Overview and Systematic Review of the Literature. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084201"},{"key":"ref_252","first-page":"2668","article-title":"Berberine prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma by inhibiting inflammation and angiogenesis in mice","volume":"11","author":"Luo","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Jiang, H., Mao, T., Sun, Z., Shi, L., Han, X., Zhang, Y., Zhang, X., Wang, J., Hu, J., and Zhang, L. (2022). Yinchen Linggui Zhugan decoction ameliorates high fat diet-induced nonalcoholic fatty liver disease by modulation of SIRT1\/Nrf2 signaling pathway and gut microbiota. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1001778"},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"Wang, S., Li, X., Zhang, B., Li, Y., Chen, K., Qi, H., Gao, M., Rong, J., Liu, L., and Wan, Y. (2024). Tangshen formula targets the gut microbiota to treat non-alcoholic fatty liver disease in HFD mice: A 16S rRNA and non-targeted metabolomics analyses. Biomed. Pharmacother., 173.","DOI":"10.1016\/j.biopha.2024.116405"},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Wang, Y., Zhao, H., Li, X., Li, N., Wang, Q., Liu, Y., Liang, Q., Shao, Z., Zhang, N., and Zhao, T. (2019). Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK\/SIRT1 Pathway. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00494"},{"key":"ref_256","first-page":"1693","article-title":"Experimental study of Tangshen formulain improved lipid metabolism and phenotypic switch of macrophage in db\/db mice","volume":"41","author":"Kong","year":"2014","journal-title":"China J. Chin. Mater. Medica"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/ptr.5659","article-title":"Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial","volume":"30","author":"Rahmani","year":"2016","journal-title":"Phytotherapy Res."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2174\/1381612822666161010115235","article-title":"Is there a role for curcumin supplementation in the treatment of non-alcoholic fatty liver disease? The data suggest yes","volume":"23","author":"Pirro","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"ref_259","doi-asserted-by":"crossref","unstructured":"Lee, D.E., Lee, S.J., Kim, S.J., Lee, H.-S., and Kwon, O.-S. (2019). Curcumin Ameliorates Nonalcoholic Fatty Liver Disease through Inhibition of O-GlcNAcylation. Nutrients, 11.","DOI":"10.3390\/nu11112702"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1039\/D1FO03752H","article-title":"Curcumin alleviates hepatic steatosis by improving mitochondrial function in postnatal overfed rats and fatty L02 cells through the SIRT3 pathway","volume":"13","author":"Du","year":"2022","journal-title":"Food Funct."},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Gong, H., Xu, H., Li, M., and Zhang, D. (2022). Molecular mechanism and therapeutic significance of dihydromyricetin in nonalcoholic fatty liver disease. Eur. J. Pharmacol., 935.","DOI":"10.1016\/j.ejphar.2022.175325"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.4014\/jmb.2406.06048","article-title":"Dihydromyricetin Alleviates Non-Alcoholic Fatty Liver Disease by Modulating Gut Microbiota and Inflammatory Signaling Pathways","volume":"34","author":"Kang","year":"2024","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1089\/ars.2017.7172","article-title":"Dihydromyricetin Ameliorates Nonalcoholic Fatty Liver Disease by Improving Mitochondrial Respiratory Capacity and Redox Homeostasis Through Modulation of SIRT3 Signaling","volume":"30","author":"Zeng","year":"2019","journal-title":"Antioxidants Redox Signal."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.lfs.2016.06.001","article-title":"Dihydromyricetin ameliorates oleic acid-induced lipid accumulation in L02 and HepG2 cells by inhibiting lipogenesis and oxidative stress","volume":"157","author":"Xie","year":"2016","journal-title":"Life Sci."},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Bahar, A.N., Keskin-Aktan, A., Akarca-Dizakar, S.\u00d6., Sonug\u00fcr, G., and Akbulut, K.G. (2024). AGK2, a SIRT2 inhibitor, ameliorates D-galactose-induced liver fibrosis by inhibiting fibrogenic factors. J. Biochem. Mol. Toxicol., 38.","DOI":"10.1002\/jbt.70000"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1074\/jbc.M113.487736","article-title":"A Novel Sirtuin 2 (SIRT2) Inhibitor with p53-dependent Pro-apoptotic Activity in Non-small Cell Lung Cancer","volume":"289","author":"Hoffmann","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2174\/1568026619666190510103416","article-title":"Recent Progress on the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers","volume":"19","author":"Wang","year":"2019","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Kaya, S.G., and Eren, G. (2023). Selective inhibition of SIRT2: A disputable therapeutic approach in cancer therapy. Bioorganic Chem., 143.","DOI":"10.1016\/j.bioorg.2023.107038"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"975","DOI":"10.2147\/JHC.S456683","article-title":"CRISPR in Targeted Therapy and Adoptive T Cell Immunotherapy for Hepatocellular Carcinoma","volume":"11","author":"Palaz","year":"2024","journal-title":"J. Hepatocell. Carcinoma"},{"key":"ref_270","doi-asserted-by":"crossref","unstructured":"He, L., Li, Z., Su, D., Du, H., Zhang, K., Zhang, W., Wang, S., Xie, F., Qiu, Y., and Ma, S. (2024). Tumor Microenvironment-Responsive Nanocapsule Delivery CRISPR\/Cas9 to Reprogram the Immunosuppressive Microenvironment in Hepatoma Carcinoma. Adv. Sci., 11.","DOI":"10.1002\/advs.202403858"},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"Yu, S., Zhao, R., Zhang, B., Lai, C., Li, L., Shen, J., Tan, X., and Shao, J. (2023). Research progress and application of the CRISPR\/Cas9 gene-editing technology based on hepatocellular carcinoma. Asian J. Pharm. Sci., 18.","DOI":"10.1016\/j.ajps.2023.100828"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1007\/s13277-015-3488-x","article-title":"Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: A potential therapeutic target","volume":"36","author":"Wu","year":"2015","journal-title":"Tumor Biol."},{"key":"ref_273","doi-asserted-by":"crossref","unstructured":"Kamal, M.A., Mandour, Y.M., El-Aziz, M.K.A., Stein, U., and El Tayebi, H.M. (2022). Small Molecule Inhibitors for Hepatocellular Carcinoma: Advances and Challenges. Molecules, 27.","DOI":"10.3390\/molecules27175537"},{"key":"ref_274","doi-asserted-by":"crossref","unstructured":"Binarci, B., K\u0131l\u0131\u00e7, E., Do\u011fan, T., \u00c7etin-Atalay, R., Kahraman, D., and Bayta\u015f, S.N. (2024). Design, Synthesis, and Evaluation of Novel Indole-Based Small Molecules as Sirtuin Inhibitors with Anticancer Activities. Drug Dev. Res., 85.","DOI":"10.1002\/ddr.70008"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"17319","DOI":"10.1021\/acs.jmedchem.4c01223","article-title":"Discovery of Novel PROTAC SIRT6 Degraders with Potent Efficacy against Hepatocellular Carcinoma","volume":"67","author":"Huang","year":"2024","journal-title":"J. Med. Chem."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.trsl.2020.07.012","article-title":"Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions","volume":"226","author":"Holmes","year":"2020","journal-title":"Transl. Res."},{"key":"ref_277","doi-asserted-by":"crossref","unstructured":"Markowiak, P., and \u015ali\u017cewska, K. (2017). Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients, 9.","DOI":"10.3390\/nu9091021"},{"key":"ref_278","doi-asserted-by":"crossref","unstructured":"Manzoor, S., Wani, S.M., Mir, S.A., and Rizwan, D. (2022). Role of probiotics and prebiotics in mitigation of different diseases. Nutrition, 96.","DOI":"10.1016\/j.nut.2022.111602"},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"Upasana (2022). Application of Probiotics, Prebiotics and Synbiotics in Maintaining Gut Health. Indian J. Nutr. Diet., 59, 388\u2013397.","DOI":"10.21048\/IJND.2022.59.3.29516"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00253-021-11646-8","article-title":"Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics","volume":"106","author":"Yadav","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12016-023-08958-0","article-title":"The Evolving Landscape of Fecal Microbial Transplantation","volume":"65","author":"Shao","year":"2023","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_282","doi-asserted-by":"crossref","unstructured":"Abenavoli, L., Maurizi, V., Rinninella, E., Tack, J., Di Berardino, A., Santori, P., Rasetti, C., Procopio, A.C., Boccuto, L., and Scarpellini, E. (2022). Fecal Microbiota Transplantation in NAFLD Treatment. Medicina, 58.","DOI":"10.3390\/medicina58111559"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3748\/wjg.v30.i8.833","article-title":"Fecal microbiota transplantation for treatment of non-alcoholic fatty liver disease: Mechanism, clinical evidence, and prospect","volume":"30","author":"Qiu","year":"2024","journal-title":"World J. Gastroenterol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/6\/466\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:57:28Z","timestamp":1760029048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/6\/466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":283,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["cells14060466"],"URL":"https:\/\/doi.org\/10.3390\/cells14060466","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,20]]}}}