{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:30:50Z","timestamp":1790613050530,"version":"4.1.0"},"reference-count":94,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Cancer Center","award":["NCC-24H1200"],"award-info":[{"award-number":["NCC-24H1200"]}]},{"name":"the National Cancer Center","award":["NCC-2510750"],"award-info":[{"award-number":["NCC-2510750"]}]},{"name":"the National Cancer Center","award":["2020R1A2B5B01002011"],"award-info":[{"award-number":["2020R1A2B5B01002011"]}]},{"name":"the National Cancer Center","award":["RS-2023-00249301"],"award-info":[{"award-number":["RS-2023-00249301"]}]},{"name":"National Research Foundation of Korea","award":["NCC-24H1200"],"award-info":[{"award-number":["NCC-24H1200"]}]},{"name":"National Research Foundation of Korea","award":["NCC-2510750"],"award-info":[{"award-number":["NCC-2510750"]}]},{"name":"National Research Foundation of Korea","award":["2020R1A2B5B01002011"],"award-info":[{"award-number":["2020R1A2B5B01002011"]}]},{"name":"National Research Foundation of Korea","award":["RS-2023-00249301"],"award-info":[{"award-number":["RS-2023-00249301"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>A20 is a ubiquitin-editing enzyme that has emerged as a key regulator of inflammatory signaling with paradoxical roles in cancer. Acting as both an oncogene and a tumor suppressor gene depending on the cellular context, A20 modulates important cell pathways, such as NF-\u03baB signaling and autophagy. In this review, we summarize the dual roles of A20 in tumorigenesis, highlighting its ability to promote tumor progression in cancers, such as breast and melanoma, while functioning as a tumor suppressor in lymphomas and hepatocellular carcinoma. We discuss the interplay of A20 with autophagy, a process that is important for maintaining cellular homeostasis and influencing tumor dynamics. By integrating recent findings, we provide insight into how dysregulation of A20 and its associated pathways can either suppress or drive cancer development, which may lead to improved therapeutic intervention.<\/jats:p>","DOI":"10.3390\/cells14070544","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T11:31:00Z","timestamp":1743766260000},"page":"544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Role of A20 in Cancer: Friend or Foe?"],"prefix":"10.3390","volume":"14","author":[{"given":"Jinju","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cancer Biology, Research Institute, National Cancer Center, Goyang-si 10408, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1946-107X","authenticated-orcid":false,"given":"Heesun","family":"Cheong","sequence":"additional","affiliation":[{"name":"Division of Cancer Biology, Research Institute, National Cancer Center, Goyang-si 10408, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.molcel.2010.10.009","article-title":"Ubiquitin Binding to A20 Znf4 Is Required for Modulation of Nf-\u03bab Signaling","volume":"40","author":"Bosanac","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1038\/emboj.2012.241","article-title":"Specific Recognition of Linear Polyubiquitin by A20 Zinc Finger 7 Is Involved in Nf-\u03bab Regulation","volume":"31","author":"Tokunaga","year":"2012","journal-title":"EMBO J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1038\/emboj.2012.240","article-title":"A20 Inhibits Lubac-Mediated Nf-\u03bab Activation by Binding Linear Polyubiquitin Chains Via Its Zinc Finger 7","volume":"31","author":"Verhelst","year":"2012","journal-title":"EMBO J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nature02794","article-title":"De-Ubiquitination and Ubiquitin Ligase Domains of A20 Downregulate Nf-Kappab Signalling","volume":"430","author":"Wertz","year":"2004","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1016\/S0021-9258(19)39896-5","article-title":"Tumor Necrosis Factor-Alpha Induction of Novel Gene Products in Human Endothelial Cells Including a Macrophage-Specific Chemotaxin","volume":"265","author":"Dixit","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1083\/jcb.145.7.1471","article-title":"The Zinc Finger Protein A20 Inhibits Tnf-Induced Nf-Kappab-Dependent Gene Expression by Interfering with an Rip- or Traf2-Mediated Transactivation Signal and Directly Binds to a Novel Nf-Kappab-Inhibiting Protein Abin","volume":"145","author":"Heyninck","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/cmi.2011.59","article-title":"Regulation of Nf-\u03bab Signaling by the A20 Deubiquitinase","volume":"9","author":"Shembade","year":"2012","journal-title":"Cell Mol. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/0022034520949486","article-title":"The Ubiquitin System and A20: Implications in Health and Disease","volume":"100","author":"Mooney","year":"2021","journal-title":"J. Dent. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.canlet.2021.04.017","article-title":"The Dual Roles of A20 in Cancer","volume":"511","author":"Shi","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e001866","DOI":"10.1136\/jitc-2020-001866","article-title":"A20 Regulates the Therapeutic Effect of Anti-Pd-1 Immunotherapy in Melanoma","volume":"8","author":"Guo","year":"2020","journal-title":"J. Imunother. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1111\/cas.14932","article-title":"Casp8 Acts through A20 to Inhibit Pd-L1 Expression: The Mechanism and Its Implication in Immunotherapy","volume":"112","author":"Zou","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/emboj.2008.285","article-title":"The Ubiquitin-Editing Enzyme A20 Requires Rnf11 to Downregulate Nf-Kappab Signalling","volume":"28","author":"Shembade","year":"2009","journal-title":"EMBO J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/cdd.2009.168","article-title":"Regulation of Death Receptor Signaling by the Ubiquitin System","volume":"17","author":"Wertz","year":"2010","journal-title":"Cell Death Differ."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.it.2013.10.005","article-title":"A20 in Inflammation and Autoimmunity","volume":"35","author":"Catrysse","year":"2014","journal-title":"Trends Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/ni1110","article-title":"The Ubiquitin-Modifying Enzyme A20 Is Required for Termination of Toll-Like Receptor Responses","volume":"5","author":"Boone","year":"2004","journal-title":"Nat. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1126\/science.289.5488.2350","article-title":"Failure to Regulate Tnf-Induced Nf-Kappab and Cell Death Responses in A20-Deficient Mice","volume":"289","author":"Lee","year":"2000","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.immuni.2011.05.013","article-title":"The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity","volume":"35","author":"Kool","year":"2011","journal-title":"Immunity"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.immuni.2010.07.017","article-title":"The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity","volume":"33","author":"Tavares","year":"2010","journal-title":"Immunity"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1038\/ncomms6103","article-title":"A20 Controls Intestinal Homeostasis through Cell-Specific Activities","volume":"5","author":"Vereecke","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_20","first-page":"E9192","article-title":"Elevated A20 Promotes Tnf-Induced and Ripk1-Dependent Intestinal Epithelial Cell Death","volume":"115","author":"Wong","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2147\/IJGM.S461561","article-title":"A20 Promoter Rs5029924 Concomitant with Rs2230926 and Rs5029937 May Be a Prognostic Predictor for Joint Deformity or Refractory Rheumatoid Arthritis","volume":"17","author":"Zhu","year":"2024","journal-title":"Int. J. Gen. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12967-015-0566-1","article-title":"Characteristics of A20 Gene Polymorphisms and Clinical Significance in Patients with Rheumatoid Arthritis","volume":"13","author":"Zhu","year":"2015","journal-title":"J. Transl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/ng.202","article-title":"Multiple Polymorphisms in the Tnfaip3 Region Are Independently Associated with Systemic Lupus Erythematosus","volume":"40","author":"Musone","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"103722","DOI":"10.1016\/j.autrev.2024.103722","article-title":"A20 Haploinsufficiency Diagnosis Beyond Systemic Lupus Erythematosus: A Systematic Review of the Literature","volume":"24","author":"Philip","year":"2025","journal-title":"Autoimmun. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.311","article-title":"Psoriasis Collaborative Association Study of. Genome-Wide Scan Reveals Association of Psoriasis with Il-23 and Nf-Kappab Pathways","volume":"41","author":"Nair","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1158\/0008-5472.CAN-17-2143","article-title":"A20\/Tnfaip3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy","volume":"78","author":"Yang","year":"2018","journal-title":"Cancer Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/ncb3609","article-title":"A20 Promotes Metastasis of Aggressive Basal-Like Breast Cancers through Multi-Monoubiquitylation Of snail1","volume":"19","author":"Lee","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41388-018-0472-0","article-title":"The Pleiotropic Effects of Tnfalpha in Breast Cancer Subtypes Is Regulated by Tnfaip3\/A20","volume":"38","author":"Lee","year":"2019","journal-title":"Oncogene"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"681","DOI":"10.21873\/anticanres.15527","article-title":"The A20\/Tnfaip3-Cdc20-Casp1 Axis Promotes Inflammation-Mediated Metastatic Disease in Triple-Negative Breast Cancer","volume":"42","author":"Song","year":"2022","journal-title":"Anticancer Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Yoon, C.I., Ahn, S.G., Bae, S.J., Shin, Y.J., Cha, C., Park, S.E., Lee, J.H., Ooshima, A., Lee, H.S., and Yang, K.M. (2019). High A20 Expression Negatively Impacts Survival in Patients with Breast Cancer. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221721"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/s41419-020-03001-y","article-title":"A20 Promotes Melanoma Progression Via the Activation of Akt Pathway","volume":"11","author":"Ma","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"152471","DOI":"10.1016\/j.prp.2019.152471","article-title":"The Potential Role of Tnfaip3 in Malignant Transformation of Gastric Carcinoma","volume":"215","author":"Du","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00109-020-01902-1","article-title":"The Impact of DNA Demethylation on the Upregulation of the Nrn1 and Tnfaip3 Genes Associated with Advanced Gastric Cancer","volume":"98","author":"Wisnieski","year":"2020","journal-title":"J. Mol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s00018-022-04139-y","article-title":"A20 Undermines Alternative Nf-Kappab Activity and Expression of Anti-Apoptotic Genes in Helicobacter Pylori Infection","volume":"79","author":"Lim","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s13148-011-0049-z","article-title":"Clinico-Pathological Significance of Tnf Alpha-Induced Protein3 (Tnfaip3) in Middle Eastern Colorectal Carcinoma","volume":"2","author":"Bavi","year":"2011","journal-title":"Clin. Epigenetics"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1093\/carcin\/bgs256","article-title":"Genetic Variation and Alterations of Genes Involved in Nfkappab\/Tnfaip3- and Nlrp3-Inflammasome Signaling Affect Susceptibility and Outcome of Colorectal Cancer","volume":"33","author":"Ungerback","year":"2012","journal-title":"Carcinogenesis"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Shao, L., Oshima, S., Duong, B., Advincula, R., Barrera, J., Malynn, B.A., and Ma, A. (2013). A20 Restricts Wnt Signaling in Intestinal Epithelial Cells and Suppresses Colon Carcinogenesis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062223"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1038\/onc.2016.468","article-title":"Mir-19a Promotes Colitis-Associated Colorectal Cancer by Regulating Tumor Necrosis Factor Alpha-Induced Protein 3-Nf-Kappab Feedback Loops","volume":"36","author":"Wang","year":"2017","journal-title":"Oncogene"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41392-023-01545-x","article-title":"A20 Promotes Colorectal Cancer Immune Evasion by Upregulating Stc1 Expression to Block Eat-Me Signal","volume":"8","author":"Luo","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41419-022-05535-9","article-title":"Nf-Kappab\/Rela Controlled A20 Limits Trail-Induced Apoptosis in Pancreatic Cancer","volume":"14","author":"Geismann","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.canlet.2018.10.019","article-title":"A20-Mediated Deubiquitination of Eralpha in the Microenvironment of Cd163(+) Macrophages Sensitizes Endometrial Cancer Cells to Estrogen","volume":"442","author":"Lv","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mce.2015.12.009","article-title":"Tnf Alpha Signaling Is Associated with Therapeutic Responsiveness to Vascular Disrupting Agents in Endocrine Tumors","volume":"423","author":"Hantel","year":"2016","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wan, M., Zhou, Q., Wang, H., Wang, Z., Zhong, X., Zhang, L., Tai, S., and Cui, Y. (2015). The Prognostic Role of Socs3 and A20 in Human Cholangiocarcinoma. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141165"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s12013-013-9556-1","article-title":"Bladder Polypoid Cystitis-Derived A20 Associates with Tumorigenesis","volume":"67","author":"Wang","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3892\/ijo.2017.3869","article-title":"Tnfaip3 Overexpression Is an Independent Factor for Poor Survival in Esophageal Squamous Cell Carcinoma","volume":"50","author":"Hadisaputri","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cancergen.2015.09.008","article-title":"Evaluation of the Germline Single Nucleotide Polymorphism Rs583522 in the Tnfaip3 Gene as a Prognostic Marker in Esophageal Cancer","volume":"208","author":"Ghadban","year":"2015","journal-title":"Cancer Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jamcollsurg.2015.12.047","article-title":"Identification of Novel Oncogenic Mutations in Thyroid Cancer","volume":"222","author":"Pitt","year":"2016","journal-title":"J. Am. Coll Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13046-016-0465-1","article-title":"Microrna-19b-3p Regulates Nasopharyngeal Carcinoma Radiosensitivity by Targeting Tnfaip3\/Nf-Kappab Axis","volume":"35","author":"Huang","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nature07969","article-title":"Frequent Inactivation of A20 in B-Cell Lymphomas","volume":"459","author":"Kato","year":"2009","journal-title":"Nature"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1182\/blood-2008-12-194852","article-title":"Tnfaip3\/A20 Functions as a Novel Tumor Suppressor Gene in Several Subtypes of Non-Hodgkin Lymphomas","volume":"114","author":"Honma","year":"2009","journal-title":"Blood"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1084\/jem.20090528","article-title":"Tnfaip3 (A20) Is a Tumor Suppressor Gene in Hodgkin Lymphoma and Primary Mediastinal B Cell Lymphoma","volume":"206","author":"Schmitz","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/nrclinonc.2013.197","article-title":"Diffuse Large B-Cell Lymphoma-Treatment Approaches in the Molecular Era","volume":"11","author":"Roschewski","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1182\/bloodadvances.2022009412","article-title":"Molecular Associations of Response to the New-Generation Btk Inhibitor Zanubrutinib in Marginal Zone Lymphoma","volume":"7","author":"Tatarczuch","year":"2023","journal-title":"Blood Adv."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1002\/ijc.25579","article-title":"Sustained Nf-Kappab Activity in Chronic Lymphocytic Leukemia Is Independent of Genetic and Epigenetic Alterations in the Tnfaip3 (A20) Locus","volume":"128","author":"Frenzel","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1179\/1607845414Y.0000000160","article-title":"Characteristics of A20 Gene Polymorphisms in T-Cell Acute Lymphocytic Leukemia","volume":"19","author":"Zhu","year":"2014","journal-title":"Hematology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12943-015-0454-6","article-title":"A20 Suppresses Hepatocellular Carcinoma Proliferation and Metastasis through Inhibition of Twist1 Expression","volume":"14","author":"Chen","year":"2015","journal-title":"Mol. Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e2250","DOI":"10.1038\/cddis.2016.154","article-title":"A20 Prevents Chronic Liver Inflammation and Cancer by Protecting Hepatocytes from Death","volume":"7","author":"Catrysse","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41419-020-2278-6","article-title":"A20 Targets Pfkl and Glycolysis to Inhibit the Progression of Hepatocellular Carcinoma","volume":"11","author":"Feng","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"14742","DOI":"10.18632\/oncotarget.7521","article-title":"A20 Inhibits the Motility of Hcc Cells Induced by Tnf-Alpha","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1158\/0008-5472.CAN-19-3578","article-title":"The Fire Within: Nf-Kappab Involvement in Non-Small Cell Lung Cancer","volume":"80","author":"Dimitrakopoulos","year":"2020","journal-title":"Cancer Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ccr.2013.03.009","article-title":"The Pivotal Role of Ikkalpha in the Development of Spontaneous Lung Squamous Cell Carcinomas","volume":"23","author":"Xiao","year":"2013","journal-title":"Cancer Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/ncb2428","article-title":"Reduced Cell Proliferation by Ikk2 Depletion in a Mouse Lung-Cancer Model","volume":"14","author":"Xia","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08462","article-title":"Requirement for Nf-Kappab Signalling in a Mouse Model of Lung Adenocarcinoma","volume":"462","author":"Meylan","year":"2009","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1038\/onc.2011.480","article-title":"Epithelial Nuclear Factor-Kappab Signaling Promotes Lung Carcinogenesis Via Recruitment of Regulatory T Lymphocytes","volume":"31","author":"Zaynagetdinov","year":"2012","journal-title":"Oncogene"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1158\/0008-5472.CAN-15-2580","article-title":"Mir-29b Mediates Nf-Kappab Signaling in Kras-Induced Non-Small Cell Lung Cancers","volume":"76","author":"Langsch","year":"2016","journal-title":"Cancer Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/jcb.29323","article-title":"Mir-605-5p Promotes Invasion and Proliferation by Targeting Tnfaip3 in Non-Small-Cell Lung Cancer","volume":"121","author":"Liao","year":"2020","journal-title":"J. Cell Biochem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"eabc3911","DOI":"10.1126\/scitranslmed.abc3911","article-title":"Down-Regulation of A20 Promotes Immune Escape of Lung Adenocarcinomas","volume":"13","author":"Breitenecker","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10735-012-9402-6","article-title":"Expression of A20 Is Reduced in Pancreatic Cancer Tissues","volume":"43","author":"Wang","year":"2012","journal-title":"J. Mol. Histol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e24651","DOI":"10.1097\/MD.0000000000024651","article-title":"The Prognostic Evaluation of Ca19-9, D-Dimer and Tnfaip3\/A20 in Patients with Pancreatic Ductal Adenocarcinoma","volume":"100","author":"Xu","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/abbs\/gmv129","article-title":"Mir-125a Regulates Chemo-Sensitivity to Gemcitabine in Human Pancreatic Cancer Cells through Targeting A20","volume":"48","author":"Yao","year":"2016","journal-title":"Acta Biochim. Et Biophys. Sin."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJMra2022774","article-title":"Autophagy in Human Diseases","volume":"383","author":"Mizushima","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological Functions of Autophagy Genes: A Disease Perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/15548627.2017.1402992","article-title":"Autophagy Balances Inflammation in Innate Immunity","volume":"14","author":"Deretic","year":"2018","journal-title":"Autophagy"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Jee, S.C., and Cheong, H. (2023). Autophagy\/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer Therapeutics. Cancers, 15.","DOI":"10.3390\/cancers15041112"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/cdd.2013.103","article-title":"Autophagy and Genomic Integrity","volume":"20","author":"Vessoni","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/45257","article-title":"Induction of Autophagy and Inhibition of Tumorigenesis by Beclin 1","volume":"402","author":"Liang","year":"1999","journal-title":"Nature"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"15077","DOI":"10.1073\/pnas.2436255100","article-title":"Beclin 1, an Autophagy Gene Essential for Early Embryonic Development, Is a Haploinsufficient Tumor Suppressor","volume":"100","author":"Yue","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.tcb.2010.03.002","article-title":"The Beclin 1-Vps34 Complex--at the Crossroads of Autophagy and Beyond","volume":"20","author":"Funderburk","year":"2010","journal-title":"Trends Cell Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/ncb0910-823","article-title":"Autophagy in Mammalian Development and Differentiation","volume":"12","author":"Mizushima","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/path.2509","article-title":"Frameshift Mutations of Autophagy-Related Genes Atg2b, Atg5, Atg9b and Atg12 in Gastric and Colorectal Cancers with Microsatellite Instability","volume":"217","author":"Kang","year":"2009","journal-title":"J. Pathol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1124\/jpet.116.233908","article-title":"Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease","volume":"358","author":"Barnard","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1158\/2159-8290.CD-14-0363","article-title":"Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance","volume":"4","author":"Guo","year":"2014","journal-title":"Cancer Discov."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1158\/2159-8290.CD-17-0952","article-title":"Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms","volume":"8","author":"Yang","year":"2018","journal-title":"Cancer Discov."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1080\/27694127.2022.2119743","article-title":"Interactions of Autophagy and the Immune System in Health and Diseases","volume":"1","author":"Pant","year":"2022","journal-title":"Autophagy Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"ra42","DOI":"10.1126\/scisignal.2000751","article-title":"Traf6 and A20 Regulate Lysine 63-Linked Ubiquitination of Beclin-1 to Control Tlr4-Induced Autophagy","volume":"3","author":"Shi","year":"2010","journal-title":"Sci. Signal."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00018-011-0819-y","article-title":"Regulation of Toll-Like Receptor Signaling by Ndp52-Mediated Selective Autophagy Is Normally Inactivated by A20","volume":"69","author":"Inomata","year":"2012","journal-title":"Cell Mol. Life Sci."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Zou, Z., Tao, T., Li, H., and Zhu, X. (2020). Mtor Signaling Pathway and Mtor Inhibitors in Cancer: Progress and Challenges. Cell Biosci., 10.","DOI":"10.1186\/s13578-020-00396-1"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1080\/15548627.2015.1055439","article-title":"Tnfaip3 Promotes Survival of Cd4 T Cells by Restricting Mtor and Promoting Autophagy","volume":"11","author":"Matsuzawa","year":"2015","journal-title":"Autophagy"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1080\/15548627.2018.1458804","article-title":"Tnfaip3-Deptor Complex Regulates Inflammasome Secretion through Autophagy in Ankylosing Spondylitis Monocytes","volume":"14","author":"Zhai","year":"2018","journal-title":"Autophagy"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1038\/ncomms6779","article-title":"Autophagy Enhances Nfkappab Activity in Specific Tissue Macrophages by Sequestering A20 to Boost Antifungal Immunity","volume":"6","author":"Kanayama","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1038\/s41467-019-09667-z","article-title":"Physical and Functional Interaction between A20 and Atg16l1-Wd40 Domain in the Control of Intestinal Homeostasis","volume":"10","author":"Slowicka","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"C339","DOI":"10.1152\/ajpcell.00493.2022","article-title":"A20 Binding and Inhibitor of Nuclear Factor Kappa B (Nf-\u03bab)-1 (Abin-1): A Novel Modulator of Mitochondrial Autophagy","volume":"324","author":"Merline","year":"2023","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbrc.2021.02.115","article-title":"A20 Regulates Inflammation through Autophagy Mediated by Nf-\u03bab Pathway in Human Nucleus Pulposus Cells and Ameliorates Disc Degeneration In vivo","volume":"549","author":"Zhang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.24976\/Discov.Med.202436187.149","article-title":"Tnfaip3 Overexpression Inhibits Diffuse Large B-Cell Lymphoma Progression by Promoting Autophagy through Tlr4\/Myd88\/Nf-Kappab Signaling Pathway","volume":"36","author":"Ning","year":"2024","journal-title":"Discov. Med."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/7\/544\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:10:02Z","timestamp":1760029802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/7\/544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":94,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["cells14070544"],"URL":"https:\/\/doi.org\/10.3390\/cells14070544","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]}}}