{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:15:40Z","timestamp":1785352540111,"version":"3.55.0"},"reference-count":64,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brigitta &amp; Norbert Muth Stiftung","award":["01-20021"],"award-info":[{"award-number":["01-20021"]}]},{"name":"Brigitta &amp; Norbert Muth Stiftung","award":["2020\u20132023"],"award-info":[{"award-number":["2020\u20132023"]}]},{"name":"Brigitta &amp; Norbert Muth Stiftung","award":["INST 371\/48-1 FUGG"],"award-info":[{"award-number":["INST 371\/48-1 FUGG"]}]},{"name":"Friedrich-Spicker-Stiftung","award":["01-20021"],"award-info":[{"award-number":["01-20021"]}]},{"name":"Friedrich-Spicker-Stiftung","award":["2020\u20132023"],"award-info":[{"award-number":["2020\u20132023"]}]},{"name":"Friedrich-Spicker-Stiftung","award":["INST 371\/48-1 FUGG"],"award-info":[{"award-number":["INST 371\/48-1 FUGG"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG) GZ","award":["01-20021"],"award-info":[{"award-number":["01-20021"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG) GZ","award":["2020\u20132023"],"award-info":[{"award-number":["2020\u20132023"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG) GZ","award":["INST 371\/48-1 FUGG"],"award-info":[{"award-number":["INST 371\/48-1 FUGG"]}]},{"name":"Frankfurter Stiftung f\u00fcr krebskranke Kinder","award":["01-20021"],"award-info":[{"award-number":["01-20021"]}]},{"name":"Frankfurter Stiftung f\u00fcr krebskranke Kinder","award":["2020\u20132023"],"award-info":[{"award-number":["2020\u20132023"]}]},{"name":"Frankfurter Stiftung f\u00fcr krebskranke Kinder","award":["INST 371\/48-1 FUGG"],"award-info":[{"award-number":["INST 371\/48-1 FUGG"]}]},{"name":"Kent Cancer Trust","award":["01-20021"],"award-info":[{"award-number":["01-20021"]}]},{"name":"Kent Cancer Trust","award":["2020\u20132023"],"award-info":[{"award-number":["2020\u20132023"]}]},{"name":"Kent Cancer Trust","award":["INST 371\/48-1 FUGG"],"award-info":[{"award-number":["INST 371\/48-1 FUGG"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Cells"],"abstract":"<jats:p>The survival of patients with locally advanced and metastatic bladder cancer (BCa) is persistently low. Hence, new treatment options are urgently needed. Artesunate (ART) a derivative of artemisinin, used in Traditional Chinese Medicine, shows anti-tumor activity extending over a broad spectrum of human cancers. As we have previously shown, ART inhibits growth in cisplatin-sensitive (parental) and cisplatin-resistant BCa cells. However, how ART acts on the metastatic potential of BCa remained unclear. To clarify, we applied ART to parental and cisplatin-resistant RT4, RT112, T24, and TCCSup BCa cell lines. We examined tumor cell adhesion to vascular endothelium and immobilized collagen and evaluated chemotactic activity, migration, and invasive activity of the BCa cells. Adhesion receptors, integrin \u03b1 and \u03b2 subtypes, integrin-linked kinase (ILK), and focal adhesion kinase (FAK) were investigated. The functional relevance of integrin expression altered by ART was determined by blocking studies. ART significantly reduced tumor cell adhesion to vascular endothelium and immobilized collagen in parental as well as in cisplatin-resistant BCa cells. Depending on cell type, ART suppressed tumor cell motility and diminished integrin expression (surface and total). Functional blocking of integrins altered by ART reduced cell adhesion and invasion of the BCa cells. Thus, the metastatic potential of parental and cisplatin-resistant BCa cells was significantly inhibited by ART, making it a promising treatment option for patients with advanced or therapy-resistant BCa.<\/jats:p>","DOI":"10.3390\/cells14080570","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T07:41:51Z","timestamp":1744270911000},"page":"570","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Artesunate Inhibits Metastatic Potential in Cisplatin-Resistant Bladder Cancer Cells by Altering Integrins"],"prefix":"10.3390","volume":"14","author":[{"given":"Fuguang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Urology and Pediatric Urology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olesya","family":"Vakhrusheva","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany"},{"name":"Department of Urology, University Hospital T\u00fcbingen, Hoppe-Seyler-Strasse 3, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Markowitsch","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Slade","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-3593","authenticated-orcid":false,"given":"Maximilian","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5107-3523","authenticated-orcid":false,"given":"Igor","family":"Tsaur","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany"},{"name":"Department of Urology, University Hospital T\u00fcbingen, Hoppe-Seyler-Strasse 3, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Jindrich","family":"Cinatl","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory for Paediatric Tumour and Virus Research, Dr. Petra Joh Research Institute, 60529 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Michaelis","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory for Paediatric Tumour and Virus Research, Dr. Petra Joh Research Institute, 60529 Frankfurt am Main, Germany"},{"name":"School of Natural Sciences, University of Kent, Canterbury CT2 7NJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2637-1681","authenticated-orcid":false,"given":"Thomas","family":"Efferth","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, 55128 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0129-7972","authenticated-orcid":false,"given":"Roman","family":"Blaheta","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Haferkamp","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6321-8707","authenticated-orcid":false,"given":"Eva","family":"Juengel","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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