{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:44:39Z","timestamp":1792979079699,"version":"4.5.0"},"reference-count":84,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sheikh Hamdan Award for Medical Sciences\/Sheikh Hamdan Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Tumor metabolism has emerged as a critical target in cancer therapy, revolutionizing our understanding of how cancer cells grow, survive, and respond to treatment. Historically, cancer research focused on genetic mutations driving tumorigenesis, but in recent decades, metabolic reprogramming has been recognized as a hallmark of cancer. The TP53 inducible glycolysis and apoptosis regulator, or TIGAR, affects a wide range of cellular and molecular processes and plays a key role in cancer cell metabolism by regulating the balance between glycolysis and antioxidant defense mechanisms. Cancer cells often exhibit a shift towards aerobic glycolysis (the Warburg effect), which allows rapid energy production and gives rise to biosynthetic intermediates for proliferation. By inhibiting glycolysis, TIGAR can reduce the proliferation rate of cancer cells, particularly in early-stage tumors or specific tissue types. This metabolic shift may limit the resources available for rapid cell division, thereby exerting a tumor-suppressive effect. However, this metabolic shift also leads to increased levels of reactive oxygen species (ROS), which can damage the cell if not properly managed. TIGAR helps protect cancer cells from excessive ROS by promoting the pentose phosphate pathway (PPP), which generates NADPH\u2014a key molecule involved in antioxidant defense. Through its actions, TIGAR decreases the glycolytic flux while increasing the diversion of glucose-6-phosphate into the PPP. This reduces ROS levels and supports biosynthesis and cell survival by maintaining the balance of nucleotides and lipids. The role of TIGAR has been emerging as a prognostic and potential therapeutic target in different types of cancers. This review highlights the role of TIGAR in different types of cancer, evaluating its potential role as a diagnostic marker and a therapeutic target.<\/jats:p>","DOI":"10.3390\/cells14080598","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T08:11:39Z","timestamp":1744704699000},"page":"598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Deciphering the Controversial Role of TP53 Inducible Glycolysis and Apoptosis Regulator (TIGAR) in Cancer Metabolism as a Potential Therapeutic Strategy"],"prefix":"10.3390","volume":"14","author":[{"given":"Fatima I.","family":"AlMaazmi","sequence":"first","affiliation":[{"name":"College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates"},{"name":"Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates"},{"name":"Immunology and NAT, Dubai Blood Donation Center, Dubai Health, Dubai P.O. Box 505055, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara J.","family":"Bou Malhab","sequence":"additional","affiliation":[{"name":"Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen","family":"ElDohaji","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates"},{"name":"Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9287-7621","authenticated-orcid":false,"given":"Maha","family":"Saber-Ayad","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates"},{"name":"Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates"},{"name":"Faculty of Medicine, Cairo University, Cairo 11562, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"T1","DOI":"10.1530\/ERC-22-0173","article-title":"100 years of the Warburg effect: A historical perspective","volume":"29","author":"Hardie","year":"2022","journal-title":"Endocr.-Relat. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s43440-023-00504-1","article-title":"The Warburg effect: A score for many instruments in the concert of cancer and cancer niche cells","volume":"75","author":"Jaworska","year":"2023","journal-title":"Pharmacol. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Cunha, A., Silva, P.M.A., Sarmento, B., and Queir\u00f3s, O. (2023). Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug Resistance. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15112610"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/brv.12140","article-title":"The return of metabolism: Biochemistry and physiology of the pentose phosphate pathway","volume":"90","author":"Stincone","year":"2015","journal-title":"Biol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/s41418-022-01022-y","article-title":"Targeting mitochondrial metabolism for precision medicine in cancer","volume":"29","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhou, W., Zhao, T., Du, J., Ji, G., Li, X., Ji, S., Tian, W., Wang, X., and Hao, A. (2019). TIGAR promotes neural stem cell differentiation through acetyl-CoA-mediated histone acetylation. Cell Death Dis., 10.","DOI":"10.1038\/s41419-019-1434-3"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Liu, Z., Wu, Y., Zhang, Y., Yuan, M., Li, X., Gao, J., Zhang, S., Xing, C., Qin, H., and Zhao, H. (2019). TIGAR Promotes Tumorigenesis and Protects Tumor Cells From Oxidative and Metabolic Stresses in Gastric Cancer. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.01258"},{"key":"ref_8","unstructured":"Zhang, C., Liu, J., Liang, Y., Wu, R., Zhao, Y., Hong, X., and Zhou, B.P. (2019). TIGAR down regulation enhances the anticancer effect of glycolysis inhibition in gastric cancer. Cell Death Dis."},{"key":"ref_9","unstructured":"Bost, F., and Kaminski, L. (2019). The metabolic modulator PGC-1\u03b1 in cancer. Am. J. Cancer Res., 9."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.4251\/wjgo.v15.i11.1852","article-title":"Glutamine addiction and therapeutic strategies in pancreatic cancer","volume":"15","author":"Ren","year":"2023","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Li, X., Peng, X., Li, Y., Wei, S., He, G., Liu, J., Li, X., Yang, S., Li, D., and Lin, W. (2024). Glutamine addiction in tumor cell: Oncogene regulation and clinical treatment. Cell Commun. Signal., 22.","DOI":"10.1186\/s12964-023-01449-x"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Li, M., Thorne, R.F., Shi, R., Zhang, X.D., Li, J., Li, J., Zhang, Q., Wu, M., and Liu, L. (2021). DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation. Adv. Sci., 8.","DOI":"10.1002\/advs.202003732"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1016\/j.molcel.2023.10.043","article-title":"CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity","volume":"83","author":"Zhang","year":"2023","journal-title":"Mol. Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-031-00793-4_1","article-title":"Fatty Acid Synthase: Structure, Function, and Regulation","volume":"99","author":"Graf","year":"2022","journal-title":"Sub-Cell. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.atherosclerosis.2021.04.002","article-title":"TIGAR mitigates atherosclerosis by promoting cholesterol efflux from macrophages","volume":"327","author":"Zhao","year":"2021","journal-title":"Atherosclerosis"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.ccell.2020.04.005","article-title":"Dietary Approaches to Cancer Therapy","volume":"37","author":"Tajan","year":"2020","journal-title":"Cancer Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.tcb.2017.06.003","article-title":"Metabolic Interactions in the Tumor Microenvironment","volume":"27","author":"Lyssiotis","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1158\/2159-8290.CD-20-1211","article-title":"Metabolic Codependencies in the Tumor Microenvironment","volume":"11","author":"Dey","year":"2021","journal-title":"Cancer Discov."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Cheung, E.C., Strathdee, D., Stevenson, D., Coomes, J., Blyth, K., and Vousden, K.H. (2024). Regulation of ROS signaling by TIGAR induces cancer-modulating responses in the tumor microenvironment. Proc. Natl. Acad. Sci. USA, 121.","DOI":"10.1073\/pnas.2416076121"},{"key":"ref_20","unstructured":"Lobato, F. (2025, March 22). TIGAR (Chromosome 12 Open Reading Frame 5). Available online: https:\/\/atlasgeneticsoncology.org\/gene\/50684\/tigar."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: The Catalogue of Somatic Mutations in Cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"20491","DOI":"10.1073\/pnas.1206530109","article-title":"Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death","volume":"109","author":"Cheung","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lee, P., Vousden, K.H., and Cheung, E.C. (2014). TIGAR, TIGAR, burning bright. Cancer Metab., 2.","DOI":"10.1186\/2049-3002-2-1"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Abate, G., Frisoni, G.B., Bourdon, J.-C., Piccirella, S., Memo, M., and Uberti, D. (2020). The pleiotropic role of p53 in functional\/dysfunctional neurons: Focus on pathogenesis and diagnosis of Alzheimer\u2019s disease. Alzheimer\u2019s Res. Ther., 12.","DOI":"10.1186\/s13195-020-00732-0"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Uhl\u00e9n, M., Zhang, C., Lee, S., Sj\u00f6stedt, E., Fagerberg, L., Bidkhori, G., Benfeitas, R., Arif, M., Liu, Z., and Edfors, F. (2017). A pathology atlas of the human cancer transcriptome. Science, 357.","DOI":"10.1126\/science.aan2507"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.devcel.2013.05.001","article-title":"TIGAR is required for efficient intestinal regeneration and tumorigenesis","volume":"25","author":"Cheung","year":"2013","journal-title":"Dev. Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"26291","DOI":"10.1074\/jbc.M116.740209","article-title":"TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer","volume":"291","author":"Ko","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/s41401-020-00588-y","article-title":"Structure, regulation, and biological functions of TIGAR and its role in diseases","volume":"42","author":"Tang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7150\/jca.33442","article-title":"Prognostic Values of TIGAR Expression and (18)F-FDG PET\/CT in Clear Cell Renal Cell Carcinoma","volume":"11","author":"Wang","year":"2020","journal-title":"J. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1158\/0008-5472.CAN-15-1439","article-title":"STK11\/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment","volume":"76","author":"Koyama","year":"2016","journal-title":"Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ccell.2019.12.012","article-title":"Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer","volume":"37","author":"Cheung","year":"2020","journal-title":"Cancer Cell"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Chu, J., Niu, X., Chang, J., Shao, M., Peng, L., Xi, Y., Lin, A., Wang, C., Cui, Q., and Luo, Y. (2020). Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma. Theranostics, 10.","DOI":"10.1101\/789271"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1158\/0008-5472.CAN-13-3517","article-title":"TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy","volume":"74","author":"Xie","year":"2014","journal-title":"Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"33436","DOI":"10.1074\/jbc.M112.384578","article-title":"Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis","volume":"287","author":"Wanka","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_35","first-page":"2509","article-title":"TIGAR promotes growth, survival and metastasis through oxidation resistance and AKT activation in glioblastoma","volume":"18","author":"Tang","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Shen, M., Zhao, X., Zhao, L., Shi, L., An, S., Huang, G., and Liu, J. (2018). Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer. Mol. Cancer, 17.","DOI":"10.1186\/s12943-018-0839-4"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1080\/10715762.2018.1489133","article-title":"The diverse role of TIGAR in cellular homeostasis and cancer","volume":"52","author":"Geng","year":"2018","journal-title":"Free Radic. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.leukres.2016.09.013","article-title":"TP53-induced glycolysis and apoptosis regulator protects from spontaneous apoptosis and predicts poor prognosis in chronic lymphocytic leukemia","volume":"50","author":"Hong","year":"2016","journal-title":"Leuk. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.2147\/CMAR.S175501","article-title":"Prognostic value of TIGAR and LC3B protein expression in nasopharyngeal carcinoma","volume":"10","author":"Wei","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12094-019-02142-7","article-title":"The efficacy and safety of docetaxel, cisplatin and fluorouracil (TPF)-based induction chemotherapy followed by concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma: A meta-analysis","volume":"22","author":"Zhou","year":"2020","journal-title":"Clin. Transl. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2006.05.036","article-title":"TIGAR, a p53-inducible regulator of glycolysis and apoptosis","volume":"126","author":"Bensaad","year":"2006","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Simabuco, F.M., Morale, M.G., Pavan, I.C., Morelli, A.P., Silva, F.R., and Tamura, R.E. (2018). p53 and metabolism: From mechanism to therapeutics. Oncotarget, 9.","DOI":"10.18632\/oncotarget.25267"},{"key":"ref_43","unstructured":"Yapindi, L., Hernandez, B.Y., and Harrod, R. (2021). siRNA-Inhibition of TIGAR Hypersensitizes Human Papillomavirus-Transformed Cells to Apoptosis Induced by Chemotherapy Drugs that Cause Oxidative Stress. J. Antivir. Antiretrovir., 13."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/1947601911408080","article-title":"KRAS Mouse Models: Modeling Cancer Harboring KRAS Mutations","volume":"2","author":"Heyer","year":"2011","journal-title":"Genes. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cell.2004.11.004","article-title":"Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome","volume":"119","author":"Olive","year":"2004","journal-title":"Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1101\/gad.14.8.994","article-title":"Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum","volume":"14","author":"Marino","year":"2000","journal-title":"Genes Dev."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Lam, A.K., Li, B., Liang, L., Xie, J., and Xu, W.W. (2022). Editorial: Novel Molecular Targets and Treatments for Gastroesophageal Cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.888861"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6776","DOI":"10.3748\/wjg.v22.i30.6776","article-title":"New advances in targeted gastric cancer treatment","volume":"22","author":"Lazar","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Xiong, Z., Xing, C., Zhang, P., Diao, Y., Guang, C., Ying, Y., and Zhang, W. (2023). Identification of a Novel Protein-Based Prognostic Model in Gastric Cancers. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030983"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zheng, G.L., Zhang, G.J., Zhao, Y., and Zheng, Z.C. (2022). Screening Protein Prognostic Biomarkers for Stomach Adenocarcinoma Based on The Cancer Proteome Atlas. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.901182"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S0140-6736(15)00055-0","article-title":"Nasopharyngeal carcinoma","volume":"387","author":"Chua","year":"2016","journal-title":"Lancet"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3892\/or.2015.4494","article-title":"Identification of the TP53-induced glycolysis and apoptosis regulator in various stages of colorectal cancer patients","volume":"35","author":"Abdulla","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"250","DOI":"10.21608\/ejhm.2022.211964","article-title":"Tissue P53-Induced Glycolysis and Apoptosis Regulator (TIGAR) is Associated with Oxidative Stress in Benign and Malignant Colorectal Lesions","volume":"86","author":"Ali","year":"2022","journal-title":"Egypt. J. Hosp. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3310\/hta13suppl1-08","article-title":"Cetuximab plus radiotherapy for the treatment of locally advanced squamous cell carcinoma of the head and neck","volume":"13","author":"Griffin","year":"2009","journal-title":"Health Technol. Assess."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Shi, D., Miao, J., Wu, H., Chen, J., Zhou, X., Hu, D., Zhao, C., Deng, W., and Xie, C. (2017). PD-L1 predicts poor prognosis for nasopharyngeal carcinoma irrespective of PD-1 and EBV-DNA load. Sci. Rep., 7.","DOI":"10.1038\/srep43627"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"960","DOI":"10.6004\/jnccn.2011.0082","article-title":"Kidney cancer","volume":"9","author":"Motzer","year":"2011","journal-title":"J. Natl. Compr. Canc Netw."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/caac.21254","article-title":"Cancer statistics, 2015","volume":"65","author":"Siegel","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"ref_58","first-page":"163","article-title":"Paraneoplastic syndromes in urologic malignancy: The many faces of renal cell carcinoma","volume":"4","author":"Palapattu","year":"2002","journal-title":"Rev. Urol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/sj.bjc.6606084","article-title":"Challenges and opportunities for converting renal cell carcinoma into a chronic disease with targeted therapies","volume":"104","author":"Gore","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1200\/JCO.2005.07.055","article-title":"Prognostic value of histologic subtypes in renal cell carcinoma: A multicenter experience","volume":"23","author":"Patard","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/1097-0142(20000801)89:3<604::AID-CNCR16>3.0.CO;2-Q","article-title":"Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma: A Swiss experience with 588 tumors","volume":"89","author":"Moch","year":"2000","journal-title":"Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.2214\/AJR.08.1727","article-title":"Renal cell carcinoma: T1 and T2 signal intensity characteristics of papillary and clear cell types correlated with pathology","volume":"192","author":"Oliva","year":"2009","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Lee, H.J., Lee, J.J., Park, J.Y., Kim, J.H., Kim, Y.M., Kim, Y.T., and Nam, J.H. (2017). Prognostic value of metabolic parameters determined by preoperative (1)(8)F-FDG PET\/CT in patients with uterine carcinosarcoma. J. Gynecol. Oncol., 28.","DOI":"10.3802\/jgo.2017.28.e43"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Namura, K., Minamimoto, R., Yao, M., Makiyama, K., Murakami, T., Sano, F., Hayashi, N., Tateishi, U., Ishigaki, H., and Kishida, T. (2010). Impact of maximum standardized uptake value (SUVmax) evaluated by 18-Fluoro-2-deoxy-D-glucose positron emission tomography\/computed tomography (18F-FDG-PET\/CT) on survival for patients with advanced renal cell carcinoma: A preliminary report. BMC Cancer, 10.","DOI":"10.1186\/1471-2407-10-667"},{"key":"ref_65","first-page":"2665","article-title":"18F-FDG-PET\/CT in potentially advanced renal cell carcinoma: A role in treatment decisions and prognosis estimation","volume":"33","author":"Ferda","year":"2013","journal-title":"Anticancer. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0256-4947.75771","article-title":"18F-FDG PET\/CT imaging in oncology","volume":"31","author":"Almuhaideb","year":"2011","journal-title":"Ann. Saudi Med."},{"key":"ref_67","first-page":"181","article-title":"Integrated FDG PET\/CT: Utility and Applications in Clinical Oncology","volume":"2","author":"Pinilla","year":"2008","journal-title":"Clin. Med. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1053\/j.gastro.2015.08.054","article-title":"Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma","volume":"149","author":"Ohashi","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/cncr.26383","article-title":"The volume-outcome relation in the surgical treatment of esophageal cancer: A systematic review and meta-analysis","volume":"118","author":"Wouters","year":"2012","journal-title":"Cancer"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1200\/JCO.2005.00.034","article-title":"Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus","volume":"23","author":"Stahl","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1200\/JCO.2005.04.7118","article-title":"Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102","volume":"25","author":"Bedenne","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S1470-2045(13)70136-0","article-title":"Chemoradiotherapy with or without cetuximab in patients with oesophageal cancer (SCOPE1): A multicentre, phase 2\/3 randomised trial","volume":"14","author":"Crosby","year":"2013","journal-title":"Lancet Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"A, J., Qian, S., Wang, G., Yan, B., Zhang, S., Huang, Q., Ni, L., Zha, W., Liu, L., and Cao, B. (2010). Chronic myeloid leukemia patients sensitive and resistant to imatinib treatment show different metabolic responses. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013186"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Qian, S., Li, J., Hong, M., Zhu, Y., Zhao, H., Xie, Y., Huang, J., Lian, Y., Li, Y., and Wang, S. (2016). TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia. J. Hematol. Oncol., 9.","DOI":"10.1186\/s13045-016-0360-4"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1056\/NEJMra0708126","article-title":"Malignant gliomas in adults","volume":"359","author":"Wen","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1001\/jama.2017.18718","article-title":"Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial","volume":"318","author":"Stupp","year":"2017","journal-title":"JAMA"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nrclinonc.2012.71","article-title":"MET: A promising anticancer therapeutic target","volume":"9","author":"Peters","year":"2012","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/MNM.0000000000000909","article-title":"Evaluation of 18F-FDG PET\/CT parameters for reflection of aggressiveness and prediction of prognosis in early-stage cervical cancer","volume":"39","author":"Zhang","year":"2018","journal-title":"Nucl. Med. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Fu, J., Yu, S., Zhao, X., Zhang, C., Shen, L., Liu, Y., and Yu, H. (2022). Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232416034"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Basak, D., Arrighi, S., Darwiche, Y., and Deb, S. (2021). Comparison of anticancer drug toxicities: Paradigm shift in adverse effect profile. Life, 12.","DOI":"10.3390\/life12010048"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/FPC.0b013e32833ffb56","article-title":"Doxorubicin pathways: Pharmacodynamics and adverse effects","volume":"21","author":"Thorn","year":"2011","journal-title":"Pharmacogenet. Genom."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Zhou, X., Xie, W., Li, Q., Zhang, Y., Zhang, J., Zhao, X., Liu, J., and Huang, G. (2013). TIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0080576"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11010-011-0993-0","article-title":"SP1 plays a pivotal role for basal activity of TIGAR promoter in liver cancer cell lines","volume":"359","author":"Zou","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1093\/neuonc\/nou147","article-title":"Targeting adaptive glioblastoma: An overview of proliferation and invasion","volume":"16","author":"Xie","year":"2014","journal-title":"Neuro-Oncology"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/8\/598\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:14:51Z","timestamp":1760030091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/8\/598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":84,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["cells14080598"],"URL":"https:\/\/doi.org\/10.3390\/cells14080598","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]}}}