{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:18Z","timestamp":1787027838530,"version":"build-2736575974"},"reference-count":83,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R03 NS087303-01"],"award-info":[{"award-number":["R03 NS087303-01"]}]},{"name":"NIH","award":["R21-NS114461"],"award-info":[{"award-number":["R21-NS114461"]}]},{"name":"NIH","award":["R01-NS110112"],"award-info":[{"award-number":["R01-NS110112"]}]},{"name":"Johns Hopkins Malaria Research Institute","award":["R03 NS087303-01"],"award-info":[{"award-number":["R03 NS087303-01"]}]},{"name":"Johns Hopkins Malaria Research Institute","award":["R21-NS114461"],"award-info":[{"award-number":["R21-NS114461"]}]},{"name":"Johns Hopkins Malaria Research Institute","award":["R01-NS110112"],"award-info":[{"award-number":["R01-NS110112"]}]},{"name":"Bloomberg Philanthropies","award":["R03 NS087303-01"],"award-info":[{"award-number":["R03 NS087303-01"]}]},{"name":"Bloomberg Philanthropies","award":["R21-NS114461"],"award-info":[{"award-number":["R21-NS114461"]}]},{"name":"Bloomberg Philanthropies","award":["R01-NS110112"],"award-info":[{"award-number":["R01-NS110112"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Cerebral malaria (CM) is a deadly complication of P. falciparum infection. Although adults with CM have a higher mortality rate, CM affects mostly children under the age of 5 years. Neurological symptoms and signs include impaired consciousness, coma, seizures, and increased intracranial hypertension. Upon survival of a CM episode, persistent neurologic deficits occur in a subset of surviving children. These sequelae include recurrent seizures, behavioral deficits, loss of developmental milestones, learning disabilities and attention deficit hyperactivity disorder, which can remain with the survivors. The underlying neuropathology of these post CM neurologic sequelae are unclear. Therefore, we probed the extensive neuronal damage that occurs in an experimental murine model of cerebral malaria (eCM), focusing on the hippocampus. In addition, we explored responses of neuro-progenitor cells (NPC\u2019s) and potential repair mechanisms. We report here that Plasmodium infection causes extensive neuronal damage in the hippocampus, characterized by a loss of neuronal NeuN and double cortin (DCX) immunostaining in eCM mice. On day 6 of eCM we also observed increased neurofilament light chain staining, indicative of neuronal fragmentation, which was accompanied by an increase in neurofilament light chain in CSF but not seen in plasma. A concomitant increase in the influx of neuroprogenitor cells in eCM was observed, suggesting ongoing neuronal repair.<\/jats:p>","DOI":"10.3390\/cells14110807","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T09:22:41Z","timestamp":1748596961000},"page":"807","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuronal Damage in Murine Experimental Cerebral Malaria, Implications for Neuronal Repair and Sequelae"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8559-5626","authenticated-orcid":false,"given":"Monique F.","family":"Stins","sequence":"first","affiliation":[{"name":"Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA"},{"name":"La Jolla Infectious Diseases Institute, LJIDI, San Diego, CA 92130, USA"},{"name":"Biomedical Research Institute of Southern California, Oceanside, CA 92046, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gramaglia","sequence":"additional","affiliation":[{"name":"La Jolla Infectious Diseases Institute, LJIDI, San Diego, CA 92130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Velez","sequence":"additional","affiliation":[{"name":"La Jolla Infectious Diseases Institute, LJIDI, San Diego, CA 92130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4128-5335","authenticated-orcid":false,"given":"Carlos A.","family":"Pardo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division Neuroimmunology and Neurological Infections, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"van der Heyde","sequence":"additional","affiliation":[{"name":"La Jolla Infectious Diseases Institute, LJIDI, San Diego, CA 92130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0140-6736(19)31097-9","article-title":"Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum, 2000\u20132017: A spatial and temporal modelling study","volume":"394","author":"Weiss","year":"2019","journal-title":"Lancet"},{"key":"ref_2","unstructured":"World Health Organization (2024). 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