{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:51:31Z","timestamp":1790088691554,"version":"4.0.1"},"reference-count":165,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NWA-ORC project CIRCULAR NWO","award":["NWA.1389.20.157"],"award-info":[{"award-number":["NWA.1389.20.157"]}]},{"name":"NWA-ORC project CIRCULAR NWO","award":["GA No 101095426 SK4BLOCK-AFH"],"award-info":[{"award-number":["GA No 101095426 SK4BLOCK-AFH"]}]},{"name":"NWO","award":["NWA.1389.20.157"],"award-info":[{"award-number":["NWA.1389.20.157"]}]},{"name":"NWO","award":["GA No 101095426 SK4BLOCK-AFH"],"award-info":[{"award-number":["GA No 101095426 SK4BLOCK-AFH"]}]},{"name":"ERC (European Research Council)","award":["NWA.1389.20.157"],"award-info":[{"award-number":["NWA.1389.20.157"]}]},{"name":"ERC (European Research Council)","award":["GA No 101095426 SK4BLOCK-AFH"],"award-info":[{"award-number":["GA No 101095426 SK4BLOCK-AFH"]}]},{"name":"Amsterdam University Medical Center","award":["NWA.1389.20.157"],"award-info":[{"award-number":["NWA.1389.20.157"]}]},{"name":"Amsterdam University Medical Center","award":["GA No 101095426 SK4BLOCK-AFH"],"award-info":[{"award-number":["GA No 101095426 SK4BLOCK-AFH"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Pulmonary hypertension (PH) is a progressive lung disease characterized by abnormal pulmonary vascular pressure and right ventricular (RV) dysfunction. Atrial arrhythmias, including atrial fibrillation (AF) and atrial flutter, are common in patients with PH and significantly contribute to disease progression and mortality. A bidirectional pathophysiological link exists between PH and AF, encompassing shared mechanisms such as endothelial dysfunction, DNA damage, autophagy, inflammation, and oxidative stress, as well as mutual risk factors, including diabetes, obesity, heart disease, and aging. Despite these shared pathways, limited research has been conducted to fully understand the intertwined relationship between PH and AF, hindering the development of effective treatments. In this review, we provide a comprehensive overview of the epidemiology of PH, the molecular mechanisms underlying the development of AF in PH, and the overlap in their pathophysiology. We also identify novel druggable targets and propose mechanism-based therapeutic approaches to treat this specific patient group. By shedding light on the molecular connection between PH and AF, this review aims to fuel the design and validation of innovative treatments to address this challenging comorbidity.<\/jats:p>","DOI":"10.3390\/cells14110839","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T08:51:04Z","timestamp":1749027064000},"page":"839","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Interplay Between Pulmonary Hypertension and Atrial Fibrillation: A Comprehensive Overview"],"prefix":"10.3390","volume":"14","author":[{"given":"Danish","family":"Sultan","sequence":"first","affiliation":[{"name":"Department of Physiology, Amsterdam UMC, Vrije Universiteit, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Pulmonary Hypertension and Thrombosis, 1081 HZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4768-234X","authenticated-orcid":false,"given":"Bianca J. J. M.","family":"Brundel","sequence":"additional","affiliation":[{"name":"Department of Physiology, Amsterdam UMC, Vrije Universiteit, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Pulmonary Hypertension and Thrombosis, 1081 HZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9830-6344","authenticated-orcid":false,"given":"Kondababu","family":"Kurakula","sequence":"additional","affiliation":[{"name":"Department of Physiology, Amsterdam UMC, Vrije Universiteit, Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Pulmonary Hypertension and Thrombosis, 1081 HZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kurakula, K., Smolders, V., Tura-Ceide, O., Jukema, J.W., Quax, P.H.A., and Goumans, M.J. (2021). 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