{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:50:40Z","timestamp":1790567440034,"version":"4.1.0"},"reference-count":243,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Diabetic retinopathy is a sight-threatening complication of diabetes mellitus, affecting millions of people worldwide. From a vascular perspective, diabetic retinopathy compromises the structure and function of the blood\u2013retinal barrier, leading to aberrant angiogenesis and vascular leakage, with consequent loss of vision. This review will delve into the vascular abnormalities caused by diabetic retinopathy in the inner blood\u2013retinal barrier, focusing primarily on retinal endothelial cells. It will then discuss how calcium signalling regulates inner blood\u2013retina barrier function and dysfunction, how calcium channels contribute to the development of diabetic retinopathy, and how studying the components of the calcium toolkit may identify new therapeutic targets.<\/jats:p>","DOI":"10.3390\/cells14120856","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T09:02:03Z","timestamp":1749200523000},"page":"856","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Calcium Signalling Profile of the Inner Blood\u2013Retinal Barrier in Diabetic Retinopathy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-0098","authenticated-orcid":false,"given":"Francesco","family":"Moccia","sequence":"first","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cV. Tiberio\u201d, University of Molise, 86100 Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-6291","authenticated-orcid":false,"given":"Silvia","family":"Dragoni","sequence":"additional","affiliation":[{"name":"School of Applied Sciences, University of Brighton, Moulsecoomb, Brighton BN24GJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Antar, S.A., Ashour, N.A., Sharaky, M., Khattab, M., Ashour, N.A., Zaid, R.T., Roh, E.J., Elkamhawy, A., and Al-Karmalawy, A.A. (2023). Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. Biomed. Pharmacother., 168.","DOI":"10.1016\/j.biopha.2023.115734"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e35285","DOI":"10.1097\/MD.0000000000035285","article-title":"Vascular complications of diabetes: A narrative review","volume":"102","author":"Lu","year":"2023","journal-title":"Medicine"},{"key":"ref_3","first-page":"e52308","article-title":"A Narrative Review of Retinopathy in Diabetic Patients","volume":"16","author":"Gupta","year":"2024","journal-title":"Cureus"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.preteyeres.2015.08.001","article-title":"The progress in understanding and treatment of diabetic retinopathy","volume":"51","author":"Stitt","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/febs.16330","article-title":"The blood-retina barrier in health and disease","volume":"290","author":"Campbell","year":"2023","journal-title":"FEBS J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Hudson, N., and Campbell, M. (2021). Tight Junctions of the Neurovascular Unit. Front. Mol. Neurosci., 14.","DOI":"10.3389\/fnmol.2021.752781"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1078\/0171-9335-00101","article-title":"Correlation of tight junction morphology with the expression of tight junction proteins in blood-brain barrier endothelial cells","volume":"79","author":"Liebner","year":"2000","journal-title":"Eur. J. Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/bjo.59.11.649","article-title":"Early breakdown of the blood-retinal barrier in diabetes","volume":"59","author":"Campos","year":"1975","journal-title":"Br. J. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1083\/jcb.200302047","article-title":"VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia","volume":"161","author":"Gerhardt","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"175586","DOI":"10.1016\/j.ejphar.2023.175586","article-title":"The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF","volume":"949","author":"Ghalehbandi","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"23463","DOI":"10.1074\/jbc.274.33.23463","article-title":"Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors","volume":"274","author":"Antonetti","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.2337\/diabetes.47.12.1953","article-title":"Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: Vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group","volume":"47","author":"Antonetti","year":"1998","journal-title":"Diabetes"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wallsh, J.O., and Gallemore, R.P. (2021). Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options. Cells, 10.","DOI":"10.3390\/cells10051049"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13643-023-02261-x","article-title":"Non-adherence and non-persistence to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy: A systematic review and meta-analysis","volume":"12","author":"Shahzad","year":"2023","journal-title":"Syst. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bootman, M.D., and Bultynck, G. (2020). Fundamentals of Cellular Calcium Signaling: A Primer. Cold Spring Harb. Perspect. Biol., 12.","DOI":"10.1101\/cshperspect.a038802"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BST20110766","article-title":"Calcium signalling remodelling and disease","volume":"40","author":"Berridge","year":"2012","journal-title":"Biochem. Soc. Trans."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ceca.2017.06.008","article-title":"Calcium signaling and molecular mechanisms underlying neurodegenerative diseases","volume":"70","author":"Pchitskaya","year":"2018","journal-title":"Cell Calcium"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41573-021-00268-4","article-title":"Advances in TRP channel drug discovery: From target validation to clinical studies","volume":"21","author":"Koivisto","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41585-023-00738-x","article-title":"Calcium signalling pathways in prostate cancer initiation and progression","volume":"20","author":"Silvestri","year":"2023","journal-title":"Nat. Rev. Urol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Moccia, F., Brunetti, V., Soda, T., Berra-Romani, R., and Scarpellino, G. (2023). Cracking the Endothelial Calcium (Ca2+) Code: A Matter of Timing and Spacing. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242316765"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coph.2019.03.008","article-title":"Heterogeneity and emergent behaviour in the vascular endothelium","volume":"45","author":"McCarron","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s41232-024-00363-0","article-title":"Ca2+ signaling in vascular smooth muscle and endothelial cells in blood vessel remodeling: A review","volume":"44","author":"Suzuki","year":"2024","journal-title":"Inflamm. Regen."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.molmet.2018.01.003","article-title":"TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation","volume":"9","author":"Sachdeva","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMra1005073","article-title":"Diabetic retinopathy","volume":"366","author":"Antonetti","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","article-title":"Global Prevalence of Diabetic Retinopathy and Projection of Burden through 2045: Systematic Review and Meta-analysis","volume":"128","author":"Teo","year":"2021","journal-title":"Ophthalmology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"95881","DOI":"10.5662\/wjm.v14.i4.95881","article-title":"Diabetic retinopathy: A review on its pathophysiology and novel treatment modalities","volume":"14","author":"Morya","year":"2024","journal-title":"World J. Methodol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101140","DOI":"10.1016\/j.disamonth.2021.101140","article-title":"Proliferative diabetic retinopathy (PDR)","volume":"67","author":"Chaudhary","year":"2021","journal-title":"Dis. Mon."},{"key":"ref_28","first-page":"440","article-title":"Diabetic retinopathy: Fibrotic proliferation and retinal detachment","volume":"69","author":"McMeel","year":"1971","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.exer.2015.04.004","article-title":"Retinal fibrosis in diabetic retinopathy","volume":"142","author":"Roy","year":"2016","journal-title":"Exp. Eye Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1017\/S0952523806233546","article-title":"Color space distortions in patients with type 2 diabetes mellitus","volume":"23","author":"Oiwa","year":"2006","journal-title":"Vis. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1242\/dmm.003772","article-title":"Predominant cone photoreceptor dysfunction in a hyperglycaemic model of non-proliferative diabetic retinopathy","volume":"3","author":"Alvarez","year":"2010","journal-title":"Dis. Model. Mech."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1475-1313.2010.00775.x","article-title":"Loss of chromatic sensitivity in AMD and diabetes: A comparative study","volume":"30","author":"Sivaprasad","year":"2010","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1167\/iovs.14-16143","article-title":"High-Fat Diet-Induced Retinal Dysfunction","volume":"56","author":"Chang","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1017\/S0952523800173122","article-title":"Neuronal and microglial response in the retina of streptozotocin-induced diabetic rats","volume":"17","author":"Zeng","year":"2000","journal-title":"Vis. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.5301\/EJO.2010.6049","article-title":"Blood-retinal barrier","volume":"21","author":"Bernardes","year":"2011","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-1-60761-938-3_5","article-title":"The blood-retinal barrier: Structure and functional significance","volume":"686","author":"Runkle","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.visres.2017.05.009","article-title":"The inner blood-retinal barrier: Cellular basis and development","volume":"139","author":"Ramos","year":"2017","journal-title":"Vision Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Dragoni, S., Moccia, F., and Bootman, M.D. (2025). The Roles of Transient Receptor Potential (TRP) Channels Underlying Aberrant Calcium Signaling in Blood-Retinal Barrier Dysfunction. Cold Spring Harb. Perspect. Biol., 17.","DOI":"10.1101\/cshperspect.a041763"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1152\/physrev.00035.2003","article-title":"Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis","volume":"84","author":"Bazzoni","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"20520","DOI":"10.1074\/jbc.M905251199","article-title":"Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin","volume":"275","author":"Bazzoni","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2013.08.020","article-title":"VE-cadherin and endothelial adherens junctions: Active guardians of vascular integrity","volume":"26","author":"Giannotta","year":"2013","journal-title":"Dev. Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10456-007-9067-z","article-title":"Vascular permeability in ocular disease and the role of tight junctions","volume":"10","author":"Erickson","year":"2007","journal-title":"Angiogenesis"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Dragoni, S., and Turowski, P. (2018). Polarised VEGFA Signalling at Vascular Blood-Neural Barriers. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051378"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.ajpath.2015.11.019","article-title":"Plasmalemma Vesicle-Associated Protein Has a Key Role in Blood-Retinal Barrier Loss","volume":"186","author":"Gorgels","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"101094","DOI":"10.1016\/j.preteyeres.2022.101094","article-title":"Caveolar and non-Caveolar Caveolin-1 in ocular homeostasis and disease","volume":"91","author":"Enyong","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"105755","DOI":"10.1016\/j.phrs.2021.105755","article-title":"Mfsd2a overexpression alleviates vascular dysfunction in diabetic retinopathy","volume":"171","author":"Zhang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_47","first-page":"2343","article-title":"Iron, ferritin, transferrin, and transferrin receptor in the adult rat retina","volume":"41","author":"Yefimova","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0306-4522(03)00590-6","article-title":"Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system","volume":"121","author":"Burdo","year":"2003","journal-title":"Neuroscience"},{"key":"ref_49","first-page":"390","article-title":"Interactions between lymphocytes and cells of the blood-retina barrier: Mechanisms of T lymphocyte adhesion to human retinal capillary endothelial cells and retinal pigment epithelial cells in vitro","volume":"71","author":"Liversidge","year":"1990","journal-title":"Immunology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00441-003-0745-x","article-title":"Endothelial-pericyte interactions in angiogenesis","volume":"314","author":"Gerhardt","year":"2003","journal-title":"Cell Tissue Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1167\/iovs.14-14046","article-title":"Notch signaling functions in retinal pericyte survival","volume":"55","author":"Primo","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0165-0173(99)00024-7","article-title":"Brain macrophages: On the role of pericytes and perivascular cells","volume":"31","author":"Thomas","year":"1999","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Trost, A., Lange, S., Schroedl, F., Bruckner, D., Motloch, K.A., Bogner, B., Kaser-Eichberger, A., Strohmaier, C., Runge, C., and Aigner, L. (2016). Brain and Retinal Pericytes: Origin, Function and Role. Front. Cell Neurosci., 10.","DOI":"10.3389\/fncel.2016.00020"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-11093-2_1","article-title":"Pericytes in the Retina","volume":"Volume 1122","author":"Trost","year":"2019","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"ref_55","first-page":"633","article-title":"Pericyte morphology and function","volume":"36","author":"Yemisci","year":"2021","journal-title":"Histol. Histopathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1084\/jem.20111622","article-title":"Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo","volume":"209","author":"Proebstl","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/ni.2477","article-title":"Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and \u2018instruct\u2019 them with pattern-recognition and motility programs","volume":"14","author":"Stark","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Huang, H. (2020). Pericyte-Endothelial Interactions in the Retinal Microvasculature. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197413"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1167\/iovs.10-7061","article-title":"Microvascular retinal endothelial and pericyte cell apoptosis in vitro: Role of hedgehog and Notch signaling","volume":"52","author":"Walshe","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/jnr.21884","article-title":"Recruitment of pericytes and astrocytes is closely related to the formation of tight junction in developing retinal vessels","volume":"87","author":"Kim","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Newman, E.A. (2015). Glial cell regulation of neuronal activity and blood flow in the retina by release of gliotransmitters. Philos. Trans. R. Soc. Lond. B Biol. Sci., 370.","DOI":"10.1098\/rstb.2014.0195"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Kugler, E.C., Greenwood, J., and MacDonald, R.B. (2021). The \u201cNeuro-Glial-Vascular\u201d Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.732820"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Florence, C.M., Baillie, L.D., and Mulligan, S.J. (2012). Dynamic volume changes in astrocytes are an intrinsic phenomenon mediated by bicarbonate ion flux. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051124"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Lafrenaye, A.D., and Simard, J.M. (2019). Bursting at the Seams: Molecular Mechanisms Mediating Astrocyte Swelling. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020330"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"100903","DOI":"10.1016\/j.preteyeres.2020.100903","article-title":"Retinal capillary basement membrane thickening: Role in the pathogenesis of diabetic retinopathy","volume":"82","author":"Roy","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Kinuthia, U.M., Wolf, A., and Langmann, T. (2020). Microglia and Inflammatory Responses in Diabetic Retinopathy. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.564077"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/imm.13479","article-title":"Retinal microglia: Functions and diseases","volume":"166","author":"Fan","year":"2022","journal-title":"Immunology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1007\/s00125-012-2692-0","article-title":"Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy","volume":"55","author":"Fu","year":"2012","journal-title":"Diabetologia"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1161\/01.ATV.0000146266.65820.a1","article-title":"7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells","volume":"24","author":"Martinet","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.RES.59.5.483","article-title":"Autoregulation of blood flow","volume":"59","author":"Johnson","year":"1986","journal-title":"Circ. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/eye.2009.108","article-title":"Microvascular lesions of diabetic retinopathy: Clues towards understanding pathogenesis?","volume":"23","author":"Curtis","year":"2009","journal-title":"Eye"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2337\/diab.44.6.603","article-title":"Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy","volume":"44","author":"Kohner","year":"1995","journal-title":"Diabetes"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.preteyeres.2008.02.002","article-title":"Regulation of retinal blood flow in health and disease","volume":"27","author":"Pournaras","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Hanaguri, J., Yokota, H., Watanabe, M., Yamagami, S., Kushiyama, A., Kuo, L., and Nagaoka, T. (2021). Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-97651-3"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s001250051171","article-title":"Ocular blood flow and associated functional deviations in diabetic retinopathy","volume":"42","author":"Schmetterer","year":"1999","journal-title":"Diabetologia"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1034\/j.1600-0420.2002.800503.x","article-title":"Ocular perfusion abnormalities in diabetes","volume":"80","author":"Ciulla","year":"2002","journal-title":"Acta Ophthalmol. Scand."},{"key":"ref_77","first-page":"356","article-title":"Total retinal volumetric blood flow rate in diabetic patients with poor glycemic control","volume":"33","author":"Grunwald","year":"1992","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1001\/archophthalmol.2011.2560","article-title":"Changes in retinal vessel diameter and incidence and progression of diabetic retinopathy","volume":"130","author":"Klein","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.preteyeres.2012.04.004","article-title":"Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease","volume":"31","author":"Kur","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1002\/glia.21068","article-title":"Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathy","volume":"58","author":"Mishra","year":"2010","journal-title":"Glia"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.exer.2005.01.015","article-title":"Dynamic contrast enhanced MRI in patients with diabetic macular edema: Initial results","volume":"81","author":"Trick","year":"2005","journal-title":"Exp. Eye Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0065-2776(04)86005-X","article-title":"Formation of bradykinin: A major contributor to the innate inflammatory response","volume":"86","author":"Joseph","year":"2005","journal-title":"Adv. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1515\/hsz-2012-0316","article-title":"Plasma kallikrein-kinin system and diabetic retinopathy","volume":"394","author":"Liu","year":"2013","journal-title":"Biol. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/bjp.2008.48","article-title":"Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors","volume":"154","author":"Abdouh","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1161\/01.RES.83.7.721","article-title":"A major role for prostacyclin in nitric oxide-induced ocular vasorelaxation in the piglet","volume":"83","author":"Hardy","year":"1998","journal-title":"Circ. Res."},{"key":"ref_86","first-page":"1891","article-title":"Bradykinin relaxation in small porcine retinal arterioles","volume":"43","author":"Jeppesen","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/ncomms2199","article-title":"Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo","volume":"3","author":"Orsenigo","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1002\/pmic.200700745","article-title":"Profiling of vitreous proteomes from proliferative diabetic retinopathy and nondiabetic patients","volume":"7","author":"Kim","year":"2007","journal-title":"Proteomics"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1021\/pr800112g","article-title":"Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy","volume":"7","author":"Gao","year":"2008","journal-title":"J. Proteome Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","article-title":"Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders","volume":"331","author":"Aiello","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.2337\/db09-1606","article-title":"TNF-alpha signals through PKCzeta\/NF-kappaB to alter the tight junction complex and increase retinal endothelial cell permeability","volume":"59","author":"Aveleira","year":"2010","journal-title":"Diabetes"},{"key":"ref_92","first-page":"329","article-title":"Interleukin-1 beta-induced disruption of the retinal vascular barrier of the central nervous system is mediated through leukocyte recruitment and histamine","volume":"150","author":"Bamforth","year":"1997","journal-title":"Am. J. Pathol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1167\/iovs.06-1358","article-title":"Multiplex bead analysis of vitreous humor of patients with vitreoretinal disorders","volume":"48","author":"Banerjee","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Rangasamy, S., McGuire, P.G., Franco Nitta, C., Monickaraj, F., Oruganti, S.R., and Das, A. (2014). Chemokine mediated monocyte trafficking into the retina: Role of inflammation in alteration of the blood-retinal barrier in diabetic retinopathy. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108508"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2337\/diabetes.55.02.06.db05-1103","article-title":"Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo","volume":"55","author":"Nieuwdorp","year":"2006","journal-title":"Diabetes"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"H2235","DOI":"10.1152\/ajpheart.00803.2011","article-title":"Shedding of the endothelial glycocalyx in arterioles, capillaries, and venules and its effect on capillary hemodynamics during inflammation","volume":"301","author":"Lipowsky","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.2337\/diabetes.51.10.3107","article-title":"Pericytes and the pathogenesis of diabetic retinopathy","volume":"51","author":"Hammes","year":"2002","journal-title":"Diabetes"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/10739680601072123","article-title":"Arteriolar involvement in the microvascular lesions of diabetic retinopathy: Implications for pathogenesis","volume":"14","author":"Gardiner","year":"2007","journal-title":"Microcirculation"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e23679","DOI":"10.1096\/fj.202302624R","article-title":"Pericyte in retinal vascular diseases: A multifunctional regulator and potential therapeutic target","volume":"38","author":"Zhang","year":"2024","journal-title":"FASEB J."},{"key":"ref_100","first-page":"523","article-title":"Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats","volume":"150","author":"Stitt","year":"1997","journal-title":"Am. J. Pathol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.nutres.2014.08.010","article-title":"Sulforaphane inhibits advanced glycation end product-induced pericyte damage by reducing expression of receptor for advanced glycation end products","volume":"34","author":"Maeda","year":"2014","journal-title":"Nutr. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10456-016-9502-0","article-title":"Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1alpha-deficient mice","volume":"19","author":"Prieto","year":"2016","journal-title":"Angiogenesis"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1167\/iovs.12-10010","article-title":"Antibody-mediated retinal pericyte injury: Implications for diabetic retinopathy","volume":"53","author":"Li","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Negri, S., Sanford, M., Shi, H., and Tarantini, S. (2023). The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia. Front. Aging Neurosci., 15.","DOI":"10.3389\/fnagi.2023.1149820"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"136258","DOI":"10.1016\/j.neulet.2021.136258","article-title":"Role of TRP ion channels in cerebral circulation and neurovascular communication","volume":"765","author":"Kuppusamy","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.06.001","article-title":"Endothelial calcium dynamics, connexin channels and blood-brain barrier function","volume":"108","author":"Wang","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Guerra, G., Lucariello, A., Perna, A., Botta, L., De Luca, A., and Moccia, F. (2018). The Role of Endothelial Ca2+ Signaling in Neurovascular Coupling: A View from the Lumen. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19040938"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Negri, S., Faris, P., Soda, T., and Moccia, F. (2021). Endothelial signaling at the core of neurovascular coupling: The emerging role of endothelial inward-rectifier K+ (Kir2.1) channels and N-methyl-d-aspartate receptors in the regulation of cerebral blood flow. Int. J. Biochem. Cell Biol., 135.","DOI":"10.1016\/j.biocel.2021.105983"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Scarpellino, G., Brunetti, V., Berra-Romani, R., De Sarro, G., Guerra, G., Soda, T., and Moccia, F. (2024). The Unexpected Role of the Endothelial Nitric Oxide Synthase at the Neurovascular Unit: Beyond the Regulation of Cerebral Blood Flow. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25169071"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Alvarado, M.G., Thakore, P., and Earley, S. (2021). Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function. Cells, 10.","DOI":"10.3390\/cells10051167"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"eabh0101","DOI":"10.1126\/sciadv.abh0101","article-title":"Local IP3 receptor-mediated Ca2+ signals compound to direct blood flow in brain capillaries","volume":"7","author":"Longden","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e2415047121","DOI":"10.1073\/pnas.2415047121","article-title":"Electrocalcium coupling in brain capillaries: Rapidly traveling electrical signals ignite local calcium signals","volume":"121","author":"Mughal","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Brunetti, V., Berra-Romani, R., Conca, F., Soda, T., Biella, G.R., Gerbino, A., Moccia, F., and Scarpellino, G. (2024). Lysosomal TRPML1 triggers global Ca2+ signals and nitric oxide release in human cerebrovascular endothelial cells. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1426783"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s00018-019-03284-1","article-title":"Group 1 metabotropic glutamate receptors trigger glutamate-induced intracellular Ca2+ signals and nitric oxide release in human brain microvascular endothelial cells","volume":"77","author":"Negri","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"106997","DOI":"10.1016\/j.vph.2022.106997","article-title":"Targeting endothelial ion signalling to rescue cerebral blood flow in cerebral disorders","volume":"145","author":"Moccia","year":"2022","journal-title":"Vasc. Pharmacol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Moccia, F., Brunetti, V., Perna, A., Guerra, G., Soda, T., and Berra-Romani, R. (2023). The Molecular Heterogeneity of Store-Operated Ca2+ Entry in Vascular Endothelial Cells: The Different roles of Orai1 and TRPC1\/TRPC4 Channels in the Transition from Ca2+-Selective to Non-Selective Cation Currents. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043259"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/jcp.24686","article-title":"A functional transient receptor potential vanilloid 4 (TRPV4) channel is expressed in human endothelial progenitor cells","volume":"230","author":"Dragoni","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1089\/scd.2013.0032","article-title":"Canonical transient receptor potential 3 channel triggers vascular endothelial growth factor-induced intracellular Ca2+ oscillations in endothelial progenitor cells isolated from umbilical cord blood","volume":"22","author":"Dragoni","year":"2013","journal-title":"Stem Cells Dev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e38689","DOI":"10.7554\/eLife.38689","article-title":"PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells","volume":"7","author":"Harraz","year":"2018","journal-title":"eLife"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Soda, T., Brunetti, V., De Sarro, G., Biella, G., Moccia, F., Berra-Romani, R., and Scarpellino, G. (2025). Transient Receptor Potential Ankyrin 1 (TRPA1) Mediates Hydrogen Sulfide-induced Ca2+ Entry and Nitric Oxide Production in Human Cerebrovascular Endothelium. Curr. Neuropharmacol.","DOI":"10.2174\/011570159X349872250124124612"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1038\/ncomms6318","article-title":"The key role of transient receptor potential melastatin-2 channels in amyloid-beta-induced neurovascular dysfunction","volume":"5","author":"Park","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"8686","DOI":"10.1038\/s41467-024-52969-0","article-title":"Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow","volume":"15","author":"Lim","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1073\/pnas.89.5.1690","article-title":"Calcium entry-dependent oscillations of cytoplasmic calcium concentration in cultured endothelial cell monolayers","volume":"89","author":"Laskey","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1161\/01.RES.76.4.522","article-title":"Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases","volume":"76","author":"Fleming","year":"1995","journal-title":"Circ. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1161\/01.ATV.17.11.3356","article-title":"Differential effects of extracellular Mg2+ on thrombin-induced and capacitative Ca2+ entry in human coronary arterial endothelial cells","volume":"17","author":"Yoshimura","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/bs.ctm.2022.09.001","article-title":"An unexpected effect of risperidone reveals a nonlinear relationship between cytosolic Ca2+ and mitochondrial Ca2+ uptake","volume":"90","author":"Bachkoenig","year":"2022","journal-title":"Curr. Top. Membr."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1074\/jbc.RA118.005913","article-title":"Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate-evoked calcium signaling","volume":"294","author":"Wilson","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1002\/jcp.26953","article-title":"Glutamate triggers intracellular Ca2+ oscillations and nitric oxide release by inducing NAADP- and InsP3 -dependent Ca2+ release in mouse brain endothelial cells","volume":"234","author":"Zuccolo","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Berra-Romani, R., Guzman-Silva, A., Vargaz-Guadarrama, A., Flores-Alonso, J.C., Alonso-Romero, J., Trevino, S., Sanchez-Gomez, J., Coyotl-Santiago, N., Garcia-Carrasco, M., and Moccia, F. (2019). Type 2 Diabetes Alters Intracellular Ca2+ Handling in Native Endothelium of Excised Rat Aorta. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010250"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1042\/bj3640235","article-title":"Ca2+ uptake by the endoplasmic reticulum Ca2+-ATPase in rat microvascular endothelial cells","volume":"364","author":"Moccia","year":"2002","journal-title":"Biochem. J."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"108559","DOI":"10.1016\/j.exer.2021.108559","article-title":"Inactivation of cysteine 674 in the sarcoplasmic\/endoplasmic reticulum calcium ATPase 2 causes retinopathy in the mouse","volume":"207","author":"Liu","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.exer.2005.04.007","article-title":"Serca isoform expression in the mammalian retina","volume":"81","author":"Krizaj","year":"2005","journal-title":"Exp. Eye Res."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Moccia, F., Negri, S., Shekha, M., Faris, P., and Guerra, G. (2019). Endothelial Ca2+ Signaling, Angiogenesis and Vasculogenesis: Just What It Takes to Make a Blood Vessel. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20163962"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s004410050641","article-title":"Immunohistochemical localization of inositol 1,4,5-trisphosphate receptors in non-neural tissues, with special reference to epithelia, the reproductive system, and muscular tissues","volume":"285","author":"Nakanishi","year":"1996","journal-title":"Cell Tissue Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0167-4889(94)90039-6","article-title":"Comparative study of high-glucose effect on phosphatidylcholine hydrolysis of cultured retinal capillary pericytes and endothelial cells","volume":"1222","author":"Li","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Li, Y., Li, H.Y., Shao, J., Zhu, L., Xie, T.H., Cai, J., Wang, W., Cai, M.X., Wang, Z.L., and Yao, Y. (2022). GRP75 Modulates Endoplasmic Reticulum-Mitochondria Coupling and Accelerates Ca2+-Dependent Endothelial Cell Apoptosis in Diabetic Retinopathy. Biomolecules, 12.","DOI":"10.21203\/rs.3.rs-2093332\/v1"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/bs.ircmb.2021.03.001","article-title":"Endolysosomal Ca2+ signaling in cardiovascular health and disease","volume":"363","author":"Negri","year":"2021","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41419-021-04069-w","article-title":"Lysosome purinergic receptor P2X4 regulates neoangiogenesis induced by microvesicles from sarcoma patients","volume":"12","author":"Palinski","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1167\/iovs.18-26344","article-title":"Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis","volume":"60","author":"McGahon","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/cvr\/cvv216","article-title":"Endothelial Galphaq\/11 is required for VEGF-induced vascular permeability and angiogenesis","volume":"108","author":"Sivaraj","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1038\/s41467-021-22771-3","article-title":"FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/stem.734","article-title":"Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration","volume":"29","author":"Dragoni","year":"2011","journal-title":"Stem Cells"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/jcp.29896","article-title":"Nicotinic acid adenine dinucleotide phosphate activates two-pore channel TPC1 to mediate lysosomal Ca2+ release in endothelial colony-forming cells","volume":"236","author":"Moccia","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1093\/emboj\/20.11.2666","article-title":"NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores","volume":"20","author":"Churchill","year":"2001","journal-title":"EMBO J."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"E4706","DOI":"10.1073\/pnas.1406029111","article-title":"VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling","volume":"111","author":"Favia","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Galeano-Otero, I., Del Toro, R., Khatib, A.M., Rosado, J.A., Ordonez-Fernandez, A., and Smani, T. (2021). SARAF and Orai1 Contribute to Endothelial Cell Activation and Angiogenesis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.639952"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/01.RES.0000338496.95579.56","article-title":"Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation","volume":"103","author":"Abdullaev","year":"2008","journal-title":"Circ. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-physiol-052521-013426","article-title":"Physiological Functions of CRAC Channels","volume":"84","author":"Emrich","year":"2022","journal-title":"Annu. Rev. Physiol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/978-3-319-57732-6_22","article-title":"Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders","volume":"993","author":"Tanwar","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"8532","DOI":"10.1073\/pnas.1608859113","article-title":"Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS","volume":"113","author":"Yuan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e011704","DOI":"10.1161\/JAHA.118.011704","article-title":"Inositol 1,4,5-Trisphosphate Receptors in Endothelial Cells Play an Essential Role in Vasodilation and Blood Pressure Regulation","volume":"8","author":"Lin","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"154340","DOI":"10.1016\/j.metabol.2020.154340","article-title":"Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity","volume":"111","author":"Wilson","year":"2020","journal-title":"Metabolism"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1161\/CIRCRESAHA.124.325574","article-title":"Loss of Endothelial TRPC1 Induces Aortic Hypercontractility and Hypertension","volume":"136","author":"Zhu","year":"2025","journal-title":"Circ. Res."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Scarpellino, G., Genova, T., Quarta, E., Distasi, C., Dionisi, M., Fiorio Pla, A., and Munaron, L. (2022). P2X Purinergic Receptors Are Multisensory Detectors for Micro-Environmental Stimuli That Control Migration of Tumoral Endothelium. Cancers, 14.","DOI":"10.3390\/cancers14112743"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Moccia, F. (2018). Endothelial Ca2+ Signaling and the Resistance to Anticancer Treatments: Partners in Crime. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010217"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/0271678X211039592","article-title":"Amyloid-beta disrupts unitary calcium entry through endothelial NMDA receptors in mouse cerebral arteries","volume":"42","author":"Peters","year":"2022","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Lim, X.R., Willemse, L., and Harraz, O.F. (2024). Amyloid beta Abeta(1-40) activates Piezo1 channels in brain capillary endothelial cells. Biophys. J.","DOI":"10.1016\/j.bpj.2024.12.025"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1177\/0271678X241235790","article-title":"Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature","volume":"44","author":"Mughal","year":"2024","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/cvr\/cvad126","article-title":"Activation of endothelial TRPM2 exacerbates blood-brain barrier degradation in ischemic stroke","volume":"120","author":"Zong","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1007\/s10571-023-01372-2","article-title":"Mitochondrial Dysfunction and Apoptosis in Brain Microvascular Endothelial Cells Following Blast Traumatic Brain Injury","volume":"43","author":"Schmitt","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1016\/j.molcel.2024.09.009","article-title":"Dual regulation of IP3 receptors by IP3 and PIP2 controls the transition from local to global Ca2+ signals","volume":"84","author":"Ivanova","year":"2024","journal-title":"Mol. Cell"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e968","DOI":"10.1038\/tp.2016.217","article-title":"IP3 accumulation and\/or inositol depletion: Two downstream lithium\u2019s effects that may mediate its behavioral and cellular changes","volume":"6","author":"Sade","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref_163","first-page":"17","article-title":"The Role of the Wnt Pathway in VEGF\/Anti-VEGF-Dependent Control of the Endothelial Cell Barrier","volume":"62","author":"Li","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.yjmcc.2009.12.010","article-title":"Role of growth factor receptor transactivation in high glucose-induced increased levels of Gq\/11alpha and signaling in vascular smooth muscle cells","volume":"49","author":"Descorbeth","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1016\/j.molcel.2021.07.014","article-title":"Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER","volume":"81","author":"Booth","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Negri, S., Faris, P., and Moccia, F. (2021). Reactive Oxygen Species and Endothelial Ca2+ Signaling: Brothers in Arms or Partners in Crime?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189821"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00109-014-1234-2","article-title":"High glucose enhances store-operated calcium entry by upregulating ORAI\/STIM via calcineurin-NFAT signalling","volume":"93","author":"Daskoulidou","year":"2015","journal-title":"J. Mol. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"95223","DOI":"10.18632\/oncotarget.20255","article-title":"VEGF-induced intracellular Ca2+ oscillations are down-regulated and do not stimulate angiogenesis in breast cancer-derived endothelial colony forming cells","volume":"8","author":"Lodola","year":"2017","journal-title":"Oncotarget"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.exphem.2015.09.002","article-title":"Dysregulation of VEGF-induced proangiogenic Ca2+ oscillations in primary myelofibrosis-derived endothelial colony-forming cells","volume":"43","author":"Dragoni","year":"2015","journal-title":"Exp. Hematol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Rahman, S., and Rahman, T. (2017). Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-13343-x"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Moccia, F., Brunetti, V., Soda, T., Faris, P., Scarpellino, G., and Berra-Romani, R. (2023). Store-Operated Ca2+ Entry as a Putative Target of Flecainide for the Treatment of Arrhythmogenic Cardiomyopathy. J. Clin. Med., 12.","DOI":"10.3390\/jcm12165295"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.bbamcr.2014.10.024","article-title":"May the remodeling of the Ca2+ toolkit in endothelial progenitor cells derived from cancer patients suggest alternative targets for anti-angiogenic treatment?","volume":"1853","author":"Moccia","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.critrevonc.2018.09.005","article-title":"The role of endothelial colony forming cells in kidney cancer\u2019s pathogenesis, and in resistance to anti-VEGFR agents and mTOR inhibitors: A speculative review","volume":"132","author":"Poletto","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIRCRESAHA.112.269506","article-title":"Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel","volume":"110","author":"Cioffi","year":"2012","journal-title":"Circ.Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/10739680802220323","article-title":"VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6","volume":"15","author":"Glass","year":"2008","journal-title":"Microcirculation"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/FBP.0000000000000524","article-title":"An overview on transient receptor potential channels superfamily","volume":"31","author":"Tsagareli","year":"2020","journal-title":"Behav. Pharmacol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/j.2040-4603.2019.tb00087.x","article-title":"Transient Receptor Potential Channels and Endothelial Cell Calcium Signaling","volume":"9","author":"Thakore","year":"2019","journal-title":"Compr. Physiol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Negri, S., Faris, P., Berra-Romani, R., Guerra, G., and Moccia, F. (2019). Endothelial Transient Receptor Potential Channels and Vascular Remodeling: Extracellular Ca2+ Entry for Angiogenesis, Arteriogenesis and Vasculogenesis. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.01618"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1111\/bph.14762","article-title":"Endothelial TRPV4 channels modulate vascular tone by Ca2+ -induced Ca2+ release at inositol 1,4,5-trisphosphate receptors","volume":"176","author":"Heathcote","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/112_2020_32","article-title":"Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues","volume":"182","author":"Scarpellino","year":"2022","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/ajh\/hpae134","article-title":"Transient Receptor Potential Channels in Vascular Mechanotransduction","volume":"38","author":"Solano","year":"2025","journal-title":"Am. J. Hypertens."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Jackson, W.F. (2022). Endothelial Ion Channels and Cell-Cell Communication in the Microcirculation. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.805149"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Negri, S., Faris, P., Rosti, V., Antognazza, M.R., Lodola, F., and Moccia, F. (2020). Endothelial TRPV1 as an Emerging Molecular Target to Promote Therapeutic Angiogenesis. Cells, 9.","DOI":"10.3390\/cells9061341"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"e63040","DOI":"10.7554\/eLife.63040","article-title":"Brain endothelial cell TRPA1 channels initiate neurovascular coupling","volume":"10","author":"Thakore","year":"2021","journal-title":"eLife"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Berra-Romani, R., Brunetti, V., Pellavio, G., Soda, T., Laforenza, U., Scarpellino, G., and Moccia, F. (2023). Allyl Isothiocianate Induces Ca2+ Signals and Nitric Oxide Release by Inducing Reactive Oxygen Species Production in the Human Cerebrovascular Endothelial Cell Line hCMEC\/D3. Cells, 12.","DOI":"10.3390\/cells12131732"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1113\/JP280162","article-title":"Nitric oxide is fundamental to neurovascular coupling in humans","volume":"598","author":"Hoiland","year":"2020","journal-title":"J. Physiol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10571-013-9931-x","article-title":"Endothelial transient receptor potential conical channel (TRPC)-3 activation induces vasogenic edema formation in the rat piriform cortex following status epilepticus","volume":"33","author":"Ryu","year":"2013","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/jat.2762","article-title":"Transient alterations of the blood-brain barrier tight junction and receptor potential channel gene expression by chlorpyrifos","volume":"33","author":"Li","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1096\/fj.14-261396","article-title":"TRPV4 regulates the integrity of the blood-cerebrospinal fluid barrier and modulates transepithelial protein transport","volume":"29","author":"Narita","year":"2015","journal-title":"FASEB J."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Rosenkranz, S.C., Shaposhnykov, A., Schnapauff, O., Epping, L., Vieira, V., Heidermann, K., Schattling, B., Tsvilovskyy, V., Liedtke, W., and Meuth, S.G. (2020). TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00849"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2011.11.044","article-title":"Critical role of TRPP2 and TRPC1 channels in stretch-induced injury of blood-brain barrier endothelial cells","volume":"1436","author":"Berrout","year":"2012","journal-title":"Brain Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"136285","DOI":"10.1016\/j.neulet.2021.136285","article-title":"Minireview: Insights into the role of TRP channels in the retinal circulation and function","volume":"765","author":"Thebault","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1016\/j.visres.2011.10.009","article-title":"TRP channel gene expression in the mouse retina","volume":"51","author":"Gilliam","year":"2011","journal-title":"Vision. Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1167\/iovs.16-20279","article-title":"TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles","volume":"57","author":"McGahon","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/978-3-642-54215-2_10","article-title":"Trpv2","volume":"222","author":"Kojima","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"e155128","DOI":"10.1172\/jci.insight.155128","article-title":"Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats","volume":"7","author":"Esquiva","year":"2022","journal-title":"JCI Insight"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Muller, C., Morales, P., and Reggio, P.H. (2018). Cannabinoid Ligands Targeting TRP Channels. Front. Mol. Neurosci., 11.","DOI":"10.3389\/fnmol.2018.00487"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Arredondo Zamarripa, D., Noguez Imm, R., Bautista Cortes, A.M., Vazquez Ruiz, O., Bernardini, M., Fiorio Pla, A., Gkika, D., Prevarskaya, N., Lopez-Casillas, F., and Liedtke, W. (2018). Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: Diabetic milieu makes a difference. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-27642-4"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Orduna Rios, M., Noguez Imm, R., Hernandez Godinez, N.M., Bautista Cortes, A.M., Lopez Escalante, D.D., Liedtke, W., Martinez Torres, A., Concha, L., and Thebault, S. (2019). TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice. PLoS ONE, 14.","DOI":"10.1101\/535526"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Monaghan, K., McNaughten, J., McGahon, M.K., Kelly, C., Kyle, D., Yong, P.H., McGeown, J.G., and Curtis, T.M. (2015). Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128359"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1152\/physrev.00016.2015","article-title":"TRPV4: Molecular Conductor of a Diverse Orchestra","volume":"96","author":"White","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000503724","article-title":"The Effect and Mechanism of TRPC1, 3, and 6 on the Proliferation, Migration, and Lumen Formation of Retinal Vascular Endothelial Cells Induced by High Glucose","volume":"63","author":"Lang","year":"2020","journal-title":"Ophthalmic Res."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ceca.2015.01.002","article-title":"Suppression of transient receptor potential canonical channel 4 inhibits vascular endothelial growth factor-induced retinal neovascularization","volume":"57","author":"Song","year":"2015","journal-title":"Cell Calcium"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"107497","DOI":"10.1016\/j.pharmthera.2020.107497","article-title":"TRPC channels: Structure, function, regulation and recent advances in small molecular probes","volume":"209","author":"Wang","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41419-023-05701-7","article-title":"The TRPM7 channel reprograms cellular glycolysis to drive tumorigenesis and angiogenesis","volume":"14","author":"Wu","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1021\/acs.molpharmaceut.8b01252","article-title":"Cannabidiol Increases Proliferation, Migration, Tubulogenesis, and Integrity of Human Brain Endothelial Cells through TRPV2 Activation","volume":"16","author":"Luo","year":"2019","journal-title":"Mol. Pharm."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Luo, H., Saubamea, B., Chasseigneaux, S., Cochois, V., Smirnova, M., Glacial, F., Perriere, N., Chaves, C., Cisternino, S., and Decleves, X. (2020). Molecular and Functional Study of Transient Receptor Potential Vanilloid 1-4 at the Rat and Human Blood-Brain Barrier Reveals Interspecies Differences. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.578514"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3724\/abbs.2022118","article-title":"Physiological levels of fluid shear stress modulate vascular function through TRPV4 sparklets","volume":"54","author":"Geng","year":"2022","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.preteyeres.2013.02.001","article-title":"Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions","volume":"34","author":"Klaassen","year":"2013","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/10739680600930347","article-title":"Ca2+ signaling, TRP channels, and endothelial permeability","volume":"13","author":"Tiruppathi","year":"2006","journal-title":"Microcirculation"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.1113\/JP275052","article-title":"Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells","volume":"595","author":"Phuong","year":"2017","journal-title":"J. Physiol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.resp.2015.08.003","article-title":"Opposing actions of TRPV4 channel activation in the lung vasculature","volume":"219","author":"Ke","year":"2015","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000343173","article-title":"Activation of TRPV4 strengthens the tight-junction barrier in human epidermal keratinocytes","volume":"26","author":"Akazawa","year":"2013","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1124\/jpet.107.134551","article-title":"Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2","volume":"326","author":"Willette","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"L652","DOI":"10.1152\/ajplung.00113.2014","article-title":"Role of MMP2 and MMP9 in TRPV4-induced lung injury","volume":"307","author":"Villalta","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41419-019-1576-3","article-title":"The expression and function of TRPV4 channels in primate retinal ganglion cells and bipolar cells","volume":"10","author":"Gao","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/glia.23979","article-title":"TRPV4 channels mediate the mechanoresponse in retinal microglia","volume":"69","author":"Redmon","year":"2021","journal-title":"Glia"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"E3569","DOI":"10.1073\/pnas.1800201115","article-title":"Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion","volume":"115","author":"Harraz","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Berra-Romani, R., Faris, P., Negri, S., Botta, L., Genova, T., and Moccia, F. (2019). Arachidonic Acid Evokes an Increase in Intracellular Ca2+ Concentration and Nitric Oxide Production in Endothelial Cells from Human Brain Microcirculation. Cells, 8.","DOI":"10.3390\/cells8070689"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1002\/jcp.30116","article-title":"Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis","volume":"236","author":"Cappelli","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Moccia, F., Dragoni, S., Cinelli, M., Montagnani, S., Amato, B., Rosti, V., Guerra, G., and Tanzi, F. (2013). How to utilize Ca2+ signals to rejuvenate the repairative phenotype of senescent endothelial progenitor cells in elderly patients affected by cardiovascular diseases: A useful therapeutic support of surgical approach?. BMC Surg., 13.","DOI":"10.1186\/1471-2482-13-S2-S46"},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Smani, T., Gomez, L.J., Regodon, S., Woodard, G.E., Siegfried, G., Khatib, A.M., and Rosado, J.A. (2018). TRP Channels in Angiogenesis and Other Endothelial Functions. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.01731"},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Novakovic, M.M., and Prakriya, M. (2025). Calcium signaling at the interface between astrocytes and brain inflammation. Curr. Opin. Neurobiol., 90.","DOI":"10.1016\/j.conb.2024.102940"},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Shahulhameed, S., Swain, S., Jana, S., Chhablani, J., Ali, M.J., Pappuru, R.R., Tyagi, M., Vishwakarma, S., Sailaja, N., and Chakrabarti, S. (2019). A Robust Model System for Retinal Hypoxia: Live Imaging of Calcium Dynamics and Gene Expression Studies in Primary Human Mixed Retinal Culture. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.01445"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00018-023-05024-y","article-title":"Glial cell alterations in diabetes-induced neurodegeneration","volume":"81","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Rohowetz, L.J., Kraus, J.G., and Koulen, P. (2018). Reactive Oxygen Species-Mediated Damage of Retinal Neurons: Drug Development Targets for Therapies of Chronic Neurodegeneration of the Retina. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113362"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1042\/BST20240261","article-title":"Interplay of mitochondrial calcium signalling and reactive oxygen species production in the brain","volume":"52","author":"Angelova","year":"2024","journal-title":"Biochem. Soc. Trans."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"e21437","DOI":"10.1096\/fj.202002755R","article-title":"CaMKIIdelta is upregulated by pro-inflammatory cytokine IL-6 in a JAK\/STAT3-dependent manner to promote angiogenesis","volume":"35","author":"Singer","year":"2021","journal-title":"FASEB J."},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Li, X., Kerindongo, R.P., Preckel, B., Kalina, J.O., Hollmann, M.W., Zuurbier, C.J., and Weber, N.C. (2023). Canagliflozin inhibits inflammasome activation in diabetic endothelial cells-Revealing a novel calcium-dependent anti-inflammatory effect of canagliflozin on human diabetic endothelial cells. Biomed. Pharmacother., 159.","DOI":"10.1016\/j.biopha.2023.114228"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"177147","DOI":"10.1016\/j.ejphar.2024.177147","article-title":"Empagliflozin prevents TNF-alpha induced endothelial dysfunction under flow -the potential involvement of calcium and sodium-hydrogen exchanger","volume":"986","author":"Li","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"e140966","DOI":"10.1172\/JCI140966","article-title":"Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging","volume":"131","author":"Propson","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Shahulhameed, S., Vishwakarma, S., Chhablani, J., Tyagi, M., Pappuru, R.R., Jakati, S., Chakrabarti, S., and Kaur, I. (2020). A Systematic Investigation on Complement Pathway Activation in Diabetic Retinopathy. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00154"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"e002269","DOI":"10.1136\/bmjopen-2012-002269","article-title":"Current treatments in diabetic macular oedema: Systematic review and meta-analysis","volume":"3","author":"Ford","year":"2013","journal-title":"BMJ Open"},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Berlansky, S., Sallinger, M., Grabmayr, H., Humer, C., Bernhard, A., Fahrner, M., and Frischauf, I. (2022). Calcium Signals during SARS-CoV-2 Infection: Assessing the Potential of Emerging Therapies. Cells, 11.","DOI":"10.3390\/cells11020253"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1186\/s13054-020-03220-x","article-title":"Auxora versus standard of care for the treatment of severe or critical COVID-19 pneumonia: Results from a randomized controlled trial","volume":"24","author":"Miller","year":"2020","journal-title":"Crit. Care"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"107458","DOI":"10.1016\/j.vph.2024.107458","article-title":"Targeting the Ca2+ signaling toolkit as an alternative strategy to mitigate SARS-CoV-2-induced cardiovascular adverse events","volume":"158","author":"Scorza","year":"2025","journal-title":"Vasc. Pharmacol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"102528","DOI":"10.1016\/j.ceca.2022.102528","article-title":"The ins and outs of virus trafficking through acidic Ca2+ stores","volume":"102","author":"Gunaratne","year":"2022","journal-title":"Cell Calcium"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ceca.2018.08.002","article-title":"A screening campaign in sea urchin egg homogenate as a platform for discovering modulators of NAADP-dependent Ca2+ signaling in human cells","volume":"75","author":"Gunaratne","year":"2018","journal-title":"Cell Calcium"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.bbamcr.2018.10.022","article-title":"Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers","volume":"1866","author":"Penny","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1126\/science.1258758","article-title":"Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment","volume":"347","author":"Sakurai","year":"2015","journal-title":"Science"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.pbiomolbio.2020.06.001","article-title":"TRPV2 channel-based therapies in the cardiovascular field. Molecular underpinnings of clinically relevant therapies","volume":"159","author":"Robbins","year":"2021","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1021\/acsmedchemlett.1c00406","article-title":"Identification, Synthesis, and Characterization of a Major Circulating Human Metabolite of TRPV4 Antagonist GSK2798745","volume":"12","author":"Pero","year":"2021","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"109405","DOI":"10.1016\/j.exer.2023.109405","article-title":"TRPV4 channels promote vascular permeability in retinal vascular disease","volume":"228","author":"Nishinaka","year":"2023","journal-title":"Exp. 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