{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T08:53:40Z","timestamp":1769849620719,"version":"3.49.0"},"reference-count":60,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Pathology and the School of Medicine and Health Sciences, University of North Dakota","award":["P20 GM103442"],"award-info":[{"award-number":["P20 GM103442"]}]},{"name":"National Institute of General Medical Sciences, NIH, under the University of North Dakota School of Medicine and Health Sciences","award":["P20 GM103442"],"award-info":[{"award-number":["P20 GM103442"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Arsenic, in the form of inorganic arsenite, is toxic to the kidney and can cause acute kidney injury, manifesting as destruction of proximal tubule cells. Nephron repair is possible through the proliferation of resident tubular progenitor cells expressing CD133 and CD24 surface markers. We simulated regenerative repair in the continued presence of i-As (III) using a cell culture model of a renal progenitor cell line expressing CD133 (PROM1) and CD24. Continued exposure and subculturing of progenitor cells to i-As (III) led to a reduction in the expression of PROM1 and CD24, as well as a decrease in the ability to differentiate into tubule-like structures. Cessation of i-As (III) and recovery for up to three passages resulted in continued repression of PROM1 and reduced ability to differentiate. Chronically exposed cells exhibited an ability to form colonies in soft agar, suggesting neoplastic transformation. Chronically exposed cells also exhibited an induction of CD44, a cell surface marker commonly found in renal cell carcinoma, as well as in tubular repair in chronic renal injury such as chronic kidney disease. These results demonstrate potential adverse outcomes of renal progenitor cells chronically exposed to a nephrotoxicant, as well as in environmental exposure to arsenic.<\/jats:p>","DOI":"10.3390\/cells14120877","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T12:53:16Z","timestamp":1749559996000},"page":"877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inorganic Arsenite [As (III)] Represses Human Renal Progenitor Cell Characteristics and Induces Neoplastic-like Transformation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3893-3829","authenticated-orcid":false,"given":"Md Ehsanul","family":"Haque","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swojani","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald A.","family":"Sens","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott H.","family":"Garrett","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"ref_1","first-page":"100052","article-title":"Arsenic as an environmental and human health antagonist: A review of its toxicity and disease initiation","volume":"5","author":"Fatoki","year":"2022","journal-title":"J. Hazard. Mater. Adv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12443","DOI":"10.1021\/acs.est.7b02881","article-title":"Estimating the High-Arsenic Domestic-Well Population in the Conterminous United States","volume":"51","author":"Ayotte","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"ref_3","unstructured":"Nordstrom, D.K. (2025, January 25). An Overview of Arsenic Mass-Poisoning in Bangladesh and West Bengal, India, Available online: https:\/\/pubs.usgs.gov\/publication\/70198882."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/10408440500534230","article-title":"Methylated arsenicals: The implications of metabolism and carcinogenicity studies in rodents to human risk assessment","volume":"36","author":"Cohen","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/toxsci\/kfr184","article-title":"Arsenic exposure and toxicology: A historical perspective","volume":"123","author":"Hughes","year":"2011","journal-title":"Toxicol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1053\/j.ajkd.2017.06.012","article-title":"Arsenic Exposure from Drinking Water and the Incidence of CKD in Low to Moderate Exposed Areas of Taiwan: A 14-Year Prospective Study","volume":"70","author":"Hsu","year":"2017","journal-title":"Am. J. Kidney Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sotomayor, C.G., Groothof, D., Vodegel, J.J., Gacit\u00faa, T.A., Gomes-Neto, A.W., Ost\u00e9, M.C.J., Pol, R.A., Ferreccio, C., Berger, S.P., and Chong, G. (2020). Circulating Arsenic is Associated with Long-Term Risk of Graft Failure in Kidney Transplant Recipients: A Prospective Cohort Study. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020417"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3109\/0886022X.2015.1013419","article-title":"Arsenic-mediated nephrotoxicity","volume":"37","author":"Sabath","year":"2015","journal-title":"Ren. Fail."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Peters, B.A., Hall, M.N., Liu, X., Neugut, Y.D., Pilsner, J.R., Levy, D., Ilievski, V., Slavkovich, V., Islam, T., and Factor-Litvak, P. (2014). Creatinine, arsenic metabolism, and renal function in an arsenic-exposed population in Bangladesh. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113760"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/tox.22673","article-title":"State of the science review of the health effects of inorganic arsenic: Perspectives for future research","volume":"34","author":"Tchounwou","year":"2019","journal-title":"Environ. Toxicol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: An update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int. Suppl."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/path.4125","article-title":"Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration","volume":"229","author":"Smeets","year":"2013","journal-title":"J. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.scr.2013.12.011","article-title":"CD133+ renal stem cells always co-express CD24 in adult human kidney tissue","volume":"12","author":"Romagnani","year":"2014","journal-title":"Stem Cell Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrneph.2012.290","article-title":"Renal progenitors: An evolutionary conserved strategy for kidney regeneration","volume":"9","author":"Romagnani","year":"2013","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s13287-021-02266-0","article-title":"Stem\/progenitor cell in kidney: Characteristics, homing, coordination, and maintenance","volume":"12","author":"Huang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.ajpath.2010.10.026","article-title":"Isolation and characterization of progenitor-like cells from human renal proximal tubules","volume":"178","author":"Lindgren","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/ckj\/sfw047","article-title":"Chronic kidney disease in children","volume":"9","author":"Becherucci","year":"2016","journal-title":"Clin. Kidney J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"10466","DOI":"10.1111\/jcmm.16976","article-title":"Role of HRTPT in kidney proximal epithelial cell regeneration: Integrative differential expression and pathway analyses using microarray and scRNA-seq","volume":"25","author":"Shrestha","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.taap.2017.05.038","article-title":"Human renal tubular cells contain CD24\/CD133 progenitor cell populations: Implications for tubular regeneration after toxicant induced damage using cadmium as a model","volume":"331","author":"Shrestha","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Singhal, S., Garrett, S.H., Somji, S., Schaefer, K., Bansal, B., Gill, J.S., Singhal, S.K., and Sens, D.A. (2023). Arsenite Exposure to Human RPCs (HRTPT) Produces a Reversible Epithelial Mesenchymal Transition (EMT): In-Vitro and In-Silico Study. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065092"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"113875","DOI":"10.1016\/j.yexcr.2023.113875","article-title":"Great potential of renal progenitor cells in kidney: From the development to clinic","volume":"434","author":"Bahrami","year":"2024","journal-title":"Exp. Cell Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.taap.2019.05.007","article-title":"Characterization and determination of cadmium resistance of CD133+\/CD24+ and CD133\u2212\/CD24+ cells isolated from the immortalized human proximal tubule cell line, RPTEC\/TERT1","volume":"375","author":"Shrestha","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Mehus, A.A., Jones, M., Trahan, M., Kinnunen, K., Berwald, K., Lindner, B., Al-Marsoummi, S., Zhou, X.D., Garrett, S.H., and Sens, D.A. (2023). Pevonedistat Inhibits SOX2 Expression and Sphere Formation but Also Drives the Induction of Terminal Differentiation Markers and Apoptosis within Arsenite-Transformed Urothelial Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119149"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/jat.1513","article-title":"Keratin 6 expression correlates to areas of squamous differentiation in multiple independent isolates of As+3-induced bladder cancer","volume":"30","author":"Cao","year":"2010","journal-title":"J. Appl. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kalyan, G., Slusser-Nore, A., Dunlevy, J.R., Bathula, C.S., Shabb, J.B., Muhonen, W., Somji, S., Sens, D.A., Garrett, S.H., and Theilig, F. (2022). Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0267599"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.toxlet.2010.08.020","article-title":"SPARC gene expression is repressed in human urothelial cells (UROtsa) exposed to or malignantly transformed by cadmium or arsenite","volume":"199","author":"Larson","year":"2010","journal-title":"Toxicol. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1681\/ASN.2006010089","article-title":"Isolation and characterization of multipotent progenitor cells from the Bowman\u2019s capsule of adult human kidneys","volume":"17","author":"Sagrinati","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1177\/096032719501401110","article-title":"Isolation and characterisation of human proximal tubular cells derived from kidney cortical segments","volume":"14","author":"McLaren","year":"1995","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Du, F., Zhao, X., and Fan, D. (2017). Soft Agar Colony Formation Assay as a Hallmark of Carcinogenesis. Bio Protoc., 7.","DOI":"10.21769\/BioProtoc.2351"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1073\/pnas.82.1.119","article-title":"Type beta transforming growth factor: A bifunctional regulator of cellular growth","volume":"82","author":"Roberts","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","first-page":"1026","article-title":"A survey of growth in soft agar and cell surface properties as markers for transformation in adult rat liver epithelial-like cell cultures","volume":"39","author":"San","year":"1979","journal-title":"Cancer Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/toxsci\/kfh086","article-title":"Inorganic Cadmium- and Arsenite-Induced Malignant Transformation of Human Bladder Urothelial Cells","volume":"79","author":"Sens","year":"2004","journal-title":"Toxicol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1681\/ASN.2007020210","article-title":"Regenerative potential of embryonic renal multipotent progenitors in acute renal failure","volume":"18","author":"Lazzeri","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Sandquist, E.J., Somji, S., Dunlevy, J.R., Garrett, S.H., Zhou, X.D., Slusser-Nore, A., and Sens, D.A. (2016). Loss of N-Cadherin Expression in Tumor Transplants Produced from As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156310"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1681\/ASN.2008070795","article-title":"Recruitment of Podocytes from Glomerular Parietal Epithelial Cells","volume":"20","author":"Appel","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Chraba\u0144ska, M., Rynkiewicz, M., Kiczmer, P., and Drozdzowska, B. (2023). Does the Immunohistochemical Expression of CD44, MMP-2, and MMP-9 in Association with the Histopathological Subtype of Renal Cell Carcinoma Affect the Survival of Patients with Renal Cancer?. Cancers, 15.","DOI":"10.3390\/cancers15041202"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Loh, C.Y., Chai, J.Y., Tang, T.F., Wong, W.F., Sethi, G., Shanmugam, M.K., Chong, P.P., and Looi, C.Y. (2019). The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges. Cells, 8.","DOI":"10.3390\/cells8101118"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1242\/jcs.000455","article-title":"Cadherin switching","volume":"121","author":"Wheelock","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"866","DOI":"10.18632\/aging.102660","article-title":"Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinoma","volume":"12","author":"Xu","year":"2020","journal-title":"Aging"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Marconi, G.D., Fonticoli, L., Rajan, T.S., Pierdomenico, S.D., Trubiani, O., Pizzicannella, J., and Diomede, F. (2021). Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis. Cells, 10.","DOI":"10.3390\/cells10071587"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jat.4554","article-title":"Role of CD44 expressed in renal tubules during maladaptive repair in renal fibrogenesis in an allopurinol-induced rat model of chronic kidney disease","volume":"44","author":"Matsushita","year":"2024","journal-title":"J. Appl. Toxicol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0014-4827(65)90211-9","article-title":"The limited in vitro lifetime of human diploid cell strains","volume":"37","author":"Hayflick","year":"1965","journal-title":"Exp. Cell Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.taap.2012.05.013","article-title":"Urinary total arsenic and 8-hydroxydeoxyguanosine are associated with renal cell carcinoma in an area without obvious arsenic exposure","volume":"262","author":"Huang","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.envint.2017.10.014","article-title":"Estimating the risk of bladder and kidney cancer from exposure to low-levels of arsenic in drinking water, Nova Scotia, Canada","volume":"110","author":"Brown","year":"2018","journal-title":"Environ. Int."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Lasorsa, F., Rutigliano, M., Milella, M., Ferro, M., Pandolfo, S.D., Crocetto, F., Autorino, R., Battaglia, M., Ditonno, P., and Lucarelli, G. (2023). Cancer Stem Cells in Renal Cell Carcinoma: Origins and Biomarkers. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713179"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/cjp2.91","article-title":"Biomarker discovery for renal cancer stem cells","volume":"4","author":"Moch","year":"2018","journal-title":"J. Pathol. Clin. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/10643389991259227","article-title":"A Review of Arsenic Poisoning and its Effects on Human Health","volume":"29","author":"Saha","year":"1999","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.scitotenv.2018.01.043","article-title":"Associations between arsenic in drinking water and occurrence of end-stage renal disease with modifications by comorbidities: A nationwide population-based study in Taiwan","volume":"626","author":"Cheng","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Gama, J.M., and Oliveira, R.C. (2025). CD44 and Its Role in Solid Cancers\u2014A Review: From Tumor Progression to Prognosis and Targeted Therapy. Front. Biosci., 30.","DOI":"10.31083\/FBL24821"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.tem.2022.02.002","article-title":"The membrane receptor CD44: Novel insights into metabolism","volume":"33","author":"Weng","year":"2022","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/2087204","article-title":"The Importance of CD44 as a Stem Cell Biomarker and Therapeutic Target in Cancer","volume":"2016","author":"Thapa","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41698-022-00296-2","article-title":"Activation of CD44\/PAK1\/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer","volume":"6","author":"Elakad","year":"2022","journal-title":"NPJ Precis. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Li, X., Ma, X., Chen, L., Gu, L., Zhang, Y., Zhang, F., Ouyang, Y., Gao, Y., Huang, Q., and Zhang, X. (2015). Prognostic value of CD44 expression in renal cell carcinoma: A systematic review and meta-analysis. Sci. Rep., 5.","DOI":"10.1038\/srep13157"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Li, W., Ma, H., Zhang, J., Zhu, L., Wang, C., and Yang, Y. (2017). Unraveling the roles of CD44\/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-14364-2"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/cas.12917","article-title":"Infiltration of tumor-associated macrophages is involved in CD44 expression in clear cell renal cell carcinoma","volume":"107","author":"Ma","year":"2016","journal-title":"Cancer Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/01.ASN.0000115703.30835.96","article-title":"CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy","volume":"15","author":"Rouschop","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Papanastasiou, A.D., Peroukidis, S., Sirinian, C., Arkoumani, E., Chaniotis, D., and Zizi-Sermpetzoglou, A. (2024). CD44 Expression in Clear Cell Renal Cell Carcinoma (ccRCC) Correlates with Tumor Grade and Patient Survival and Is Affected by Gene Methylation. Genes, 15.","DOI":"10.3390\/genes15050537"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Senbanjo, L.T., and Chellaiah, M.A. (2017). CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells. Front. Cell Dev. Biol., 5.","DOI":"10.3389\/fcell.2017.00018"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2217\/bmm-2017-0142","article-title":"Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma","volume":"12","author":"Zanjani","year":"2018","journal-title":"Biomark. Med."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Franzin, R., Stasi, A., De Palma, G., Picerno, A., Curci, C., Sebastiano, S., Campioni, M., Cicirelli, A., Rizzo, A., and Di Lorenzo, V.F. (2023). Human Adult Renal Progenitor Cells Prevent Cisplatin-Nephrotoxicity by Inducing CYP1B1 Overexpression and miR-27b-3p Down-Regulation through Extracellular Vesicles. 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