{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:23:08Z","timestamp":1784967788581,"version":"3.55.0"},"reference-count":71,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Eryptosis is a programmed cellular death involving red blood cells (RBCs). It is a physiological mechanism that leads to the removal of defective erythrocytes, similarly to apoptosis. Its typical features are cell shrinkage, cell membrane blebbing, and membrane scrambling with the consequent exposure of the aminophospholipid phosphatidylserine on the outer surface of RBCs. Different mechanisms play a role in the pathogenesis of eryptosis, such as the increase in cytosolic calcium concentration, oxidative stress, inflammation, and uremic toxins. If erythrocyte synthesis does not compensate for the accelerated eryptosis, anemia may develop. Moreover, enhanced eryptosis contributes to the pathogenesis of different clinical diseases, such as diabetes, sepsis, metabolic syndrome, and uremia. In particular, in patients with chronic kidney disease (CKD), deficiencies of erythropoietin and iron may further reduce the lifespan of RBCs. In this review, we focused on eryptosis in CKD and end-stage renal disease on peritoneal dialysis (PD) and hemodialysis (HD).<\/jats:p>","DOI":"10.3390\/cells14130967","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T10:44:41Z","timestamp":1750761881000},"page":"967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Red Cell Death in Renal Disease: The Role of Eryptosis in CKD and Dialysis Patients"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-9800","authenticated-orcid":false,"given":"Grazia Maria","family":"Virz\u00ec","sequence":"first","affiliation":[{"name":"Department of Nephrology, Dialysis and Transplant, St Bortolo Hospital, 36100 Vicenza, Italy"},{"name":"IRRIV\u2014International Renal Research Institute Vicenza, 36100 Vicenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Clementi","sequence":"additional","affiliation":[{"name":"IRRIV\u2014International Renal Research Institute Vicenza, 36100 Vicenza, Italy"},{"name":"Department of Nephrology and Dialysis, Santa Marta and Santa Venera Hospital, 95024 Acireale, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6697-4065","authenticated-orcid":false,"given":"Claudio","family":"Ronco","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Transplant, St Bortolo Hospital, 36100 Vicenza, Italy"},{"name":"IRRIV\u2014International Renal Research Institute Vicenza, 36100 Vicenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Zanella","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Transplant, St Bortolo Hospital, 36100 Vicenza, Italy"},{"name":"IRRIV\u2014International Renal Research Institute Vicenza, 36100 Vicenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref_1","first-page":"481","article-title":"Red Blood Cells-Derived Components as Biomimetic Functional Materials: Matching Versatile Delivery Strategies Based on Structure and Function","volume":"47","author":"Liu","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"124658","DOI":"10.1016\/j.ijpharm.2024.124658","article-title":"Recent Advances with Erythrocytes as Therapeutics Carriers","volume":"665","author":"Maleki","year":"2024","journal-title":"Int. J. Pharm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.7150\/thno.87425","article-title":"Red Blood Cells in Biology and Translational Medicine: Natural Vehicle Inspires New Biomedical Applications","volume":"14","author":"Zhang","year":"2024","journal-title":"Theranostics"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kumar, S.D., Ghosh, J., Ghosh, S., and Eswarappa, S.M. (2025). Emerging Concepts in the Molecular Cell Biology and Functions of Mammalian Erythrocytes. J. Biol. Chem., 301.","DOI":"10.1016\/j.jbc.2025.108331"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1159\/000447895","article-title":"A Comprehensive Review on Eryptosis","volume":"39","author":"Pretorius","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lang, E., and Lang, F. (2015). Triggers, Inhibitors, Mechanisms, and Significance of Eryptosis: The Suicidal Erythrocyte Death. Biomed Res. Int., 2015.","DOI":"10.1155\/2015\/513518"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000086406","article-title":"Mechanisms of Suicidal Erythrocyte Death","volume":"15","author":"Lang","year":"2005","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exphem.2021.01.001","article-title":"Erythroid Enucleation: A Gateway into a \u201cBloody\u201d World","volume":"95","author":"Menon","year":"2021","journal-title":"Exp. Hematol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/jha2.1051","article-title":"New Insights into the Mechanisms of Red Blood Cell Enucleation: From Basics to Clinical Applications","volume":"5","author":"Zhuo","year":"2024","journal-title":"EJHaem"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/bjh.14194","article-title":"Advances in Understanding the Mechanisms of Erythropoiesis in Homeostasis and Disease","volume":"174","author":"Liang","year":"2016","journal-title":"Br. J. Haematol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/iub.226","article-title":"Erythropoiesis: Model Systems, Molecular Regulators, and Developmental Programs","volume":"61","author":"Tsiftsoglou","year":"2009","journal-title":"IUBMB Life"},{"key":"ref_12","first-page":"1451","article-title":"Molecular and Cellular Mechanisms That Regulate Human Erythropoiesis","volume":"140","author":"Caulier","year":"2022","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2141.2006.06279.x","article-title":"A Detailed Study of Time-Dependent Changes in Human Red Blood Cells: From Reticulocyte Maturation to Erythrocyte Senescence","volume":"135","author":"Gifford","year":"2006","journal-title":"Br. J. Haematol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lutz, H.U., and Bogdanova, A. (2013). Mechanisms Tagging Senescent Red Blood Cells for Clearance in Healthy Humans. Front. Physiol., 4.","DOI":"10.3389\/fphys.2013.00387"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000087725","article-title":"Erythrocyte Aging: A More than Superficial Resemblance to Apoptosis?","volume":"16","author":"Bosman","year":"2005","journal-title":"Cell Physiol. Biochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s10495-025-02081-5","article-title":"Cell Death Signaling in Human Erythron: Erythrocytes Lose the Complexity of Cell Death Machinery upon Maturation","volume":"30","author":"Tkachenko","year":"2025","journal-title":"Apoptosis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1089\/ars.2013.5747","article-title":"Oxidative Stress and Suicidal Erythrocyte Death","volume":"21","author":"Lang","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1748-1716.2006.01564.x","article-title":"Osmotic Shock-Induced Suicidal Death of Erythrocytes","volume":"187","author":"Lang","year":"2006","journal-title":"Acta Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000315102","article-title":"Ceramide in Suicidal Death of Erythrocytes","volume":"26","author":"Lang","year":"2010","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000185448","article-title":"Eryptosis, a Window to Systemic Disease","volume":"22","author":"Lang","year":"2008","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1159\/000342534","article-title":"Physiology and Pathophysiology of Eryptosis","volume":"39","author":"Lang","year":"2012","journal-title":"Transfus. Med. Hemother."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000443784","article-title":"Uremic Toxicity-Induced Eryptosis and Monocyte Modulation: The Erythrophagocytosis as a Novel Pathway to Renal Anemia","volume":"41","author":"Bonan","year":"2016","journal-title":"Blood Purif."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1159\/000335798","article-title":"Regulation of Phosphatidylserine Exposure in Red Blood Cells","volume":"28","author":"Nguyen","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.biocel.2012.04.019","article-title":"Killing Me Softly-Suicidal Erythrocyte Death","volume":"44","author":"Lang","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/ijlh.14039","article-title":"Influence of Hemolysis on Nucleated Red Blood Cells Count","volume":"45","author":"Cheng","year":"2023","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Alghareeb, S.A., Alfhili, M.A., and Fatima, S. (2023). Molecular Mechanisms and Pathophysiological Significance of Eryptosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065079"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.2215\/CJN.05541008","article-title":"Health-Related Quality of Life in CKD Patients: Correlates and Evolution over Time","volume":"4","author":"Mujais","year":"2009","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_28","first-page":"11","article-title":"Cardio-Renal Anemia Syndrome","volume":"12","author":"Efstratiadis","year":"2008","journal-title":"Hippokratia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2215\/CJN.05301107","article-title":"Anemia and Risk of Hospitalization in Pediatric Chronic Kidney Disease","volume":"4","author":"Staples","year":"2009","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Kurella Tamura, M., Vittinghoff, E., Yang, J., Go, A.S., Seliger, S.L., Kusek, J.W., Lash, J., Cohen, D.L., Simon, J., and Batuman, V. (2016). Anemia and Risk for Cognitive Decline in Chronic Kidney Disease. BMC Nephrol., 17.","DOI":"10.1186\/s12882-016-0226-6"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0272-6386(96)90130-4","article-title":"The Impact of Anemia on Cardiomyopathy, Morbidity, and and Mortality in End-Stage Renal Disease","volume":"28","author":"Foley","year":"1996","journal-title":"Am. J. Kidney Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1182\/blood.V54.4.877.877","article-title":"Serum Erythropoietin Concentration in Chronic Renal Failure: Relationship to Degree of Anemia and Excretory Renal Function","volume":"54","author":"Radtke","year":"1979","journal-title":"Blood"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000355752","article-title":"Stimulation of Suicidal Erythrocyte Death by Increased Extracellular Phosphate Concentrations","volume":"38","author":"Voelkl","year":"2013","journal-title":"Kidney Blood Press. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1159\/000522133","article-title":"What Should Be Responsible for Eryptosis in Chronic Kidney Disease?","volume":"47","author":"Li","year":"2022","journal-title":"Kidney Blood Press. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000334163","article-title":"Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes","volume":"33","author":"Lang","year":"2012","journal-title":"Blood Purif."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/ki.1991.295","article-title":"Urinary Albumin, Transferrin and Iron Excretion in Diabetic Patients","volume":"40","author":"Howard","year":"1991","journal-title":"Kidney Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.kint.2021.08.024","article-title":"Proteinuric Chronic Kidney Disease Is Associated with Altered Red Blood Cell Lifespan, Deformability and Metabolism","volume":"100","author":"Bissinger","year":"2021","journal-title":"Kidney Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/MNH.0000000000000957","article-title":"Eryptosis: A Driver of Anemia in Chronic Kidney Disease","volume":"33","author":"Bissinger","year":"2024","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_39","first-page":"316384","article-title":"Increased Caspase-3 Immunoreactivity of Erythrocytes in STZ Diabetic Rats","volume":"2012","author":"Kaya","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1111\/jcmm.17362","article-title":"Mechanisms of 8-Aminoquinoline Induced Haemolytic Toxicity in a G6PDd Humanized Mouse Model","volume":"26","author":"Flaherty","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ahmed, M.S.E., Abed, M., Voelkl, J., and Lang, F. (2013). Triggering of Suicidal Erythrocyte Death by Uremic Toxin Indoxyl Sulfate. BMC Nephrol., 14.","DOI":"10.1186\/1471-2369-14-244"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000350141","article-title":"The Uremic Toxin Acrolein Promotes Suicidal Erythrocyte Death","volume":"37","author":"Ahmed","year":"2013","journal-title":"Kidney Blood Press. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9555","DOI":"10.1016\/S0021-9258(18)47969-0","article-title":"Mechanism of Inhibition of Glycolysis by Vanadate","volume":"262","author":"Benabe","year":"1987","journal-title":"J. Biol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.3390\/toxins7114390","article-title":"Indolic Uremic Solutes Enhance Procoagulant Activity of Red Blood Cells through Phosphatidylserine Exposure and Microparticle Release","volume":"7","author":"Gao","year":"2015","journal-title":"Toxins"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Virz\u00ec, G.M., Mattiotti, M., Clementi, A., Milan Manani, S., Battaglia, G.G., Ronco, C., and Zanella, M. (2022). In Vitro Induction of Eryptosis by Uremic Toxins and Inflammation Mediators in Healthy Red Blood Cells. J. Clin. Med., 11.","DOI":"10.3390\/jcm11185329"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Dias, G.F., Bonan, N.B., Steiner, T.M., Tozoni, S.S., Rodrigues, S., Nakao, L.S., Kuntsevich, V., Pecoits Filho, R., Kotanko, P., and Moreno-Amaral, A.N. (2018). Indoxyl Sulfate, a Uremic Toxin, Stimulates Reactive Oxygen Species Production and Erythrocyte Cell Death Supposedly by an Organic Anion Transporter 2 (OAT2) and NADPH Oxidase Activity-Dependent Pathways. Toxins, 10.","DOI":"10.3390\/toxins10070280"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"C291-7","DOI":"10.1152\/ajpcell.00318.2013","article-title":"Dynamic Adhesion of Eryptotic Erythrocytes to Immobilized Platelets via Platelet Phosphatidylserine Receptors","volume":"306","author":"Walker","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hikisz, P., and Jacenik, D. (2023). The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity. Cells, 12.","DOI":"10.3390\/cells12060879"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"121686","DOI":"10.1016\/j.jhazmat.2019.121686","article-title":"Formation of Di-Cysteine Acrolein Adduct Decreases Cytotoxicity of Acrolein by ROS Alleviation and Apoptosis Intervention","volume":"387","author":"Yin","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1021\/acs.jafc.0c01345","article-title":"Interaction of Acrylamide, Acrolein, and 5-Hydroxymethylfurfural with Amino Acids and DNA","volume":"68","author":"Ou","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Kopera, M., Gwozdzinski, K., and Pieniazek, A. (2024). Acrolein Induces Changes in Cell Membrane and Cytosol Proteins of Erythrocytes. Molecules, 29.","DOI":"10.3390\/molecules29112519"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1002\/1097-0142(19841201)54:11<2513::AID-CNCR2820541133>3.0.CO;2-I","article-title":"Invasive Thymoma with Myasthenia Gravis","volume":"54","author":"Monden","year":"1984","journal-title":"Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00109-014-1151-4","article-title":"Suicidal Erythrocyte Death in End-Stage Renal Disease","volume":"92","author":"Abed","year":"2014","journal-title":"J. Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000477608","article-title":"Erythrocyte Sodium Sensitivity and Eryptosis in Chronic Hemodialysis Patients","volume":"42","author":"Kuntsevich","year":"2017","journal-title":"Kidney Blood Press. Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Caprara, C., Virz\u00ec, G.M., Chieregato, K., Marchionna, N., Corradi, V., Brendolan, A., Ronco, C., and Zanella, M. (2024). Immunomodulation Driven by Theranova Filter during a Single HD Session. J. Clin. Med., 13.","DOI":"10.3390\/jcm13072147"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"gfae069-1528","DOI":"10.1093\/ndt\/gfae069.1528","article-title":"#1573 Effects of Haemodialysis Coupled with Hemadsorption on Uremic Toxins Removal, Oxidative Stress and Cellular Death","volume":"39","author":"Marcello","year":"2024","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1159\/000452600","article-title":"Reduced Erythrocyte Survival in Uremic Patients Under Hemodialysis or Peritoneal Dialysis","volume":"41","author":"Bissinger","year":"2016","journal-title":"Kidney Blood Press. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1053\/j.ajkd.2011.03.031","article-title":"Red Blood Cell Survival in Long-Term Dialysis Patients","volume":"58","author":"Vos","year":"2011","journal-title":"Am. J. Kidney Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1681\/ASN.V1091982","article-title":"Increased Erythrocyte Phosphatidylserine Exposure in Chronic Renal Failure","volume":"10","author":"Bonomini","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1159\/000501541","article-title":"Eryptosis Is Altered in Peritoneal Dialysis Patients","volume":"48","author":"Clementi","year":"2019","journal-title":"Blood Purif."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Virz\u00ec, G.M., Milan Manani, S., Marturano, D., Clementi, A., Lerco, S., Tantillo, I., Giuliani, A., Battaglia, G.G., Ronco, C., and Zanella, M. (2022). Eryptosis in Peritoneal Dialysis-Related Peritonitis: The Potential Role of Inflammation in Mediating the Increase in Eryptosis in PD. J. Clin. Med., 11.","DOI":"10.3390\/jcm11236918"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Bester, J., and Pretorius, E. (2016). Effects of IL-1\u03b2, IL-6 and IL-8 on Erythrocytes, Platelets and Clot Viscoelasticity. Sci. Rep., 6.","DOI":"10.1038\/srep32188"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1159\/000458745","article-title":"Stimulation of Erythrocyte Cell Membrane Scrambling by C-Reactive Protein","volume":"41","author":"Abed","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Virz\u00ec, G.M., Morisi, N., Marturano, D., Milan Manani, S., Tantillo, I., Ronco, C., and Zanella, M. (2024). Peritoneal Inflammation in PD-Related Peritonitis Induces Systemic Eryptosis: In Vitro and In Vivo Assessments. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25084284"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/ejh.12875","article-title":"Pathophysiological aspects of red blood cells in end-stage renal disease patients resistant to recombinant human erythropoietin therapy","volume":"98","author":"Georgatzakou","year":"2017","journal-title":"Eur. J. Haematol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1139\/cjpp-2017-0285","article-title":"Short-term effects of hemodiafiltration versus conventional hemodialysis on erythrocyte performance","volume":"96","author":"Georgatzakou","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6639199","DOI":"10.1155\/2021\/6639199","article-title":"Reactive Oxygen Species and Their Involvement in Red Blood Cell Damage in Chronic Kidney Disease","volume":"2021","author":"Gwozdzinski","year":"2021","journal-title":"Oxidative Med. Cell Longev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000126922","article-title":"Altered erythrocyte membrane protein composition in chronic kidney disease stage 5 patients under haemodialysis and recombinant human erythropoietin therapy","volume":"26","author":"Costa","year":"2008","journal-title":"Blood Purif."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/prca.201500127","article-title":"Red blood cell abnormalities and the pathogenesis of anemia in end-stage renal disease","volume":"10","author":"Georgatzakou","year":"2016","journal-title":"Proteom. Clin. Appl."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Zheng, K., Qian, Y., Wang, H., Song, D., You, H., Hou, B., Han, F., Zhu, Y., Feng, F., and Lam, S.M. (2024). Combinatorial lipidomics and proteomics underscore erythrocyte lipid membrane aberrations in the development of adverse cardio-cerebrovascular complications in maintenance hemodialysis patients. Redox Biol., 78.","DOI":"10.1016\/j.redox.2024.103389"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s40620-018-0556-5","article-title":"Circulating proteins as predictors of cardiovascular mortality in end-stage renal disease","volume":"32","author":"Feldreich","year":"2019","journal-title":"J. Nephrol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/13\/967\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:57:36Z","timestamp":1760032656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/13\/967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":71,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["cells14130967"],"URL":"https:\/\/doi.org\/10.3390\/cells14130967","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}