{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:49:13Z","timestamp":1788922153313,"version":"build-2803163510"},"reference-count":58,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swedish Research Council","award":["2022-01182"],"award-info":[{"award-number":["2022-01182"]}]},{"name":"Swedish Research Council","award":["NNF20OC0065099"],"award-info":[{"award-number":["NNF20OC0065099"]}]},{"name":"Swedish Research Council","award":["FP00127760"],"award-info":[{"award-number":["FP00127760"]}]},{"name":"Uppsala University","award":["2022-01182"],"award-info":[{"award-number":["2022-01182"]}]},{"name":"Uppsala University","award":["NNF20OC0065099"],"award-info":[{"award-number":["NNF20OC0065099"]}]},{"name":"Uppsala University","award":["FP00127760"],"award-info":[{"award-number":["FP00127760"]}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["2022-01182"],"award-info":[{"award-number":["2022-01182"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20OC0065099"],"award-info":[{"award-number":["NNF20OC0065099"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["FP00127760"],"award-info":[{"award-number":["FP00127760"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"OHE-MN","award":["2022-01182"],"award-info":[{"award-number":["2022-01182"]}]},{"name":"OHE-MN","award":["NNF20OC0065099"],"award-info":[{"award-number":["NNF20OC0065099"]}]},{"name":"OHE-MN","award":["FP00127760"],"award-info":[{"award-number":["FP00127760"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Lateral spinal cord injury including lateral hemisection (LHS) leads to asymmetric postural and motor deficits. After traumatic brain injury, asymmetric postural deficits are partly developed through activation of opioid receptors. We here characterized the effects of LHS on hindlimb postural asymmetry (HL-PA), a proxy for neurological impairments, and assessed the involvement of opioid system. In acute experiments on rats, high lumbar LHS induced HL-PA, characterized by ipsilateral hindlimb flexion. This asymmetry persisted after complete spinal cord transection at the hemisection level. Treatment with naloxone, a general opioid antagonist, abolished HL-PA both before and after transection, suggesting that the LHS effects are mediated through opioid receptors and that neuroplasticity of lumbar opioid circuits underlies the persistent asymmetry. Surprisingly, cervical LHS performed after complete lumbar spinal cord transection also led to HL-PA. However, the hindlimb was flexed on the contralateral side, and the effect was resistant to naloxone treatment. This asymmetry may be caused by endocrine factors, which convey side-specific messages through the humoral pathway after their release from supraspinal structures. Thus, after lateral spinal cord injury, the asymmetric postural deficits may be driven by an interplay between opposing lumbar opioid and neuroendocrine non-opioid mechanisms.<\/jats:p>","DOI":"10.3390\/cells14130980","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T07:55:43Z","timestamp":1751442943000},"page":"980","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute Postural Effects of Spinal Cord Injury: Dual Neural Opioid and Endocrine Non-Opioid Mechanism"],"prefix":"10.3390","volume":"14","author":[{"given":"Hiroyuki","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biosciences, Biomedicinskt Centrum BMC, Uppsala University, Husargatan 3, 751 24 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-4509","authenticated-orcid":false,"given":"Igor","family":"Lavrov","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-870X","authenticated-orcid":false,"given":"Mathias","family":"Hallberg","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biosciences, Biomedicinskt Centrum BMC, Uppsala University, Husargatan 3, 751 24 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Schouenborg","sequence":"additional","affiliation":[{"name":"Neuronano Research Center, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5945-6625","authenticated-orcid":false,"given":"Mengliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgy","family":"Bakalkin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biosciences, Biomedicinskt Centrum BMC, Uppsala University, Husargatan 3, 751 24 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sc.2009.149","article-title":"Outcome after Incomplete Spinal Cord Injury: Central Cord versus Brown-Sequard Syndrome","volume":"48","author":"Wirz","year":"2010","journal-title":"Spinal Cord"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.celrep.2019.03.010","article-title":"Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury","volume":"27","author":"Takeoka","year":"2019","journal-title":"Cell Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1093\/brain\/awu078","article-title":"Chasing Central Nervous System Plasticity: The Brainstem\u2019s Contribution to Locomotor Recovery in Rats with Spinal Cord Injury","volume":"137","author":"Bachmann","year":"2014","journal-title":"Brain"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1093\/brain\/awx071","article-title":"The Life and Legacy of Brown-S\u00e9quard","volume":"140","author":"Aminoff","year":"2017","journal-title":"Brain"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1038\/s41467-019-13854-3","article-title":"Descending Motor Circuitry Required for NT-3 Mediated Locomotor Recovery after Spinal Cord Injury in Mice","volume":"10","author":"Han","year":"2019","journal-title":"Nat. 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