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A comprehensive search for relevant research was conducted on the PubMed, SCOPUS, and ScienceDirect databases, resulting in the identification of 28 studies that met the inclusion criteria. Of the cohort studies, 26 (92.8%) demonstrated a significant association between autoimmune diseases and increased cardiovascular risk. The major mechanisms include chronic inflammation, endothelial dysfunction, oxidative stress, and immune cell dysregulation. Essential biological components, including T cells, B cells, and neutrophils, were identified as contributors to atherosclerotic processes through cytokine secretion, expression of adhesion molecules, and thrombogenic activity. In contrast, two studies (7.1%) found no statistically significant association. In conclusion, autoimmune diseases significantly increase cardiovascular risk through complicated immunological mechanisms. Comprehending these pathways could influence future therapeutic approaches to reduce cardiovascular complications in affected patients.<\/jats:p>","DOI":"10.3390\/cells14131023","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T05:54:52Z","timestamp":1751608492000},"page":"1023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Interplay Between Autoimmune Disorders Affecting the Coagulation and Platelet Systems and Their Implications for Cardiovascular Diseases: A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3770-6166","authenticated-orcid":false,"given":"Kiana","family":"Mohammadian","sequence":"first","affiliation":[{"name":"Division of Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz 71348, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melika","family":"Asayesh","sequence":"additional","affiliation":[{"name":"Student Research Committee, Hamedan University of Medical Science, Hamedan 65319, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5625-9970","authenticated-orcid":false,"given":"Fatemeh","family":"Fakhar","sequence":"additional","affiliation":[{"name":"Division of Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz 71348, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Keramat","sequence":"additional","affiliation":[{"name":"VAS-European Independent Foundation in Angiology\/Vascular Medicine, Via GB Grassi 74, 20157 Milan, Italy"},{"name":"Support Association of Patients of Buerger\u2019s Disease, Buerger\u2019s Disease NGO, Mashhad 9183785195, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-9898","authenticated-orcid":false,"given":"Agata","family":"Stanek","sequence":"additional","affiliation":[{"name":"VAS-European Independent Foundation in Angiology\/Vascular Medicine, Via GB Grassi 74, 20157 Milan, Italy"},{"name":"Department of Internal Medicine, Metabolic Diseases and Angiology, Faculty of Health Sciences in Katowice, Medical University of Silesia, Zio\u0142owa 45\/47, 40-635 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wilhelm, G., Mertowska, P., Mertowski, S., Przysucha, A., Stru\u017cyna, J., Grywalska, E., and Torres, K. 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