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We highlight the dual role of cellular senescence in both normal development and pathological conditions, emphasizing the need for further research to elucidate these mechanisms and develop targeted interventions. We discuss how oxidative stress and mitochondrial dysfunction affect senescence determinants. We present emerging therapeutic strategies aimed at targeting senescence and inflammation in the placenta. We also introduce Rytvela, an interleukin-1 (IL-1) receptor modulator developed in our laboratory, which selectively attenuates pro-inflammatory signaling while preserving essential immune responses, which in turn mitigate senescence. By addressing senescence-related dysfunctions, such interventions may improve placental performance and fetal outcomes, opening up new directions for the clinical management of IUGR.<\/jats:p>","DOI":"10.3390\/cells14141097","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T11:25:17Z","timestamp":1752751517000},"page":"1097","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of Cellular Senescence in IUGR: Impact on Fetal Morbidity and Development"],"prefix":"10.3390","volume":"14","author":[{"given":"Aliabbas","family":"Zia","sequence":"first","affiliation":[{"name":"Research Center of Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC H3T 1C5, Canada"},{"name":"Department of Pharmacology, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Sahebdel","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2190-7196","authenticated-orcid":false,"given":"Yosra","family":"Er-Reguyeg","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Laval University, Qu\u00e9bec City, QC G1V 0A6, Canada"},{"name":"Ophthalmology Department, H\u00f4pital Maisonneuve-Rosemont Research Center, Montreal, QC H1T 2M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Desjarlais","sequence":"additional","affiliation":[{"name":"Research Center of Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC H3T 1C5, Canada"},{"name":"Ophthalmology Department, H\u00f4pital Maisonneuve-Rosemont Research Center, Montreal, QC H1T 2M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8904-9502","authenticated-orcid":false,"given":"Jean-Clement","family":"Mars","sequence":"additional","affiliation":[{"name":"Research Center of Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC H3T 1C5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Lodygensky","sequence":"additional","affiliation":[{"name":"Research Center of Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC H3T 1C5, Canada"},{"name":"Department of Pediatrics, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1C5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Chemtob","sequence":"additional","affiliation":[{"name":"Research Center of Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC H3T 1C5, Canada"},{"name":"Department of Pharmacology, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada"},{"name":"Ophthalmology Department, H\u00f4pital Maisonneuve-Rosemont Research Center, Montreal, QC H1T 2M4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4137\/CMPed.S40070","article-title":"Intrauterine Growth Restriction: Antenatal and Postnatal Aspects","volume":"10","author":"Sharma","year":"2016","journal-title":"Clin. 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