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The genetic tractability of zebrafish allows investigators to generate molecularly defined models that provide a means of studying the functional circuits of digestion in vivo. Optical transparency during development allows for the use of optogenetics and calcium imaging to elucidate the mechanisms underlying GI-related symptoms associated with ASD. The array of commonly reported symptoms implicates altered sensorimotor integration at various points along the GI tract, from the pharynx to the anus. We will examine the reflex arcs that facilitate swallowing, nutrient-sensing, absorption, peristalsis, and evacuation. The high level of conservation of these processes across vertebrates also enables us to explore potential therapeutic avenues to mitigate GI distress in ASD and other NDDs.<\/jats:p>","DOI":"10.3390\/cells14151170","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:37:23Z","timestamp":1753861043000},"page":"1170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Going with the Flow: Sensorimotor Integration Along the Zebrafish GI Tract"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-7694","authenticated-orcid":false,"given":"Millie E.","family":"Rogers","sequence":"first","affiliation":[{"name":"Department of Biology, University of Miami, Coral Gables, FL 33146, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Garcia-Pradas","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Miami, Coral Gables, FL 33146, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone A.","family":"Thom","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Miami, Coral Gables, FL 33146, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2056-573X","authenticated-orcid":false,"given":"Roberto A.","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Miami, Coral Gables, FL 33146, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Dallman","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Miami, Coral Gables, FL 33146, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1113\/JP280581","article-title":"Gut peptide regulation of food intake\u2014Evidence for the modulation of hedonic feeding","volume":"600","author":"Woodward","year":"2022","journal-title":"J. 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