{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:34:04Z","timestamp":1760060044403,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82200191","OHIC2023Y07"],"award-info":[{"award-number":["82200191","OHIC2023Y07"]}]},{"name":"Open Fund Project of Hubei Province Key Laboratory of Occupational Hazard Identification and Control","award":["82200191","OHIC2023Y07"],"award-info":[{"award-number":["82200191","OHIC2023Y07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Acute myeloid leukemia (AML) is a malignant hematological tumor with a high prevalence in elderly people, and circular RNA (circRNA) plays an important role in age-related diseases. Induction of cancer cell senescence is a highly promising therapeutic strategy; however, the presence of senescence-associated circRNAs in AML remains to be elucidated. Here, we show that the expression patterns of circRNAs differed between elderly AML patients and healthy volunteers. circSATB1 was significantly overexpressed in elderly patients and AML cells. Knockdown of circSATB1 resulted in the inhibition of proliferation and arrest of the cell cycle in the G0\/G1 phase; no effect on apoptosis or DNA integrity was observed, and precocious cellular senescence was promoted, characterized by no change in telomere length. Database analysis revealed that there may be two miRNA and nine RNA-binding proteins (RBPs) involved in regulating the cellular functions of circSATB1. Our observations uncover circSATB1-orchestrated cell senescence in AML, which provides clues for finding more modest therapeutic targets for AML.<\/jats:p>","DOI":"10.3390\/cells14151181","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T06:37:47Z","timestamp":1754030267000},"page":"1181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["circSATB1 Modulates Cell Senescence in Age-Related Acute Myeloid Leukemia: A Mechanistic Proposal"],"prefix":"10.3390","volume":"14","author":[{"given":"Linxiang","family":"Han","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, School of Medical, Wuhan University of Science and Technology, Wuhan 430065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Environmental Hygiene and Occupational Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Environmental Hygiene and Occupational Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China"},{"name":"Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingcheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medical, Wuhan University of Science and Technology, Wuhan 430065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medical, Wuhan University of Science and Technology, Wuhan 430065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haodong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medical, Wuhan University of Science and Technology, Wuhan 430065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medical, Wuhan University of Science and Technology, Wuhan 430065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medical, Wuhan University of Science and Technology, Wuhan 430065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-6651","authenticated-orcid":false,"given":"Yu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Environmental Hygiene and Occupational Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China"},{"name":"Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref_1","first-page":"n2026","article-title":"Advances in acute myeloid leukemia","volume":"375","author":"Newell","year":"2021","journal-title":"BMJ Clin. Res. Ed."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1038\/s41467-023-42571-1","article-title":"A circular RNA activated by TGF\u03b2 promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Carcel\u00e9n-Fraile, M.d.C., D\u00e9niz-Ram\u00edrez, N.d.P., Sabina-Campos, J., Aibar-Almaz\u00e1n, A., Rivas-Campo, Y., Gonz\u00e1lez-Mart\u00edn, A.M., and Castellote-Caballero, Y. (2024). Exercise and Nutrition in the Mental Health of the Older Adult Population: A Randomized Controlled Clinical Trial. Nutrients, 16.","DOI":"10.3390\/nu16111741"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3324\/haematol.2022.280801","article-title":"The clinical impact of the molecular landscape of acute myeloid leukemia","volume":"108","author":"Kayser","year":"2023","journal-title":"Haematologica"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11912-024-01503-y","article-title":"Novel Therapeutic Targets in Acute Myeloid Leukemia (AML)","volume":"26","author":"Wysota","year":"2024","journal-title":"Curr. Oncol. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1182\/blood.2022018092","article-title":"Metabolism in acute myeloid leukemia: Mechanistic insights and therapeutic targets","volume":"141","author":"Mishra","year":"2023","journal-title":"Blood"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000536152","article-title":"Pathophysiology of Acute Myeloid Leukemia","volume":"147","author":"Wachter","year":"2024","journal-title":"Acta Haematol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1080\/10428194.2023.2237153","article-title":"IDH2 mutations in acute myeloid leukemia","volume":"64","author":"Babakhanlou","year":"2023","journal-title":"Leuk. Lymphoma"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2158015","DOI":"10.1080\/16078454.2022.2158015","article-title":"Acute myeloid leukemia: Challenges for diagnosis and treatment in Latin America","volume":"28","author":"Rego","year":"2023","journal-title":"Hematology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-neuro-082823-020615","article-title":"The Role of Retrotransposons and Endogenous Retroviruses in Age-Dependent Neurodegenerative Disorders","volume":"47","author":"Frost","year":"2024","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1002\/alz.12960","article-title":"Identification of circRNAs linked to Alzheimer\u2019s disease and related dementias","volume":"19","author":"Puri","year":"2023","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00018-025-05684-y","article-title":"Circular RNA circSTX12 regulates osteo-adipogenic balance and proliferation of BMSCs in senile osteoporosis","volume":"82","author":"Gu","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12943-024-02096-7","article-title":"Cellular senescence and SASP in tumor progression and therapeutic opportunities","volume":"23","author":"Dong","year":"2024","journal-title":"Mol. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41467-024-55577-0","article-title":"The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment","volume":"16","author":"Lan","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e230499","DOI":"10.1530\/REP-23-0499","article-title":"Reproductive Ageing: Inflammation, immune cells, and cellular senescence in the aging ovary","volume":"168","author":"Isola","year":"2024","journal-title":"Reproduction"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1080\/10428194.2024.2367040","article-title":"Acute myeloid leukemia (AML) with chromosome 3 inversion: Biology, management, and clinical outcome","volume":"65","author":"Alhajahjeh","year":"2024","journal-title":"Leuk. Lymphoma"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood.2023022697","article-title":"Clonal relapse dynamics in acute myeloid leukemia following allogeneic hematopoietic cell transplantation","volume":"144","author":"Wienecke","year":"2024","journal-title":"Blood"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.31083\/j.jin2206136","article-title":"Identification of a lncRNA\/circRNA-miRNA-mRNA ceRNA Network in Alzheimer\u2019s Disease","volume":"22","author":"Su","year":"2023","journal-title":"J. Integr. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s11011-023-01194-7","article-title":"CircRNA-104718 promotes glioma malignancy through regulation of miR-218-5p\/HMGB1 signalling pathway","volume":"38","author":"Yan","year":"2023","journal-title":"Metab. Brain Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/tox.22980","article-title":"CircRNA circ_POLA2 promotes lung cancer cell stemness via regulating the miR-326\/GNB1 axis","volume":"35","author":"Fan","year":"2020","journal-title":"Environ. Toxicol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00414-023-03131-w","article-title":"Integrative lncRNA, circRNA, and mRNA analysis reveals expression profiles of six forensic body fluids\/tissue","volume":"138","author":"Liu","year":"2024","journal-title":"Int. J. Leg. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Xu, Y., Zhang, S., Niu, H., Ye, Y., Hu, F., Chen, S., Li, X., Luo, X., Jiang, S., and Liu, Y. (2015). STIM1 accelerates cell senescence in a remodeled microenvironment but enhances the epithelial-to-mesenchymal transition in prostate cancer. Sci. Rep., 5.","DOI":"10.1038\/srep11754"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-019-1607-3","article-title":"Inducing and exploiting vulnerabilities for the treatment of liver cancer","volume":"574","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"101507","DOI":"10.1016\/j.arr.2021.101507","article-title":"Stress and telomere shortening: Insights from cellular mechanisms","volume":"73","author":"Lin","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/15384101.2015.1125243","article-title":"Telomere maintenance is pivotal for high-risk neuroblastoma","volume":"15","author":"Hertwig","year":"2016","journal-title":"Cell Cycle"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yal\u00e7in, Z., Selenz, C., and Jacobs, J.J.L. (2017). Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction. Front. Genet., 8.","DOI":"10.3389\/fgene.2017.00067"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Liu, J., Wang, L., Wang, Z., and Liu, J.P. (2019). Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing. Cells, 8.","DOI":"10.3390\/cells8010054"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.arr.2016.03.002","article-title":"Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions","volume":"33","author":"Oshima","year":"2017","journal-title":"Ageing Res. Rev."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/15\/1181\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:20:07Z","timestamp":1760034007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/15\/1181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":28,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["cells14151181"],"URL":"https:\/\/doi.org\/10.3390\/cells14151181","relation":{},"ISSN":["2073-4409"],"issn-type":[{"type":"electronic","value":"2073-4409"}],"subject":[],"published":{"date-parts":[[2025,7,31]]}}}