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Male C57BL\/6 mice received Lf (4 mg per mouse, i.p. injection) immediately after whole-body gamma-irradiation at a dose of 7.5 Gy from a 60Co source. The effect of Lf on mouse behavior was evaluated using \u201cOpen field\u201d and \u201cElevated plus-maze\u201d tests. The proportion of cells with DNA replication was determined by 5-ethynyl-2\u2032-deoxyuridine incorporation (thymidine analog) and detected by a click reaction with azide Alexa Fluor 568. Lf treatment increased animal survival during the experiment (30 days), compensated for radiation-induced body weight loss, and prevented suppression of motor and exploratory activities. A pronounced anti-radiation effect of Lf on mouse brain cells has been demonstrated. A single injection of the protein allowed preserving 2-fold more proliferating cells and immature neurons in the dentate gyrus of the hippocampus of irradiated animals during the acute period of post-radiation injury development.<\/jats:p>","DOI":"10.3390\/cells14151198","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T15:30:06Z","timestamp":1754321406000},"page":"1198","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential of Lactoferrin Against the Radiation-Induced Brain Injury"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6100-2830","authenticated-orcid":false,"given":"Marina Yu.","family":"Kopaeva","sequence":"first","affiliation":[{"name":"National Research Center \u201cKurchatov Institute\u201d, 1 Akademika Kurchatova sq., 123182 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3757-5292","authenticated-orcid":false,"given":"Anton B.","family":"Cherepov","sequence":"additional","affiliation":[{"name":"National Research Center \u201cKurchatov Institute\u201d, 1 Akademika Kurchatova sq., 123182 Moscow, Russia"},{"name":"Institute of General Pathology and Pathophysiology, 8 Baltiyskaya St., 125315 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina B.","family":"Alchinova","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, 8 Baltiyskaya St., 125315 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5173-7907","authenticated-orcid":false,"given":"Daria A.","family":"Shaposhnikova","sequence":"additional","affiliation":[{"name":"National Research Center \u201cKurchatov Institute\u201d, 1 Akademika Kurchatova sq., 123182 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna V.","family":"Rybakova","sequence":"additional","affiliation":[{"name":"National Research Center \u201cKurchatov Institute\u201d, 1 Akademika Kurchatova sq., 123182 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandr P.","family":"Trashkov","sequence":"additional","affiliation":[{"name":"National Research Center \u201cKurchatov Institute\u201d, 1 Akademika Kurchatova sq., 123182 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pazzaglia, S., Briganti, G., Mancuso, M., and Saran, A. 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