{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:35:20Z","timestamp":1780338920349,"version":"3.54.1"},"reference-count":75,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n MAPFRE-Guanarteme","award":["OA21\/110"],"award-info":[{"award-number":["OA21\/110"]}]},{"name":"Fundaci\u00f3n MAPFRE-Guanarteme","award":["PIFIISC22\/34"],"award-info":[{"award-number":["PIFIISC22\/34"]}]},{"name":"Fundaci\u00f3n MAPFRE-Guanarteme","award":["PID2021-123716OB-I100"],"award-info":[{"award-number":["PID2021-123716OB-I100"]}]},{"name":"Fundaci\u00f3n MAPFRE-Guanarteme","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}]},{"name":"Fundaci\u00f3n MAPFRE-Guanarteme","award":["ICI21\/00111"],"award-info":[{"award-number":["ICI21\/00111"]}]},{"name":"Fundaci\u00f3n MAPFRE-Guanarteme","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}]},{"name":"Fundaci\u00f3n MAPFRE-Guanarteme","award":["RD24\/0004\/0023"],"award-info":[{"award-number":["RD24\/0004\/0023"]}]},{"name":"Fundaci\u00f3n MAPFRE-Guanarteme","award":["CPP2022-009633"],"award-info":[{"award-number":["CPP2022-009633"]}]},{"name":"Fundaci\u00f3n MAPFRE-Guanarteme","award":["2022\/BMD-7223 (CIFRA_COR-CM)"],"award-info":[{"award-number":["2022\/BMD-7223 (CIFRA_COR-CM)"]}]},{"name":"Fundaci\u00f3n MAPFRE-Guanarteme","award":["ProID2020010073"],"award-info":[{"award-number":["ProID2020010073"]}]},{"name":"Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FUNCANIS)","award":["OA21\/110"],"award-info":[{"award-number":["OA21\/110"]}]},{"name":"Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FUNCANIS)","award":["PIFIISC22\/34"],"award-info":[{"award-number":["PIFIISC22\/34"]}]},{"name":"Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FUNCANIS)","award":["PID2021-123716OB-I100"],"award-info":[{"award-number":["PID2021-123716OB-I100"]}]},{"name":"Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FUNCANIS)","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}]},{"name":"Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FUNCANIS)","award":["ICI21\/00111"],"award-info":[{"award-number":["ICI21\/00111"]}]},{"name":"Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FUNCANIS)","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}]},{"name":"Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FUNCANIS)","award":["RD24\/0004\/0023"],"award-info":[{"award-number":["RD24\/0004\/0023"]}]},{"name":"Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FUNCANIS)","award":["CPP2022-009633"],"award-info":[{"award-number":["CPP2022-009633"]}]},{"name":"Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FUNCANIS)","award":["2022\/BMD-7223 (CIFRA_COR-CM)"],"award-info":[{"award-number":["2022\/BMD-7223 (CIFRA_COR-CM)"]}]},{"name":"Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias (FUNCANIS)","award":["ProID2020010073"],"award-info":[{"award-number":["ProID2020010073"]}]},{"name":"Spanish Ministry of Science and Innovation (MCIN\/AEI\/10.13039\/501100011033)","award":["OA21\/110"],"award-info":[{"award-number":["OA21\/110"]}]},{"name":"Spanish Ministry of Science and Innovation (MCIN\/AEI\/10.13039\/501100011033)","award":["PIFIISC22\/34"],"award-info":[{"award-number":["PIFIISC22\/34"]}]},{"name":"Spanish Ministry of Science and Innovation (MCIN\/AEI\/10.13039\/501100011033)","award":["PID2021-123716OB-I100"],"award-info":[{"award-number":["PID2021-123716OB-I100"]}]},{"name":"Spanish Ministry of Science and Innovation (MCIN\/AEI\/10.13039\/501100011033)","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}]},{"name":"Spanish Ministry of Science and Innovation (MCIN\/AEI\/10.13039\/501100011033)","award":["ICI21\/00111"],"award-info":[{"award-number":["ICI21\/00111"]}]},{"name":"Spanish Ministry of Science and Innovation (MCIN\/AEI\/10.13039\/501100011033)","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}]},{"name":"Spanish Ministry of Science and Innovation (MCIN\/AEI\/10.13039\/501100011033)","award":["RD24\/0004\/0023"],"award-info":[{"award-number":["RD24\/0004\/0023"]}]},{"name":"Spanish Ministry of Science and Innovation (MCIN\/AEI\/10.13039\/501100011033)","award":["CPP2022-009633"],"award-info":[{"award-number":["CPP2022-009633"]}]},{"name":"Spanish Ministry of Science and Innovation (MCIN\/AEI\/10.13039\/501100011033)","award":["2022\/BMD-7223 (CIFRA_COR-CM)"],"award-info":[{"award-number":["2022\/BMD-7223 (CIFRA_COR-CM)"]}]},{"name":"Spanish Ministry of Science and Innovation (MCIN\/AEI\/10.13039\/501100011033)","award":["ProID2020010073"],"award-info":[{"award-number":["ProID2020010073"]}]},{"name":"Spanish Ministry of Economy and Competitiveness Instituto de Salud Carlos III-Fondo de Investigaci\u00f3n en Salud","award":["OA21\/110"],"award-info":[{"award-number":["OA21\/110"]}]},{"name":"Spanish Ministry of Economy and Competitiveness Instituto de Salud Carlos III-Fondo de Investigaci\u00f3n en Salud","award":["PIFIISC22\/34"],"award-info":[{"award-number":["PIFIISC22\/34"]}]},{"name":"Spanish Ministry of Economy and Competitiveness Instituto de Salud Carlos III-Fondo de Investigaci\u00f3n en Salud","award":["PID2021-123716OB-I100"],"award-info":[{"award-number":["PID2021-123716OB-I100"]}]},{"name":"Spanish Ministry of Economy and Competitiveness Instituto de Salud Carlos III-Fondo de Investigaci\u00f3n en Salud","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}]},{"name":"Spanish Ministry of Economy and Competitiveness Instituto de Salud Carlos III-Fondo de Investigaci\u00f3n en Salud","award":["ICI21\/00111"],"award-info":[{"award-number":["ICI21\/00111"]}]},{"name":"Spanish Ministry of Economy and Competitiveness Instituto de Salud Carlos III-Fondo de Investigaci\u00f3n en Salud","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}]},{"name":"Spanish Ministry of Economy and Competitiveness Instituto de Salud Carlos III-Fondo de Investigaci\u00f3n en Salud","award":["RD24\/0004\/0023"],"award-info":[{"award-number":["RD24\/0004\/0023"]}]},{"name":"Spanish Ministry of Economy and Competitiveness Instituto de Salud Carlos III-Fondo de Investigaci\u00f3n en Salud","award":["CPP2022-009633"],"award-info":[{"award-number":["CPP2022-009633"]}]},{"name":"Spanish Ministry of Economy and Competitiveness Instituto de Salud Carlos III-Fondo de Investigaci\u00f3n en Salud","award":["2022\/BMD-7223 (CIFRA_COR-CM)"],"award-info":[{"award-number":["2022\/BMD-7223 (CIFRA_COR-CM)"]}]},{"name":"Spanish Ministry of Economy and Competitiveness Instituto de Salud Carlos III-Fondo de Investigaci\u00f3n en Salud","award":["ProID2020010073"],"award-info":[{"award-number":["ProID2020010073"]}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["OA21\/110"],"award-info":[{"award-number":["OA21\/110"]}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["PIFIISC22\/34"],"award-info":[{"award-number":["PIFIISC22\/34"]}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["PID2021-123716OB-I100"],"award-info":[{"award-number":["PID2021-123716OB-I100"]}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["ICI21\/00111"],"award-info":[{"award-number":["ICI21\/00111"]}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["RD24\/0004\/0023"],"award-info":[{"award-number":["RD24\/0004\/0023"]}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["CPP2022-009633"],"award-info":[{"award-number":["CPP2022-009633"]}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["2022\/BMD-7223 (CIFRA_COR-CM)"],"award-info":[{"award-number":["2022\/BMD-7223 (CIFRA_COR-CM)"]}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["ProID2020010073"],"award-info":[{"award-number":["ProID2020010073"]}]},{"DOI":"10.13039\/501100004837","name":"European Union, the Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["OA21\/110"],"award-info":[{"award-number":["OA21\/110"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"European Union, the Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["PIFIISC22\/34"],"award-info":[{"award-number":["PIFIISC22\/34"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"European Union, the Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["PID2021-123716OB-I100"],"award-info":[{"award-number":["PID2021-123716OB-I100"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"European Union, the Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"European Union, the Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["ICI21\/00111"],"award-info":[{"award-number":["ICI21\/00111"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"European Union, the Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"European Union, the Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["RD24\/0004\/0023"],"award-info":[{"award-number":["RD24\/0004\/0023"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"European Union, the Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["CPP2022-009633"],"award-info":[{"award-number":["CPP2022-009633"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"European Union, the Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["2022\/BMD-7223 (CIFRA_COR-CM)"],"award-info":[{"award-number":["2022\/BMD-7223 (CIFRA_COR-CM)"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"European Union, the Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["ProID2020010073"],"award-info":[{"award-number":["ProID2020010073"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Comunidad de Madrid","award":["OA21\/110"],"award-info":[{"award-number":["OA21\/110"]}]},{"name":"Comunidad de Madrid","award":["PIFIISC22\/34"],"award-info":[{"award-number":["PIFIISC22\/34"]}]},{"name":"Comunidad de Madrid","award":["PID2021-123716OB-I100"],"award-info":[{"award-number":["PID2021-123716OB-I100"]}]},{"name":"Comunidad de Madrid","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}]},{"name":"Comunidad de Madrid","award":["ICI21\/00111"],"award-info":[{"award-number":["ICI21\/00111"]}]},{"name":"Comunidad de Madrid","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}]},{"name":"Comunidad de Madrid","award":["RD24\/0004\/0023"],"award-info":[{"award-number":["RD24\/0004\/0023"]}]},{"name":"Comunidad de Madrid","award":["CPP2022-009633"],"award-info":[{"award-number":["CPP2022-009633"]}]},{"name":"Comunidad de Madrid","award":["2022\/BMD-7223 (CIFRA_COR-CM)"],"award-info":[{"award-number":["2022\/BMD-7223 (CIFRA_COR-CM)"]}]},{"name":"Comunidad de Madrid","award":["ProID2020010073"],"award-info":[{"award-number":["ProID2020010073"]}]},{"name":"Gobierno de Canarias (cofounded by FEDER)","award":["OA21\/110"],"award-info":[{"award-number":["OA21\/110"]}]},{"name":"Gobierno de Canarias (cofounded by FEDER)","award":["PIFIISC22\/34"],"award-info":[{"award-number":["PIFIISC22\/34"]}]},{"name":"Gobierno de Canarias (cofounded by FEDER)","award":["PID2021-123716OB-I100"],"award-info":[{"award-number":["PID2021-123716OB-I100"]}]},{"name":"Gobierno de Canarias (cofounded by FEDER)","award":["PI20\/01577"],"award-info":[{"award-number":["PI20\/01577"]}]},{"name":"Gobierno de Canarias (cofounded by FEDER)","award":["ICI21\/00111"],"award-info":[{"award-number":["ICI21\/00111"]}]},{"name":"Gobierno de Canarias (cofounded by FEDER)","award":["RD21\/0005\/0029"],"award-info":[{"award-number":["RD21\/0005\/0029"]}]},{"name":"Gobierno de Canarias (cofounded by FEDER)","award":["RD24\/0004\/0023"],"award-info":[{"award-number":["RD24\/0004\/0023"]}]},{"name":"Gobierno de Canarias (cofounded by FEDER)","award":["CPP2022-009633"],"award-info":[{"award-number":["CPP2022-009633"]}]},{"name":"Gobierno de Canarias (cofounded by FEDER)","award":["2022\/BMD-7223 (CIFRA_COR-CM)"],"award-info":[{"award-number":["2022\/BMD-7223 (CIFRA_COR-CM)"]}]},{"name":"Gobierno de Canarias (cofounded by FEDER)","award":["ProID2020010073"],"award-info":[{"award-number":["ProID2020010073"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Oxaliplatin-induced peripheral neurotoxicity (OIPN) represents a major challenge in cancer therapy, characterized by dorsal root ganglia (DRG) inflammation and disruption of neuro-glio-vascular unit function. In this study, we investigated the involvement of the scaffold protein IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) and dehydropeptidase-1 (DPEP1) in the DRG response to oxaliplatin (OxPt) and the modulatory effect of cilastatin. Behavioral assessment showed a robust nocifensive response to cold stimuli in OxPt-treated rats, attenuated by cilastatin co-treatment. Our confocal study revealed different cellular and subcellular expression patterns of IQGAP1 and DPEP1 in neurons, glia, and endothelial cells, where both signals overlap approximately one-third. OxPt enhanced cytosolic aggregation of IQGAP1 in neurons and upregulation of signal in glia, accompanied by co-expression of TNF\u03b1 and IL-6, indicating involvement in the inflammatory process. DPEP1 showed altered subcellular distribution in OxPt-treated animals, suggesting a potential role in the inflammatory cascade. Notably, IQGAP1 expression was diminished in endothelial membranes under OxPt, while cilastatin preserved endothelial IQGAP1-CD31 colocalization, suggesting partial restoration of blood-nerve barrier integrity. These findings identify IQGAP1 and DPEP1 as key players in DRG inflammation and position cilastatin as a promising modulator of OIPN through neuro-glio-vascular stabilization.<\/jats:p>","DOI":"10.3390\/cells14161294","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:18:14Z","timestamp":1755695894000},"page":"1294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cilastatin Modulates DPEP1- and IQGAP1-Associated Neuro-Glio-Vascular Inflammation in Oxaliplatin-Induced Peripheral Neurotoxicity"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-2933","authenticated-orcid":false,"given":"Rita","family":"Mart\u00edn-Ram\u00edrez","sequence":"first","affiliation":[{"name":"Laboratorio de Biolog\u00eda del Desarrollo, UD de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de La Laguna, 38206 San Crist\u00f3bal de La Laguna, Spain"},{"name":"Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, 38071 San Crist\u00f3bal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3514-4616","authenticated-orcid":false,"given":"Mar\u00eda \u00c1ngeles","family":"Gonz\u00e1lez-Nicol\u00e1s","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Renal, Departamento de Nefrolog\u00eda, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"\u00c1lvarez-Tosco","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda del Desarrollo, UD de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de La Laguna, 38206 San Crist\u00f3bal de La Laguna, Spain"},{"name":"Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, 38071 San Crist\u00f3bal de La Laguna, Spain"},{"name":"Unidad de Investigaci\u00f3n, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria, Instituto de Investigaci\u00f3n Sanitaria de Canarias (IISC), 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4559-7798","authenticated-orcid":false,"given":"F\u00e9lix","family":"Mach\u00edn","sequence":"additional","affiliation":[{"name":"Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, 38071 San Crist\u00f3bal de La Laguna, Spain"},{"name":"Unidad de Investigaci\u00f3n, Hospital Universitario Nuestra Se\u00f1ora de la Candelaria, Instituto de Investigaci\u00f3n Sanitaria de Canarias (IISC), 38010 Santa Cruz de Tenerife, Spain"},{"name":"Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, 35450 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-1188","authenticated-orcid":false,"given":"Julio","family":"\u00c1vila","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda del Desarrollo, UD de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de La Laguna, 38206 San Crist\u00f3bal de La Laguna, Spain"},{"name":"Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, 38071 San Crist\u00f3bal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Morales","sequence":"additional","affiliation":[{"name":"Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, 38071 San Crist\u00f3bal de La Laguna, Spain"},{"name":"Departamento de Medicina, Facultad de Ciencias de la Salud, Universidad de La Laguna, 38200 San Crist\u00f3bal de La Laguna, Spain"},{"name":"Servicio de Oncolog\u00eda M\u00e9dica, Hospiten Rambla, Grupo Hospiten, 38001 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-679X","authenticated-orcid":false,"given":"Alberto","family":"L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Renal, Departamento de Nefrolog\u00eda, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-5774","authenticated-orcid":false,"given":"Pablo","family":"Mart\u00edn-Vasallo","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda del Desarrollo, UD de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de La Laguna, 38206 San Crist\u00f3bal de La Laguna, Spain"},{"name":"Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, 38071 San Crist\u00f3bal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2174\/1570159X15666170915143217","article-title":"Prevention and Treatment for Chemotherapy-Induced Peripheral Neuropathy: Therapies Based on CIPN Mechanisms","volume":"17","author":"Hu","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neurol.2018.09.016","article-title":"Neuropathic Pain: Definition, Assessment and Epidemiology","volume":"175","author":"Bouhassira","year":"2019","journal-title":"Rev. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s43440-020-00109-y","article-title":"Chemotherapy-Induced Peripheral Neuropathy: Part 1\u2014Current State of Knowledge and Perspectives for Pharmacotherapy","volume":"72","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuron.2012.02.008","article-title":"Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms","volume":"73","author":"Baron","year":"2012","journal-title":"Neuron"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.pain.2014.09.020","article-title":"Incidence, Prevalence, and Predictors of Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis","volume":"155","author":"Seretny","year":"2014","journal-title":"Pain"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuroscience.2011.10.010","article-title":"Mitochondrial Abnormality in Sensory, but Not Motor, Axons in Paclitaxel-Evoked Painful Peripheral Neuropathy in the Rat","volume":"199","author":"Xiao","year":"2011","journal-title":"Neuroscience"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(99)01307-0","article-title":"Neuropathic Pain: Aetiology, Symptoms, Mechanisms, and Management","volume":"353","author":"Woolf","year":"1999","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ctrv.2008.01.003","article-title":"A Review on Oxaliplatin-Induced Peripheral Nerve Damage","volume":"34","author":"Argyriou","year":"2008","journal-title":"Cancer Treat. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3747\/co.v18i1.708","article-title":"Oxaliplatin: A Review in the Era of Molecularly Targeted Therapy","volume":"18","author":"Alcindor","year":"2011","journal-title":"Curr. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1200\/JCO.2014.58.8533","article-title":"Clinical Course of Oxaliplatin-Induced Neuropathy: Results From the Randomized Phase III Trial N08CB (Alliance)","volume":"33","author":"Pachman","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/jnc.14607","article-title":"Identification of Drug Transporters Contributing to Oxaliplatin-induced Peripheral Neuropathy","volume":"148","author":"Fujita","year":"2019","journal-title":"J. Neurochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1158\/1535-7163.MCT-08-0840","article-title":"Platinum Neurotoxicity Pharmacogenetics","volume":"8","author":"McWhinney","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.2174\/092986708786848569","article-title":"Mechanisms Underlying Chemotherapy-Induced Neurotoxicity and the Potential for Neuroprotective Strategies","volume":"15","author":"Park","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3390\/toxics3020187","article-title":"Updates on Oxaliplatin-Induced Peripheral Neurotoxicity (OXAIPN)","volume":"3","author":"Argyriou","year":"2015","journal-title":"Toxics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1007\/s00415-020-09942-w","article-title":"Oxaliplatin-Induced Peripheral Neuropathy: Clinical Features, Mechanisms, Prevention and Treatment","volume":"268","author":"Kang","year":"2021","journal-title":"J. Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"\u00c1lvarez-Tosco, K., Gonz\u00e1lez-Fern\u00e1ndez, R., Gonz\u00e1lez-Nicol\u00e1s, M.\u00c1., Mart\u00edn-Ram\u00edrez, R., Morales, M., Guti\u00e9rrez, R., D\u00edaz-Flores, L., Arnau, M.R., Mach\u00edn, F., and \u00c1vila, J. (2024). Dorsal Root Ganglion Inflammation by Oxaliplatin Toxicity: DPEP1 as Possible Target for Peripheral Neuropathy Prevention. BMC Neurosci., 25.","DOI":"10.1186\/s12868-024-00891-y"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"eabm0142","DOI":"10.1126\/sciadv.abm0142","article-title":"Dipeptidase-1 Governs Renal Inflammation during Ischemia Reperfusion Injury","volume":"8","author":"Lau","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/ki.2012.199","article-title":"Cilastatin Protects against Cisplatin-Induced Nephrotoxicity without Compromising Its Anticancer Efficiency in Rats","volume":"82","author":"Humanes","year":"2012","journal-title":"Kidney Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1080\/14740338.2020.1796967","article-title":"Cilastatin as a Protective Agent against Drug-Induced Nephrotoxicity: A Literature Review","volume":"19","author":"Shayan","year":"2020","journal-title":"Expert. Opin. Drug Saf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1042\/bj2440465","article-title":"Renal Dipeptidase Is One of the Membrane Proteins Released by Phosphatidylinositol-Specific Phospholipase C","volume":"244","author":"Hooper","year":"1987","journal-title":"Biochem. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.21037\/tcr-2024-2436","article-title":"Insight into Dipeptidase 1: Structure, Function, and Mechanism in Gastrointestinal Cancer Diseases","volume":"13","author":"Wang","year":"2024","journal-title":"Transl. Cancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/bjc.2013.363","article-title":"Dipeptidase 1 (DPEP1) Is a Marker for the Transition from Low-Grade to High-Grade Intraepithelial Neoplasia and an Adverse Prognostic Factor in Colorectal Cancer","volume":"109","author":"Eisenach","year":"2013","journal-title":"Br. J. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0022-2836(02)00632-0","article-title":"Crystal Structure of Human Renal Dipeptidase Involved in \u03b2-Lactam Hydrolysis","volume":"321","author":"Nitanai","year":"2002","journal-title":"J. Mol. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1515\/BC.2009.033","article-title":"Glutathione Dysregulation and the Etiology and Progression of Human Diseases","volume":"390","author":"Ballatori","year":"2009","journal-title":"Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1074\/jbc.M111.315705","article-title":"Glutathione Degradation Is a Key Determinant of Glutathione Homeostasis","volume":"287","author":"Lagniel","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular Mechanisms and Health Implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1038\/s41467-021-25377-x","article-title":"A Single Genetic Locus Controls Both Expression of DPEP1\/CHMP1A and Kidney Disease Development via Ferroptosis","volume":"12","author":"Guan","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1016\/S0021-9258(20)65143-2","article-title":"Glutathione-Degrading Enzymes of Microvillus Membranes","volume":"257","author":"Kozak","year":"1982","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0952-3278(94)90152-X","article-title":"Differential Tissue Expression of Immunoreactive Dehydropeptidase I, a Peptidyl Leukotriene Metabolizing Enzyme","volume":"50","author":"Inamura","year":"1994","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bbrc.2020.08.063","article-title":"DPEP1 Promotes the Proliferation of Colon Cancer Cells via the DPEP1\/MYC Feedback Loop Regulation","volume":"532","author":"Liu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41419-019-1943-0","article-title":"DPEP1 Is a Direct Target of MiR-193a-5p and Promotes Hepatoblastoma Progression by PI3K\/Akt\/MTOR Pathway","volume":"10","author":"Cui","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zhang, G., Schetter, A., He, P., Funamizu, N., Gaedcke, J., Ghadimi, B.M., Ried, T., Hassan, R., Yfantis, H.G., and Lee, D.H. (2012). DPEP1 Inhibits Tumor Cell Invasiveness, Enhances Chemosensitivity and Predicts Clinical Outcome in Pancreatic Ductal Adenocarcinoma. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0031507"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10549-008-9905-8","article-title":"Loss of Expression of Chromosome 16q Genes DPEP1 and CTCF in Lobular Carcinoma in Situ of the Breast","volume":"113","author":"Green","year":"2009","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Kinoshita, T. (2020). Biosynthesis and Biology of Mammalian GPI-Anchored Proteins. Open Biol., 10.","DOI":"10.1098\/rsob.190290"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3390\/jpm4020282","article-title":"Differential Transcriptome Profile of Peripheral White Cells to Identify Biomarkers Involved in Oxaliplatin Induced Neuropathy","volume":"4","author":"Morales","year":"2014","journal-title":"J. Pers. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"20517","DOI":"10.1016\/S0021-9258(17)32023-9","article-title":"Identification of a Human RasGAP-Related Protein Containing Calmodulin-Binding Motifs","volume":"269","author":"Weissbach","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.molimm.2015.02.012","article-title":"IQGAP1: Insights into the Function of a Molecular Puppeteer","volume":"65","author":"Abel","year":"2015","journal-title":"Mol. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/bbrc.1998.9371","article-title":"Binding of Myosin Essential Light Chain to the Cytoskeleton-Associated Protein IQGAP1","volume":"251","author":"Weissbach","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"427","DOI":"10.15252\/embr.201439834","article-title":"The Biology of IQGAP Proteins: Beyond the Cytoskeleton","volume":"16","author":"Hedman","year":"2015","journal-title":"EMBO Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.cellsig.2011.12.005","article-title":"IQGAP1 and Its Binding Proteins Control Diverse Biological Functions","volume":"24","author":"White","year":"2012","journal-title":"Cell. Signal."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12324","DOI":"10.1074\/jbc.M109535200","article-title":"The Mechanism for Regulation of the F-Actin Binding Activity of IQGAP1 by Calcium\/Calmodulin","volume":"277","author":"Mateer","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"13871","DOI":"10.1074\/jbc.M413482200","article-title":"IQGAP1 Promotes Neurite Outgrowth in a Phosphorylation-Dependent Manner","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nn1619","article-title":"Calcium-Dependent Interaction of Lis1 with IQGAP1 and Cdc42 Promotes Neuronal Motility","volume":"9","author":"Kholmanskikh","year":"2006","journal-title":"Nat. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.biocel.2010.09.014","article-title":"IQGAP1 Translocates to the Nucleus in Early S-Phase and Contributes to Cell Cycle Progression after DNA Replication Arrest","volume":"43","author":"Johnson","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1242\/jcs.016881","article-title":"A Dual Role for IQGAP1 in Regulating Exocytosis","volume":"121","author":"Rittmeyer","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1083\/jcb.200709076","article-title":"The Interaction of IQGAP1 with the Exocyst Complex Is Required for Tumor Cell Invasion Downstream of Cdc42 and RhoA","volume":"181","author":"Recchi","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11381","DOI":"10.1073\/pnas.1019711108","article-title":"Dephosphorylation of the Nuclear Factor of Activated T Cells (NFAT) Transcription Factor Is Regulated by an RNA-Protein Scaffold Complex","volume":"108","author":"Sharma","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1523\/JNEUROSCI.0830-07.2007","article-title":"IQGAP1 Regulates Adult Neural Progenitors In Vivo and Vascular Endothelial Growth Factor-Triggered Neural Progenitor Migration In Vitro","volume":"27","author":"Balenci","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_49","first-page":"1385","article-title":"IQGAP1: A Microtubule-Microfilament Scaffolding Protein with Multiple Roles in Nerve Cell Development and Synaptic Plasticity","volume":"27","author":"Jausoro","year":"2012","journal-title":"Histol. Histopathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1523\/JNEUROSCI.6582-10.2011","article-title":"CLIP-170 and IQGAP1 Cooperatively Regulate Dendrite Morphology","volume":"31","author":"Swiech","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"120187","DOI":"10.1016\/j.lfs.2021.120187","article-title":"Unlocking the Potential of TRPV1 Based SiRNA Therapeutics for the Treatment of Chemotherapy-Induced Neuropathic Pain","volume":"288","author":"Akhilesh","year":"2022","journal-title":"Life Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Luo, X., Gu, Y., Tao, X., Serhan, C.N., and Ji, R.-R. (2019). Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00745"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"110944","DOI":"10.1016\/j.intimp.2023.110944","article-title":"Loperamide, a Peripheral Mu-Opioid Receptor Agonist, Attenuates Chemotherapy-Induced Neuropathic Pain in Rats","volume":"124","author":"Gadepalli","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e00302","DOI":"10.1016\/j.neurot.2023.10.012","article-title":"Peripheral Mu-Opioid Receptor Activation by Dermorphin [D-Arg2, Lys4] (1\u20134) Amide Alleviates Behavioral and Neurobiological Aberrations in Rat Model of Chemotherapy-Induced Neuropathic Pain","volume":"21","author":"Gadepalli","year":"2024","journal-title":"Neurotherapeutics"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"111100","DOI":"10.1016\/j.intimp.2023.111100","article-title":"Bergenin Ameliorates Chemotherapy-Induced Neuropathic Pain in Rats by Modulating TRPA1\/TRPV1\/NR2B Signalling","volume":"125","author":"Akhilesh","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Moreno-Gordaliza, E., Gonz\u00e1lez-Nicol\u00e1s, M.\u00c1., L\u00e1zaro, A., Barbas, C., G\u00f3mez-G\u00f3mez, M.M., and L\u00f3pez-Gonz\u00e1lvez, \u00c1. (2024). Untargeted Metabolomics Analysis of Serum and Urine Unveils the Protective Effect of Cilastatin on Altered Metabolic Pathways during Cisplatin-Induced Acute Kidney Injury. Biochem. Pharmacol., 227.","DOI":"10.1016\/j.bcp.2024.116435"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1254\/jphs.13244FP","article-title":"Goshajinkigan, a Traditional Japanese Medicine, Prevents Oxaliplatin-Induced Acute Peripheral Neuropathy by Suppressing Functional Alteration of TRP Channels in Rat","volume":"125","author":"Mizuno","year":"2014","journal-title":"J. Pharmacol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/jmi.12093","article-title":"Statistical Tests for Measures of Colocalization in Biological Microscopy","volume":"252","author":"McDonald","year":"2013","journal-title":"J. Microsc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/cyto.a.20896","article-title":"Quantifying Colocalization by Correlation: The Pearson Correlation Coefficient Is Superior to the Mander\u2019s Overlap Coefficient","volume":"77A","author":"Adler","year":"2010","journal-title":"Cytom. Part A"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Armitage, P., Berry, G., and Matthews, J.N.S. (2001). Statistical Methods in Medical Research, Wiley-Blackwell. [4th ed.].","DOI":"10.1002\/9780470773666"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez, R., Gonz\u00e1lez-Nicol\u00e1s, M.\u00c1., Morales, M., \u00c1vila, J., L\u00e1zaro, A., and Mart\u00edn-Vasallo, P. (2022). FKBP51, AmotL2 and IQGAP1 Involvement in Cilastatin Prevention of Cisplatin-Induced Tubular Nephrotoxicity in Rats. Cells, 11.","DOI":"10.3390\/cells11091585"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neuint.2009.10.003","article-title":"TNF\u03b1 Induced Oxidative Stress Dependent Akt Signaling Affects Actin Cytoskeletal Organization in Glioma Cells","volume":"56","author":"Ghosh","year":"2010","journal-title":"Neurochem. Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"24753","DOI":"10.1074\/jbc.M111165200","article-title":"IQGAP1 Is a Component of Cdc42 Signaling to the Cytoskeleton","volume":"277","author":"Li","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.3892\/ol.2017.6525","article-title":"Alterations in IQGAP1 Expression and Localization in Colorectal Carcinoma and Liver Metastases Following Oxaliplatin-Based Chemotherapy","volume":"14","author":"Rotoli","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1242\/jcs.02379","article-title":"IQGAP1: A Key Regulator of Adhesion and Migration","volume":"118","author":"Noritake","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"11143","DOI":"10.1074\/jbc.RA118.003276","article-title":"Interleukin-6 Promotes Pancreatic Cancer Cell Migration by Rapidly Activating the Small GTPase CDC42","volume":"293","author":"Razidlo","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.neuint.2006.05.007","article-title":"Morphological Alterations and Induction of Oxidative Stress in Glial Cells Caused by the Branched-Chain \u03b1-Keto Acids Accumulating in Maple Syrup Urine Disease","volume":"49","author":"Funchal","year":"2006","journal-title":"Neurochem. Int."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1161\/01.ATV.0000231524.14873.e7","article-title":"IQGAP1 Mediates VE-Cadherin\u2013Based Cell\u2013Cell Contacts and VEGF Signaling at Adherence Junctions Linked to Angiogenesis","volume":"26","author":"Tojo","year":"2006","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/01.RES.0000136522.58649.60","article-title":"IQGAP1, a Novel Vascular Endothelial Growth Factor Receptor Binding Protein, Is Involved in Reactive Oxygen Species\u2014Dependent Endothelial Migration and Proliferation","volume":"95","author":"Hilenski","year":"2004","journal-title":"Circ. Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Meyer, R.D., Sacks, D.B., and Rahimi, N. (2008). IQGAP1-Dependent Signaling Pathway Regulates Endothelial Cell Proliferation and Angiogenesis. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003848"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Yang, L., Zhang, R., Li, M., Wu, X., Wang, J., Huang, L., Shi, X., Li, Q., and Su, B. (2014). A Functional MiR-124 Binding-Site Polymorphism in IQGAP1 Affects Human Cognitive Performance. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107065"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Keshari, P.K., Harbo, H.F., Myhr, K.-M., Aarseth, J.H., Bos, S.D., and Berge, T. (2016). Allelic Imbalance of Multiple Sclerosis Susceptibility Genes IKZF3 and IQGAP1 in Human Peripheral Blood. BMC Genet., 17.","DOI":"10.1186\/s12863-016-0367-4"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/1756-185X.14182","article-title":"The Relationship between Common Variants in the DPEP1 Gene and the Susceptibility and Clinical Severity of Osteoarthritis","volume":"24","author":"Zhang","year":"2021","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/CIRCGENETICS.108.829804","article-title":"Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population","volume":"2","author":"Chasman","year":"2009","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_75","unstructured":"Xcode Life (2025, August 02). DPEP1 Gene; Xcode Life. Available online: https:\/\/www.xcode.life\/gene\/DPEP1.html."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/16\/1294\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:31:52Z","timestamp":1760034712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/16\/1294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":75,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["cells14161294"],"URL":"https:\/\/doi.org\/10.3390\/cells14161294","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]}}}