{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T23:30:54Z","timestamp":1776727854306,"version":"3.51.2"},"reference-count":801,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Pathology, University of Pittsburgh Medical Center","award":["2022YQ039"],"award-info":[{"award-number":["2022YQ039"]}]},{"name":"Shanghai Chest Hospital","award":["2022YQ039"],"award-info":[{"award-number":["2022YQ039"]}]},{"name":"Shanghai Municipal Health Commission","award":["2022YQ039"],"award-info":[{"award-number":["2022YQ039"]}]},{"name":"Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program","award":["2022YQ039"],"award-info":[{"award-number":["2022YQ039"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Schwann cells (SCs) are the primary glial cells of the Peripheral Nervous System (PNS), which insulate and provide protection and nutrients to the axons. Technological and experimental advances in neuroscience, focusing on the biology of SCs, their interactions with other cells, and their role in the pathogenesis of various diseases, have paved the way for exploring new treatment strategies that aim to harness the direct protective or causative properties of SCs in neurological disorders. SCs express cytokines, chemokines, neurotrophic growth factors, matrix metalloproteinases, extracellular matrix proteins, and extracellular vesicles, which promote the inherent potential of the injured neurons to survive and accelerate axonal elongation. The ability of SCs to support the development and functioning of neurons is lost in certain hereditary, autoimmune, metabolic, traumatic, and toxic conditions, suggesting their role in specific neurological diseases. Thus, targeting, modifying, and replacing SC strategies, as well as utilizing SC-derived factors and exosomes, have been considered novel therapeutic opportunities for neuropathological conditions. Preclinical and clinical data have demonstrated that SCs and SC-derived factors can serve as viable cell therapy for reconstructing the local tissue microenvironment and promoting nerve anatomical and functional recovery in both peripheral and central nerve injury repair, as well as in peripheral neuropathies. However, despite the promising successes of genetic engineering of SCs, which are now in preclinical and clinical trials, improving tactics to obtain \u2018repair\u2019 SCs and their products from different sources is the key goal for future clinical success. Finally, further development of innovative therapeutic approaches to target and modify SC survival and function in vivo is also urgently needed.<\/jats:p>","DOI":"10.3390\/cells14171336","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T15:03:14Z","timestamp":1756393394000},"page":"1336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pathologic and Therapeutic Schwann Cells"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-7395","authenticated-orcid":false,"given":"Michael R.","family":"Shurin","sequence":"first","affiliation":[{"name":"Division of Clinical Immunopathology, Department of Pathology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunopathology, Department of Pathology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jessen, K.R., Mirsky, R., and Lloyd, A.C. (2015). Schwann Cells: Development and Role in Nerve Repair. Cold Spring Harb. Perspect. Biol., 7.","DOI":"10.1101\/cshperspect.a020487"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Bosch-Queralt, M., Fledrich, R., and Stassart, R.M. (2023). Schwann cell functions in peripheral nerve development and repair. Neurobiol. Dis., 176.","DOI":"10.1016\/j.nbd.2022.105952"},{"key":"ref_3","first-page":"698","article-title":"Glia: Schwann cells provide life support for axons","volume":"15","author":"Whalley","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.expneurol.2015.03.009","article-title":"Molecular regulators of nerve conduction\u2014Lessons from inherited neuropathies and rodent genetic models","volume":"267","author":"Li","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref_5","unstructured":"Arcilla, C.K., and Tadi, P. (2025). Neuroanatomy, Unmyelinated Nerve Fibers. StatPearls, StatPearls Publishing LLC."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/glia.20778","article-title":"Biology and pathology of nonmyelinating Schwann cells","volume":"56","author":"Griffin","year":"2008","journal-title":"Glia"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/s41467-024-44845-8","article-title":"Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception","volume":"15","author":"Kumar","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e171275","DOI":"10.1172\/jci.insight.171275","article-title":"Schwann cells modulate nociception in neurofibromatosis 1","volume":"9","author":"Raut","year":"2024","journal-title":"JCI Insight"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Wei, Z., Fei, Y., Su, W., and Chen, G. (2019). Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination. Front. Cell. Neurosci., 13.","DOI":"10.3389\/fncel.2019.00116"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1126\/science.aax6452","article-title":"Specialized cutaneous Schwann cells initiate pain sensation","volume":"365","author":"Abdo","year":"2019","journal-title":"Science"},{"key":"ref_11","unstructured":"Stavros, J.B., Fabian, H.R., and Welwin, L. (2020). Non-Myelinating Schwann Cells in Health and Disease. Demyelination Disorders, IntechOpen. Chapter 4."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1007\/s10875-014-0015-6","article-title":"Molecules involved in the crosstalk between immune- and peripheral nerve Schwann cells","volume":"34","author":"Tzekova","year":"2014","journal-title":"J. Clin. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/glia.20903","article-title":"Expression of antigen processing and presenting molecules by Schwann cells in inflammatory neuropathies","volume":"58","author":"Heidenreich","year":"2010","journal-title":"Glia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1369\/0022155418778543","article-title":"Immunofluorescent Localization of Non-myelinating Schwann Cells and Their Interactions with Immune Cells in Mouse Thymus","volume":"66","author":"Hu","year":"2018","journal-title":"J. Histochem. Cytochem."},{"key":"ref_15","first-page":"2890","article-title":"Distribution of non-myelinating Schwann cells and their associations with leukocytes in mouse spleen revealed by immunofluorescence staining","volume":"62","author":"Ma","year":"2018","journal-title":"Eur. J. Histochem."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Wu, G., Wen, X., Kuang, R., Lui, K.W., He, B., Li, G., and Zhu, Z. (2023). Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury. Cell. Mol. Neurobiol., 44.","DOI":"10.1007\/s10571-023-01442-5"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1002\/glia.24257","article-title":"Human repair-related Schwann cells adopt functions of antigen-presenting cells in vitro","volume":"70","author":"Berner","year":"2022","journal-title":"Glia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2011.09.053","article-title":"Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche","volume":"147","author":"Yamazaki","year":"2011","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1113\/JP270874","article-title":"The repair Schwann cell and its function in regenerating nerves","volume":"594","author":"Jessen","year":"2016","journal-title":"J. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fornasari, B.E., Zen, F., Nato, G., Fogli, M., Luzzati, F., Ronchi, G., Raimondo, S., and Gambarotta, G. (2022). Blood Vessels: The Pathway Used by Schwann Cells to Colonize Nerve Conduits. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042254"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/s41593-020-00707-2","article-title":"Schwann cell energy to die for","volume":"23","author":"Trimarco","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4103\/1673-5374.286956","article-title":"Interaction between Schwann cells and other cells during repair of peripheral nerve injury","volume":"16","author":"Qu","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1083\/jcb.201503019","article-title":"Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves","volume":"210","author":"Carty","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/j.celrep.2018.08.004","article-title":"Macrophages Regulate Schwann Cell Maturation after Nerve Injury","volume":"24","author":"Stratton","year":"2018","journal-title":"Cell Rep."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Zhang, H., Zhang, Z., and Lin, H. (2023). Research progress on the reduced neural repair ability of aging Schwann cells. Front. Cell Neurosci., 17.","DOI":"10.3389\/fncel.2023.1228282"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.conb.2017.09.003","article-title":"Schwann cells as drivers of tissue repair and regeneration","volume":"47","author":"Carr","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/wrr.12647","article-title":"Role of Schwann cells in cutaneous wound healing","volume":"26","author":"Silva","year":"2018","journal-title":"Wound Repair. Regen."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/pcmr.12134","article-title":"Links between Schwann cells and melanocytes in development and disease","volume":"26","author":"Deo","year":"2013","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jbmr.4735","article-title":"Schwann Cells Contribute to Alveolar Bone Regeneration by Promoting Cell Proliferation","volume":"38","author":"Zhang","year":"2023","journal-title":"J. Bone Miner. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/glia.23532","article-title":"Repair Schwann cell update: Adaptive reprogramming, EMT, and stemness in regenerating nerves","volume":"67","author":"Jessen","year":"2019","journal-title":"Glia"},{"key":"ref_31","first-page":"1931","article-title":"Mechanisms and treatment strategies of demyelinating and dysmyelinating Charcot-Marie-Tooth disease","volume":"18","author":"Hertzog","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e32653","DOI":"10.1097\/MD.0000000000032653","article-title":"Mechanism of Schwann cells in diabetic peripheral neuropathy: A review","volume":"102","author":"Li","year":"2023","journal-title":"Medicine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/glia.23509","article-title":"The conceptual introduction of the \u201cdemyelinating Schwann cell\u201d in peripheral demyelinating neuropathies","volume":"67","author":"Park","year":"2019","journal-title":"Glia"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1007\/s00018-019-03431-8","article-title":"Behind the pathology of macrophage-associated demyelination in inflammatory neuropathies: Demyelinating Schwann cells","volume":"77","author":"Park","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"518","DOI":"10.4103\/1673-5374.205000","article-title":"Axon degeneration: Make the Schwann cell great again","volume":"12","author":"Wong","year":"2017","journal-title":"Neural Regen. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"He, K., Wang, H., Huo, R., Jiang, S.-H., and Xue, J. (2024). Schwann cells and enteric glial cells: Emerging stars in colorectal cancer. Biochim. Biophys. Acta (BBA) Rev. Cancer, 1879.","DOI":"10.1016\/j.bbcan.2024.189160"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/092986708783330593","article-title":"Schwann cell transplantation for CNS repair","volume":"15","author":"Lavdas","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1515\/revneuro-2014-0068","article-title":"Schwann cell transplantation for spinal cord injury repair: Its significant therapeutic potential and prospectus","volume":"26","author":"Kanno","year":"2015","journal-title":"Rev. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Monje, P.V. (2020). Schwann Cell Cultures: Biology, Technology and Therapeutics. Cells, 9.","DOI":"10.3390\/cells9081848"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Fu, H., Hu, D., Chen, J., Wang, Q., Zhang, Y., Qi, C., and Yu, T. (2022). Repair of the Injured Spinal Cord by Schwann Cell Transplantation. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.800513"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0022-510X(81)90082-4","article-title":"Transplantation of rat Schwann cells grown in tissue culture into the mouse spinal cord","volume":"49","author":"Duncan","year":"1981","journal-title":"J. Neurol. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/BF01216702","article-title":"Response of axons and glia at the site of anastomosis between the optic nerve and cellular or acellular sciatic nerve grafts","volume":"17","author":"Berry","year":"1988","journal-title":"J. Neurocytol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1469-7580.1997.19010035.x","article-title":"Schwann cell invasion of the central nervous system of the myelin mutants","volume":"190","author":"Duncan","year":"1997","journal-title":"J. Anat."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.expneurol.2004.11.033","article-title":"Demyelination and Schwann cell responses adjacent to injury epicenter cavities following chronic human spinal cord injury","volume":"192","author":"Guest","year":"2005","journal-title":"Exp. Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Sardella-Silva, G., Mietto, B.S., and Ribeiro-Resende, V.T. (2021). Four Seasons for Schwann Cell Biology, Revisiting Key Periods: Development, Homeostasis, Repair, and Aging. Biomolecules, 11.","DOI":"10.3390\/biom11121887"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9215","DOI":"10.1523\/JNEUROSCI.20-24-09215.2000","article-title":"Schwann cells are removed from the spinal cord after effecting recovery from paraplegia","volume":"20","author":"Jasmin","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_47","first-page":"177","article-title":"Role of endogenous Schwann cells in tissue repair after spinal cord injury","volume":"8","author":"Zhang","year":"2013","journal-title":"Neural Regen. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00401-019-02011-1","article-title":"Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph\/ephrin signaling","volume":"138","author":"Bachelin","year":"2019","journal-title":"Acta Neuropathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.stem.2010.04.002","article-title":"CNS-Resident Glial Progenitor\/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination","volume":"6","author":"Zawadzka","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.1523\/JNEUROSCI.2409-16.2017","article-title":"Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury","volume":"37","author":"Assinck","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Chen, C.Z., Neumann, B., F\u00f6rster, S., and Franklin, R.J.M. (2021). Schwann cell remyelination of the central nervous system: Why does it happen and what are the benefits?. Open Biol., 11.","DOI":"10.1098\/rsob.200352"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/glia.20490","article-title":"Transplantation of Schwann cells and\/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery","volume":"55","author":"Pearse","year":"2007","journal-title":"Glia"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1073\/pnas.87.5.1855","article-title":"Schwann cells promote the survival of rat retinal ganglion cells after optic nerve section","volume":"87","author":"Maffei","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1055\/s-2001-18812","article-title":"Autologous Schwann cells drive regeneration through a 6-cm autogenous venous nerve conduit","volume":"17","author":"Strauch","year":"2001","journal-title":"J. Reconstr. Microsurg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/glia.20458","article-title":"Transplanted Schwann cells, not olfactory ensheathing cells, myelinate optic nerve fibres","volume":"55","author":"Li","year":"2007","journal-title":"Glia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1089\/neu.2007.0334","article-title":"Co-transplantation of neural stem cells and NT-3-overexpressing Schwann cells in transected spinal cord","volume":"24","author":"Zhang","year":"2007","journal-title":"J. Neurotrauma"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nm1056","article-title":"cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury","volume":"10","author":"Pearse","year":"2004","journal-title":"Nat. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.expneurol.2014.05.022","article-title":"Long-term survival, axonal growth-promotion, and myelination of Schwann cells grafted into contused spinal cord in adult rats","volume":"261","author":"Wang","year":"2014","journal-title":"Exp. Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2014.09.038","article-title":"Schwann cell transplantation and descending propriospinal regeneration after spinal cord injury","volume":"1619","author":"Deng","year":"2015","journal-title":"Brain Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1523\/JNEUROSCI.1070-14.2015","article-title":"Schwann cells generated from neonatal skin-derived precursors or neonatal peripheral nerve improve functional recovery after acute transplantation into the partially injured cervical spinal cord of the rat","volume":"35","author":"Sparling","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.stemcr.2020.05.017","article-title":"Transplantation of Skin Precursor-Derived Schwann Cells Yields Better Locomotor Outcomes and Reduces Bladder Pathology in Rats with Chronic Spinal Cord Injury","volume":"15","author":"Assinck","year":"2020","journal-title":"Stem Cell Rep."},{"key":"ref_62","first-page":"47","article-title":"Action of Schwann cells implanted in cerebral hemorrhage lesion","volume":"20","author":"Wan","year":"2007","journal-title":"Biomed. Environ. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3727\/000000007783464768","article-title":"Schwann cell transplantation improves reticulospinal axon growth and forelimb strength after severe cervical spinal cord contusion","volume":"16","author":"Schaal","year":"2007","journal-title":"Cell Transplant."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Pearse, D.D., Bastidas, J., Izabel, S.S., and Ghosh, M. (2018). Schwann Cell Transplantation Subdues the Pro-Inflammatory Innate Immune Cell Response after Spinal Cord Injury. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092550"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s11011-019-00433-0","article-title":"Schwann cell transplantation exerts neuroprotective roles in rat model of spinal cord injury by combating inflammasome activation and improving motor recovery and remyelination","volume":"34","author":"Mousavi","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/glia.23161","article-title":"Human Schwann cells exhibit long-term cell survival, are not tumorigenic and promote repair when transplanted into the contused spinal cord","volume":"65","author":"Bastidas","year":"2017","journal-title":"Glia"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neulet.2008.07.041","article-title":"Treatment of chronic thoracic spinal cord injury patients with autologous Schwann cell transplantation: An interim report on safety considerations and possible outcomes","volume":"443","author":"Saberi","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.3727\/096368912X633752","article-title":"Transplantation of autologous activated Schwann cells in the treatment of spinal cord injury: Six cases, more than five years of follow-up","volume":"21","author":"Zhou","year":"2012","journal-title":"Cell Transplant."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/MOT.0000000000000026","article-title":"Clinical translation of autologous Schwann cell transplantation for the treatment of spinal cord injury","volume":"18","author":"Guest","year":"2013","journal-title":"Curr. Opin. Organ. Transplant."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.3727\/096368914X685014","article-title":"A prospective randomized double-blind clinical trial using a combination of olfactory ensheathing cells and Schwann cells for the treatment of chronic complete spinal cord injuries","volume":"23","author":"Chen","year":"2014","journal-title":"Cell Transplant."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/sc.2015.142","article-title":"Co-transplantation of autologous bone marrow mesenchymal stem cells and Schwann cells through cerebral spinal fluid for the treatment of patients with chronic spinal cord injury: Safety and possible outcome","volume":"54","author":"Hafizi","year":"2016","journal-title":"Spinal Cord."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/bs.pbr.2016.12.012","article-title":"From transplanting Schwann cells in experimental rat spinal cord injury to their transplantation into human injured spinal cord in clinical trials","volume":"231","author":"Bunge","year":"2017","journal-title":"Prog. Brain Res."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Monje, P.V., Deng, L., and Xu, X.M. (2021). Human Schwann Cell Transplantation for Spinal Cord Injury: Prospects and Challenges in Translational Medicine. Front. Cell Neurosci., 15.","DOI":"10.3389\/fncel.2021.690894"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1089\/neu.2016.4895","article-title":"Safety of Autologous Human Schwann Cell Transplantation in Subacute Thoracic Spinal Cord Injury","volume":"34","author":"Anderson","year":"2017","journal-title":"J. Neurotrauma"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/978-1-4939-7649-2_31","article-title":"Intraspinal Delivery of Schwann Cells for Spinal Cord Injury","volume":"1739","author":"Santamaria","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/neu.2020.7590","article-title":"Phase 1 Safety Trial of Autologous Human Schwann Cell Transplantation in Chronic Spinal Cord Injury","volume":"39","author":"Gant","year":"2022","journal-title":"J. Neurotrauma"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Jessen, K.R., and Mirsky, R. (2019). The Success and Failure of the Schwann Cell Response to Nerve Injury. Front. Cell Neurosci., 13.","DOI":"10.3389\/fncel.2019.00033"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/1098-1136(200009)31:3<232::AID-GLIA40>3.0.CO;2-8","article-title":"Areas of demyelination do not attract significant numbers of schwann cells transplanted into normal white matter","volume":"31","author":"Iwashita","year":"2000","journal-title":"Glia"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/exnr.2000.7440","article-title":"Schwann cells transplanted into normal and X-irradiated adult white matter do not migrate extensively and show poor long-term survival","volume":"164","author":"Iwashita","year":"2000","journal-title":"Exp. Neurol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00687001","article-title":"Spinal cord multiple sclerosis lesions in Japanese patients: Schwann cell remyelination occurs in areas that lack glial fibrillary acidic protein (GFAP)","volume":"65","author":"Itoyama","year":"1985","journal-title":"Acta Neuropathol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF00688052","article-title":"The interaction of Schwann cells with CNS axons in regions containing normal astrocytes","volume":"71","author":"Blakemore","year":"1986","journal-title":"Acta Neuropathol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1523\/JNEUROSCI.1822-16.2017","article-title":"Myelin-Associated Glycoprotein Inhibits Schwann Cell Migration and Induces Their Death","volume":"37","author":"Chaudhry","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/micr.20192","article-title":"Nerve conduit filled with GDNF gene-modified Schwann cells enhances regeneration of the peripheral nerve","volume":"26","author":"Li","year":"2006","journal-title":"Microsurgery"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1523\/JNEUROSCI.2973-12.2013","article-title":"A novel growth-promoting pathway formed by GDNF-overexpressing Schwann cells promotes propriospinal axonal regeneration, synapse formation, and partial recovery of function after spinal cord injury","volume":"33","author":"Deng","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"066006","DOI":"10.1088\/1741-2552\/ac9e1e","article-title":"Transgenic Schwann cells overexpressing POU6F1 promote sciatic nerve regeneration within acellular nerve allografts","volume":"19","author":"Li","year":"2022","journal-title":"J. Neural Eng."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/glia.20340","article-title":"Schwann cells genetically engineered to express PSA show enhanced migratory potential without impairment of their myelinating ability in vitro","volume":"53","author":"Lavdas","year":"2006","journal-title":"Glia"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/brain\/awm155","article-title":"Grafts of Schwann cells engineered to express PSA-NCAM promote functional recovery after spinal cord injury","volume":"130","author":"Papastefanaki","year":"2007","journal-title":"Brain"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.expneurol.2009.10.024","article-title":"Schwann cells engineered to express the cell adhesion molecule L1 accelerate myelination and motor recovery after spinal cord injury","volume":"221","author":"Lavdas","year":"2010","journal-title":"Exp. Neurol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1089\/neu.2006.23.453","article-title":"Schwann cell transplantation for repair of the adult spinal cord","volume":"23","author":"Oudega","year":"2006","journal-title":"J. Neurotrauma"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/10790268.2008.11760720","article-title":"Novel combination strategies to repair the injured mammalian spinal cord","volume":"31","author":"Bunge","year":"2008","journal-title":"J. Spinal Cord. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/B978-0-444-52137-8.00032-2","article-title":"Realizing the maximum potential of Schwann cells to promote recovery from spinal cord injury","volume":"109","author":"Bunge","year":"2012","journal-title":"Handb. Clin. Neurol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1113\/JP271531","article-title":"Efficacy of Schwann cell transplantation for spinal cord repair is improved with combinatorial strategies","volume":"594","author":"Bunge","year":"2016","journal-title":"J. Physiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.expneurol.2007.06.023","article-title":"Transduced Schwann cells promote axon growth and myelination after spinal cord injury","volume":"207","author":"Golden","year":"2007","journal-title":"Exp. Neurol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1523\/JNEUROSCI.2661-13.2014","article-title":"Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury","volume":"34","author":"Kanno","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/bit.26088","article-title":"Enhanced noradrenergic axon regeneration into schwann cell-filled PVDF-TrFE conduits after complete spinal cord transection","volume":"114","author":"Lee","year":"2017","journal-title":"Biotechnol. Bioeng."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1002\/ar.24721","article-title":"Effect of Schwann cell transplantation combined with electroacupuncture on axonal regeneration and remyelination in rats with spinal cord injury","volume":"304","author":"Tan","year":"2021","journal-title":"Anat. Rec."},{"key":"ref_97","first-page":"391","article-title":"Effect of electroacupuncture combined with Schwann cell transplantation on limb locomotor ability, regional remyelination and expression of spinal CD4 and CD8 proteins in compressive spinal injury rats","volume":"44","author":"Tan","year":"2019","journal-title":"Zhen Ci Yan Jiu"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Bernardo, A., and Visentin, S. (2023). Demyelinating Diseases: From Molecular Mechanisms to Therapeutic Strategies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054596"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Franklin, R.J.M., Bodini, B., and Goldman, S.A. (2024). Remyelination in the Central Nervous System. Cold Spring Harb. Perspect. Biol., 16.","DOI":"10.1101\/cshperspect.a041371"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Cayre, M., Falque, M., Mercier, O., Magalon, K., and Durbec, P. (2021). Myelin Repair: From Animal Models to Humans. Front. Cell Neurosci., 15.","DOI":"10.3389\/fncel.2021.604865"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Kegler, K., Spitzbarth, I., Imbschweiler, I., Wewetzer, K., Baumg\u00e4rtner, W., and Seehusen, F. (2015). Contribution of Schwann Cells to Remyelination in a Naturally Occurring Canine Model of CNS Neuroinflammation. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133916"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/glia.22270","article-title":"Increased p75 neurotrophin receptor expression in the canine distemper virus model of multiple sclerosis identifies aldynoglial Schwann cells that emerge in response to axonal damage","volume":"60","author":"Imbschweiler","year":"2012","journal-title":"Glia"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2990.2005.00637.x","article-title":"The case for a central nervous system (CNS) origin for the Schwann cells that remyelinate CNS axons following concurrent loss of oligodendrocytes and astrocytes","volume":"31","author":"Blakemore","year":"2005","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00401-019-01980-7","article-title":"The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"137","author":"Brambilla","year":"2019","journal-title":"Acta Neuropathol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molmed.2018.11.005","article-title":"Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology","volume":"25","author":"Voet","year":"2019","journal-title":"Trends Mol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Bhagavati, S. (2021). Autoimmune Disorders of the Nervous System: Pathophysiology, Clinical Features, and Therapy. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.664664"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.molmed.2009.04.001","article-title":"Multiple sclerosis\u2014A response-to-damage model","volume":"15","author":"Hart","year":"2009","journal-title":"Trends Mol. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41582-022-00620-1","article-title":"Epstein\u2013Barr virus and MS\u2014A causal link","volume":"18","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1212\/CON.0000000000001136","article-title":"Epidemiology and Pathophysiology of Multiple Sclerosis","volume":"28","author":"Ward","year":"2022","journal-title":"Continuum"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ana.410050105","article-title":"Remyelination in multiple sclerosis","volume":"5","author":"Prineas","year":"1979","journal-title":"Ann. Neurol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1749-6632.1984.tb14773.x","article-title":"Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques","volume":"436","author":"Prineas","year":"1984","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/ana.24620","article-title":"Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis","volume":"79","author":"Bodini","year":"2016","journal-title":"Ann. Neurol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"8097","DOI":"10.1007\/s11033-021-06755-6","article-title":"Remyelination in PNS and CNS: Current and upcoming cellular and molecular strategies to treat disabling neuropathies","volume":"48","author":"Momenzadeh","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1007\/s11010-021-04119-z","article-title":"A review of possible therapies for multiple sclerosis","volume":"476","author":"Li","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/ana.410140313","article-title":"Schwann cell remyelination of demyelinated axons in spinal cord multiple sclerosis lesions","volume":"14","author":"Itoyama","year":"1983","journal-title":"Ann. Neurol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0022-510X(91)90064-E","article-title":"Extensive proliferation of peripheral type myelin in necrotic spinal cord lesions of multiple sclerosis","volume":"102","author":"Yamamoto","year":"1991","journal-title":"J. Neurol. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"100128","DOI":"10.1016\/j.labinv.2023.100128","article-title":"Schwann Cell Remyelination in the Multiple Sclerosis Central Nervous System","volume":"103","author":"Ghezzi","year":"2023","journal-title":"Lab. Investig."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1440-1789.2009.01071.x","article-title":"Neuromyelitis optica with intraspinal expansion of Schwann cell remyelination","volume":"30","author":"Ikota","year":"2010","journal-title":"Neuropathology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrd.2017.115","article-title":"Remyelination therapies: A new direction and challenge in multiple sclerosis","volume":"16","author":"Plemel","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_121","first-page":"11149","article-title":"Transplantation of olfactory ensheathing cells promotes partial recovery in rats with experimental autoimmune encephalomyelitis","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_122","first-page":"533","article-title":"Remyelination of the corpus callosum by olfactory ensheathing cell in an experimental model of multiple sclerosis","volume":"53","author":"Alamouti","year":"2015","journal-title":"Acta Medica Iran."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Zujovic, V., Doucerain, C., Hidalgo, A., Bachelin, C., Lachapelle, F., Weissert, R., Stadelmann, C., Linington, C., and Baron-Van Evercooren, A. (2012). Exogenous schwann cells migrate, remyelinate and promote clinical recovery in experimental auto-immune encephalomyelitis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042667"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF00684997","article-title":"Chronic relapsing experimental allergic encephalomyelitis: CNS plaque development in unsuppressed and suppressed animals","volume":"43","author":"Raine","year":"1978","journal-title":"Acta Neuropathol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e18246","DOI":"10.7554\/eLife.18246","article-title":"Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery","volume":"5","author":"Mei","year":"2016","journal-title":"Elife"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/glia.24335","article-title":"TREM2-dependent microglial function is essential for remyelination and subsequent neuroprotection","volume":"71","author":"Wang","year":"2023","journal-title":"Glia"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00401-020-02193-z","article-title":"TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis","volume":"140","author":"Cignarella","year":"2020","journal-title":"Acta Neuropathol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41419-024-06579-9","article-title":"TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits","volume":"15","author":"Zhang","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Li, Z.Q., Li, T.X., Tian, M., Ren, Z.S., Yuan, C.Y., Yang, R.K., Shi, S.J., Li, H., and Kou, Z.Z. (2022). Glial cells and neurologic autoimmune disorders. Front. Cell Neurosci., 16.","DOI":"10.3389\/fncel.2022.1028653"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s00415-021-10749-6","article-title":"Comparative analysis of clinical and imaging data between patients with myelin oligodendrocyte glycoprotein antibody disease and patients with aquaporin 4 antibody-positive neuromyelitis optica spectrum disorder","volume":"269","author":"Xie","year":"2022","journal-title":"J. Neurol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1002\/glia.23788","article-title":"Schwann cells: Rescuers of central demyelination","volume":"68","year":"2020","journal-title":"Glia"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.4103\/1673-5374.300980","article-title":"Oxidative stress factors in Parkinson\u2019s disease","volume":"16","author":"Dorszewska","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_133","first-page":"6691390","article-title":"Oxidative Stress: A New Pathophysiological Pathway in Parkinson\u2019s Disease and a Potential Target of the Brain-Sport Crosstalk","volume":"2025","author":"Caproni","year":"2025","journal-title":"Park. Dis."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s43094-022-00425-5","article-title":"Detailed insight into the pathophysiology and the behavioral complications associated with the Parkinson\u2019s disease and its medications","volume":"8","author":"Wal","year":"2022","journal-title":"Future J. Pharm. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s004010050406","article-title":"Changes of unmyelinated nerve fibers in sural nerve in amyotrophic lateral sclerosis, Parkinson\u2019s disease and multiple system atrophy","volume":"91","author":"Kanda","year":"1996","journal-title":"Acta Neuropathol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/cns.13282","article-title":"Activated Schwann cells and increased inflammatory cytokines IL-1\u03b2, IL-6, and TNF-\u03b1 in patients\u2019 sural nerve are lack of tight relationship with specific sensory disturbances in Parkinson\u2019s disease","volume":"26","author":"Zhang","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.mcn.2006.01.007","article-title":"Upregulation of alpha-synuclein in neurons and glia in inflammatory demyelinating disease","volume":"31","author":"Papadopoulos","year":"2006","journal-title":"Mol. Cell Neurosci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.parkreldis.2018.10.003","article-title":"Phosphorylated \u03b1-synuclein deposits in sural nerve deriving from Schwann cells: A biomarker for Parkinson\u2019s disease","volume":"60","author":"Zhang","year":"2019","journal-title":"Park. Relat. Disord."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1007\/s12035-023-03345-4","article-title":"Involvement of Abnormal p-\u03b1-syn Accumulation and TLR2-Mediated Inflammation of Schwann Cells in Enteric Autonomic Nerve Dysfunction of Parkinson\u2019s Disease: An Animal Model Study","volume":"60","author":"Jiang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12974-023-02720-1","article-title":"\u03b1-Synuclein induces prodromal symptoms of Parkinson\u2019s disease via activating TLR2\/MyD88\/NF-\u03baB pathway in Schwann cells of vagus nerve in a rat model","volume":"20","author":"Cheng","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41420-024-01824-8","article-title":"Phosphorylated \u03b1-synuclein deposited in Schwann cells interacting with TLR2 mediates cell damage and induces Parkinson\u2019s disease autonomic dysfunction","volume":"10","author":"Li","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_142","first-page":"T31","article-title":"Central effects of GLP-1: New opportunities for treatments of neurodegenerative diseases","volume":"221","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/j.1476-5381.2011.01272.x","article-title":"Neuroprotective effect of the glucagon-like peptide-1 receptor agonist, synthetic exendin-4, in streptozotocin-induced diabetic rats","volume":"164","author":"Liu","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Takaku, S., Tsukamoto, M., Niimi, N., Yako, H., and Sango, K. (2021). Exendin-4 Promotes Schwann Cell Survival\/Migration and Myelination In Vitro. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062971"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1172\/JCI68295","article-title":"Exenatide and the treatment of patients with Parkinson\u2019s disease","volume":"123","author":"Dickson","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Ma, C., Zhang, W., and Cao, M. (2021). Role of the Peripheral Nervous System in PD Pathology, Diagnosis, and Treatment. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.598457"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0006-8993(90)90336-A","article-title":"Cografts of adrenal medulla with peripheral nerve enhance the survivability of transplanted adrenal chromaffin cells and recovery of the host nigrostriatal dopaminergic system in MPTP-treated young adult mice","volume":"537","author":"Date","year":"1990","journal-title":"Brain Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0014-4886(91)90170-H","article-title":"Functional enhancement of intrastriatal dopamine-containing grafts by the co-transplantation of sciatic nerve tissue in 6-hydroxydopamine-lesioned rats","volume":"113","author":"Young","year":"1991","journal-title":"Exp. Neurol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1523\/JNEUROSCI.19-06-02301.1999","article-title":"A glial cell line-derived neurotrophic factor-secreting clone of the Schwann cell line SCTM41 enhances survival and fiber outgrowth from embryonic nigral neurons grafted to the striatum and to the lesioned substantia nigra","volume":"19","author":"Wilby","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.expneurol.2004.01.013","article-title":"Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms","volume":"187","author":"Timmer","year":"2004","journal-title":"Exp. Neurol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/s41419-021-03967-3","article-title":"SKP-SCs transplantation alleviates 6-OHDA-induced dopaminergic neuronal injury by modulating autophagy","volume":"12","author":"Ma","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1995-7645(11)60237-X","article-title":"Co\u2013transplantation of macaque autologous Schwann cells and human embryonic nerve stem cells in treatment of macaque Parkinson\u2019s disease","volume":"5","author":"Xia","year":"2012","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/s41591-023-02505-2","article-title":"Emerging diagnostics and therapeutics for Alzheimer disease","volume":"29","author":"Self","year":"2023","journal-title":"Nat. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"117253","DOI":"10.1016\/j.jns.2020.117253","article-title":"Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer\u2019s disease","volume":"421","author":"Bhatia","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"101619","DOI":"10.1016\/j.arr.2022.101619","article-title":"Oxidative stress: The core pathogenesis and mechanism of Alzheimer\u2019s disease","volume":"77","author":"Bai","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Zota, I., Chanoumidou, K., Gravanis, A., and Charalampopoulos, I. (2024). Stimulating myelin restoration with BDNF: A promising therapeutic approach for Alzheimer\u2019s disease. Front. Cell. Neurosci., 18.","DOI":"10.3389\/fncel.2024.1422130"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00401-017-1738-2","article-title":"Parietal white matter lesions in Alzheimer\u2019s disease are associated with cortical neurodegenerative pathology, but not with small vessel disease","volume":"134","author":"McAleese","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ame2.12207","article-title":"Stem cell therapy for Alzheimer\u2019s disease: An overview of experimental models and reality","volume":"5","author":"Qin","year":"2022","journal-title":"Anim. Model. Exp. Med."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Ifediora, N., Canoll, P., and Hargus, G. (2024). Human stem cell transplantation models of Alzheimer\u2019s disease. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1354164"},{"key":"ref_160","first-page":"245","article-title":"Effects of cotransplantated Schwann cells and neural stem cells in a rat model of Alzheimer\u2019s disease","volume":"6","author":"Zhan","year":"2011","journal-title":"Neural Regen. Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.3892\/etm.2017.4183","article-title":"Schwann cells promote the capability of neural stem cells to differentiate into neurons and secret neurotrophic factors","volume":"13","author":"Yu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13024-022-00588-y","article-title":"TREM2 dependent and independent functions of microglia in Alzheimer\u2019s disease","volume":"17","author":"Hou","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"eabq0095","DOI":"10.1126\/scitranslmed.abq0095","article-title":"A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer\u2019s disease","volume":"14","author":"Zhao","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Palaiogeorgou, A.M., Papakonstantinou, E., Golfinopoulou, R., Sigala, M., Mitsis, T., Papageorgiou, L., Diakou, I., Pierouli, K., Dragoumani, K., and Spandidos, D.A. (2023). Recent approaches on Huntington\u2019s disease (Review). Biomed. Rep., 18.","DOI":"10.3892\/br.2022.1587"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"110673","DOI":"10.1016\/j.brainresbull.2023.110673","article-title":"Advances in stem cell and other therapies for Huntington\u2019s disease: An update","volume":"199","author":"Conner","year":"2023","journal-title":"Brain Res. Bull."},{"key":"ref_166","first-page":"e47526","article-title":"Huntington\u2019s Disease: Understanding Its Novel Drugs and Treatments","volume":"15","author":"Dhingra","year":"2023","journal-title":"Cureus"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Zayed, M.A., Sultan, S., Alsaab, H.O., Yousof, S.M., Alrefaei, G.I., Alsubhi, N.H., Alkarim, S., Al Ghamdi, K.S., Bagabir, S.A., and Jana, A. (2022). Stem-Cell-Based Therapy: The Celestial Weapon against Neurological Disorders. Cells, 11.","DOI":"10.3390\/cells11213476"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"11795735221092517","DOI":"10.1177\/11795735221092517","article-title":"Current and Possible Future Therapeutic Options for Huntington\u2019s Disease","volume":"14","author":"Ferguson","year":"2022","journal-title":"J. Cent. Nerv. Syst. Dis."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Garcia, L.M., Hacker, J.L., Sase, S., Adang, L., and Almad, A. (2020). Glial cells in the driver seat of leukodystrophy pathogenesis. Neurobiol. Dis., 146.","DOI":"10.1016\/j.nbd.2020.105087"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00401-017-1739-1","article-title":"Leukodystrophies: A proposed classification system based on pathological changes and pathogenetic mechanisms","volume":"134","author":"Bugiani","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Aerts-Kaya, F., and van Til, N.P. (2023). Gene and Cellular Therapies for Leukodystrophies. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15112522"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.beem.2014.10.001","article-title":"Metachromatic leukodystrophy: Disease spectrum and approaches for treatment","volume":"29","author":"Boelens","year":"2015","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13023-019-1220-4","article-title":"Peripheral neuropathy in metachromatic leukodystrophy: Current status and future perspective","volume":"14","author":"Beerepoot","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00005072-197707000-00005","article-title":"Ultrastructural findings of peripheral nerve in a preclinical case of adult metachromatic leukodystrophy","volume":"36","author":"Argyrakis","year":"1977","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF00686778","article-title":"Ultrastructure of peripheral nerve in metachromatic leucodystrophy","volume":"7","author":"Cravioto","year":"1966","journal-title":"Acta Neuropathol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"9482","DOI":"10.1523\/JNEUROSCI.2287-07.2007","article-title":"Increasing sulfatide synthesis in myelin-forming cells of arylsulfatase A-deficient mice causes demyelination and neurological symptoms reminiscent of human metachromatic leukodystrophy","volume":"27","author":"Ramakrishnan","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Sanchez-\u00c1lvarez, N.T., Bautista-Ni\u00f1o, P.K., Trejos-Su\u00e1rez, J., and Serrano-D\u00edaz, N.C. (2022). A model of metformin mitochondrial metabolism in metachromatic leukodystrophy: First description of human Schwann cells transfected with CRISPR-Cas9. Open Biol., 12.","DOI":"10.1098\/rsob.210371"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/268753a0","article-title":"Myelination of mouse axons by Schwann cells transplanted from normal and abnormal human nerves","volume":"268","author":"Aguayo","year":"1977","journal-title":"Nature"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1089\/hum.1998.9.14-2111","article-title":"Transduced fibroblasts and metachromatic leukodystrophy lymphocytes transfer arylsulfatase A to myelinating glia and deficient cells in vitro","volume":"9","author":"Sangalli","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/08830738030180090201","article-title":"Globoid cell leukodystrophy (Krabbe\u2019s disease): Update","volume":"18","author":"Suzuki","year":"2003","journal-title":"J. Child. Neurol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0006-8993(94)91222-X","article-title":"Progressive dysfunction of twitcher Schwann cells is evaluated better in vitro than in vivo","volume":"637","author":"Komiyama","year":"1994","journal-title":"Brain Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0006-8993(98)01142-1","article-title":"Responses to cyclic AMP is impaired in the twitcher Schwann cells in vitro","volume":"816","author":"Yamada","year":"1999","journal-title":"Brain Res."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Shaimardanova, A.A., Chulpanova, D.S., Solovyeva, V.V., Mullagulova, A.I., Kitaeva, K.V., Allegrucci, C., and Rizvanov, A.A. (2020). Metachromatic Leukodystrophy: Diagnosis, Modeling, and Treatment Approaches. Front. Med., 7.","DOI":"10.3389\/fmed.2020.576221"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1002\/glia.24008","article-title":"Mechanisms of demyelination and neurodegeneration in globoid cell leukodystrophy","volume":"69","author":"Feltri","year":"2021","journal-title":"Glia"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/sj.bmt.1703650","article-title":"Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH)","volume":"30","author":"Day","year":"2002","journal-title":"Bone Marrow Transplant."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/ene.14393","article-title":"Amyotrophic lateral sclerosis: A clinical review","volume":"27","author":"Masrori","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Moss, K.R., and Saxena, S. (2025). Schwann Cells in Neuromuscular Disorders: A Spotlight on Amyotrophic Lateral Sclerosis. Cells, 14.","DOI":"10.3390\/cells14010047"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/S0140-6736(17)31287-4","article-title":"Amyotrophic lateral sclerosis","volume":"390","author":"Hardiman","year":"2017","journal-title":"Lancet"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Gentile, F., Scarlino, S., Falzone, Y.M., Lunetta, C., Tremolizzo, L., Quattrini, A., and Riva, N. (2019). The Peripheral Nervous System in Amyotrophic Lateral Sclerosis: Opportunities for Translational Research. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.00601"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/nan.12332","article-title":"Non-motor involvement in amyotrophic lateral sclerosis: New insight from nerve and vessel analysis in skin biopsy","volume":"43","author":"Nolano","year":"2017","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1002\/cne.23848","article-title":"Degeneration of proprioceptive sensory nerve endings in mice harboring amyotrophic lateral sclerosis-causing mutations","volume":"523","author":"Vaughan","year":"2015","journal-title":"J. Comp. Neurol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3858\/emm.2009.41.3.017","article-title":"Sensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis","volume":"41","author":"Guo","year":"2009","journal-title":"Exp. Mol. Med."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Ki, S.M., Jeong, H.S., and Lee, J.E. (2021). Primary Cilia in Glial Cells: An Oasis in the Journey to Overcoming Neurodegenerative Diseases. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.736888"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: Evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp. Neurol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1007\/s12035-021-02658-6","article-title":"Neuromuscular Junction Dysfunction in Amyotrophic Lateral Sclerosis","volume":"59","author":"Verma","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/glia.23768","article-title":"Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL-34, and SCF in amyotrophic lateral sclerosis","volume":"68","author":"Trias","year":"2020","journal-title":"Glia"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.4103\/NRR.NRR-D-23-01815","article-title":"Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: A case report","volume":"20","author":"Khan","year":"2025","journal-title":"Neural Regen. Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41593-021-01005-1","article-title":"Disentangling glial diversity in peripheral nerves at single-nuclei resolution","volume":"25","author":"Yim","year":"2022","journal-title":"Nat. Neurosci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"e1362242025","DOI":"10.1523\/JNEUROSCI.1362-24.2025","article-title":"Pmp2+ Schwann Cells Maintain the Survival of Large-Caliber Motor Axons","volume":"45","author":"Kozlowski","year":"2025","journal-title":"J. Neurosci."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"9246","DOI":"10.1523\/JNEUROSCI.21-23-09246.2001","article-title":"Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: Associated mutations develop motor neuron disease","volume":"21","author":"Nagai","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1073\/pnas.92.3.689","article-title":"Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis","volume":"92","author":"Ripps","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/ng0596-43","article-title":"Motor neurons in Cu\/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury","volume":"13","author":"Reaume","year":"1996","journal-title":"Nat. Genet."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","article-title":"ALS: A disease of motor neurons and their nonneuronal neighbors","volume":"52","author":"Cleveland","year":"2006","journal-title":"Neuron"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.nbd.2008.08.010","article-title":"Mutant SOD1 from spinal cord of G93A rats is destabilized and binds to inner mitochondrial membrane","volume":"32","author":"Ahtoniemi","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Peggion, C., Scalcon, V., Massimino, M.L., Nies, K., Lopreiato, R., Rigobello, M.P., and Bertoli, A. (2022). SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the Role of Glial and Muscle Cells. Antioxidants, 11.","DOI":"10.3390\/antiox11040614"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/bit.28083","article-title":"Tissue-engineered in vitro modeling of the impact of Schwann cells in amyotrophic lateral sclerosis","volume":"119","author":"Louit","year":"2022","journal-title":"Biotechnol. Bioeng."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/glia.20836","article-title":"Live imaging of amyotrophic lateral sclerosis pathogenesis: Disease onset is characterized by marked induction of GFAP in Schwann cells","volume":"57","author":"Keller","year":"2009","journal-title":"Glia"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00429-009-0226-4","article-title":"Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice","volume":"214","author":"Chen","year":"2010","journal-title":"Brain Struct. Funct."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1073\/pnas.0813339106","article-title":"Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice","volume":"106","author":"Lobsiger","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jphs.2023.07.006","article-title":"Schwann cell derived-peroxiredoxin protects motor neurons against hydrogen peroxide-induced cell death in mouse motor neuron cell line NSC-34","volume":"153","author":"Kosuge","year":"2023","journal-title":"J. Pharmacol. Sci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"101635","DOI":"10.1016\/j.tice.2021.101635","article-title":"Peroxiredoxin 6 secreted by Schwann-like cells protects neuron against ischemic stroke in rats via PTEN\/PI3K\/AKT pathway","volume":"73","author":"Tang","year":"2021","journal-title":"Tissue Cell"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1523\/JNEUROSCI.1748-18.2020","article-title":"Properties of Glial Cell at the Neuromuscular Junction Are Incompatible with Synaptic Repair in the SOD1(G37R) ALS Mouse Model","volume":"40","author":"Martineau","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Alhindi, A., Shand, M., Smith, H.L., Leite, A.S., Huang, Y.T., van der Hoorn, D., Ridgway, Z., Faller, K.M.E., Jones, R.A., and Gillingwater, T.H. (2023). Neuromuscular junction denervation and terminal Schwann cell loss in the hTDP-43 overexpression mouse model of amyotrophic lateral sclerosis. Neuropathol. Appl. Neurobiol., 49.","DOI":"10.1111\/nan.12925"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.nbd.2012.05.014","article-title":"Selective knockdown of mutant SOD1 in Schwann cells ameliorates disease in G85R mutant SOD1 transgenic mice","volume":"48","author":"Wang","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"fcab081","DOI":"10.1093\/braincomms\/fcab081","article-title":"Terminal Schwann cells at the human neuromuscular junction","volume":"3","author":"Alhindi","year":"2021","journal-title":"Brain Commun."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1523\/JNEUROSCI.1379-14.2015","article-title":"Early and persistent abnormal decoding by glial cells at the neuromuscular junction in an ALS model","volume":"35","author":"Arbour","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1113\/JP270213","article-title":"New perspectives on amyotrophic lateral sclerosis: The role of glial cells at the neuromuscular junction","volume":"595","author":"Arbour","year":"2017","journal-title":"J. Physiol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.semcdb.2020.02.011","article-title":"Perisynaptic schwann cells\u2014The multitasking cells at the developing neuromuscular junctions","volume":"104","author":"Gawor","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"e13981","DOI":"10.1111\/acel.13981","article-title":"Cellular and molecular evidence that synaptic Schwann cells contribute to aging of mouse neuromuscular junctions","volume":"22","author":"Hastings","year":"2023","journal-title":"Aging Cell"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.expneurol.2015.09.014","article-title":"Altered terminal Schwann cell morphology precedes denervation in SOD1 mice","volume":"275","author":"Carrasco","year":"2016","journal-title":"Exp. Neurol."},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Liu, J.X., Br\u00e4nnstr\u00f6m, T., Andersen, P.M., and Pedrosa-Domell\u00f6f, F. (2013). Distinct changes in synaptic protein composition at neuromuscular junctions of extraocular muscles versus limb muscles of ALS donors. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057473"},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Harrison, J.M., and Rafuse, V.F. (2020). Muscle fiber-type specific terminal Schwann cell pathology leads to sprouting deficits following partial denervation in SOD1(G93A) mice. Neurobiol. Dis., 145.","DOI":"10.1016\/j.nbd.2020.105052"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/ana.23781","article-title":"Matrix metalloproteinase 3 deletion preserves denervated motor endplates after traumatic nerve injury","volume":"73","author":"Chao","year":"2013","journal-title":"Ann. Neurol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.15252\/emmm.201607257","article-title":"CXCL12alpha\/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals","volume":"9","author":"Negro","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s40478-022-01495-5","article-title":"Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor","volume":"10","author":"Negro","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s10072-023-07259-w","article-title":"Masitinib as a neuroprotective agent: A scoping review of preclinical and clinical evidence","volume":"45","author":"Hamad","year":"2024","journal-title":"Neurol. Sci."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1055\/s-0041-1731630","article-title":"Peripheral Nerve Healing: So Near and Yet So Far","volume":"35","author":"Baradaran","year":"2021","journal-title":"Semin. Plast. Surg."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/5584_2018_254","article-title":"Adult Stem Cell-Based Strategies for Peripheral Nerve Regeneration","volume":"1119","author":"Kozik","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Leon-Andrino, A., Noriega, D.C., Lapuente, J.P., Perez-Valdecantos, D., Caballero-Garcia, A., Herrero, A.J., and Cordova, A. (2022). Biological Approach in the Treatment of External Popliteal Sciatic Nerve (Epsn) Neurological Injury: Review. J. Clin. Med., 11.","DOI":"10.3390\/jcm11102804"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1523\/JNEUROSCI.12-09-03310.1992","article-title":"Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve regeneration","volume":"12","author":"Guenard","year":"1992","journal-title":"J. Neurosci."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2174\/187152711795563930","article-title":"Derivation of clinically applicable schwann cells from bone marrow stromal cells for neural repair and regeneration","volume":"10","author":"Cai","year":"2011","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000368188","article-title":"Mesenchymal stem cells as a source of Schwann cells: Their anticipated use in peripheral nerve regeneration","volume":"200","author":"Wakao","year":"2014","journal-title":"Cells Tissues Organs"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3727\/096368915X690198","article-title":"The Use of Autologous Schwann Cells to Supplement Sciatic Nerve Repair with a Large Gap: First in Human Experience","volume":"25","author":"Levi","year":"2016","journal-title":"Cell Transplant."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3171\/2016.12.FOCUS16474","article-title":"First human experience with autologous Schwann cells to supplement sciatic nerve repair: Report of 2 cases with long-term follow-up","volume":"42","author":"Gersey","year":"2017","journal-title":"Neurosurg. Focus."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Wang, Q., Chen, F.Y., Ling, Z.M., Su, W.F., Zhao, Y.Y., Chen, G., and Wei, Z.Y. (2022). The Effect of Schwann Cells\/Schwann Cell-Like Cells on Cell Therapy for Peripheral Neuropathy. Front. Cell Neurosci., 16.","DOI":"10.3389\/fncel.2022.836931"},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Zhang, L., Xie, J., Dai, W., Lu, B., and Yi, S. (2025). Schwann cells in regeneration and cancer. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1506552"},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Balakrishnan, A., Belfiore, L., Chu, T.H., Fleming, T., Midha, R., Biernaskie, J., and Schuurmans, C. (2020). Insights Into the Role and Potential of Schwann Cells for Peripheral Nerve Repair From Studies of Development and Injury. Front. Mol. Neurosci., 13.","DOI":"10.3389\/fnmol.2020.608442"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Jiang, M., Chen, M., and Liu, N. (2024). Interactions between Schwann cell and extracellular matrix in peripheral nerve regeneration. Front. Neurol., 15.","DOI":"10.3389\/fneur.2024.1372168"},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Rao, Z., Lin, Z., Song, P., Quan, D., and Bai, Y. (2022). Biomaterial-Based Schwann Cell Transplantation and Schwann Cell-Derived Biomaterials for Nerve Regeneration. Front. Cell Neurosci., 16.","DOI":"10.3389\/fncel.2022.926222"},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Su, Q., Nasser, M.I., He, J., Deng, G., Ouyang, Q., Zhuang, D., Deng, Y., Hu, H., Liu, N., and Li, Z. (2022). Engineered Schwann Cell-Based Therapies for Injury Peripheral Nerve Reconstruction. Front. Cell Neurosci., 16.","DOI":"10.3389\/fncel.2022.865266"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1523\/JNEUROSCI.0951-20.2020","article-title":"Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury","volume":"40","author":"Reed","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.7150\/thno.40919","article-title":"Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3171\/2020.8.JNS202349","article-title":"Schwann cell delivery via a novel 3D collagen matrix conduit improves outcomes in critical length nerve gap repairs","volume":"135","author":"Burks","year":"2021","journal-title":"J. Neurosurg."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"102438","DOI":"10.1016\/j.npep.2024.102438","article-title":"The phenotypic changes of Schwann cells promote the functional repair of nerve injury","volume":"106","author":"Liao","year":"2024","journal-title":"Neuropeptides"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.biomaterials.2014.10.009","article-title":"Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve","volume":"37","author":"Georgiou","year":"2015","journal-title":"Biomaterials"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3171\/2017.5.SPINE161100","article-title":"Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and regeneration across a critical size defect of 15 mm in the rat sciatic nerve","volume":"28","author":"Heimann","year":"2018","journal-title":"J. Neurosurg. Spine"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3171\/2013.4.JNS121189","article-title":"Transplantation of Schwann cells in a collagen tube for the repair of large, segmental peripheral nerve defects in rats","volume":"119","author":"Berrocal","year":"2013","journal-title":"J. Neurosurg."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn.2018.13","article-title":"Fibrinogen in neurological diseases: Mechanisms, imaging and therapeutics","volume":"19","author":"Petersen","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0896-6273(02)00617-7","article-title":"Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation","volume":"33","author":"Akassoglou","year":"2002","journal-title":"Neuron"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1089\/ten.tea.2017.0457","article-title":"An Optimized Collagen-Fibrin Blend Engineered Neural Tissue Promotes Peripheral Nerve Repair","volume":"24","author":"Schuh","year":"2018","journal-title":"Tissue Eng. Part A"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.biopha.2017.05.099","article-title":"Curcumin accelerates the repair of sciatic nerve injury in rats through reducing Schwann cells apoptosis and promoting myelinization","volume":"92","author":"Zhao","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"136391","DOI":"10.1016\/j.neulet.2021.136391","article-title":"Curcumin enhances the proliferation and myelinization of Schwann cells through Runx2 to repair sciatic nerve injury","volume":"770","author":"Wang","year":"2022","journal-title":"Neurosci. Lett."},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Jahromi, H.K., Farzin, A., Hasanzadeh, E., Barough, S.E., Mahmoodi, N., Najafabadi, M.R.H., Farahani, M.S., Mansoori, K., Shirian, S., and Ai, J. (2020). Enhanced sciatic nerve regeneration by poly-L-lactic acid\/multi-wall carbon nanotube neural guidance conduit containing Schwann cells and curcumin encapsulated chitosan nanoparticles in rat. Mater. Sci. Eng. C Mater. Biol. Appl., 109.","DOI":"10.1016\/j.msec.2019.110564"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"117959","DOI":"10.1016\/j.lfs.2020.117959","article-title":"Resveratrol regulates the recovery of rat sciatic nerve crush injury by promoting the autophagy of Schwann cells","volume":"256","author":"Zhang","year":"2020","journal-title":"Life Sci."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1002\/term.2284","article-title":"Enhanced in vivo survival of Schwann cells by a synthetic oxygen carrier promotes sciatic nerve regeneration and functional recovery","volume":"12","author":"Ma","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.3171\/FOC.2009.26.2.E4","article-title":"Transplantation of autologous Schwann cells for the repair of segmental peripheral nerve defects","volume":"26","author":"Hood","year":"2009","journal-title":"Neurosurg. Focus."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.4103\/1673-5374.253511","article-title":"Therapeutic strategies for peripheral nerve injury: Decellularized nerve conduits and Schwann cell transplantation","volume":"14","author":"Han","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref_258","doi-asserted-by":"crossref","unstructured":"Vallejo, F.A., Diaz, A., Errante, E.L., Smartz, T., Khan, A., Silvera, R., Brooks, A.E., Lee, Y.S., Burks, S.S., and Levi, A.D. (2022). Systematic review of the therapeutic use of Schwann cells in the repair of peripheral nerve injuries: Advancements from animal studies to clinical trials. Front. Cell Neurosci., 16.","DOI":"10.3389\/fncel.2022.929593"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.brainresbull.2010.07.001","article-title":"BD\u2122 PuraMatrix\u2122 peptide hydrogel seeded with Schwann cells for peripheral nerve regeneration","volume":"83","author":"McGrath","year":"2010","journal-title":"Brain Res. Bull."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/jbm.b.33952","article-title":"Sciatic nerve regeneration by transplantation of Schwann cells via erythropoietin controlled-releasing polylactic acid\/multiwalled carbon nanotubes\/gelatin nanofibrils neural guidance conduit","volume":"106","author":"Salehi","year":"2018","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.actbio.2024.03.029","article-title":"Dual-layer conduit containing VEGF-A\u2014Transfected Schwann cells promotes peripheral nerve regeneration via angiogenesis","volume":"180","author":"Huang","year":"2024","journal-title":"Acta Biomater."},{"key":"ref_262","first-page":"1250","article-title":"Laminin-chitosan-PLGA conduit co-transplanted with Schwann and neural stem cells to repair the injured recurrent laryngeal nerve","volume":"16","author":"Li","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10856-020-06436-z","article-title":"Co-transplantation of Schwann cells and neural stem cells in the laminin-chitosan-PLGA nerve conduit to repair the injured recurrent laryngeal nerve in SD rats","volume":"31","author":"Li","year":"2020","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/107632700320748","article-title":"A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration","volume":"6","author":"Hadlock","year":"2000","journal-title":"Tissue Eng."},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Takeya, H., Itai, S., Kimura, H., Kurashina, Y., Amemiya, T., Nagoshi, N., Iwamoto, T., Sato, K., Shibata, S., and Matsumoto, M. (2023). Schwann cell-encapsulated chitosan-collagen hydrogel nerve conduit promotes peripheral nerve regeneration in rodent sciatic nerve defect models. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-39141-2"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.ultrasmedbio.2004.06.005","article-title":"The effects of low-intensity ultrasound on peripheral nerve regeneration in poly(DL-lactic acid-co-glycolic acid) conduits seeded with Schwann cells","volume":"30","author":"Chang","year":"2004","journal-title":"Ultrasound Med. Biol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"101985","DOI":"10.1016\/j.tice.2022.101985","article-title":"Low-intensity pulsed ultrasound promotes proliferation and myelinating genes expression of Schwann cells through NRG1\/ErbB signaling pathway","volume":"80","author":"Huang","year":"2023","journal-title":"Tissue Cell"},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Ling, J., He, C., Zhang, S., Zhao, Y., Zhu, M., Tang, X., Li, Q., Xu, L., and Yang, Y. (2023). Progress in methods for evaluating Schwann cell myelination and axonal growth in peripheral nerve regeneration via scaffolds. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1308761"},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Bol\u00edvar, S., Navarro, X., and Udina, E. (2020). Schwann Cell Role in Selectivity of Nerve Regeneration. Cells, 9.","DOI":"10.3390\/cells9092131"},{"key":"ref_270","doi-asserted-by":"crossref","unstructured":"Liu, T., Wang, Y., Lu, L., and Liu, Y. (2022). SPIONs mediated magnetic actuation promotes nerve regeneration by inducing and maintaining repair-supportive phenotypes in Schwann cells. J. Nanobiotechnol., 20.","DOI":"10.1186\/s12951-022-01337-5"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1002\/jnr.22426","article-title":"Short-term low-frequency electrical stimulation enhanced remyelination of injured peripheral nerves by inducing the promyelination effect of brain-derived neurotrophic factor on Schwann cell polarization","volume":"88","author":"Wan","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.expneurol.2015.03.022","article-title":"Brief electrical stimulation improves nerve regeneration after delayed repair in Sprague Dawley rats","volume":"269","author":"Elzinga","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1089\/ten.tea.2010.0519","article-title":"Biphasic electrical targeting plays a significant role in schwann cell activation","volume":"17","author":"Kim","year":"2011","journal-title":"Tissue Eng. Part. A"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"8974","DOI":"10.7150\/thno.44912","article-title":"Mechanical stimulation of Schwann cells promote peripheral nerve regeneration via extracellular vesicle-mediated transfer of microRNA 23b-3p","volume":"10","author":"Xia","year":"2020","journal-title":"Theranostics"},{"key":"ref_275","doi-asserted-by":"crossref","unstructured":"Chen, S.H., Wang, H.W., Yang, P.C., Chen, S.S., Ho, C.H., Yang, P.C., Kao, Y.C., Liu, S.W., Chiu, H., and Lin, Y.J. (2024). Schwann cells acquire a repair phenotype after assembling into spheroids and show enhanced in vivo therapeutic potential for promoting peripheral nerve repair. Bioeng. Transl. Med., 9.","DOI":"10.1002\/btm2.10635"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"9721375","DOI":"10.1155\/2023\/9721375","article-title":"Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats","volume":"2023","author":"Wang","year":"2023","journal-title":"Mediat. Inflamm."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.freeradbiomed.2022.04.016","article-title":"Melatonin promotes peripheral nerve repair through Parkin-mediated mitophagy","volume":"185","author":"Li","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/jpi.12125","article-title":"Proliferative effects of melatonin on Schwann cells: Implication for nerve regeneration following peripheral nerve injury","volume":"56","author":"Chang","year":"2014","journal-title":"J. Pineal Res."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/ejn.14998","article-title":"Melatonin promotes Schwann cell proliferation and migration via the shh signalling pathway after peripheral nerve injury","volume":"53","author":"Pan","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"ref_280","doi-asserted-by":"crossref","unstructured":"Klymenko, A., and Lutz, D. (2022). Melatonin signalling in Schwann cells during neuroregeneration. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.999322"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"e70184","DOI":"10.1002\/ctm2.70184","article-title":"Cannabinoid receptor 2 facilitates the Schwann cells-dependent peripheral nerve regeneration","volume":"15","author":"Xu","year":"2025","journal-title":"Clin. Transl. Med."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"23518","DOI":"10.1021\/acsnano.4c07285","article-title":"Nerve Regeneration Potential of Antioxidant-Modified Black Phosphorus Quantum Dots in Peripheral Nerve Injury","volume":"18","author":"Shen","year":"2024","journal-title":"ACS Nano"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: A systematic analysis for the Global Burden of Disease Study 2021","volume":"23","author":"Steinmetz","year":"2024","journal-title":"Lancet Neurol."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41572-019-0092-1","article-title":"Diabetic neuropathy","volume":"5","author":"Feldman","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_285","first-page":"657","article-title":"Novel drugs affecting diabetic peripheral neuropathy","volume":"27","author":"Saleh","year":"2024","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1111\/j.1471-4159.2004.02824.x","article-title":"Neurotrophin-3-induced production of nerve growth factor is suppressed in Schwann cells exposed to high glucose: Involvement of the polyol pathway","volume":"91","author":"Suzuki","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bbrc.2004.05.159","article-title":"Reduced cell replication and induction of apoptosis by advanced glycation end products in rat Schwann cells","volume":"320","author":"Sekido","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/978-981-32-9636-7_22","article-title":"Schwann Cells as Crucial Players in Diabetic Neuropathy","volume":"1190","author":"Naruse","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/B978-0-444-53480-4.00029-1","article-title":"Mechanisms of diabetic neuropathy: Schwann cells","volume":"126","author":"Mizisin","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"764","DOI":"10.7150\/ijms.19535","article-title":"Attenuation of Oxidative Stress-Induced Cell Apoptosis in Schwann RSC96 Cells by Ocimum Gratissimum Aqueous Extract","volume":"14","author":"Chao","year":"2017","journal-title":"Int. J. Med. Sci."},{"key":"ref_291","doi-asserted-by":"crossref","unstructured":"Tiong, Y.L., Ng, K.Y., Koh, R.Y., Ponnudurai, G., and Chye, S.M. (2019). Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-\u03baB, mTOR, Wnt Signalling Pathways. Antioxidants, 8.","DOI":"10.3390\/antiox8070198"},{"key":"ref_292","doi-asserted-by":"crossref","unstructured":"Li, H., Jiang, L., Zhang, S., Miao, X., and Jiang, S.-H. (2025). Pan-cancer analysis reveals multifaceted roles of nonmyelinating Schwann cells in gastrointestinal cancers. Cancer Lett., in press.","DOI":"10.1016\/j.canlet.2025.217850"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s004010050764","article-title":"Reactive, degenerative, and proliferative Schwann cell responses in experimental galactose and human diabetic neuropathy","volume":"95","author":"Kalichman","year":"1998","journal-title":"Acta Neuropathol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/jn.01123.2010","article-title":"Impaired sensory nerve function and axon morphology in mice with diabetic neuropathy","volume":"106","author":"Lennertz","year":"2011","journal-title":"J. Neurophysiol."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0140-6736(65)92154-9","article-title":"Schwann-cell abnormalities in diabetic neuropathy","volume":"1","author":"Thomas","year":"1965","journal-title":"Lancet"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s004010050783","article-title":"Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy","volume":"95","author":"Mizisin","year":"1998","journal-title":"Acta Neuropathol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00018-023-05024-y","article-title":"Glial cell alterations in diabetes-induced neurodegeneration","volume":"81","year":"2024","journal-title":"Cell Mol. Life Sci."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1159\/000489373","article-title":"Expression of Nrf2 Promotes Schwann Cell-Mediated Sciatic Nerve Recovery in Diabetic Peripheral Neuropathy","volume":"46","author":"Tang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2337\/db19-0517","article-title":"Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice","volume":"69","author":"Eid","year":"2020","journal-title":"Diabetes"},{"key":"ref_300","doi-asserted-by":"crossref","unstructured":"Yang, Y.M., Ma, H.B., Xiong, Y., Wu, Q., and Gao, X.K. (2025). PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy. J. Biomed. Sci., 32.","DOI":"10.1186\/s12929-024-01115-5"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/jnc.15877","article-title":"Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination","volume":"166","author":"Eid","year":"2023","journal-title":"J. Neurochem."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0074-7742(02)50081-7","article-title":"Role of the Schwann cell in diabetic neuropathy","volume":"50","author":"Eckersley","year":"2002","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41419-021-03930-2","article-title":"TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K\/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bbrc.2004.06.011","article-title":"Methylglyoxal induces apoptosis through activation of p38 MAPK in rat Schwann cells","volume":"320","author":"Fukunaga","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"117459","DOI":"10.1016\/j.lfs.2020.117459","article-title":"Schwann cells apoptosis is induced by high glucose in diabetic peripheral neuropathy","volume":"248","author":"Liu","year":"2020","journal-title":"Life Sci."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"20230809","DOI":"10.1515\/med-2023-0809","article-title":"Ferroptosis involves in Schwann cell death in diabetic peripheral neuropathy","volume":"18","author":"Wu","year":"2023","journal-title":"Open Med."},{"key":"ref_307","doi-asserted-by":"crossref","unstructured":"Han, J., Tan, P., Li, Z., Wu, Y., Li, C., Wang, Y., Wang, B., Zhao, S., and Liu, Y. (2014). Fuzi attenuates diabetic neuropathy in rats and protects schwann cells from apoptosis induced by high glucose. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086539"},{"key":"ref_308","doi-asserted-by":"crossref","unstructured":"Wang, B.B., Wang, J.L., Yuan, J., Quan, Q.H., Ji, R.F., Tan, P., Han, J., and Liu, Y.G. (2016). Sugar Composition Analysis of Fuzi Polysaccharides by HPLC-MS(n) and Their Protective Effects on Schwann Cells Exposed to High Glucose. Molecules, 21.","DOI":"10.3390\/molecules21111496"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/ptr.7641","article-title":"Jatrorrhizine ameliorates Schwann cell myelination via inhibiting HDAC3 ability to recruit Atxn2l for regulating the NRG1-ErbB2-PI3K-AKT pathway in diabetic peripheral neuropathy mice","volume":"37","author":"Gong","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.biopha.2018.06.069","article-title":"Trehalose prevents sciatic nerve damage to and apoptosis of Schwann cells of streptozotocin-induced diabetic C57BL\/6J mice","volume":"105","author":"Pan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s10072-014-1647-2","article-title":"Minocycline improves peripheral and autonomic neuropathy in type 2 diabetes: MIND study","volume":"35","author":"Syngle","year":"2014","journal-title":"Neurol. Sci."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.stem.2023.04.006","article-title":"Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy","volume":"30","author":"Majd","year":"2023","journal-title":"Cell Stem Cell"},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2174\/187152710793237412","article-title":"Schwann cells as a therapeutic target for peripheral neuropathies","volume":"9","author":"Lehmann","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/jphp.12244","article-title":"Erythropoietin attenuates oxidative stress and apoptosis in Schwann cells isolated from streptozotocin-induced diabetic rats","volume":"66","author":"Yu","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s11064-015-1516-2","article-title":"Erythropoietin attenuates advanced glycation endproducts-induced toxicity of Schwann cells in vitro","volume":"40","author":"Yu","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1007\/s11064-017-2333-6","article-title":"NGF Attenuates High Glucose-Induced ER Stress, Preventing Schwann Cell Apoptosis by Activating the PI3K\/Akt\/GSK3\u03b2 and ERK1\/2 Pathways","volume":"42","author":"Li","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbrc.2022.12.071","article-title":"BMP5 ameliorates diabetic peripheral neuropathy by augmenting mitochondrial function and inhibiting apoptosis in Schwann cells","volume":"643","author":"Pang","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"111557","DOI":"10.1016\/j.yexcr.2019.111557","article-title":"Taurine protects against myelin damage of sciatic nerve in diabetic peripheral neuropathy rats by controlling apoptosis of schwann cells via NGF\/Akt\/GSK3\u03b2 pathway","volume":"383","author":"Li","year":"2019","journal-title":"Exp. Cell Res."},{"key":"ref_319","doi-asserted-by":"crossref","unstructured":"An, J., Zhang, X., Jia, K., Zhang, C., Zhu, L., Cheng, M., Li, F., Zhao, S., and Hao, J. (2021). Trichostatin A increases BDNF protein expression by improving XBP-1s\/ATF6\/GRP78 axis in Schwann cells of diabetic peripheral neuropathy. Biomed. Pharmacother., 133.","DOI":"10.1016\/j.biopha.2020.111062"},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.3727\/096368912X657710","article-title":"Transplantation of neural crest-like cells derived from induced pluripotent stem cells improves diabetic polyneuropathy in mice","volume":"22","author":"Okawa","year":"2013","journal-title":"Cell Transplant."},{"key":"ref_321","doi-asserted-by":"crossref","unstructured":"Akter, S., Choubey, M., Mohib, M.M., Arbee, S., Sagor, M.A.T., and Mohiuddin, M.S. (2023). Stem Cell Therapy in Diabetic Polyneuropathy: Recent Advancements and Future Directions. Brain Sci., 13.","DOI":"10.3390\/brainsci13020255"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s13770-024-00638-0","article-title":"Therapeutic Effect of Schwann Cell-Like Cells Differentiated from Human Tonsil-Derived Mesenchymal Stem Cells on Diabetic Neuropathy in db\/db Mice","volume":"21","author":"Yum","year":"2024","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_323","doi-asserted-by":"crossref","unstructured":"Abd Razak, N.H., Idris, J., Hassan, N.H., Zaini, F., Muhamad, N., and Daud, M.F. (2024). Unveiling the Role of Schwann Cell Plasticity in the Pathogenesis of Diabetic Peripheral Neuropathy. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202408.1297.v1"},{"key":"ref_324","doi-asserted-by":"crossref","unstructured":"Wu, L., Wang, X.J., Luo, X., Zhang, J., Zhao, X., and Chen, Q. (2024). Diabetic peripheral neuropathy based on Schwann cell injury: Mechanisms of cell death regulation and therapeutic perspectives. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1427679"},{"key":"ref_325","doi-asserted-by":"crossref","unstructured":"Sango, K., Yako, H., Niimi, N., and Takaku, S. (2024). Immortalized Schwann cell lines as useful tools for pathogenesis-based therapeutic approaches to diabetic peripheral neuropathy. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1531209"},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00401-015-1466-4","article-title":"Inflammatory neuropathies: Pathology, molecular markers and targets for specific therapeutic intervention","volume":"130","author":"Ubogu","year":"2015","journal-title":"Acta Neuropathol."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/mus.20893","article-title":"The immunocompetence of Schwann cells","volume":"37","author":"Hu","year":"2008","journal-title":"Muscle Nerve"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.nbd.2013.03.005","article-title":"The neuroinflammatory role of Schwann cells in disease","volume":"55","author":"Ydens","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1002\/glia.23200","article-title":"Schwann cell dedifferentiation-associated demyelination leads to exocytotic myelin clearance in inflammatory segmental demyelination","volume":"65","author":"Jang","year":"2017","journal-title":"Glia"},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00018-022-04683-7","article-title":"Adaptive autophagy reprogramming in Schwann cells during peripheral demyelination","volume":"80","author":"Jo","year":"2023","journal-title":"Cell Mol. Life Sci."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/annonc\/mdw613","article-title":"Vasculitic neuropathy induced by pembrolizumab","volume":"28","author":"Aya","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1056\/NEJMc1515584","article-title":"Pembrolizumab-Induced Demyelinating Polyradiculoneuropathy","volume":"375","author":"Nicolas","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_333","doi-asserted-by":"crossref","unstructured":"Voskens, C.J., Goldinger, S.M., Loquai, C., Robert, C., Kaehler, K.C., Berking, C., Bergmann, T., Bockmeyer, C.L., Eigentler, T., and Fluck, M. (2013). The price of tumor control: An analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053745"},{"key":"ref_334","doi-asserted-by":"crossref","unstructured":"Zoccarato, M., Grisold, W., Grisold, A., Poretto, V., Boso, F., and Giometto, B. (2021). Paraneoplastic Neuropathies: What\u2019s New Since the 2004 Recommended Diagnostic Criteria. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.706169"},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/CCO.0000000000000681","article-title":"Neurological complications of chimeric antigen receptor T cells and immune-checkpoint inhibitors: Ongoing challenges in daily practice","volume":"32","author":"Berzero","year":"2020","journal-title":"Curr. Opin. Oncol."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11912-020-00935-6","article-title":"Neurological Complications of CAR T Cell Therapy","volume":"22","author":"Landry","year":"2020","journal-title":"Curr. Oncol. Rep."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1023\/A:1008362714023","article-title":"Inflammatory demyelinating polyneuropathy: A complication of immunotherapy in malignant melanoma","volume":"11","author":"Anthoney","year":"2000","journal-title":"Ann. Oncol."},{"key":"ref_338","doi-asserted-by":"crossref","unstructured":"Kamil, K., Yazid, M.D., Idrus, R.B.H., Das, S., and Kumar, J. (2019). Peripheral Demyelinating Diseases: From Biology to Translational Medicine. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.00087"},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"e16365","DOI":"10.1111\/ene.16365","article-title":"Guillain-Barr\u00e9 syndrome: A comprehensive review","volume":"31","author":"Bellanti","year":"2024","journal-title":"Eur. J. Neurol."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1007\/s13311-022-01221-y","article-title":"The Role of the Complement System in Chronic Inflammatory Demyelinating Polyneuropathy: Implications for Complement-Targeted Therapies","volume":"19","author":"Querol","year":"2022","journal-title":"Neurotherapeutics"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"289","DOI":"10.21037\/atm-20-2285","article-title":"Detection of anti-ganglioside antibodies in Guillain-Barr\u00e9 syndrome","volume":"11","author":"Zhu","year":"2023","journal-title":"Ann. Transl. Med."},{"key":"ref_342","doi-asserted-by":"crossref","unstructured":"Shastri, A., Al Aiyan, A., Kishore, U., and Farrugia, M.E. (2023). Immune-Mediated Neuropathies: Pathophysiology and Management. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087288"},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/ana.410360517","article-title":"Molecular mimicry between GQ1b ganglioside and lipopolysaccharides of Campylobacter jejuni isolated from patients with Fisher\u2019s syndrome","volume":"36","author":"Yuki","year":"1994","journal-title":"Ann. Neurol."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"116576","DOI":"10.1016\/j.jns.2019.116576","article-title":"Antiganglioside antibodies in neurological diseases","volume":"408","author":"Wanleenuwat","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1365-2249.1994.tb06142.x","article-title":"Cellular mRNA expression of interferon-gamma, IL-4 and transforming growth factor-beta (TGF-beta) by rat mononuclear cells stimulated with peripheral nerve myelin antigens in experimental allergic neuritis","volume":"98","author":"Zhu","year":"1994","journal-title":"Clin. Exp. Immunol."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41586-023-06916-6","article-title":"Autoreactive T cells target peripheral nerves in Guillain\u2013Barr\u00e9 syndrome","volume":"626","author":"Mallone","year":"2024","journal-title":"Nature"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/brain\/awg030","article-title":"Autoimmunoreactivity to Schwann cells in patients with inflammatory neuropathies","volume":"126","author":"Kwa","year":"2003","journal-title":"Brain"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12974-021-02301-0","article-title":"Autoantibody screening in Guillain\u2013Barr\u00e9 syndrome","volume":"18","author":"Franco","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/ana.410390512","article-title":"Immune attack on the Schwann cell surface in acute inflammatory demyelinating polyneuropathy","volume":"39","author":"Sheikh","year":"1996","journal-title":"Ann. Neurol."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"S169","DOI":"10.1086\/513795","article-title":"Mechanisms of Schwann cell damage in inflammatory neuropathy","volume":"176","author":"Koski","year":"1997","journal-title":"J. Infect. Dis."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ana.410300205","article-title":"Presence of the terminal complement complex (C5b-9) precedes myelin degradation in immune-mediated demyelination of the rat peripheral nervous system","volume":"30","author":"Stoll","year":"1991","journal-title":"Ann. Neurol."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"e158524","DOI":"10.1172\/JCI158524","article-title":"Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barr\u00e9 syndrome mouse model","volume":"132","author":"McGonigal","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1046\/j.1471-4159.1996.66010303.x","article-title":"Complement regulatory molecules on human myelin and glial cells: Differential expression affects the deposition of activated complement proteins","volume":"66","author":"Koski","year":"1996","journal-title":"J. Neurochem."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/(SICI)1098-1136(199708)20:4<308::AID-GLIA4>3.0.CO;2-1","article-title":"Dibutyryl cyclic AMP and inflammatory cytokines mediate C3 expression in Schwann cells","volume":"20","author":"Dashiell","year":"1997","journal-title":"Glia"},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jinf.2016.08.006","article-title":"The role of primary infection of Schwann cells in the aetiology of infective inflammatory neuropathies","volume":"73","author":"Neal","year":"2016","journal-title":"J. Infect."},{"key":"ref_356","doi-asserted-by":"crossref","unstructured":"Bedoui, Y., De Larichaudy, D., Daniel, M., Ah-Pine, F., Selambarom, J., Guiraud, P., and Gasque, P. (2022). Deciphering the Role of Schwann Cells in Inflammatory Peripheral Neuropathies Post Alphavirus Infection. Cells, 12.","DOI":"10.3390\/cells12010100"},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/jns.12373","article-title":"Perisynaptic Schwann cells phagocytose nerve terminal debris in a mouse model of Guillain-Barr\u00e9 syndrome","volume":"25","author":"Cunningham","year":"2020","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrneurol.2017.84","article-title":"Autoantibodies in chronic inflammatory neuropathies: Diagnostic and therapeutic implications","volume":"13","author":"Querol","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1136\/jnnp-2014-309697","article-title":"Chronic inflammatory demyelinating polyradiculoneuropathy: From pathology to phenotype","volume":"86","author":"Mathey","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/ene.14133","article-title":"Antibody- and macrophage-mediated segmental demyelination in chronic inflammatory demyelinating polyneuropathy: Clinical, electrophysiological, immunological and pathological correlates","volume":"27","author":"Vallat","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/jnnp-2016-315480","article-title":"Nodes, paranodes and neuropathies","volume":"89","author":"Fehmi","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12974-024-03090-y","article-title":"IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset","volume":"21","author":"Budding","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"ref_363","first-page":"850","article-title":"Pathogenesis of chronic inflammatory demyelinating polyneuropathy","volume":"71","author":"Aranami","year":"2013","journal-title":"Nihon Rinsho"},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1093\/brain\/123.8.1660","article-title":"Expression of the co-stimulatory molecule BB-1, the ligands CTLA-4 and CD28 and their mRNAs in chronic inflammatory demyelinating polyneuropathy","volume":"123","author":"Murata","year":"2000","journal-title":"Brain"},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1093\/brain\/123.10.2020","article-title":"Expression of accessory molecules for T-cell activation in peripheral nerve of patients with CIDP and vasculitic neuropathy","volume":"123","author":"Bosboom","year":"2000","journal-title":"Brain"},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12974-016-0711-7","article-title":"Loss of Schwann cell plasticity in chronic inflammatory demyelinating polyneuropathy (CIDP)","volume":"13","author":"Joshi","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1007\/s10072-021-05583-7","article-title":"Paraproteinemia and neuropathy","volume":"42","author":"Koike","year":"2021","journal-title":"Neurol. Sci."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/B978-0-12-823912-4.00020-7","article-title":"Chapter 15\u2014Paraneoplastic neuropathies and peripheral nerve hyperexcitability disorders","volume":"Volume 200","author":"Giometto","year":"2024","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/BF00227726","article-title":"Immunoelectron microscopic localization of monoclonal IgM antibodies in gammopathy associated with peripheral demyelinative neuropathy","volume":"85","author":"Lach","year":"1993","journal-title":"Acta Neuropathol."},{"key":"ref_370","doi-asserted-by":"crossref","unstructured":"Rison, R.A., and Beydoun, S.R. (2016). Paraproteinemic neuropathy: A practical review. BMC Neurol., 16.","DOI":"10.1186\/s12883-016-0532-4"},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.mayocp.2017.02.003","article-title":"Monoclonal Gammopathy-Associated Peripheral Neuropathy: Diagnosis and Management","volume":"92","author":"Chaudhry","year":"2017","journal-title":"Mayo Clin. Proc."},{"key":"ref_372","first-page":"920","article-title":"Neurological manifestations in cryoglobulinemia","volume":"158","author":"Maisonobe","year":"2002","journal-title":"Rev. Neurol."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1128\/CMR.00118-13","article-title":"Pathogens penetrating the central nervous system: Infection pathways and the cellular and molecular mechanisms of invasion","volume":"27","author":"Dando","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nri2971","article-title":"Illuminating viral infections in the nervous system","volume":"11","author":"McGavern","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_375","doi-asserted-by":"crossref","unstructured":"Bello-Morales, R., Andreu, S., and L\u00f3pez-Guerrero, J.A. (2020). The Role of Herpes Simplex Virus Type 1 Infection in Demyelination of the Central Nervous System. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145026"},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neurol.2009.07.004","article-title":"Chronic viral infections of the central nervous system: Aspects specific to multiple sclerosis","volume":"165","author":"Giraudon","year":"2009","journal-title":"Rev. Neurol."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s12035-024-04329-8","article-title":"Potential Mechanisms Underlying COVID-19-Mediated Central and Peripheral Demyelination: Roles of the RAAS and ADAM-17","volume":"62","author":"Oliveira","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1902\/jop.2005.76.12.2306","article-title":"Cytomegalovirus-associated periodontitis and Guillain-Barr\u00e9 syndrome","volume":"76","author":"Tabanella","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.clineuro.2004.11.009","article-title":"Guillain-Barr\u00e9 syndrome and hemophagocytic lymphohistiocytosis in a patient with severe chronic active Epstein-Barr virus infection syndrome","volume":"108","author":"Takahashi","year":"2005","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0022-510X(02)00418-5","article-title":"HIV-associated Guillain-Barr\u00e9 syndrome","volume":"208","author":"Brannagan","year":"2003","journal-title":"J. Neurol. Sci."},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1056\/NEJM200101043440117","article-title":"Guillain-Barr\u00e9 syndrome after reactivation of varicella-zoster virus","volume":"344","author":"Roccatagliata","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/WCO.0b013e328364c036","article-title":"Infectious neuropathies","volume":"26","author":"Sindic","year":"2013","journal-title":"Curr. Opin. Neurol."},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ana.10645","article-title":"Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons","volume":"54","author":"Keswani","year":"2003","journal-title":"Ann. Neurol."},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1529-8027.2001.006001021.x","article-title":"HIV neuropathy: Insights in the pathology of HIV peripheral nerve disease","volume":"6","author":"Pardo","year":"2001","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"16071","DOI":"10.1073\/pnas.2232366100","article-title":"Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination","volume":"100","author":"Rambukkana","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1128\/IAI.05403-11","article-title":"Neurotrophin receptor TrkC is an entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells","volume":"79","author":"Weinkauf","year":"2011","journal-title":"Infect. Immun."},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0022-510X(72)90171-2","article-title":"The effects of diphtheria toxin on developing peripheral myelin in culture","volume":"15","author":"Hughes","year":"1972","journal-title":"J. Neurol. Sci."},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/infdis\/145.1.94","article-title":"Diphtheria toxin and related proteins: Effect of route of injection on toxicity and the determination of cytotoxicity for various cultured cells","volume":"145","author":"Pappenheimer","year":"1982","journal-title":"J. Infect. Dis."},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4103\/JPN.JPN_130_17","article-title":"Prospective Study of Diphtheria for Neurological Complications","volume":"13","author":"Prasad","year":"2018","journal-title":"J. Pediatr. Neurosci."},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41572-019-0131-y","article-title":"Diphtheria","volume":"5","author":"Sharma","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1128\/JB.00762-09","article-title":"Comparative sequence analysis of Mycobacterium leprae and the new leprosy-causing Mycobacterium lepromatosis","volume":"191","author":"Han","year":"2009","journal-title":"J. Bacteriol."},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.clindermatol.2014.07.008","article-title":"Mechanisms of nerve injury in leprosy","volume":"33","author":"Scollard","year":"2015","journal-title":"Clin. Dermatol."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ibneur.2023.05.009","article-title":"What happens when Schwann cells are exposed to Mycobacterium leprae\u2013A systematic review","volume":"15","author":"Lara","year":"2023","journal-title":"IBRO Neurosci. Rep."},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1007\/s13311-021-01153-z","article-title":"Treatment and Evaluation Advances in Leprosy Neuropathy","volume":"18","author":"Ebenezer","year":"2021","journal-title":"Neurotherapeutics"},{"key":"ref_395","doi-asserted-by":"crossref","unstructured":"Medeiros, R.C.A., Girardi, K., Cardoso, F.K.L., Mietto, B.S., Pinto, T.G.T., Gomez, L.S., Rodrigues, L.S., Gandini, M., Amaral, J.J., and Antunes, S.L.G. (2016). Subversion of Schwann cell glucose metabolism by Mycobacterium leprae. J. Biol. Chem., 291.","DOI":"10.1074\/jbc.M116.725283"},{"key":"ref_396","doi-asserted-by":"crossref","unstructured":"Rosa, T., Marques, M.A.M., DeBoard, Z., Hutchins, K., Silva, C.A.A., Montague, C.R., Yuan, T., Amaral, J.J., Atella, G.C., and Rosa, P.S. (2021). Corrigendum: Reductive Power Generated by Mycobacterium leprae Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis. Front. Cell Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.765326"},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/imr.12962","article-title":"Reduction of host cell mitochondrial activity as Mycobacterium leprae\u2019s strategy to evade host innate immunity","volume":"301","author":"Oliveira","year":"2021","journal-title":"Immunol. Rev."},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"e200075","DOI":"10.1590\/0074-02760200075","article-title":"Effect of Mycobacterium leprae on neurotrophins expression in human Schwann cells and mouse sciatic nerves","volume":"115","author":"Nogueira","year":"2020","journal-title":"Mem. Do Inst. Oswaldo Cruz"},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(97)00105-6","article-title":"Schwann cell extracellular matrix protein production is modulated by Mycobacterium leprae and macrophage secretory products","volume":"151","author":"Singh","year":"1997","journal-title":"J. Neurol. Sci."},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/NEN.0b013e3181c6515c","article-title":"Schwann cells producing matrix metalloproteinases under Mycobacterium leprae stimulation may play a role in the outcome of leprous neuropathy","volume":"69","author":"Oliveira","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/NEN.0b013e31828bfc60","article-title":"Transforming growth factor-\u03b21 may be a key mediator of the fibrogenic properties of neural cells in leprosy","volume":"72","author":"Petito","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1097\/01.jnen.0000182982.09978.66","article-title":"Cytokines and Mycobacterium leprae induce apoptosis in human Schwann cells","volume":"64","author":"Oliveira","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_403","doi-asserted-by":"crossref","unstructured":"Souza, B.J.d., Mendes, M.A., Sperandio da Silva, G.M., Sammarco-Rosa, P., Moraes, M.O.d., Jardim, M.R., Sarno, E.N., Pinheiro, R.O., and Mietto, B.S. (2022). Gene Expression Profile of Mycobacterium leprae Contribution in the Pathology of Leprosy Neuropathy. Front. Med., 9.","DOI":"10.3389\/fmed.2022.861586"},{"key":"ref_404","first-page":"174","article-title":"Demyelination in peripheral nerves: Much to learn from leprosy neuropathy","volume":"3","author":"Mietto","year":"2016","journal-title":"J. Mult. Scler."},{"key":"ref_405","doi-asserted-by":"crossref","unstructured":"Hess, S., and Rambukkana, A. (2019). Cell biology of intracellular adaptation of Mycobacterium leprae in the peripheral nervous system. Bacteria and Intracellularity, Wiley.","DOI":"10.1128\/microbiolspec.BAI-0020-2019"},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/eji.1830180622","article-title":"Specific lysis by CD8+ T cells of Schwann cells expressing Mycobacterium leprae antigens","volume":"18","author":"Steinhoff","year":"1988","journal-title":"Eur. J. Immunol."},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1046\/j.1440-1711.2000.00939.x","article-title":"Novel mechanisms in the immunopathogenesis of leprosy nerve damage: The role of Schwann cells, T cells and Mycobacterium leprae","volume":"78","author":"Spierings","year":"2000","journal-title":"Immunol. Cell Biol."},{"key":"ref_408","doi-asserted-by":"crossref","first-page":"242","DOI":"10.47276\/lr.79.3.242","article-title":"The biology of nerve injury in leprosy","volume":"79","author":"Scollard","year":"2008","journal-title":"Lepr. Rev."},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"e39006","DOI":"10.1097\/MD.0000000000039006","article-title":"An update of the diagnosis, treatment, and prevention of leprosy: A narrative review","volume":"103","author":"Huang","year":"2024","journal-title":"Medicine"},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1055\/s-0035-1558981","article-title":"Inherited Neuropathies","volume":"35","author":"Fridman","year":"2015","journal-title":"Semin. Neurol."},{"key":"ref_411","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s12276-024-01250-x","article-title":"Advances and challenges in modeling inherited peripheral neuropathies using iPSCs","volume":"56","author":"Prior","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neulet.2015.01.059","article-title":"Demyelinating CMT--what\u2019s known, what\u2019s new and what\u2019s in store?","volume":"596","author":"Brennan","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_413","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1523\/JNEUROSCI.2481-21.2022","article-title":"Disruption of Endosomal Sorting in Schwann Cells Leads to Defective Myelination and Endosomal Abnormalities Observed in Charcot-Marie-Tooth Disease","volume":"42","author":"McLean","year":"2022","journal-title":"J. Neurosci."},{"key":"ref_414","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1212\/01.WNL.0000171978.70849.c5","article-title":"NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models and in patients","volume":"65","author":"Sahenk","year":"2005","journal-title":"Neurology"},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/glia.20386","article-title":"Schwann cells and the pathogenesis of inherited motor and sensory neuropathies (Charcot-Marie-Tooth disease)","volume":"54","author":"Berger","year":"2006","journal-title":"Glia"},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"300060519862064","DOI":"10.1177\/0300060519862064","article-title":"Novel mutation in the periaxin gene causal to Charcot-Marie-Tooth disease type 4F","volume":"48","author":"Chen","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref_417","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1523\/JNEUROSCI.18-02-00731.1998","article-title":"Overloaded endoplasmic reticulum-Golgi compartments, a possible pathomechanism of peripheral neuropathies caused by mutations of the peripheral myelin protein PMP22","volume":"18","author":"Prior","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_418","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/brain\/123.5.1001","article-title":"Mutation-dependent alteration in cellular distribution of peripheral myelin protein 22 in nerve biopsies from Charcot-Marie-Tooth type 1A","volume":"123","author":"Hanemann","year":"2000","journal-title":"Brain"},{"key":"ref_419","doi-asserted-by":"crossref","first-page":"10672","DOI":"10.1523\/JNEUROSCI.23-33-10672.2003","article-title":"Emerging role for autophagy in the removal of aggresomes in Schwann cells","volume":"23","author":"Fortun","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_420","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/978-981-32-9636-7_19","article-title":"Schwann Cell and the Pathogenesis of Charcot-Marie-Tooth Disease","volume":"1190","author":"Murakami","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_421","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.nbd.2004.02.007","article-title":"Impairment of PMP22 transgenic Schwann cells differentiation in culture: Implications for Charcot-Marie-Tooth type 1A disease","volume":"16","author":"Nobbio","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"ref_422","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/acn3.50965","article-title":"Transmembrane protease serine 5: A novel Schwann cell plasma marker for CMT1A","volume":"7","author":"Wang","year":"2020","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_423","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.1093\/nar\/gks313","article-title":"Genome-wide analysis of EGR2\/SOX10 binding in myelinating peripheral nerve","volume":"40","author":"Srinivasan","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_424","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1093\/brain\/awae158","article-title":"PMP22 duplication dysregulates lipid homeostasis and plasma membrane organization in developing human Schwann cells","volume":"174","author":"Prior","year":"2024","journal-title":"Brain"},{"key":"ref_425","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/jnc.13951","article-title":"Src and phospho-FAK kinases are activated by allopregnanolone promoting Schwann cell motility, morphology and myelination","volume":"141","author":"Melfi","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_426","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4103\/1673-5374.290885","article-title":"Membrane progesterone receptors (mPRs\/PAQRs) in Schwann cells represent a promising target for the promotion of neuroregeneration","volume":"16","author":"Castelnovo","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_427","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ncpneuro0583","article-title":"Mechanisms of disease: Inherited demyelinating neuropathies--from basic to clinical research","volume":"3","author":"Nave","year":"2007","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"ref_428","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/nm957","article-title":"Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A)","volume":"9","author":"Sereda","year":"2003","journal-title":"Nat. Med."},{"key":"ref_429","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1172\/JCI57549","article-title":"Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1","volume":"121","author":"Garofalo","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_430","doi-asserted-by":"crossref","first-page":"e359","DOI":"10.1212\/WNL.0000000000006811","article-title":"Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1","volume":"92","author":"Fridman","year":"2019","journal-title":"Neurology"},{"key":"ref_431","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1093\/brain\/aws299","article-title":"Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice","volume":"135","author":"Patzko","year":"2012","journal-title":"Brain"},{"key":"ref_432","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1093\/hmg\/ddt318","article-title":"Curcumin facilitates a transitory cellular stress response in Trembler-J mice","volume":"22","author":"Okamoto","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_433","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nm1023","article-title":"Ascorbic acid treatment corrects the phenotype of a mouse model of Charcot-Marie-Tooth disease","volume":"10","author":"Passage","year":"2004","journal-title":"Nat. Med."},{"key":"ref_434","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1001\/jamaneurol.2013.3178","article-title":"High-dosage ascorbic acid treatment in Charcot-Marie-Tooth disease type 1A: Results of a randomized, double-masked, controlled trial","volume":"70","author":"Lewis","year":"2013","journal-title":"JAMA Neurol."},{"key":"ref_435","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S1474-4422(11)70025-4","article-title":"Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): A double-blind randomised trial","volume":"10","author":"Pareyson","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_436","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/mt.2013.250","article-title":"AAV1.NT-3 gene therapy for charcot-marie-tooth neuropathy","volume":"22","author":"Sahenk","year":"2014","journal-title":"Mol. Ther."},{"key":"ref_437","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41434-021-00231-3","article-title":"AAV1.NT-3 gene therapy for X-linked Charcot-Marie-Tooth neuropathy type 1","volume":"29","author":"Ozes","year":"2022","journal-title":"Gene Ther."},{"key":"ref_438","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.expneurol.2008.04.015","article-title":"Neurotrophin-3 deficient Schwann cells impair nerve regeneration","volume":"212","author":"Sahenk","year":"2008","journal-title":"Exp. Neurol."},{"key":"ref_439","doi-asserted-by":"crossref","unstructured":"Park, S., Jung, N., Myung, S., Choi, Y., Chung, K.W., Choi, B.O., and Jung, S.C. (2018). Differentiation of Human Tonsil-Derived Mesenchymal Stem Cells into Schwann-Like Cells Improves Neuromuscular Function in a Mouse Model of Charcot-Marie-Tooth Disease Type 1A. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082393"},{"key":"ref_440","doi-asserted-by":"crossref","unstructured":"Nam, Y.H., Park, S., Yum, Y., Jeong, S., Park, H.E., Kim, H.J., Lim, J., Choi, B.O., and Jung, S.C. (2023). Preclinical Efficacy of Peripheral Nerve Regeneration by Schwann Cell-like Cells Differentiated from Human Tonsil-Derived Mesenchymal Stem Cells in C22 Mice. Biomedicines, 11.","DOI":"10.3390\/biomedicines11123334"},{"key":"ref_441","doi-asserted-by":"crossref","first-page":"146533","DOI":"10.1016\/j.brainres.2019.146533","article-title":"Gene therapy to promote regeneration in Charcot-Marie-Tooth disease","volume":"1727","author":"Sahenk","year":"2020","journal-title":"Brain Res."},{"key":"ref_442","doi-asserted-by":"crossref","unstructured":"Stavrou, M., Sargiannidou, I., Georgiou, E., Kagiava, A., and Kleopa, K.A. (2021). Emerging Therapies for Charcot-Marie-Tooth Inherited Neuropathies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22116048"},{"key":"ref_443","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1007\/s00415-019-09319-8","article-title":"Hereditary neuropathy with liability to pressure palsies","volume":"267","author":"Attarian","year":"2020","journal-title":"J. Neurol."},{"key":"ref_444","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1093\/hmg\/ddaa082","article-title":"Pmp22 super-enhancer deletion causes tomacula formation and conduction block in peripheral nerves","volume":"29","author":"Pantera","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"ref_445","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.nmd.2022.04.002","article-title":"Dosage effects of PMP22 on nonmyelinating Schwann cells in hereditary neuropathy with liability to pressure palsies","volume":"32","author":"Koike","year":"2022","journal-title":"Neuromuscul. Disord."},{"key":"ref_446","first-page":"22","article-title":"Peripheral neuropathy and gastroenterologic disorders: An overview on an underrecognized association","volume":"89","author":"Spagnoli","year":"2018","journal-title":"Acta Biomed."},{"key":"ref_447","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/brain\/awh429","article-title":"Peripheral neuropathy in patients with inflammatory bowel disease","volume":"128","author":"Gondim","year":"2005","journal-title":"Brain"},{"key":"ref_448","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0733-8619(03)00059-8","article-title":"Neurologic manifestations of gastrointestinal disease","volume":"20","author":"Skeen","year":"2002","journal-title":"Neurol. Clin."},{"key":"ref_449","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/00007611-199706000-00005","article-title":"Neurologic and neuropsychiatric complications of Crohn\u2019s disease","volume":"90","author":"Elsehety","year":"1997","journal-title":"South. Med. J."},{"key":"ref_450","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/jamaneurol.2015.0475","article-title":"Risk of Neuropathy Among 28,232 Patients with Biopsy-Verified Celiac Disease","volume":"72","author":"Thawani","year":"2015","journal-title":"JAMA Neurol."},{"key":"ref_451","doi-asserted-by":"crossref","unstructured":"Goluba, K., Kunrade, L., Riekstina, U., and Parfejevs, V. (2022). Schwann Cells in Digestive System Disorders. Cells, 11.","DOI":"10.3390\/cells11050832"},{"key":"ref_452","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/stem.3045","article-title":"Concise Review: Cellular and Molecular Mechanisms of Postnatal Injury-Induced Enteric Neurogenesis","volume":"37","author":"Jonscher","year":"2019","journal-title":"Stem Cells"},{"key":"ref_453","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41388-023-02909-x","article-title":"The nerve cells in gastrointestinal cancers: From molecular mechanisms to clinical intervention","volume":"43","author":"Lyu","year":"2024","journal-title":"Oncogene"},{"key":"ref_454","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1053\/j.gastro.2004.02.024","article-title":"Inflammatory neuropathies of the enteric nervous system","volume":"126","author":"Guerrini","year":"2004","journal-title":"Gastroenterology"},{"key":"ref_455","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1053\/j.gastro.2020.07.018","article-title":"Glial Cell-Derived Neurotrophic Factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease","volume":"159","author":"Soret","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_456","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/stcltm\/szac076","article-title":"Schwann Cells in the Aganglionic Colon of Hirschsprung Disease Can Generate Neurons for Regenerative Therapy","volume":"11","author":"Pan","year":"2022","journal-title":"Stem Cells Transl. Med."},{"key":"ref_457","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1600-0404.1991.tb04937.x","article-title":"Acute and chronic pain syndromes in multiple sclerosis","volume":"84","author":"Stenager","year":"1991","journal-title":"Acta Neurol. Scand."},{"key":"ref_458","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11916-019-0800-2","article-title":"Advances in the Understanding and Management of Chronic Pain in Multiple Sclerosis: A Comprehensive Review","volume":"23","author":"Urits","year":"2019","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_459","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s11910-012-0320-5","article-title":"Pain and multiple sclerosis: Pathophysiology and treatment","volume":"13","author":"Solaro","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_460","first-page":"e22419","article-title":"Neuropathic Pain in Neurologic Disorders: A Narrative Review","volume":"14","author":"Mitsikostas","year":"2022","journal-title":"Cureus"},{"key":"ref_461","unstructured":"Mehta, A., Beck, M., and Sunder-Plassmann, G. (2024, June 08). Neurological manifestations of Fabry disease, Fabry Disease: Perspectives from 5 Years of FOS., Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK11602\/."},{"key":"ref_462","doi-asserted-by":"crossref","first-page":"e172869","DOI":"10.1172\/jci.insight.172869","article-title":"Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity","volume":"9","author":"Waltz","year":"2024","journal-title":"JCI Insight"},{"key":"ref_463","doi-asserted-by":"crossref","first-page":"175955","DOI":"10.1016\/j.ejphar.2023.175955","article-title":"Potential role of Schwann cells in neuropathic pain","volume":"956","author":"Zhang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_464","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1146\/annurev-neuro-110920-030610","article-title":"Beyond Wrapping: Canonical and Noncanonical Functions of Schwann Cells","volume":"45","author":"Taveggia","year":"2022","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_465","doi-asserted-by":"crossref","first-page":"1744806920963809","DOI":"10.1177\/1744806920963809","article-title":"Schwann cells and trigeminal neuralgia","volume":"16","author":"Liao","year":"2020","journal-title":"Mol. Pain"},{"key":"ref_466","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1111\/bph.16413","article-title":"Schwann cell TRPA1 elicits reserpine-induced fibromyalgia pain in mice","volume":"181","author":"Brum","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"ref_467","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.freeradbiomed.2025.01.040","article-title":"Characterisation of periorbital mechanical allodynia in the reserpine-induced fibromyalgia model in mice: The role of the Schwann cell TRPA1\/NOX1 signalling pathway","volume":"229","author":"Brum","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"ref_468","doi-asserted-by":"crossref","first-page":"5590","DOI":"10.1523\/JNEUROSCI.3342-12.2013","article-title":"Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain","volume":"33","author":"Orita","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_469","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/glia.23325","article-title":"Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury","volume":"66","author":"Poplawski","year":"2018","journal-title":"Glia"},{"key":"ref_470","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2018.03.063","article-title":"Microencapsulated Schwann cell transplantation inhibits P2X2\/3 receptors overexpression in a sciatic nerve injury rat model with neuropathic pain","volume":"676","author":"Zhang","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_471","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s12974-022-02603-x","article-title":"Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_472","doi-asserted-by":"crossref","first-page":"9121","DOI":"10.1523\/JNEUROSCI.0663-20.2020","article-title":"Deletion of the Gene Encoding the NMDA Receptor GluN1 Subunit in Schwann Cells Causes Ultrastructural Changes in Remak Bundles and Hypersensitivity in Pain Processing","volume":"40","author":"Brifault","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_473","doi-asserted-by":"crossref","unstructured":"Snijders, R.A.H., Brom, L., Theunissen, M., and van den Beuken-van Everdingen, M.H.J. (2023). Update on Prevalence of Pain in Patients with Cancer 2022: A Systematic Literature Review and Meta-Analysis. Cancers, 15.","DOI":"10.3390\/cancers15030591"},{"key":"ref_474","doi-asserted-by":"crossref","first-page":"e01223","DOI":"10.1016\/j.heliyon.2019.e01223","article-title":"Reciprocal interactions between cancer and Schwann cells contribute to oral cancer progression and pain","volume":"5","author":"Salvo","year":"2019","journal-title":"Heliyon"},{"key":"ref_475","doi-asserted-by":"crossref","unstructured":"Salvo, E., Tu, N.H., Scheff, N.N., Dubeykovskaya, Z.A., Chavan, S.A., Aouizerat, B.E., and Ye, Y. (2021). TNF\u03b1 promotes oral cancer growth, pain, and Schwann cell activation. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-81500-4"},{"key":"ref_476","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1002\/glia.24391","article-title":"Schwann cells as a target cell for the treatment of cancer pain","volume":"71","author":"Zhang","year":"2023","journal-title":"Glia"},{"key":"ref_477","doi-asserted-by":"crossref","unstructured":"Mulpuri, Y., Tu, N.H., Inoue, K., Harden, G., Nicholson, S.J., Seenauth, A., Huang, Y., Escobar, K.G., Moayedi, Y., and Bunnett, N.W. (2025). TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer. Front. Pain. Res., 6.","DOI":"10.3389\/fpain.2025.1532885"},{"key":"ref_478","doi-asserted-by":"crossref","first-page":"101433","DOI":"10.1016\/j.omtm.2025.101433","article-title":"Selective RNAi silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury","volume":"33","author":"Gani","year":"2025","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_479","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0074-7742(09)87015-3","article-title":"Chapter 15: Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regeneration","volume":"87","author":"Magnaghi","year":"2009","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_480","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1007\/s11064-019-02830-4","article-title":"Inhibition of Neuronal Nitric Oxide Synthase by Ethyl Pyruvate in Schwann Cells Protects Against Peripheral Nerve Degeneration","volume":"44","author":"Chung","year":"2019","journal-title":"Neurochem. Res."},{"key":"ref_481","doi-asserted-by":"crossref","first-page":"1759091419838949","DOI":"10.1177\/1759091419838949","article-title":"Heme Oxygenase 1 in Schwann Cells Regulates Peripheral Nerve Degeneration Against Oxidative Stress","volume":"11","author":"Kim","year":"2019","journal-title":"ASN Neuro"},{"key":"ref_482","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.expneurol.2008.03.028","article-title":"Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degeneration","volume":"212","author":"Keilhoff","year":"2008","journal-title":"Exp. Neurol."},{"key":"ref_483","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1007\/s12035-016-0262-z","article-title":"Lithium Reversibly Inhibits Schwann Cell Proliferation and Differentiation Without Inducing Myelin Loss","volume":"54","author":"Berg","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_484","doi-asserted-by":"crossref","first-page":"106441","DOI":"10.1016\/j.ejps.2023.106441","article-title":"Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model","volume":"185","author":"Schepers","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_485","doi-asserted-by":"crossref","unstructured":"Zhou, J., Li, S., Gao, J., Hu, Y., Chen, S., Luo, X., Zhang, H., Luo, Z., and Huang, J. (2020). Epothilone B Facilitates Peripheral Nerve Regeneration by Promoting Autophagy and Migration in Schwann Cells. Front. Cell Neurosci., 14.","DOI":"10.3389\/fncel.2020.00143"},{"key":"ref_486","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuroscience.2023.05.029","article-title":"Deferoxamine Promotes Peripheral Nerve Regeneration by Enhancing Schwann Cell Function and Promoting Axon Regeneration of Dorsal Root Ganglion","volume":"524","author":"Zhang","year":"2023","journal-title":"Neuroscience"},{"key":"ref_487","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1007\/s00018-020-03516-9","article-title":"Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury","volume":"77","author":"Nocera","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"ref_488","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nn.2762","article-title":"HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells","volume":"14","author":"Jacob","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_489","doi-asserted-by":"crossref","first-page":"9135","DOI":"10.1523\/JNEUROSCI.1370-16.2016","article-title":"Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury","volume":"36","author":"Ma","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_490","doi-asserted-by":"crossref","unstructured":"Gomez-Sanchez, J.A., Patel, N., Martirena, F., Fazal, S.V., Mutschler, C., and Cabedo, H. (2022). Emerging Role of HDACs in Regeneration and Ageing in the Peripheral Nervous System: Repair Schwann Cells as Pivotal Targets. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23062996"},{"key":"ref_491","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12974-021-02273-1","article-title":"Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NF\u03baB to promote axonal regeneration and remyelination","volume":"18","author":"Yadav","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_492","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1111\/bph.15231","article-title":"A novel histone deacetylase 6 inhibitor improves myelination of Schwann cells in a model of Charcot-Marie-Tooth disease type 1A","volume":"177","author":"Ha","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_493","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41467-025-55835-9","article-title":"Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8","volume":"16","author":"Hertzog","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_494","doi-asserted-by":"crossref","unstructured":"Hui, T.K., Lai, X.S., Dong, X., Jing, H., Liu, Z., Fei, E., Chen, W.B., Wang, S., Ren, D., and Zou, S. (2021). Ablation of Lrp4 in Schwann Cells Promotes Peripheral Nerve Regeneration in Mice. Biology, 10.","DOI":"10.3390\/biology10060452"},{"key":"ref_495","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s12565-019-00514-1","article-title":"Carvacrol effectively protects demyelination by suppressing transient receptor potential melastatin 7 (TRPM7) in Schwann cells","volume":"95","author":"Chun","year":"2020","journal-title":"Anat. Sci. Int."},{"key":"ref_496","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00262-019-02424-7","article-title":"Immunomodulation by Schwann cells in disease","volume":"69","author":"Zhang","year":"2020","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_497","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/jnc.12135","article-title":"Ly6C+ Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury","volume":"125","author":"Saiwai","year":"2013","journal-title":"J. Neurochem."},{"key":"ref_498","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s00262-018-02296-3","article-title":"Schwann cells shape the neuro-immune environs and control cancer progression","volume":"68","author":"Martyn","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_499","doi-asserted-by":"crossref","unstructured":"Shurin, G.V., Vats, K., Kruglov, O., Bunimovich, Y.L., and Shurin, M.R. (2022). Tumor-Induced T Cell Polarization by Schwann Cells. Cells, 11.","DOI":"10.3390\/cells11223541"},{"key":"ref_500","doi-asserted-by":"crossref","first-page":"101234","DOI":"10.1016\/j.omtm.2024.101234","article-title":"Novel AAV variants with improved tropism for human Schwann cells","volume":"32","author":"Drouyer","year":"2024","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_501","doi-asserted-by":"crossref","first-page":"146572","DOI":"10.1016\/j.brainres.2019.146572","article-title":"Gene therapy approaches targeting Schwann cells for demyelinating neuropathies","volume":"1728","author":"Sargiannidou","year":"2020","journal-title":"Brain Res."},{"key":"ref_502","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/ana.24441","article-title":"Intraneural GJB 1 gene delivery improves nerve pathology in a model of X-linked C harcot\u2013M arie\u2013T ooth disease","volume":"78","author":"Sargiannidou","year":"2015","journal-title":"Ann. Neurol."},{"key":"ref_503","doi-asserted-by":"crossref","first-page":"E2421","DOI":"10.1073\/pnas.1522202113","article-title":"Intrathecal gene therapy rescues a model of demyelinating peripheral neuropathy","volume":"113","author":"Kagiava","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_504","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1093\/hmg\/ddz199","article-title":"Gene replacement therapy after neuropathy onset provides therapeutic benefit in a model of CMT1X","volume":"28","author":"Kagiava","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_505","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/hmg\/ddy056","article-title":"Intrathecal gene therapy in mouse models expressing CMT1X mutations","volume":"27","author":"Kagiava","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_506","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/brain\/awz064","article-title":"Gene replacement therapy in a model of Charcot-Marie-Tooth 4C neuropathy","volume":"142","author":"Schiza","year":"2019","journal-title":"Brain"},{"key":"ref_507","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1016\/j.ymthe.2023.08.020","article-title":"AAV9-mediated <em>SH3TC2<\/em> gene replacement therapy targeted to Schwann cells for the treatment of CMT4C","volume":"31","author":"Georgiou","year":"2023","journal-title":"Mol. Ther."},{"key":"ref_508","doi-asserted-by":"crossref","first-page":"279","DOI":"10.5607\/en.2019.28.2.279","article-title":"miR-381 Attenuates Peripheral Neuropathic Phenotype Caused by Overexpression of PMP22","volume":"28","author":"Lee","year":"2019","journal-title":"Exp. Neurobiol."},{"key":"ref_509","doi-asserted-by":"crossref","unstructured":"O\u2019Carroll, S.J., Cook, W.H., and Young, D. (2020). AAV Targeting of Glial Cell Types in the Central and Peripheral Nervous System and Relevance to Human Gene Therapy. Front. Mol. Neurosci., 13.","DOI":"10.3389\/fnmol.2020.618020"},{"key":"ref_510","doi-asserted-by":"crossref","unstructured":"Kagiava, A., Richter, J., Tryfonos, C., Leal-Julia, M., Sargiannidou, I., Christodoulou, C., Bosch, A., and Kleopa, K.A. (2021). Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-02694-1"},{"key":"ref_511","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.omtm.2023.07.011","article-title":"Gene replacement therapy in two Golgi-retained CMT1X mutants before and after the onset of demyelinating neuropathy","volume":"30","author":"Kagiava","year":"2023","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_512","doi-asserted-by":"crossref","first-page":"101184","DOI":"10.1016\/j.omtm.2023.101184","article-title":"New perspectives for gene therapy of the X-linked form of Charcot-Marie-Tooth disease","volume":"32","author":"Bortolozzi","year":"2024","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_513","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s43856-023-00400-y","article-title":"AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cells","volume":"3","author":"Yoshioka","year":"2023","journal-title":"Commun. Med."},{"key":"ref_514","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1038\/s41467-021-22593-3","article-title":"AAV2\/9-mediated silencing of PMP22 prevents the development of pathological features in a rat model of Charcot-Marie-Tooth disease 1\u2009A","volume":"12","author":"Gautier","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_515","doi-asserted-by":"crossref","first-page":"e159814","DOI":"10.1172\/JCI159814","article-title":"A translatable RNAi-driven gene therapy silences PMP22\/Pmp22 genes and improves neuropathy in CMT1A mice","volume":"132","author":"Stavrou","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_516","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.nbd.2017.01.006","article-title":"Pmp22 mutant allele-specific siRNA alleviates demyelinating neuropathic phenotype in vivo","volume":"100","author":"Lee","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"ref_517","doi-asserted-by":"crossref","unstructured":"Boutary, S., Caillaud, M., El Madani, M., Vallat, J.M., Loisel-Duwattez, J., Rouyer, A., Richard, L., Gracia, C., Urbinati, G., and Desma\u00eble, D. (2021). Squalenoyl siRNA PMP22 nanoparticles are effective in treating mouse models of Charcot-Marie-Tooth disease type 1 A. Commun. Biol., 4.","DOI":"10.1038\/s42003-021-01839-2"},{"key":"ref_518","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1172\/JCI96499","article-title":"PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models","volume":"128","author":"Zhao","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_519","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.actbio.2018.06.014","article-title":"In vitro efficacy of a gene-activated nerve guidance conduit incorporating non-viral PEI-pDNA nanoparticles carrying genes encoding for NGF, GDNF and c-Jun","volume":"75","author":"Lackington","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_520","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/glia.22712","article-title":"Schwann cells transduced with a lentiviral vector encoding Fgf-2 promote motor neuron regeneration following sciatic nerve injury","volume":"62","author":"Allodi","year":"2014","journal-title":"Glia"},{"key":"ref_521","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.4103\/1673-5374.121614","article-title":"Nanoparticles carrying neurotrophin-3-modified Schwann cells promote repair of sciatic nerve defects","volume":"8","author":"Zong","year":"2013","journal-title":"Neural Regen. Res."},{"key":"ref_522","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1089\/ten.tea.2014.0416","article-title":"c-Jun gene-modified Schwann cells: Upregulating multiple neurotrophic factors and promoting neurite outgrowth","volume":"21","author":"Huang","year":"2015","journal-title":"Tissue Eng. Part A"},{"key":"ref_523","doi-asserted-by":"crossref","first-page":"8600","DOI":"10.1096\/fj.201802065RR","article-title":"Time-restricted release of multiple neurotrophic factors promotes axonal regeneration and functional recovery after peripheral nerve injury","volume":"33","author":"Huang","year":"2019","journal-title":"Faseb J."},{"key":"ref_524","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/gt.2011.7","article-title":"Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration","volume":"18","author":"Homs","year":"2011","journal-title":"Gene Ther."},{"key":"ref_525","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1097\/j.pain.0000000000002356","article-title":"Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: Implications in pain","volume":"162","author":"Shin","year":"2021","journal-title":"Pain"},{"key":"ref_526","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1002\/glia.24251","article-title":"Piezo channels contribute to the regulation of myelination in Schwann cells","volume":"70","author":"Acheta","year":"2022","journal-title":"Glia"},{"key":"ref_527","doi-asserted-by":"crossref","first-page":"111937","DOI":"10.1016\/j.yexcr.2020.111937","article-title":"Long non-coding RNA MALAT1 promotes the proliferation and migration of Schwann cells by elevating BDNF through sponging miR-129-5p","volume":"390","author":"Wu","year":"2020","journal-title":"Exp. Cell Res."},{"key":"ref_528","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s10020-022-00501-9","article-title":"Upregulated lncARAT in Schwann cells promotes axonal regeneration by recruiting and activating proregenerative macrophages","volume":"28","author":"Yin","year":"2022","journal-title":"Mol. Med."},{"key":"ref_529","doi-asserted-by":"crossref","first-page":"136893","DOI":"10.1016\/j.neulet.2022.136893","article-title":"miR-328a-3p modulates the proliferative and migratory abilities of Schwann cells in peripheral nerves","volume":"791","author":"Qiao","year":"2022","journal-title":"Neurosci. Lett."},{"key":"ref_530","doi-asserted-by":"crossref","first-page":"114295","DOI":"10.1016\/j.expneurol.2022.114295","article-title":"Down-regulation miR-146a-5p in Schwann cell-derived exosomes induced macrophage M1 polarization by impairing the inhibition on TRAF6\/NF-kappaB pathway after peripheral nerve injury","volume":"362","author":"Sun","year":"2023","journal-title":"Exp. Neurol."},{"key":"ref_531","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/17407745231207970","article-title":"Gene-targeted therapy for neurofibromatosis and schwannomatosis: The path to clinical trials","volume":"21","author":"Staedtke","year":"2024","journal-title":"Clin. Trials"},{"key":"ref_532","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s40487-024-00279-2","article-title":"Gene Therapy for Neurofibromatosis Type 2-Related Schwannomatosis: Recent Progress, Challenges, and Future Directions","volume":"12","author":"Yuan","year":"2024","journal-title":"Oncol. Ther."},{"key":"ref_533","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/sj.cgt.7701037","article-title":"Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47Delta","volume":"14","author":"Prabhakar","year":"2007","journal-title":"Cancer Gene Ther."},{"key":"ref_534","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/cgt.2009.71","article-title":"Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter","volume":"17","author":"Prabhakar","year":"2010","journal-title":"Cancer Gene Ther."},{"key":"ref_535","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1089\/hum.2012.094","article-title":"Regression of schwannomas induced by adeno-associated virus-mediated delivery of caspase-1","volume":"24","author":"Prabhakar","year":"2013","journal-title":"Hum. Gene Ther."},{"key":"ref_536","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41417-018-0077-3","article-title":"Schwannoma gene therapy by adeno-associated virus delivery of the pore-forming protein Gasdermin-D","volume":"26","author":"Ahmed","year":"2019","journal-title":"Cancer Gene Ther."},{"key":"ref_537","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41434-019-0080-9","article-title":"Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors","volume":"26","author":"Bai","year":"2019","journal-title":"Gene Ther."},{"key":"ref_538","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/neuonc\/noz065","article-title":"Gene therapy with apoptosis-associated speck-like protein, a newly described schwannoma tumor suppressor, inhibits schwannoma growth in vivo","volume":"21","author":"Ahmed","year":"2019","journal-title":"Neuro-Oncology"},{"key":"ref_539","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.omtm.2022.06.012","article-title":"Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2","volume":"26","author":"Prabhakar","year":"2022","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_540","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/s41417-023-00645-8","article-title":"FOXM1 promotes neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor progression in a NUF2-dependent manner","volume":"30","author":"Aimaier","year":"2023","journal-title":"Cancer Gene Ther."},{"key":"ref_541","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/s41434-021-00264-8","article-title":"Schwann cell gene therapies in sight","volume":"28","year":"2021","journal-title":"Gene Ther."},{"key":"ref_542","doi-asserted-by":"crossref","first-page":"e1900294","DOI":"10.1002\/pmic.201900294","article-title":"Proteomic Profile of Human Schwann Cells","volume":"20","author":"Ferdoushi","year":"2020","journal-title":"Proteomics"},{"key":"ref_543","doi-asserted-by":"crossref","first-page":"114069","DOI":"10.1016\/j.expneurol.2022.114069","article-title":"New insights into peripheral nerve regeneration: The role of secretomes","volume":"354","author":"Contreras","year":"2022","journal-title":"Exp. Neurol."},{"key":"ref_544","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1091\/mbc.11.7.2283","article-title":"Progesterone synthesized by Schwann cells during myelin formation regulates neuronal gene expression","volume":"11","author":"Chan","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"ref_545","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1046\/j.0953-816x.2001.01463.x","article-title":"Synthesis of progesterone in Schwann cells: Regulation by sensory neurons","volume":"13","author":"Robert","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"ref_546","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.ghir.2004.03.007","article-title":"Local synthesis and dual actions of progesterone in the nervous system: Neuroprotection and myelination","volume":"14","author":"Schumacher","year":"2004","journal-title":"Growth Horm. IGF Res."},{"key":"ref_547","doi-asserted-by":"crossref","unstructured":"Li, G., Zhang, S., Zou, Y., Ai, H., Zheng, X., Qian, K., Lei, C., and Fu, W. (2024). The therapeutic potential of exosomes in immunotherapy. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1424081"},{"key":"ref_548","doi-asserted-by":"crossref","unstructured":"Putthanbut, N., Lee, J.Y., and Borlongan, C.V. (2024). Extracellular vesicle therapy in neurological disorders. J. Biomed. Sci., 31.","DOI":"10.1186\/s12929-024-01075-w"},{"key":"ref_549","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1021\/acsnano.9b01004","article-title":"Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders","volume":"13","author":"Riazifar","year":"2019","journal-title":"ACS Nano"},{"key":"ref_550","doi-asserted-by":"crossref","first-page":"113895","DOI":"10.1016\/j.expneurol.2021.113895","article-title":"Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system","volume":"347","author":"Zhang","year":"2022","journal-title":"Exp. Neurol."},{"key":"ref_551","doi-asserted-by":"crossref","first-page":"e14752","DOI":"10.1111\/cns.14752","article-title":"Exosomes as a therapeutic tool to promote neurorestoration and cognitive function in neurological conditions: Achieve two ends with a single effort","volume":"30","author":"Fallahi","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref_552","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13287-024-03837-7","article-title":"Exosomes repairment for sciatic nerve injury: A cell-free therapy","volume":"15","author":"Xin","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"ref_553","doi-asserted-by":"crossref","first-page":"jcs239004","DOI":"10.1242\/jcs.239004","article-title":"Schwann cell reprogramming into repair cells increases miRNA-21 expression in exosomes promoting axonal growth","volume":"133","author":"Saquel","year":"2020","journal-title":"J. Cell Sci."},{"key":"ref_554","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.21037\/atm-20-5965","article-title":"Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt\/mTOR\/p70S6K pathway","volume":"8","author":"Wu","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_555","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/glia.22558","article-title":"Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system","volume":"61","author":"Picou","year":"2013","journal-title":"Glia"},{"key":"ref_556","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/glia.24087","article-title":"Schwann cell-derived exosomes: Janus-faced mediators of regeneration and disease","volume":"70","author":"Wong","year":"2022","journal-title":"Glia"},{"key":"ref_557","doi-asserted-by":"crossref","unstructured":"Ghosh, M., and Pearse, D.D. (2023). Schwann Cell-Derived Exosomal Vesicles: A Promising Therapy for the Injured Spinal Cord. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242417317"},{"key":"ref_558","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-021-02215-x","article-title":"Increasing toll-like receptor 2 on astrocytes induced by Schwann cell-derived exosomes promotes recovery by inhibiting CSPGs deposition after spinal cord injury","volume":"18","author":"Pan","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_559","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10529-021-03198-8","article-title":"Autophagy induced by Schwann cell-derived exosomes promotes recovery after spinal cord injury in rats","volume":"44","author":"Pan","year":"2022","journal-title":"Biotechnol. Lett."},{"key":"ref_560","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41419-023-05607-4","article-title":"Schwann cell-derived exosomes containing MFG-E8 modify macrophage\/microglial polarization for attenuating inflammation via the SOCS3\/STAT3 pathway after spinal cord injury","volume":"14","author":"Ren","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_561","doi-asserted-by":"crossref","unstructured":"Huang, J.H., Chen, Y.N., He, H., Fu, C.H., Xu, Z.Y., and Lin, F.Y. (2023). Schwann cells-derived exosomes promote functional recovery after spinal cord injury by promoting angiogenesis. Front. Cell Neurosci., 16.","DOI":"10.3389\/fncel.2022.1077071"},{"key":"ref_562","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s13770-022-00517-6","article-title":"Chitosan Nerve Grafts Incorporated with SKP-SC-EVs Induce Peripheral Nerve Regeneration","volume":"20","author":"Zhou","year":"2023","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_563","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.actbio.2021.07.026","article-title":"Repair of peripheral nerve defects by nerve grafts incorporated with extracellular vesicles from skin-derived precursor Schwann cells","volume":"134","author":"Yu","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_564","first-page":"378","article-title":"Chitosan\/PLGA-based tissue engineered nerve grafts with SKP-SC-EVs enhance sciatic nerve regeneration in dogs through miR-30b-5p-mediated regulation of axon growth","volume":"40","author":"Yu","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_565","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13287-020-02125-4","article-title":"Improvement of sensory neuron growth and survival via negatively regulating PTEN by miR-21-5p-contained small extracellular vesicles from skin precursor-derived Schwann cells","volume":"12","author":"Cong","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_566","doi-asserted-by":"crossref","first-page":"123086","DOI":"10.1016\/j.lfs.2024.123086","article-title":"Therapeutic effect of exosomes derived from Schwann cells in the repair of peripheral nerve injury","volume":"357","author":"Wang","year":"2024","journal-title":"Life Sci."},{"key":"ref_567","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1089\/neu.2023.0650","article-title":"Beneficial Effects of Human Schwann Cell-Derived Exosomes in Mitigating Secondary Damage After Penetrating Ballistic-Like Brain Injury","volume":"41","author":"Nishimura","year":"2024","journal-title":"J. Neurotrauma"},{"key":"ref_568","doi-asserted-by":"crossref","first-page":"e00555","DOI":"10.1016\/j.neurot.2025.e00555","article-title":"Human Schwann cell exosome treatment attenuates secondary injury mechanisms, histopathological consequences, and behavioral deficits after traumatic brain injury","volume":"22","author":"Blaya","year":"2025","journal-title":"Neurotherapeutics"},{"key":"ref_569","doi-asserted-by":"crossref","unstructured":"Wang, L., Lu, X., Szalad, A., Liu, X.S., Zhang, Y., Wang, X., Golembieski, W.A., Powell, B., Mccann, M., and Lu, M. (2024). Schwann cell-derived exosomes ameliorate peripheral neuropathy induced by ablation of dicer in Schwann cells. Front. Cell. Neurosci., 18.","DOI":"10.3389\/fncel.2024.1462228"},{"key":"ref_570","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"ref_571","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2337\/db19-0432","article-title":"Exosomes Derived From Schwann Cells Ameliorate Peripheral Neuropathy in Type 2 Diabetic Mice","volume":"69","author":"Wang","year":"2020","journal-title":"Diabetes"},{"key":"ref_572","doi-asserted-by":"crossref","unstructured":"Saquel, C., Catalan, R.J., Lopez-Leal, R., Ramirez, R.A., Necu\u00f1ir, D., Wyneken, U., Lamaze, C., and Court, F.A. (2022). Neuronal activity-dependent ATP enhances the pro-growth effect of repair Schwann cell extracellular vesicles by increasing their miRNA-21 loading. Front. Cell Neurosci., 16.","DOI":"10.3389\/fncel.2022.943506"},{"key":"ref_573","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1007\/s12035-023-03488-4","article-title":"Schwann Cell-Derived Exosomes Ameliorate Paclitaxel-Induced Peripheral Neuropathy Through the miR-21-Mediated PTEN Signaling Pathway","volume":"60","author":"You","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_574","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.2147\/IJN.S500159","article-title":"Human Schwann Cell-Derived Extracellular Vesicle Isolation, Bioactivity Assessment, and Omics Characterization","volume":"20","author":"Khan","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"ref_575","first-page":"593","article-title":"Schwann cell extracellular matrix molecules and their receptors","volume":"15","author":"Chernousov","year":"2000","journal-title":"Histol. Histopathol."},{"key":"ref_576","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0166-2236(83)90235-7","article-title":"Interrelationship between Schwann cell function and extracellular matrix production","volume":"6","author":"Bunge","year":"1983","journal-title":"Trends Neurosci."},{"key":"ref_577","doi-asserted-by":"crossref","unstructured":"Torres-Mej\u00eda, E., Tr\u00fcmbach, D., Kleeberger, C., Dornseifer, U., Orschmann, T., B\u00e4cker, T., Brenke, J.K., Hadian, K., Wurst, W., and L\u00f3pez-Schier, H. (2020). Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis. Sci. Rep., 10.","DOI":"10.1038\/s41598-019-56877-y"},{"key":"ref_578","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/j.biomaterials.2013.11.087","article-title":"Chitosan\/silk fibroin-based, Schwann cell-derived extracellular matrix-modified scaffolds for bridging rat sciatic nerve gaps","volume":"35","author":"Gu","year":"2014","journal-title":"Biomaterials"},{"key":"ref_579","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.expneurol.2014.01.002","article-title":"Skin derived precursor Schwann cells improve behavioral recovery for acute and delayed nerve repair","volume":"254","author":"Khuong","year":"2014","journal-title":"Exp. Neurol."},{"key":"ref_580","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neures.2017.12.007","article-title":"Skin derived precursor Schwann cell-generated acellular matrix modified chitosan\/silk scaffolds for bridging rat sciatic nerve gap","volume":"135","author":"Zhu","year":"2018","journal-title":"Neurosci. Res."},{"key":"ref_581","first-page":"572","article-title":"Skin derived precursors induced Schwann cells mediated tissue engineering-aided neuroregeneration across sciatic nerve defect","volume":"33","author":"Xue","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_582","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/term.2987","article-title":"Extracellular matrix cues modulate Schwann cell morphology, proliferation, and protein expression","volume":"14","author":"Xu","year":"2020","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_583","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.actbio.2018.04.001","article-title":"Hydrogel derived from porcine decellularized nerve tissue as a promising biomaterial for repairing peripheral nerve defects","volume":"73","author":"Lin","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_584","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1021\/acsabm.1c00616","article-title":"Properties Regulation and Biological Applications of Decellularized Peripheral Nerve Matrix Hydrogel","volume":"4","author":"Liu","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_585","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.7150\/thno.50825","article-title":"Nanofibrous nerve guidance conduits decorated with decellularized matrix hydrogel facilitate peripheral nerve injury repair","volume":"11","author":"Zheng","year":"2021","journal-title":"Theranostics"},{"key":"ref_586","doi-asserted-by":"crossref","unstructured":"Rao, Z., Lin, T., Qiu, S., Zhou, J., Liu, S., Chen, S., Wang, T., Liu, X., Zhu, Q., and Bai, Y. (2021). Decellularized nerve matrix hydrogel scaffolds with longitudinally oriented and size-tunable microchannels for peripheral nerve regeneration. Mater. Sci. Eng. C Mater. Biol. Appl., 120.","DOI":"10.1016\/j.msec.2020.111791"},{"key":"ref_587","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/dvdy.650","article-title":"Neural dependency in wound healing and regeneration","volume":"253","author":"Noble","year":"2024","journal-title":"Dev. Dyn."},{"key":"ref_588","first-page":"9","article-title":"Defective wound healing in patients with paraplegia and quadriplegia","volume":"155","author":"Basson","year":"1982","journal-title":"Surg. Gynecol. Obstet."},{"key":"ref_589","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.trsl.2021.05.003","article-title":"Cutaneous innervation in impaired diabetic wound healing","volume":"236","author":"Nowak","year":"2021","journal-title":"Transl. Res."},{"key":"ref_590","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neubiorev.2009.08.004","article-title":"The cutaneous sensory system","volume":"34","author":"McGlone","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_591","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1097\/j.pain.0000000000002169","article-title":"Demise of nociceptive Schwann cells causes nerve retraction and pain hyperalgesia","volume":"162","author":"Rinwa","year":"2021","journal-title":"Pain"},{"key":"ref_592","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/exd.13681","article-title":"New insights into the roles of myofibroblasts and innervation during skin healing and innovative therapies to improve scar innervation","volume":"27","author":"Lebonvallet","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_593","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41467-017-01488-2","article-title":"Injury-activated glial cells promote wound healing of the adult skin in mice","volume":"9","author":"Parfejevs","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_594","doi-asserted-by":"crossref","unstructured":"Zhou, S., Wan, L., Liu, X., Hu, D., Lu, F., Chen, X., and Liang, F. (2022). Diminished schwann cell repair responses play a role in delayed diabetes-associated wound healing. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.814754"},{"key":"ref_595","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12035-022-03090-0","article-title":"Transcriptional Control of Peripheral Nerve Regeneration","volume":"60","author":"Zhang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_596","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.7150\/thno.72317","article-title":"Dedifferentiated Schwann cell-derived TGF-\u03b23 is essential for the neural system to promote wound healing","volume":"12","author":"Ou","year":"2022","journal-title":"Theranostics"},{"key":"ref_597","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.matbio.2022.03.001","article-title":"Schwann cells contribute to keloid formation","volume":"108","author":"Direder","year":"2022","journal-title":"Matrix Biol."},{"key":"ref_598","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1038\/s12276-022-00874-1","article-title":"The transcriptional profile of keloidal Schwann cells","volume":"54","author":"Direder","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_599","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1039\/D4TB02601B","article-title":"Schwann cell-derived exosomes accelerate periodontal bone regeneration with osteogenesis, angiogenesis, and neurogenesis","volume":"13","author":"Cui","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"ref_600","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.stemcr.2013.04.004","article-title":"Sox2-mediated regulation of adult neural crest precursors and skin repair","volume":"1","author":"Johnston","year":"2013","journal-title":"Stem Cell Rep."},{"key":"ref_601","doi-asserted-by":"crossref","unstructured":"Johnston, A.P.W., and Miller, F.D. (2022). The Contribution of Innervation to Tissue Repair and Regeneration. Cold Spring Harb. Perspect. Biol., 14.","DOI":"10.1101\/cshperspect.a041233"},{"key":"ref_602","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s13287-021-02433-3","article-title":"Schwann cells promote prevascularization and osteogenesis of tissue-engineered bone via bone marrow mesenchymal stem cell-derived endothelial cells","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_603","first-page":"206","article-title":"A multifunctional neuromodulation platform utilizing Schwann cell-derived exosomes orchestrates bone microenvironment via immunomodulation, angiogenesis and osteogenesis","volume":"23","author":"Hao","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_604","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.bbrc.2020.07.094","article-title":"Schwann Cell-derived exosomes promote bone regeneration and repair by enhancing the biological activity of porous Ti6Al4V scaffolds","volume":"531","author":"Wu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_605","doi-asserted-by":"crossref","first-page":"9846","DOI":"10.1073\/pnas.1410097111","article-title":"Clonal analysis reveals nerve-dependent and independent roles on mammalian hind limb tissue maintenance and regeneration","volume":"111","author":"Rinkevich","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_606","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/jre.12472","article-title":"Denervation effectively aggravates rat experimental periodontitis","volume":"52","author":"Yu","year":"2017","journal-title":"J. Periodontal Res."},{"key":"ref_607","first-page":"313","article-title":"Dental pulp stem cells alleviate Schwann cell pyroptosis via mitochondrial transfer to enhance facial nerve regeneration","volume":"47","author":"Zheng","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_608","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1158\/0008-5472.CAN-16-1536","article-title":"Surgery for Cancer: A Trigger for Metastases","volume":"77","author":"Tohme","year":"2017","journal-title":"Cancer Res."},{"key":"ref_609","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ncponc0999","article-title":"Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: Learning from failures","volume":"4","author":"Demicheli","year":"2007","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"ref_610","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1093\/annonc\/mdn386","article-title":"The effects of surgery on tumor growth: A century of investigations","volume":"19","author":"Demicheli","year":"2008","journal-title":"Ann. Oncol."},{"key":"ref_611","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10585-018-9896-8","article-title":"Potential impact of invasive surgical procedures on primary tumor growth and metastasis","volume":"35","author":"Alieva","year":"2018","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_612","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1002\/ijc.32820","article-title":"Premetastatic niches, exosomes and circulating tumor cells: Early mechanisms of tumor dissemination and the relation to surgery","volume":"146","author":"Raskov","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_613","doi-asserted-by":"crossref","unstructured":"Shurin, M.R., Baraldi, J.H., and Shurin, G.V. (2021). Neuroimmune Regulation of Surgery-Associated Metastases. Cells, 10.","DOI":"10.3390\/cells10020454"},{"key":"ref_614","doi-asserted-by":"crossref","unstructured":"Bordonaro, M., and Lazarova, D. (2024). Hypothesis: Cancer Hormesis and Its Potential for Cancer Therapeutics. Life, 14.","DOI":"10.3390\/life14030401"},{"key":"ref_615","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.canlet.2012.05.021","article-title":"Concomitant tumor resistance","volume":"324","author":"Chiarella","year":"2012","journal-title":"Cancer Lett."},{"key":"ref_616","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1007\/s00432-010-0818-7","article-title":"Biphasic effect of a primary tumor on the growth of secondary tumor implants","volume":"136","author":"Bruzzo","year":"2010","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_617","first-page":"5575","article-title":"A primary tumor promotes dormancy of solitary tumor cells before inhibiting angiogenesis","volume":"61","author":"Guba","year":"2001","journal-title":"Cancer Res."},{"key":"ref_618","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/ijc.2910270618","article-title":"On the mechanism of tumor \u201cconcomitant immunity\u201d","volume":"27","author":"Gorelik","year":"1981","journal-title":"Int. J. Cancer"},{"key":"ref_619","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/00000658-200007000-00009","article-title":"Significant detection of circulating cancer cells in the blood by reverse transcriptase-polymerase chain reaction during colorectal cancer resection","volume":"232","author":"Yamaguchi","year":"2000","journal-title":"Ann. Surg."},{"key":"ref_620","doi-asserted-by":"crossref","unstructured":"Onuma, A.E., Zhang, H., Gil, L., Huang, H., and Tsung, A. (2020). Surgical Stress Promotes Tumor Progression: A Focus on the Impact of the Immune Response. J. Clin. Med., 9.","DOI":"10.3390\/jcm9124096"},{"key":"ref_621","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.semcancer.2022.01.006","article-title":"Surgery-mediated tumor-promoting effects on the immune microenvironment","volume":"86","author":"Cheng","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"ref_622","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00432-024-05704-7","article-title":"Effect of acute inflammatory reaction induced by biopsy on tumor microenvironment","volume":"150","author":"Chen","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_623","doi-asserted-by":"crossref","unstructured":"Baraldi, J.H., Martyn, G.V., Shurin, G.V., and Shurin, M.R. (2022). Tumor Innervation: History, Methodologies, and Significance. Cancers, 14.","DOI":"10.3390\/cancers14081979"},{"key":"ref_624","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.trecan.2020.07.005","article-title":"Tumor Innervation: Cancer Has Some Nerve","volume":"6","author":"Reavis","year":"2020","journal-title":"Trends Cancer"},{"key":"ref_625","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41568-019-0237-2","article-title":"Nerves in cancer","volume":"20","author":"Zahalka","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"ref_626","doi-asserted-by":"crossref","first-page":"e147276","DOI":"10.1172\/JCI147276","article-title":"Tumor innervation: Peripheral nerves take control of the tumor microenvironment","volume":"131","author":"Gysler","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_627","doi-asserted-by":"crossref","unstructured":"Erin, N., Shurin, G.V., Baraldi, J.H., and Shurin, M.R. (2022). Regulation of Carcinogenesis by Sensory Neurons and Neuromediators. Cancers, 14.","DOI":"10.3390\/cancers14092333"},{"key":"ref_628","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1007\/s00018-017-2578-x","article-title":"How Schwann cells facilitate cancer progression in nerves","volume":"74","author":"Deborde","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"ref_629","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4049\/jimmunol.1900828","article-title":"The Neuroimmune Axis in the Tumor Microenvironment","volume":"204","author":"Shurin","year":"2020","journal-title":"J. Immunol."},{"key":"ref_630","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.trecan.2023.05.002","article-title":"Neuro-immune interactions and immuno-oncology","volume":"9","author":"Khanmammadova","year":"2023","journal-title":"Trends Cancer"},{"key":"ref_631","doi-asserted-by":"crossref","unstructured":"Yurteri, \u00dc., \u00c7ifciba\u015f\u0131, K., Friess, H., Ceyhan, G.O., Istvanffy, R., and Demir, I.E. (2022). Schwann Cells in Peripheral Cancers: Bystanders or Promoters?. Adv. Biol., 6.","DOI":"10.1002\/adbi.202200033"},{"key":"ref_632","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/pin.12641","article-title":"Mesenchymal-epithelial transition of pancreatic cancer cells at perineural invasion sites is induced by Schwann cells","volume":"68","author":"Yamazaki","year":"2018","journal-title":"Pathol. Int."},{"key":"ref_633","doi-asserted-by":"crossref","first-page":"5927","DOI":"10.1158\/0008-5472.CAN-18-1702","article-title":"Schwann Cells Augment Cell Spreading and Metastasis of Lung Cancer","volume":"78","author":"Zhou","year":"2018","journal-title":"Cancer Res."},{"key":"ref_634","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/s13046-022-02556-2","article-title":"A reciprocal feedback between colon cancer cells and Schwann cells promotes the proliferation and metastasis of colon cancer","volume":"41","author":"Han","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_635","doi-asserted-by":"crossref","unstructured":"Chen, S., and Chen, M. (2022). Schwann cells promote the migration and invasion of colorectal cancer cells via the activated NF-\u03baB\/IL-8 axis in the tumor microenvironment. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1026670"},{"key":"ref_636","doi-asserted-by":"crossref","unstructured":"Ferdoushi, A., Li, X., Griffin, N., Faulkner, S., Jamaluddin, M.F.B., Gao, F., Jiang, C.C., van Helden, D.F., Tanwar, P.S., and Jobling, P. (2020). Schwann Cell Stimulation of Pancreatic Cancer Cells: A Proteomic Analysis. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.01601"},{"key":"ref_637","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.7150\/thno.42440","article-title":"Tumor-neuroglia interaction promotes pancreatic cancer metastasis","volume":"10","author":"Su","year":"2020","journal-title":"Theranostics"},{"key":"ref_638","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/jcb.25300","article-title":"Schwann Cells Increase Prostate and Pancreatic Tumor Cell Invasion Using Laminin Binding A6 Integrin","volume":"117","author":"Sroka","year":"2016","journal-title":"J. Cell Biochem."},{"key":"ref_639","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/glia.24497","article-title":"Schwann cell-derived exosomes promote lung cancer progression via miRNA-21-5p","volume":"72","author":"Zhou","year":"2024","journal-title":"Glia"},{"key":"ref_640","doi-asserted-by":"crossref","unstructured":"Cao, S., Wang, Y., Zhou, Y., Zhang, Y., Ling, X., Zhang, L., Li, J., Yang, Y., Wang, W., and Shurin, M.R. (2022). A Novel Therapeutic Target for Small-Cell Lung Cancer: Tumor-Associated Repair-like Schwann Cells. Cancers, 14.","DOI":"10.3390\/cancers14246132"},{"key":"ref_641","doi-asserted-by":"crossref","first-page":"104211","DOI":"10.1016\/j.cellimm.2020.104211","article-title":"Schwann cells promote lung cancer proliferation by promoting the M2 polarization of macrophages","volume":"357","author":"Zhou","year":"2020","journal-title":"Cell. Immunol."},{"key":"ref_642","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3892\/or.2015.4366","article-title":"Schwann cells promote EMT and the Schwann-like differentiation of salivary adenoid cystic carcinoma cells via the BDNF\/TrkB axis","volume":"35","author":"Shan","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_643","doi-asserted-by":"crossref","first-page":"14315","DOI":"10.1007\/s00432-023-05133-y","article-title":"Glial cell-derived soluble factors increase the metastatic potential of pancreatic adenocarcinoma cells and induce epithelial-to-mesenchymal transition","volume":"149","author":"Kuzmanov","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_644","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.21037\/jgo-24-309","article-title":"Promotion of perineural invasion of cholangiocarcinoma by Schwann cells via nerve growth factor","volume":"15","author":"Qian","year":"2024","journal-title":"J. Gastrointestig. Oncol."},{"key":"ref_645","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3390\/neuroglia5020012","article-title":"How Schwann Cells Are Involved in Brain Metastasis","volume":"5","author":"Allgood","year":"2024","journal-title":"Neuroglia"},{"key":"ref_646","doi-asserted-by":"crossref","first-page":"dju184","DOI":"10.1093\/jnci\/dju184","article-title":"Investigation of Schwann cells at neoplastic cell sites before the onset of cancer invasion","volume":"106","author":"Demir","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_647","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1172\/JCI82658","article-title":"Schwann cells induce cancer cell dispersion and invasion","volume":"126","author":"Deborde","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_648","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1172\/JCI86801","article-title":"Cancer\u2019s got nerve: Schwann cells drive perineural invasion","volume":"126","author":"Azam","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_649","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1158\/2159-8290.CD-22-0829","article-title":"The boring Schwann cells: Tumor Me-TAST-asis along nerves","volume":"12","author":"Amit","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_650","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1158\/2159-8290.CD-21-1690","article-title":"Reprogrammed Schwann Cells Organize into Dynamic Tracks that Promote Pancreatic Cancer Invasion","volume":"12","author":"Deborde","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_651","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/s41419-024-07030-9","article-title":"Cervical cancer-produced neuromedin-B reprograms Schwann cells to initiate perineural invasion","volume":"15","author":"Gao","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_652","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1111\/jcmm.17897","article-title":"Dedifferentiated Schwann cells promote perineural invasion mediated by the PACAP paracrine signalling in cervical cancer","volume":"27","author":"Chen","year":"2023","journal-title":"J. Cell Mol. Med."},{"key":"ref_653","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.36922\/gpd.3146","article-title":"Perineural invasion in prostate cancer is associated with Schwann cells and disruption of circadian rhythm-related gene expression: A bioinformatics approach","volume":"3","author":"Silva","year":"2024","journal-title":"GPD"},{"key":"ref_654","doi-asserted-by":"crossref","unstructured":"de Franchis, V., Petrungaro, S., Pizzichini, E., Camerini, S., Casella, M., Somma, F., Mandolini, E., Carpino, G., Overi, D., and Cardinale, V. (2024). Cholangiocarcinoma Malignant Traits Are Promoted by Schwann Cells through TGF\u03b2 Signaling in a Model of Perineural Invasion. Cells, 13.","DOI":"10.3390\/cells13050366"},{"key":"ref_655","doi-asserted-by":"crossref","unstructured":"Santi, M.D., Zhang, M., Salvo, E., Asam, K., Viet, C.T., Xie, T., Amit, M., Aouizerat, B., and Ye, Y. (2022). Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells. Adv. Biol., 6.","DOI":"10.1002\/adbi.202200187"},{"key":"ref_656","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10456-022-09858-1","article-title":"Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression","volume":"26","author":"Rocha","year":"2023","journal-title":"Angiogenesis"},{"key":"ref_657","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10561-021-09920-0","article-title":"Schwann-like cell conditioned medium promotes angiogenesis and nerve regeneration","volume":"23","author":"Yu","year":"2022","journal-title":"Cell Tissue Bank."},{"key":"ref_658","doi-asserted-by":"crossref","unstructured":"Sun, J., Zeng, Q., Wu, Z., Li, Z., Gao, Q., Liao, Z., Li, H., Ling, C., Chen, C., and Wang, H. (2024). Enhancing intraneural revascularization following peripheral nerve injury through hypoxic Schwann-cell-derived exosomes: An insight into endothelial glycolysis. J. Nanobiotechnol., 22.","DOI":"10.1186\/s12951-024-02536-y"},{"key":"ref_659","doi-asserted-by":"crossref","first-page":"2192098","DOI":"10.1080\/2162402X.2023.2192098","article-title":"Melanoma-associated repair-like Schwann cells suppress anti-tumor T-cells via 12\/15-LOX\/COX2-associated eicosanoid production","volume":"12","author":"Kruglov","year":"2023","journal-title":"Oncoimmunology"},{"key":"ref_660","doi-asserted-by":"crossref","unstructured":"Zhang, S., Chen, J., Cheng, F., and Zheng, F. (2024). The Emerging Role of Schwann Cells in the Tumor Immune Microenvironment and Its Potential Clinical Application. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252413722"},{"key":"ref_661","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1172\/JCI99424","article-title":"Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis","volume":"128","author":"Liao","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_662","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1038\/s41467-023-40314-w","article-title":"Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment","volume":"14","author":"Xue","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_663","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41417-024-00727-1","article-title":"Schwann cell derived pleiotrophin stimulates fibroblast for proliferation and excessive collagen deposition in plexiform neurofibroma","volume":"31","author":"Tian","year":"2024","journal-title":"Cancer Gene Ther."},{"key":"ref_664","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cell.2010.08.039","article-title":"EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting","volume":"143","author":"Parrinello","year":"2010","journal-title":"Cell"},{"key":"ref_665","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/glia.22934","article-title":"Fibroblast-derived tenascin-C promotes Schwann cell migration through \u03b21-integrin dependent pathway during peripheral nerve regeneration","volume":"64","author":"Zhang","year":"2016","journal-title":"Glia"},{"key":"ref_666","doi-asserted-by":"crossref","unstructured":"Fornasari, B.E., El Soury, M., Nato, G., Fucini, A., Carta, G., Ronchi, G., Crosio, A., Perroteau, I., Geuna, S., and Raimondo, S. (2020). Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation. Cells, 9.","DOI":"10.3390\/cells9061366"},{"key":"ref_667","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00262-016-1929-z","article-title":"Schwann cells: A new player in the tumor microenvironment","volume":"66","author":"Bunimovich","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_668","doi-asserted-by":"crossref","first-page":"1058667","DOI":"10.1155\/2022\/1058667","article-title":"Schwann Cells in the Tumor Microenvironment: Need More Attention","volume":"2022","author":"Sun","year":"2022","journal-title":"J. Oncol."},{"key":"ref_669","doi-asserted-by":"crossref","unstructured":"Deborde, S., and Wong, R.J. (2022). The Role of Schwann Cells in Cancer. Adv. Biol., 6.","DOI":"10.1002\/adbi.202200089"},{"key":"ref_670","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1158\/0008-5472.CAN-18-3872","article-title":"Melanoma-Induced Reprogramming of Schwann Cell Signaling Aids Tumor Growth","volume":"79","author":"Shurin","year":"2019","journal-title":"Cancer Res."},{"key":"ref_671","doi-asserted-by":"crossref","unstructured":"Shurin, M.R., Wheeler, S.E., Shurin, G.V., Zhong, H., and Zhou, Y. (2024). Schwann cells in the normal and pathological lung microenvironment. Front. Mol. Biosci., 11.","DOI":"10.3389\/fmolb.2024.1365760"},{"key":"ref_672","doi-asserted-by":"crossref","first-page":"S673","DOI":"10.1016\/j.jtho.2019.08.1428","article-title":"Schwann Cells Are Overexpressed and Inversely Correlated with Survival of Non-Small Cell Lung Cancer Patients","volume":"14","author":"Zhou","year":"2019","journal-title":"J. Thorac. Oncol."},{"key":"ref_673","doi-asserted-by":"crossref","first-page":"eadd6995","DOI":"10.1126\/sciadv.add6995","article-title":"Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion","volume":"9","author":"Sun","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_674","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1111\/cas.16164","article-title":"Adrenergic microenvironment driven by cancer-associated Schwann cells contributes to chemoresistance in patients with lung cancer","volume":"115","author":"Otani","year":"2024","journal-title":"Cancer Sci."},{"key":"ref_675","doi-asserted-by":"crossref","first-page":"7288","DOI":"10.18632\/oncotarget.27204","article-title":"Schwann cell reprogramming and lung cancer progression: A meta-analysis of transcriptome data","volume":"10","author":"Silva","year":"2019","journal-title":"Oncotarget"},{"key":"ref_676","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41416-024-02915-0","article-title":"Extracellular vesicles from pancreatic cancer and its tumour microenvironment promote increased Schwann cell migration","volume":"132","author":"Wong","year":"2025","journal-title":"Br. J. Cancer"},{"key":"ref_677","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41416-023-02539-w","article-title":"Tumour-associated macrophages and Schwann cells promote perineural invasion via paracrine loop in pancreatic ductal adenocarcinoma","volume":"130","author":"Zhang","year":"2024","journal-title":"Br. J. Cancer"},{"key":"ref_678","doi-asserted-by":"crossref","first-page":"114981","DOI":"10.1016\/j.expneurol.2024.114981","article-title":"Nerve injury converts Schwann cells in a long-term repair-like state in human neuroma tissue","volume":"382","author":"Deininger","year":"2024","journal-title":"Exp. Neurol."},{"key":"ref_679","doi-asserted-by":"crossref","unstructured":"Kong, E., Li, Y., Deng, M., Hua, T., Yang, M., Li, J., Feng, X., and Yuan, H. (2022). Glycometabolism Reprogramming of Glial Cells in Central Nervous System: Novel Target for Neuropathic Pain. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.861290"},{"key":"ref_680","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41586-021-04075-0","article-title":"Dietary palmitic acid promotes a prometastatic memory via Schwann cells","volume":"599","author":"Pascual","year":"2021","journal-title":"Nature"},{"key":"ref_681","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1002\/glia.24586","article-title":"Pancreatic Schwann cell reprogramming supports cancer-associated neuronal remodeling","volume":"72","author":"Mann","year":"2024","journal-title":"Glia"},{"key":"ref_682","doi-asserted-by":"crossref","unstructured":"Edwards, H.L., Mulvey, M.R., and Bennett, M.I. (2019). Cancer-Related Neuropathic Pain. Cancers, 11.","DOI":"10.3390\/cancers11030373"},{"key":"ref_683","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1007\/s10072-022-06083-y","article-title":"Paraneoplastic neurological syndrome: Growing spectrum and relevance","volume":"43","author":"Ganaraja","year":"2022","journal-title":"Neurol. Sci."},{"key":"ref_684","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/ana.24951","article-title":"Chemotherapy-induced peripheral neuropathy: A current review","volume":"81","author":"Staff","year":"2017","journal-title":"Ann. Neurol."},{"key":"ref_685","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10549-016-3939-0","article-title":"Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: Prevalence, risk factors, and fall risk","volume":"159","author":"Bao","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_686","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/pathophysiology30020010","article-title":"Neurotrophin-3 (NT-3) as a Potential Biomarker of the Peripheral Nervous System Damage Following Breast Cancer Treatment","volume":"30","author":"Tonyan","year":"2023","journal-title":"Pathophysiology"},{"key":"ref_687","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.ygyno.2005.01.017","article-title":"The administration of chemotherapy in a patient with Charcot-Marie-Tooth and ovarian cancer","volume":"97","author":"Martino","year":"2005","journal-title":"Gynecol. Oncol."},{"key":"ref_688","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/00043426-200304000-00010","article-title":"Vincristine-induced neuropathy as the initial presentation of charcot-marie-tooth disease in acute lymphoblastic leukemia: A Pediatric Oncology Group study","volume":"25","author":"Chauvenet","year":"2003","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_689","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s40487-021-00168-y","article-title":"Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment","volume":"9","author":"Burgess","year":"2021","journal-title":"Oncol. Ther."},{"key":"ref_690","doi-asserted-by":"crossref","unstructured":"Desforges, A.D., Hebert, C.M., Spence, A.L., Reid, B., Dhaibar, H.A., Cruz-Topete, D., Cornett, E.M., Kaye, A.D., Urits, I., and Viswanath, O. (2022). Treatment and diagnosis of chemotherapy-induced peripheral neuropathy: An update. Biomed. Pharmacother., 147.","DOI":"10.1016\/j.biopha.2022.112671"},{"key":"ref_691","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s00204-023-03468-6","article-title":"Lysosomal dysfunction in Schwann cells is involved in bortezomib-induced peripheral neurotoxicity","volume":"97","author":"Wu","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_692","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1248\/bpb.b22-00668","article-title":"Specific Cellular Effects of Low Bortezomib Concentrations on Purified Cultures of Schwann Cells, Satellite Glial Cells, Macrophages, and Dorsal Root Ganglion Neurons","volume":"46","author":"Zhou","year":"2023","journal-title":"Biol. Pharm. Bull."},{"key":"ref_693","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1002\/glia.21065","article-title":"Pathological adaptive responses of Schwann cells to endoplasmic reticulum stress in bortezomib-induced peripheral neuropathy","volume":"58","author":"Shin","year":"2010","journal-title":"Glia"},{"key":"ref_694","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.expneurol.2006.07.022","article-title":"Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells","volume":"203","author":"Peters","year":"2007","journal-title":"Exp. Neurol."},{"key":"ref_695","doi-asserted-by":"crossref","unstructured":"Imai, S., Koyanagi, M., Azimi, Z., Nakazato, Y., Matsumoto, M., Ogihara, T., Yonezawa, A., Omura, T., Nakagawa, S., and Wakatsuki, S. (2017). Taxanes and platinum derivatives impair Schwann cells via distinct mechanisms. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-05784-1"},{"key":"ref_696","doi-asserted-by":"crossref","first-page":"116751","DOI":"10.1016\/j.taap.2023.116751","article-title":"Platinum-based chemotherapy induces demyelination of Schwann cells in oral squamous cell carcinoma treatment","volume":"481","author":"Wang","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_697","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12640-020-00176-2","article-title":"Behavioral, Electrophysiological, and Histological Characterization of a New Rat Model for Neoadjuvant Chemotherapy-Induced Neuropathic Pain: Therapeutic Potential of Duloxetine and Allopregnanolone Concomitant Treatment","volume":"38","author":"Matta","year":"2020","journal-title":"Neurotox. Res."},{"key":"ref_698","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1158\/0008-5472.CAN-20-2799","article-title":"Pronociceptive roles of schwann cell\u2013derived galectin-3 in taxane-induced peripheral neuropathy","volume":"81","author":"Koyanagi","year":"2021","journal-title":"Cancer Res."},{"key":"ref_699","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s12185-011-0850-7","article-title":"Delayed treatment with vitamin C and N-acetyl-L-cysteine protects Schwann cells without compromising the anti-myeloma activity of bortezomib","volume":"93","author":"Nakano","year":"2011","journal-title":"Int. J. Hematol."},{"key":"ref_700","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1111\/jnc.15015","article-title":"Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro-myelinating genes","volume":"157","author":"Huff","year":"2021","journal-title":"J. Neurochem."},{"key":"ref_701","doi-asserted-by":"crossref","first-page":"108514","DOI":"10.1016\/j.neuropharm.2021.108514","article-title":"Cilostazol is an effective causal therapy for preventing paclitaxel-induced peripheral neuropathy by suppression of Schwann cell dedifferentiation","volume":"188","author":"Koyanagi","year":"2021","journal-title":"Neuropharmacology"},{"key":"ref_702","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1007\/s00204-025-04030-2","article-title":"Dihydromyricetin restores lysosomal function in Schwann cells to alleviate bortezomib-induced peripheral neuropathy via ERK\/TFEB signaling","volume":"99","author":"Liu","year":"2025","journal-title":"Arch. Toxicol."},{"key":"ref_703","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/term.2972","article-title":"Mesenchymal stem cells in chemotherapy-induced peripheral neuropathy: A new challenging approach that requires further investigations","volume":"14","author":"Ahmed","year":"2020","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_704","doi-asserted-by":"crossref","unstructured":"Chiu, D., Rhee, J., and Gonzalez Castro, L.N. (2023). Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes. Antibodies, 12.","DOI":"10.3390\/antib12030050"},{"key":"ref_705","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1001\/archneurol.2009.341","article-title":"Paraneoplastic neurologic syndrome in the PNS Euronetwork database: A European study from 20 centers","volume":"67","author":"Giometto","year":"2010","journal-title":"Arch. Neurol."},{"key":"ref_706","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/acn3.554","article-title":"Antibodies against cell adhesion molecules and neural structures in paraneoplastic neuropathies","volume":"5","author":"Siles","year":"2018","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_707","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF00334892","article-title":"Paraneoplastic cerebellar degeneration with a circulating antibody against neurons and non-neuronal cells","volume":"86","author":"Tomimoto","year":"1993","journal-title":"Acta Neuropathol."},{"key":"ref_708","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1038\/s41467-021-21859-0","article-title":"Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8","volume":"12","author":"Weiss","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_709","doi-asserted-by":"crossref","first-page":"S629","DOI":"10.1016\/j.ijrobp.2013.06.1664","article-title":"Are Schwann Cells a Target in Radiation for Perineural Invasion?","volume":"87","author":"Bakst","year":"2013","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_710","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13046-021-02198-w","article-title":"Autophagic Schwann cells promote perineural invasion mediated by the NGF\/ATG7 paracrine pathway in pancreatic cancer","volume":"41","author":"Zhang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_711","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/glia.70032","article-title":"Interplay Between Schwann Cells and Peripheral Cancers: Mechanisms and Therapeutic Targets in Cancer Progression","volume":"73","author":"He","year":"2025","journal-title":"Glia"},{"key":"ref_712","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/glia.20776","article-title":"How does the Schwann cell lineage form tumors in NF1?","volume":"56","author":"Carroll","year":"2008","journal-title":"Glia"},{"key":"ref_713","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1016\/j.ajpath.2014.04.006","article-title":"Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis","volume":"184","author":"Rahrmann","year":"2014","journal-title":"Am. J. Pathol."},{"key":"ref_714","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1158\/0008-5472.CAN-11-4092","article-title":"PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors","volume":"72","author":"Keng","year":"2012","journal-title":"Cancer Res."},{"key":"ref_715","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ajpath.2012.11.017","article-title":"Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis","volume":"182","author":"Kazmi","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_716","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1038\/s41388-021-01979-z","article-title":"Tumorigenesis in neurofibromatosis type 1: Role of the microenvironment","volume":"40","author":"Jiang","year":"2021","journal-title":"Oncogene"},{"key":"ref_717","doi-asserted-by":"crossref","first-page":"625","DOI":"10.5858\/2007-131-625-PADAUP","article-title":"Perineurioma: A distinctive and underrecognized peripheral nerve sheath neoplasm","volume":"131","author":"Macarenco","year":"2007","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_718","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0041-1726110","article-title":"Perineurioma: A Rare Entity of Peripheral Nerve Sheath Tumors","volume":"83","author":"Brand","year":"2022","journal-title":"J. Neurol. Surg. A Cent. Eur. Neurosurg."},{"key":"ref_719","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1007\/s00701-023-05765-6","article-title":"What is new in intraneural perineurioma?","volume":"165","author":"Lenartowicz","year":"2023","journal-title":"Acta Neurochir."},{"key":"ref_720","doi-asserted-by":"crossref","first-page":"eaal3753","DOI":"10.1126\/science.aal3753","article-title":"Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla","volume":"357","author":"Furlan","year":"2017","journal-title":"Science"},{"key":"ref_721","first-page":"297","article-title":"Neurofibromin in neurofibromatosis type 1\u2014Mutations in NF1gene as a cause of disease","volume":"18","author":"Abramowicz","year":"2014","journal-title":"Dev. Period. Med."},{"key":"ref_722","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1055\/s-0038-1627471","article-title":"Neurofibromatosis and Schwannomatosis","volume":"38","author":"Plotkin","year":"2018","journal-title":"Semin. Neurol."},{"key":"ref_723","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00381-009-1024-2","article-title":"Neurofibromatosis type 1 and high-grade tumors of the central nervous system","volume":"26","author":"Rosenfeld","year":"2010","journal-title":"Childs Nerv. Syst."},{"key":"ref_724","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/B978-0-444-52902-2.00053-9","article-title":"Neurofibromatosis type 1 (NF1): Diagnosis and management","volume":"115","author":"Ferner","year":"2013","journal-title":"Handb. Clin. Neurol."},{"key":"ref_725","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s13311-017-0518-y","article-title":"Cancer of the Peripheral Nerve in Neurofibromatosis Type 1","volume":"14","author":"Staedtke","year":"2017","journal-title":"Neurotherapeutics"},{"key":"ref_726","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.1068452","article-title":"Neurofibromas in NF1: Schwann cell origin and role of tumor environment","volume":"296","author":"Zhu","year":"2002","journal-title":"Science"},{"key":"ref_727","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tcb.2009.05.003","article-title":"Neurofibroma development in NF1\u2014Insights into tumour initiation","volume":"19","author":"Parrinello","year":"2009","journal-title":"Trends Cell Biol."},{"key":"ref_728","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0002-9440(10)63992-2","article-title":"Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells","volume":"158","author":"Muir","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref_729","doi-asserted-by":"crossref","unstructured":"White, E.E., and Rhodes, S.D. (2024). The NF1+\/- Immune Microenvironment: Dueling Roles in Neurofibroma Development and Malignant Transformation. Cancers, 16.","DOI":"10.3390\/cancers16050994"},{"key":"ref_730","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.celrep.2013.08.033","article-title":"Injury signals cooperate with Nf1 loss to relieve the tumor-suppressive environment of adult peripheral nerve","volume":"5","author":"Ribeiro","year":"2013","journal-title":"Cell Rep."},{"key":"ref_731","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1038\/s41388-022-02290-1","article-title":"Malignant peripheral nerve sheath tumor: Models, biology, and translation","volume":"41","author":"Somatilaka","year":"2022","journal-title":"Oncogene"},{"key":"ref_732","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ccell.2018.01.005","article-title":"Programming of Schwann Cells by Lats1\/2-TAZ\/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis","volume":"33","author":"Wu","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_733","doi-asserted-by":"crossref","first-page":"e2100063","DOI":"10.1002\/pmic.202100063","article-title":"Secretome analysis of human schwann cells derived from malignant peripheral nerve sheath tumor","volume":"22","author":"Ferdoushi","year":"2022","journal-title":"Proteomics"},{"key":"ref_734","doi-asserted-by":"crossref","unstructured":"Sanchez, L.D., Bui, A., and Klesse, L.J. (2021). Targeted Therapies for the Neurofibromatoses. Cancers, 13.","DOI":"10.3390\/cancers13236032"},{"key":"ref_735","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/s11912-024-01527-4","article-title":"Past, Present, and Future Therapeutic Strategies for NF-1-Associated Tumors","volume":"26","author":"Na","year":"2024","journal-title":"Curr. Oncol. Rep."},{"key":"ref_736","doi-asserted-by":"crossref","unstructured":"Williams, K.B., and Largaespada, D.A. (2020). New Model Systems and the Development of Targeted Therapies for the Treatment of Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors. Genes, 11.","DOI":"10.3390\/genes11050477"},{"key":"ref_737","doi-asserted-by":"crossref","first-page":"110385","DOI":"10.1016\/j.celrep.2022.110385","article-title":"Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas","volume":"38","author":"Mazuelas","year":"2022","journal-title":"Cell Rep."},{"key":"ref_738","doi-asserted-by":"crossref","first-page":"e70036","DOI":"10.1002\/gcc.70036","article-title":"Schwann Cells Deficient in Neurofibromin Lack Sensitivity to Their Biomechanical Microenvironment","volume":"64","author":"Rambo","year":"2025","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_739","doi-asserted-by":"crossref","unstructured":"Fay, C.X., Zunica, E.R.M., Awad, E., Bradley, W., Church, C., Liu, J., Liu, H., Crossman, D.K., Mobley, J.A., and Kirwan, J.P. (2025). Global proteomics and affinity mass spectrometry analysis of human Schwann cells indicates that variation in and loss of neurofibromin (NF1) alters protein expression and cellular and mitochondrial metabolism. Sci. Rep., 15.","DOI":"10.1038\/s41598-024-84493-y"},{"key":"ref_740","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1101\/gad.13.8.978","article-title":"Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein","volume":"13","author":"Giovannini","year":"1999","journal-title":"Genes. Dev."},{"key":"ref_741","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41467-024-44755-9","article-title":"Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance","volume":"15","author":"Vasudevan","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_742","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/neuros\/nyaa455","article-title":"Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer","volume":"88","author":"Vasudevan","year":"2021","journal-title":"Neurosurgery"},{"key":"ref_743","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1038\/s41388-020-1374-5","article-title":"Pathomechanisms in schwannoma development and progression","volume":"39","author":"Helbing","year":"2020","journal-title":"Oncogene"},{"key":"ref_744","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s12253-013-9644-y","article-title":"Merlin, the NF2 gene product","volume":"19","year":"2013","journal-title":"Pathol. Oncol. Res."},{"key":"ref_745","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/s41467-023-37226-0","article-title":"Cellular mechanisms of heterogeneity in NF2-mutant schwannoma","volume":"14","author":"Vitte","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_746","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11060-014-1710-0","article-title":"Phase II study of mTORC1 inhibition by everolimus in neurofibromatosis type 2 patients with growing vestibular schwannomas","volume":"122","author":"Goutagny","year":"2015","journal-title":"J. Neurooncol."},{"key":"ref_747","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/00006123-199605000-00004","article-title":"The neuroimaging and clinical spectrum of neurofibromatosis 2","volume":"38","author":"Mautner","year":"1996","journal-title":"Neurosurgery"},{"key":"ref_748","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/978-3-031-23705-8_12","article-title":"Schwannomas of Brain and Spinal Cord","volume":"1405","author":"Gerganov","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_749","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000331394","article-title":"What Is the Site of Origin of Cochleovestibular Schwannomas?","volume":"17","author":"Roosli","year":"2011","journal-title":"Audiol. Neurotol."},{"key":"ref_750","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.nec.2004.02.005","article-title":"Pathologic classification of peripheral nerve tumors","volume":"15","author":"Skovronsky","year":"2004","journal-title":"Neurosurg. Clin. N. Am."},{"key":"ref_751","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41419-023-06141-z","article-title":"Hearing loss and vestibular schwannoma: New insights into Schwann cells implication","volume":"14","author":"Mohamed","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_752","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/s41467-023-42762-w","article-title":"Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state","volume":"15","author":"Barrett","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_753","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/glia.20316","article-title":"Constitutive neuregulin-1\/ErbB signaling contributes to human vestibular schwannoma proliferation","volume":"53","author":"Hansen","year":"2006","journal-title":"Glia"},{"key":"ref_754","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1038\/sj.onc.1208730","article-title":"Activation of the neuregulin-1\/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors","volume":"24","author":"Stonecypher","year":"2005","journal-title":"Oncogene"},{"key":"ref_755","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.ajpath.2023.05.016","article-title":"Inhibition of Erb-B2 Receptor Tyrosine Kinase 3 and Associated Regulatory Pathways Potently Impairs Malignant Peripheral Nerve Sheath Tumor Proliferation and Survival","volume":"193","author":"Black","year":"2023","journal-title":"Am. J. Pathol."},{"key":"ref_756","doi-asserted-by":"crossref","first-page":"eabd4816","DOI":"10.1126\/scitranslmed.abd4816","article-title":"Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models","volume":"13","author":"Wu","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_757","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1148\/rg.2019180200","article-title":"Intradural Extramedullary Spinal Neoplasms: Radiologic-Pathologic Correlation","volume":"39","author":"Koeller","year":"2019","journal-title":"Radiographics"},{"key":"ref_758","first-page":"390","article-title":"Tumours of the nerve root sheath in the spine","volume":"53","author":"Allut","year":"2011","journal-title":"Rev. Neurol."},{"key":"ref_759","doi-asserted-by":"crossref","first-page":"3568359","DOI":"10.1155\/2017\/3568359","article-title":"Spinal Nerves Schwannomas: Experience on 367 Cases-Historic Overview on How Clinical, Radiological, and Surgical Practices Have Changed over a Course of 60 Years","volume":"2017","author":"Lenzi","year":"2017","journal-title":"Neurol. Res. Int."},{"key":"ref_760","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3171\/spi.2005.2.4.0447","article-title":"Spinal extradural schwannoma","volume":"2","author":"Celli","year":"2005","journal-title":"J. Neurosurg. Spine"},{"key":"ref_761","doi-asserted-by":"crossref","first-page":"191","DOI":"10.15386\/mpr-1708","article-title":"A clinicopathological study of peripheral schwannomas","volume":"94","author":"Majumder","year":"2021","journal-title":"Med. Pharm. Rep."},{"key":"ref_762","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3171\/2017.2.JNS153004","article-title":"Clinicopathological variables of sporadic schwannomas of peripheral nerve in 291 patients and expression of biologically relevant markers","volume":"129","author":"Young","year":"2018","journal-title":"J. Neurosurg."},{"key":"ref_763","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1053\/j.jfas.2016.12.003","article-title":"Peripheral Nerve Schwannoma: A Review of Varying Clinical Presentations and Imaging Findings","volume":"56","author":"Albert","year":"2017","journal-title":"J. Foot Ankle Surg."},{"key":"ref_764","doi-asserted-by":"crossref","unstructured":"Guedes, F., Zager, E.L., Garozzo, D., Rasulic, L., and Socolovsky, M. (2021). Schwannomatosis: Review of Diagnosis and Management. Diagnostic Assessment and Treatment of Peripheral Nerve Tumors, Springer International Publishing.","DOI":"10.1007\/978-3-030-77633-6"},{"key":"ref_765","first-page":"91","article-title":"Neurofibromatosis type 2","volume":"70","author":"Evans","year":"2011","journal-title":"Adv. Otorhinolaryngol."},{"key":"ref_766","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1750-1172-4-16","article-title":"Neurofibromatosis type 2 (NF2): A clinical and molecular review","volume":"4","author":"Evans","year":"2009","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_767","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1016\/j.gim.2022.05.007","article-title":"Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation","volume":"24","author":"Plotkin","year":"2022","journal-title":"Genet. Med."},{"key":"ref_768","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1212\/WNL.0000000000003418","article-title":"Revisiting neurofibromatosis type 2 diagnostic criteria to exclude LZTR1-related schwannomatosis","volume":"88","author":"Smith","year":"2017","journal-title":"Neurology"},{"key":"ref_769","doi-asserted-by":"crossref","first-page":"e38957","DOI":"10.1016\/j.heliyon.2024.e38957","article-title":"Typical NF2 and LTZR1 Mutations Are Retained in an Immortalized Human Schwann Cell Model of Schwannomatosis","volume":"10","author":"Melfi","year":"2024","journal-title":"Heliyon"},{"key":"ref_770","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1177\/0300985819846872","article-title":"Schwannosis in Three Foals and a Calf","volume":"56","author":"Miranda","year":"2019","journal-title":"Vet. Pathol."},{"key":"ref_771","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0090-3019(87)90031-0","article-title":"Chronic regenerative changes in the spinal cord after cord compression injury in rats","volume":"27","author":"Wallace","year":"1987","journal-title":"Surg. Neurol."},{"key":"ref_772","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s004010050411","article-title":"The expression of nerve growth factor receptor on Schwann cells and the effect of these cells on the regeneration of axons in traumatically injured human spinal cord","volume":"91","author":"Wang","year":"1996","journal-title":"Acta Neuropathol."},{"key":"ref_773","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/neu.2000.17.781","article-title":"Schwannosis: Role of gliosis and proteoglycan in human spinal cord injury","volume":"17","author":"Bruce","year":"2000","journal-title":"J. Neurotrauma"},{"key":"ref_774","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/bpa.12009","article-title":"A 32-year-old male with brainstem lesions","volume":"23","author":"Kanakis","year":"2013","journal-title":"Brain Pathol."},{"key":"ref_775","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1212\/WNL.22.7.726","article-title":"Intramedullary nerve fiber and Schwann cell proliferation within the spinal cord (schwannosis)","volume":"22","author":"Adelman","year":"1972","journal-title":"Neurology"},{"key":"ref_776","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00686861","article-title":"Intraspinal schwannosis of Lissauer\u2019s zone terminalis (formes frustes of Recklinghausen\u2019s neurofibromatosis or reactive?)","volume":"25","author":"Hori","year":"1973","journal-title":"Acta Neuropathol."},{"key":"ref_777","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1749-6632.1986.tb48058.x","article-title":"The malformative central nervous system lesions in the central and peripheral forms of neurofibromatosis. A neuropathological study of 22 cases","volume":"486","author":"Rubinstein","year":"1986","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_778","doi-asserted-by":"crossref","unstructured":"Owen, R.S., Ramarathinam, S.H., Bailey, A., Gastaldello, A., Hussey, K., Skipp, P.J., Purcell, A.W., and Siddle, H.V. (2021). The differentiation state of the Schwann cell progenitor drives phenotypic variation between two contagious cancers. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1010033"},{"key":"ref_779","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ccell.2018.03.013","article-title":"The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils","volume":"33","author":"Stammnitz","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_780","doi-asserted-by":"crossref","first-page":"e35314","DOI":"10.7554\/eLife.35314","article-title":"The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer","volume":"7","author":"Caldwell","year":"2018","journal-title":"eLife"},{"key":"ref_781","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s00018-019-03435-4","article-title":"Curse of the devil: Molecular insights into the emergence of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii)","volume":"77","author":"Patchett","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"ref_782","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1180616","article-title":"The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer","volume":"327","author":"Murchison","year":"2010","journal-title":"Science"},{"key":"ref_783","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1007\/s00018-019-03259-2","article-title":"Two of a kind: Transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii)","volume":"77","author":"Patchett","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"ref_784","doi-asserted-by":"crossref","unstructured":"Ong, C.E.B., Cheng, Y., Siddle, H.V., Lyons, A.B., Woods, G.M., and Flies, A.S. (2022). Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours. Open Biol., 12.","DOI":"10.1098\/rsob.220208"},{"key":"ref_785","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1016\/j.vaccine.2015.01.039","article-title":"Evidence for induction of humoral and cytotoxic immune responses against devil facial tumor disease cells in Tasmanian devils (Sarcophilus harrisii) immunized with killed cell preparations","volume":"33","author":"Kreiss","year":"2015","journal-title":"Vaccine"},{"key":"ref_786","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14760584.2020.1711058","article-title":"An oral bait vaccination approach for the Tasmanian devil facial tumor diseases","volume":"19","author":"Flies","year":"2020","journal-title":"Expert. Rev. Vaccines"},{"key":"ref_787","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.3748\/wjg.15.2287","article-title":"Mucosal Schwann cell \u201cHamartoma\u201d: A new entity?","volume":"15","author":"Pasquini","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_788","first-page":"223","article-title":"Mucosal Schwann cell hamartoma: A benign and little-known entity","volume":"116","year":"2024","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_789","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/PAS.0b013e31818dd6ca","article-title":"Mucosal Schwann cell \u201chamartoma\u201d: Clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas","volume":"33","author":"Gibson","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_790","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4132\/jptm.2016.07.02","article-title":"Mucosal Schwann Cell Hamartoma in Colorectal Mucosa: A Rare Benign Lesion That Resembles Gastrointestinal Neuroma","volume":"51","author":"Han","year":"2017","journal-title":"J. Pathol. Transl. Med."},{"key":"ref_791","first-page":"e57674","article-title":"Schwann Cell Hamartoma Presenting as a Colonic Polyp: A Rare Case Report with a Literature Review","volume":"16","author":"Altaf","year":"2024","journal-title":"Cureus"},{"key":"ref_792","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/glia.23045","article-title":"Proteomics and transcriptomics of peripheral nerve tissue and cells unravel new aspects of the human Schwann cell repair phenotype","volume":"64","author":"Weiss","year":"2016","journal-title":"Glia"},{"key":"ref_793","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/ejn.13055","article-title":"Human Schwann-like cells derived from adipose-derived mesenchymal stem cells rapidly de-differentiate in the absence of stimulating medium","volume":"43","author":"Faroni","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"ref_794","doi-asserted-by":"crossref","unstructured":"Horner, S.J., Couturier, N., Gueiber, D.C., Hafner, M., and Rudolf, R. (2022). Development and In Vitro Differentiation of Schwann Cells. Cells, 11.","DOI":"10.3390\/cells11233753"},{"key":"ref_795","doi-asserted-by":"crossref","unstructured":"Hopf, A., Schaefer, D.J., Kalbermatten, D.F., Guzman, R., and Madduri, S. (2020). Schwann Cell-Like Cells: Origin and Usability for Repair and Regeneration of the Peripheral and Central Nervous System. Cells, 9.","DOI":"10.3390\/cells9091990"},{"key":"ref_796","doi-asserted-by":"crossref","unstructured":"Zhang, M., Jiang, M.H., Kim, D.W., Ahn, W., Chung, E., Son, Y., and Chi, G. (2017). Comparative Analysis of the Cell Fates of Induced Schwann Cells from Subcutaneous Fat Tissue and Naive Schwann Cells in the Sciatic Nerve Injury Model. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/1252851"},{"key":"ref_797","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.stemcr.2017.04.011","article-title":"Schwann Cell Precursors from Human Pluripotent Stem Cells as a Potential Therapeutic Target for Myelin Repair","volume":"8","author":"Kim","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_798","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13287-020-01772-x","article-title":"Directly induced human Schwann cell precursors as a valuable source of Schwann cells","volume":"11","author":"Kim","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_799","doi-asserted-by":"crossref","first-page":"14","DOI":"10.15283\/ijsc22008","article-title":"Direct Conversion to Achieve Glial Cell Fates: Oligodendrocytes and Schwann Cells","volume":"15","author":"Yun","year":"2022","journal-title":"Int. J. Stem Cells"},{"key":"ref_800","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.neuron.2014.06.016","article-title":"Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration","volume":"83","author":"Painter","year":"2014","journal-title":"Neuron"},{"key":"ref_801","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.conb.2017.10.022","article-title":"Aging Schwann cells: Mechanisms, implications, future directions","volume":"47","author":"Painter","year":"2017","journal-title":"Curr. Opin. 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