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This review documents the key clinical and laboratory features that have either been discovered since the previous update (published August 2004) or were characterized earlier but have since been confirmed or expanded in subsequent studies. These advancements regarding regulation of insulin secretion, pancreatic regeneration, apoptosis and carcinogenesis, and gene expression and growth factors provide a deeper understanding of how the autonomic nervous system interacts with the pancreas, offering potential avenues for therapeutic interventions in pancreatic diseases.<\/jats:p>","DOI":"10.3390\/cells14171371","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T15:02:57Z","timestamp":1756825377000},"page":"1371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recent Advancements in the Relationship Between the Autonomic Nervous System and the Pancreas, Encompassing the Regulation of Regeneration and Apoptosis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2183-9174","authenticated-orcid":false,"given":"Takayoshi","family":"Kiba","sequence":"first","affiliation":[{"name":"Department of Medical Technology, Faculty of Life Sciences, Okayama University of Science, Okayama 700-0005, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1097\/00006676-200408000-00019","article-title":"Relationships between the autonomic nervous system and the pancreas including regulation of regeneration and apoptosis: Recent developments","volume":"29","author":"Kiba","year":"2004","journal-title":"Pancreas"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Estefan\u00eda, M.M., Ganier, O., Hern\u00e1ndez, P., Schvartzman, J.B., Mechali, M., and Krimer, D.B. (2012). DNA replication fading as proliferating cells advance in their commitment to terminal differentiation. Sci. Rep., 2.","DOI":"10.1038\/srep00279"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1002\/dvdy.21740","article-title":"Biphasic Ngn3 expression in the developing pancreas","volume":"237","author":"Villasenor","year":"2008","journal-title":"Dev. Dyn."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1210\/er.2007-0016","article-title":"An illustrated review of early pancreas development in the mouse","volume":"28","author":"Hald","year":"2007","journal-title":"Endocr. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1210\/en.2005-0997","article-title":"Islet endothelial cells and pancreatic beta-cell proliferation: Studies in vitro and during pregnancy in adult rats","volume":"147","author":"Johansson","year":"2006","journal-title":"Endocrinology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.mod.2009.09.006","article-title":"Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation","volume":"126","author":"Zhang","year":"2009","journal-title":"Mech. Dev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1387\/ijdb.072444cb","article-title":"Genes controlling pancreas ontogeny","volume":"52","author":"Bonal","year":"2008","journal-title":"Int. J. Dev. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Pavlinkova, G., and Smolik, O. (2024). NEUROD1: Transcriptional and epigenetic regulator of human and mouse neuronal and endocrine cell lineage programs. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1435546"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3727\/000000006783981431","article-title":"Induction of pancreatic stem\/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology","volume":"15","author":"Noguchi","year":"2006","journal-title":"Cell Transplant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"36482","DOI":"10.1074\/jbc.M109.028852","article-title":"MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells","volume":"284","author":"Neve","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.2174\/092986709788802980","article-title":"Combination of MafA, PDX-1 and NeuroD is a useful tool to efficiently induce insulin-producing surrogate beta-cells","volume":"16","author":"Kaneto","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.2337\/db10-0190","article-title":"MafA and MafB regulate genes critical to beta-cells in a unique temporal manner","volume":"59","author":"Artner","year":"2010","journal-title":"Diabetes"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ydbio.2005.07.021","article-title":"Prox1 activity controls pancreas morphogenesis and participates in the production of \u201csecondary transition\u201d pancreatic endocrine cells","volume":"286","author":"Wang","year":"2005","journal-title":"Dev. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1111\/febs.16075","article-title":"Ptf1a function and transcriptional cis-regulation, a cornerstone in vertebrate pancreas development","volume":"289","author":"Duque","year":"2022","journal-title":"FEBS J."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Aftab, S., Semenec, L., Chu, J.S., and Chen, N. (2008). Identification and characterization of novel human tissue-specific RFX transcription factors. BMC Evol. Biol., 8.","DOI":"10.1186\/1471-2148-8-226"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2337\/db09-0986","article-title":"The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression","volume":"59","author":"Bonal","year":"2010","journal-title":"Diabetes"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nature08748","article-title":"Rfx6 directs islet formation and insulin production in mice and humans","volume":"463","author":"Smith","year":"2010","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1677\/JOE-08-0296","article-title":"Identification and action of N-myc downstream regulated gene 4 A2 in rat pancreas","volume":"201","author":"Wang","year":"2009","journal-title":"J. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.devcel.2009.05.012","article-title":"Sox17 regulates organ lineage segregation of ventral foregut progenitor cells","volume":"17","author":"Spence","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ydbio.2009.07.017","article-title":"Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration","volume":"334","author":"Anderson","year":"2009","journal-title":"Dev. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5688\/aj710478","article-title":"Physiology of the autonomic nervous system","volume":"71","author":"McCorry","year":"2007","journal-title":"Am. J. Pharm. Educ."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Lkhagvasuren, B., Mee-Inta, O., Zhao, Z.W., Hiramoto, T., Boldbaatar, D., and Kuo, Y.M. (2021). Pancreas-Brain Crosstalk. Front. Neuroanat., 15.","DOI":"10.3389\/fnana.2021.691777"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"G1113","DOI":"10.1152\/ajpgi.00177.2006","article-title":"Substance P treatment stimulates chemokine synthesis in pancreatic acinar cells via the activation of NF-\u03baB","volume":"291","author":"Ramnath","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"G10","DOI":"10.1152\/ajpgi.00077.2010","article-title":"The islet-acinar axis of the pancreas: More than just insulin","volume":"299","author":"Barreto","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF02784941","article-title":"Neural regulation of the endocrine pancreas","volume":"18","author":"Brunicardi","year":"1995","journal-title":"Int. J. Pancreatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1196\/annals.1447.033","article-title":"Islet glia, neurons, and beta cells","volume":"1150","author":"Tsui","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s001250051322","article-title":"Autonomic regulation of islet hormone secretion\u2014Implications for health and disease","volume":"43","year":"2000","journal-title":"Diabetologia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1097-0029(19970601)37:5\/6<399::AID-JEMT4>3.0.CO;2-9","article-title":"Distribution and ultrastructure of the autonomic nerves in the mouse pancreas","volume":"37","author":"Ushiki","year":"1997","journal-title":"Microsc. Res. Tech."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"151880","DOI":"10.1016\/j.aanat.2021.151880","article-title":"Prenatal development of sympathetic innervation of the human pancreas","volume":"240","author":"Krivova","year":"2022","journal-title":"Ann. Anat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.neuroscience.2008.04.050","article-title":"Spatial and temporal dynamics of innervation during the development of fetal human pancreas","volume":"154","author":"Amella","year":"2008","journal-title":"Neuroscience"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.autneu.2006.10.001","article-title":"Autonomic pathways regulating pancreatic exocrine secretion","volume":"133","author":"Love","year":"2007","journal-title":"Auton. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000201527","article-title":"Regulation of interdigestive gastrointestinal motility and secretion","volume":"58","author":"DiMagno","year":"1997","journal-title":"Digestion"},{"key":"ref_33","first-page":"1","article-title":"Regulation of Pancreatic Secretion","volume":"10","author":"Chandra","year":"2015","journal-title":"Pancreapedia Exocrine Pancreas Knowl. Base"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/nm.2371","article-title":"Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans","volume":"17","author":"Dando","year":"2011","journal-title":"Nat. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/cne.21736","article-title":"Distribution and neurochemical identification of pancreatic afferents in the mouse","volume":"509","author":"Fasanella","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"ref_36","first-page":"26","article-title":"Neurology and neuropathology of the pancreatic innervation","volume":"3","author":"Salvioli","year":"2002","journal-title":"JOP"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"MacDonald, A.J., Yang, Y.H.C., Cruz, A.M., Beall, C., and Ellacott, K.L.J. (2021). Brain-Body Control of Glucose Homeostasis\u2014Insights from Model Organisms. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.662769"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.numecd.2013.09.006","article-title":"Increased density of inhibitory noradrenergic parenchymal nerve fibers in hypertrophic islets of Langerhans of obese mice","volume":"24","author":"Giannulis","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1677\/joe.0.1480531","article-title":"Expression of alpha 2 and beta-adrenoceptor subtypes in human islets of Langerhans","volume":"148","author":"Lacey","year":"1996","journal-title":"J. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/S1262-3636(10)70466-3","article-title":"Central control of glucose homeostasis: The brain\u2013endocrine pancreas axis","volume":"36","author":"Thorens","year":"2010","journal-title":"Diabetes Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1007\/s00125-009-1494-5","article-title":"Loss of islet sympathetic nerves and impairment of glucagon secretion in the NOD mouse: Relationship to invasive insulitis","volume":"52","author":"Taborsky","year":"2009","journal-title":"Diabetologia"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Campbell-Thompson, M., Butterworth, E.A., Boatwright, J.L., Nair, M.A., Nasif, L.H., Nasif, K., Revell, A.Y., Riva, A., Mathews, C.E., and Gerling, I.C. (2021). Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-85659-8"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/dom.12346","article-title":"Neural regulation of pancreatic islet cell mass and function","volume":"16","author":"Thorens","year":"2014","journal-title":"Diabetes Obes. Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"E96","DOI":"10.1152\/ajpendo.00415.2006","article-title":"Hypoglycemic detection at the portal vein is mediated by capsaicin-sensitive primary sensory neurons","volume":"293","author":"Fujita","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-4684-5931-9_10","article-title":"Neural control of islet function by norepinephrine and sympathetic neuropeptides","volume":"291","author":"Dunning","year":"1991","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"E378","DOI":"10.1152\/ajpendo.2001.280.2.E378","article-title":"Parasympathetic inhibition of sympathetic neural activity to the pancreas","volume":"280","author":"Benthem","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2337\/diab.38.9.1193","article-title":"Hypoglycemia in IDDM","volume":"38","author":"Cryer","year":"1989","journal-title":"Diabetes"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.2337\/diabetes.51.10.2997","article-title":"Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats","volume":"51","author":"Mei","year":"2002","journal-title":"Diabetes"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1007\/s00125-012-2699-6","article-title":"3-D imaging and illustration of the perfusive mouse islet sympathetic innervation and its remodelling in injury","volume":"55","author":"Chiu","year":"2012","journal-title":"Diabetologia"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"21456","DOI":"10.1073\/pnas.1211659110","article-title":"Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function","volume":"109","author":"Speier","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1267\/ahc.11052","article-title":"Temporal and Spatial Cellular Distribution of Neural Crest Derivatives and Alpha Cells during Islet Development","volume":"45","author":"Shimada","year":"2012","journal-title":"Acta Histochem. Cytochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.neuroscience.2007.09.079","article-title":"Pancreatic innervation in mouse development and beta-cell regeneration","volume":"150","author":"Burris","year":"2007","journal-title":"Neuroscience"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Cabrera-V\u00e1squez, S., Navarro-Tableros, V., S\u00e1nchez-Soto, C., Guti\u00e9rrez-Ospina, G., and Hiriart, M. (2009). Remodelling sympathetic innervation in rat pancreatic islets ontogeny. BMC Dev. Biol., 9.","DOI":"10.1186\/1471-213X-9-34"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Proshchina, A.E., Krivova, Y.S., Barabanov, V.M., and Saveliev, S.V. (2014). Ontogeny of neuro-insular complexes and islets innervation in the human pancreas. Front. Endocrinol., 5.","DOI":"10.3389\/fendo.2014.00057"},{"key":"ref_55","first-page":"465","article-title":"Nerve growth factor and its receptors in the human fetal pancreas","volume":"38","year":"2009","journal-title":"Pancreas"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1242\/dev.091256","article-title":"GDNF is required for neural colonization of the pancreas","volume":"140","author":"Pascual","year":"2013","journal-title":"Development"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1097-0185(20010101)262:1<1::AID-AR1006>3.0.CO;2-2","article-title":"Enteric neural crest-derived cells: Origin, identification, migration, and differentiation","volume":"262","author":"Young","year":"2001","journal-title":"Anat. Rec."},{"key":"ref_58","unstructured":"Kandel, E.R., Schwartz, J.H., and Jessell, T.M. (2000). Principles of Neural Science, McGraw-Hill. [4th ed.]."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.celrep.2013.06.019","article-title":"Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation","volume":"4","author":"Borden","year":"2013","journal-title":"Cell Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"E786","DOI":"10.1152\/ajpendo.00202.2010","article-title":"Vagal control of pancreatic \u03b2-cell proliferation","volume":"299","author":"Lausier","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/1096-9861(20010319)431:4<405::AID-CNE1079>3.0.CO;2-D","article-title":"Parasympathetic and sympathetic control of the pancreas: A role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake","volume":"431","author":"Buijs","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1523\/JNEUROSCI.4523-03.2004","article-title":"Heterogeneous requirement of NGF for sympathetic target innervation in vivo","volume":"24","author":"Glebova","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0092-8674(89)90412-1","article-title":"Directed expression of NGF to pancreatic beta cells in transgenic mice leads to selective hyperinnervation of the islets","volume":"58","author":"Edwards","year":"1989","journal-title":"Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1172\/JCI107292","article-title":"Glucagon release induced by pancreatic nerve stimulation in the dog","volume":"52","author":"Marliss","year":"1973","journal-title":"J. Clin. Investig."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1172\/JCI113763","article-title":"Pancreatic noradrenergic nerves are activated by neuroglucopenia but not by hypotension or hypoxia in the dog","volume":"82","author":"Havel","year":"1988","journal-title":"J. Clin. Investig."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1242\/dev.015859","article-title":"Signals from the neural crest regulate beta-cell mass in the pancreas","volume":"135","author":"Nekrep","year":"2008","journal-title":"Development"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s00125-017-4408-y","article-title":"Pancreatic neuro-insular network in young mice revealed by 3D panoramic histology","volume":"61","author":"Tang","year":"2018","journal-title":"Diabetologia"},{"key":"ref_68","first-page":"297","article-title":"Immunocytochemical study of tyrosine hydroxylase and dopamine \u03b2-hydroxylase immunoreactivities in the rat pancreas","volume":"57","author":"Oomori","year":"1994","journal-title":"Arch. Histol. Cytol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.autneu.2004.11.004","article-title":"Noradrenergic innervation of rabbit pancreatic ganglia","volume":"117","author":"Yi","year":"2005","journal-title":"Auton. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11010-006-9142-6","article-title":"Enhanced beta-adrenergic receptors in the brain and pancreas during pancreatic regeneration in weanling rats","volume":"289","author":"Das","year":"2006","journal-title":"Mol. Cell Biochem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/07435800500406163","article-title":"Muscarinic M1 and M3 receptor binding alterations in pancreas during pancreatic regeneration of young rats","volume":"31","author":"Renuka","year":"2005","journal-title":"Endocr. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.2337\/db06-S013","article-title":"Neuropeptides and the Regulation of Islet Function","volume":"55","author":"Ahren","year":"2006","journal-title":"Diabetes"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.2337\/diab.40.11.1365","article-title":"Structural and Functional Considerations of GABA in Islets of Langerhans: \u03b2-Cells and Nerves","volume":"40","author":"Sorenson","year":"1991","journal-title":"Diabetes"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1210\/endo.137.8.8754779","article-title":"Localization of gamma-aminobutyric acid and glutamic acid decarboxylase in the pancreas of the nonobese diabetic mouse","volume":"137","author":"Faveeuw","year":"1996","journal-title":"Endocrinology"},{"key":"ref_75","unstructured":"J\u00e4nig, W. (2022). Functional Anatomy of the Peripheral Sympathetic and Parasympathetic Systems. The Integrative Action of the Autonomic Nervous System: Neurobiology of Homeostasis, Cambridge University Press."},{"key":"ref_76","first-page":"565","article-title":"Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function","volume":"22","author":"Gilon","year":"2001","journal-title":"Endocr. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/0016-5085(95)90702-5","article-title":"Pancreatic polypeptide microinjection into the dorsal motor nucleus inhibits pancreatic secretion in rats","volume":"108","author":"Okumura","year":"1995","journal-title":"Gastroenterology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.00062.2017","article-title":"Distribution and function of the muscarinic receptor subtypes in the cardiovascular system","volume":"50","author":"Saternos","year":"2018","journal-title":"Physiol. Genom."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.2337\/db13-1371","article-title":"Control of insulin secretion by cholinergic signaling in the human pancreatic islet","volume":"63","author":"Molina","year":"2014","journal-title":"Diabetes"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.ebiom.2015.11.003","article-title":"Modulation of Autoimmune T-Cell Memory by Stem Cell Educator Therapy: Phase 1\/2 Clinical Trial","volume":"2","author":"Delgado","year":"2015","journal-title":"EBioMedicine"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cmet.2006.04.009","article-title":"A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo","volume":"3","author":"Gautam","year":"2006","journal-title":"Cell Metab."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/35065604","article-title":"Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean","volume":"410","author":"Yamada","year":"2001","journal-title":"Nature"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0304-4157(98)00011-2","article-title":"MARCKS, membranes, and calmodulin: Kinetics of their interaction","volume":"1376","author":"Arbuzova","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cmet.2011.05.008","article-title":"Innervation patterns of autonomic axons in the human endocrine pancreas","volume":"14","author":"Abdulreda","year":"2011","journal-title":"Cell Metab."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1172\/JCI117483","article-title":"Involvement of the autonomic nervous system in the in vivo memory to glucose of pancreatic beta cell in rats","volume":"94","author":"Magnan","year":"1994","journal-title":"J. Clin. Investig."},{"key":"ref_86","first-page":"577","article-title":"Characterization of vagal innervation of the rat pancreas using lectin horseradish peroxidase conjugates","volume":"6","author":"Berthoud","year":"1982","journal-title":"J. Auton. Nerv. Syst."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1210\/en.2011-2040","article-title":"Minireview: The Role of the Autonomic Nervous System in Mediating the Glucagon Response to Hypoglycemia","volume":"153","author":"Taborsky","year":"2012","journal-title":"Endocrinology"},{"key":"ref_88","first-page":"E1034","article-title":"Vagotomy in young obese hyperglycemic mice: Effects on syndrome development and islet proliferation","volume":"274","author":"Edvell","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"G461","DOI":"10.1152\/ajpgi.00119.2003","article-title":"Musings on the wanderer: What\u2019s new in our understanding of vago-vagal reflexes? V. Remodeling of vagus and enteric neural circuitry after vagal injury","volume":"285","author":"Li","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_90","first-page":"E644","article-title":"Glucose-induced changes in pancreatic islet blood flow mediated by central nervous system","volume":"251","author":"Jansson","year":"1986","journal-title":"Am. J. Physiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.1163971","article-title":"Regulation of pancreatic beta cell mass by neuronal signals from the liver","volume":"322","author":"Imai","year":"2008","journal-title":"Science"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1053\/gast.1996.v110.pm8608899","article-title":"Ventromedial hypothalamic lesion-induced vagal hyperactivity stimulates rat pancreatic cell proliferation","volume":"110","author":"Kiba","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1172\/JCI69154","article-title":"Nervous glucose sensing regulates postnatal \u03b2 cell proliferation and glucose homeostasis","volume":"124","author":"Tarussio","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41421-022-00485-0","article-title":"Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas","volume":"9","author":"Zhao","year":"2023","journal-title":"Cell Discov."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/284033a0","article-title":"Neural regulation of pancreatic hormone secretion by the C-terminal tetrapeptide of CCK","volume":"284","author":"Rehfeld","year":"1980","journal-title":"Nature"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.lfs.2010.03.021","article-title":"Central infusion of leptin improves insulin resistance and suppresses beta cell function, but not beta-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat model","volume":"86","author":"Park","year":"2010","journal-title":"Life Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12307-018-0207-3","article-title":"Role of the Nervous System in Tumor Angiogenesis","volume":"11","author":"Kuol","year":"2018","journal-title":"Cancer Microenviron."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41420-021-00450-y","article-title":"Role of the nervous system in cancers: A review","volume":"7","author":"Wang","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000464420","article-title":"Gene Expression Analysis in Rat Pancreas Observed with Whole-Transcript Exon Array after Ventromedial Hypothalamic Lesions","volume":"24","author":"Kiba","year":"2017","journal-title":"Ann. Neurosci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1158\/0008-5472.CAN-14-3180","article-title":"Nerve-Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression","volume":"75","author":"Jobling","year":"2015","journal-title":"Cancer Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1095\/biolreprod51.1.99","article-title":"Growth of the rat prostate gland is facilitated by the autonomic nervous system","volume":"51","author":"McVary","year":"1994","journal-title":"Biol. Reprod."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbi.2015.12.014","article-title":"Sympathetic innervation, norepinephrine content, and norepinephrine turnover in orthotopic and spontaneous models of breast cancer","volume":"53","author":"Szpunar","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/ncponc1134","article-title":"Do stress-related psychosocial factors contribute to cancer incidence and survival?","volume":"5","author":"Chida","year":"2008","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1158\/0008-5472.CAN-13-2050","article-title":"Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma","volume":"74","author":"Stopczynski","year":"2014","journal-title":"Cancer Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.aah5072","article-title":"Adrenergic nerves activate an angio-metabolic switch in prostate cancer","volume":"358","author":"Zahalka","year":"2017","journal-title":"Science"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41392-020-0205-z","article-title":"Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies","volume":"5","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41586-019-1219-y","article-title":"Progenitors from the central nervous system drive neurogenesis in cancer","volume":"569","author":"Mauffrey","year":"2019","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1236361","DOI":"10.1126\/science.1236361","article-title":"Autonomic nerve development contributes to prostate cancer progression","volume":"341","author":"Magnon","year":"2013","journal-title":"Science"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41419-019-2116-x","article-title":"Schwann cells support oncogenic potential of pancreatic cancer cells through TGF\u03b2 signaling","volume":"10","author":"Roger","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S1470-2045(09)70337-7","article-title":"Role of nervous system in cancer aetiopathogenesis","volume":"11","author":"Ondicova","year":"2010","journal-title":"Lancet Oncol."},{"key":"ref_111","first-page":"825","article-title":"Norepinephrine-induced invasion by pancreatic cancer cells is inhibited by propranolol","volume":"22","author":"Guo","year":"2009","journal-title":"Oncol. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ijc.24063","article-title":"Is norepinephrine an etiological factor in some types of cancer?","volume":"124","author":"Fitzgerald","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature10368","article-title":"A stress response pathway regulates DNA damage through \u03b22-adrenoreceptors and \u03b2-arrestin-1","volume":"477","author":"Hara","year":"2011","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13046-025-03377-9","article-title":"Tumor-associated macrophages remodel the suppressive tumor immune microenvironment and targeted therapy for immunotherapy","volume":"44","author":"Yang","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/JLB.MR0218-056RR","article-title":"The emerging roles of macrophages in cancer metastasis and response to chemotherapy","volume":"106","author":"Sanchez","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1158\/2159-8290.CD-18-0046","article-title":"Cholinergic signaling via muscarinic receptors directly and indirectly suppresses pancreatic tumorigenesis and cancer stemness","volume":"8","author":"Renz","year":"2018","journal-title":"Cancer Discov."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"22501","DOI":"10.18632\/oncotarget.15019","article-title":"Subdiaphragmatic vagotomy promotes tumor growth and reduces survival via TNF\u03b1 in a murine pancreatic cancer model","volume":"8","author":"Partecke","year":"2017","journal-title":"Oncotarget"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1158\/0008-5472.CAN-11-0908","article-title":"STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis","volume":"71","author":"Corcoran","year":"2011","journal-title":"Cancer Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1349-7006.2006.00340.x","article-title":"Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro","volume":"97","author":"Huang","year":"2006","journal-title":"Cancer Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/cncr.23231","article-title":"GABA B receptor is a novel drug target for pancreatic cancer","volume":"112","author":"Schuller","year":"2008","journal-title":"Cancer"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"10389","DOI":"10.1158\/0008-5472.CAN-07-0858","article-title":"Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer","volume":"67","author":"Landen","year":"2007","journal-title":"Cancer Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1158\/1535-7163.MCT-12-0809","article-title":"Interaction of the sympathetic nerve with pancreatic cancer cells promotes perineural invasion through the activation of STAT3 signaling","volume":"12","author":"Guo","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"250ra115","DOI":"10.1126\/scitranslmed.3009569","article-title":"Denervation suppresses gastric tumorigenesis","volume":"6","author":"Zhao","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1172\/JCI34587","article-title":"Chop deletion reduces oxidative stress, improves \u03b2 cell function, and promotes cell survival in multiple mouse models of diabetes","volume":"118","author":"Song","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/onc.2012.163","article-title":"Nicotine\/cigarette smoke promotes metastasis of pancreatic cancer through \u03b17nAChR-mediated MUC4 upregulation","volume":"32","author":"Momi","year":"2013","journal-title":"Oncogene"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/JTO.0000000000000066","article-title":"Overexpression of muscarinic receptor 3 promotes metastasis and predicts poor prognosis in non-small-cell lung cancer","volume":"9","author":"Lin","year":"2014","journal-title":"J. Thorac. Oncol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2016.11.005","article-title":"Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling","volume":"31","author":"Hayakawa","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1038\/ncomms7744","article-title":"Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets","volume":"6","author":"Witkiewicz","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1136\/jclinpath-2018-205124","article-title":"TRKA expression and NTRK1 gene copy number across solid tumours","volume":"71","author":"Mauri","year":"2018","journal-title":"J. Clin. Pathol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41571-018-0113-0","article-title":"NTRK fusion-positive cancers and TRK inhibitor therapy","volume":"15","author":"Cocco","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cancergen.2025.03.006","article-title":"Mutation status in yes-associated protein 1 (YAP1) in an insulinoma cell line Rin-5F","volume":"294\u2013295","author":"Kiba","year":"2025","journal-title":"Cancer Genet."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jneuroim.2005.10.017","article-title":"Neural-immune interactions: An integrative view of the bidirectional relationship between the brain and immune systems","volume":"172","author":"Wrona","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Dalle, S., Abderrahmani, A., and Renard, E. (2023). Pharmacological inhibitors of \u03b2-cell dysfunction and death as therapeutics for diabetes. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1076343"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Kendall, D.A., and Yudowski, G.A. (2017). Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease. Front. Cell. Neurosci., 10.","DOI":"10.3389\/fncel.2016.00294"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Kim, J., Lee, K.J., Kim, J.S., Rho, J.G., Shin, J.J., Song, W.K., Lee, E.K., Egan, J.M., Kim, W., and Jo, D.-G. (2016). Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic \u03b2 Cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150981"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nm.3265","article-title":"Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes","volume":"19","author":"Jourdan","year":"2013","journal-title":"Nat. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1172\/JCI44011","article-title":"Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic \u03b2 cell death and diabetes","volume":"120","author":"Fujimoto","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12964-025-02135-w","article-title":"The inducible role of autophagy in cell death: Emerging evidence and future perspectives","volume":"23","author":"Huang","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"bqac184","DOI":"10.1210\/endocr\/bqac184","article-title":"Inside the \u03b2 Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis","volume":"164","author":"Kulkarni","year":"2022","journal-title":"Endocrinology"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"10305","DOI":"10.1073\/pnas.1402571111","article-title":"CTSH regulates \u03b2-cell function and disease progression in newly diagnosed type 1 diabetes patients","volume":"111","author":"Brorsson","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1007\/s10620-024-08530-6","article-title":"Circulating Markers of Necroptosis in Acute Pancreatitis","volume":"69","author":"Belfrage","year":"2024","journal-title":"Dig. Dis. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/febs.14738","article-title":"Necroptosis directly induces the release of full-length biologically active IL-33 in vitro and in an inflammatory disease model","volume":"8","author":"Shlomovitz","year":"2019","journal-title":"FEBS J."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: Past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1111\/jdi.13691","article-title":"Autonomic dysfunction, diabetes and metabolic syndrome","volume":"12","author":"Yu","year":"2021","journal-title":"J. Diabetes Investig."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.peptides.2008.02.022","article-title":"Ghrelin infused into the portal vein inhibits glucose-stimulated insulin secretion in Wistar rats","volume":"29","author":"Cui","year":"2008","journal-title":"Peptides"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"C1793","DOI":"10.1152\/ajpcell.00168.2025","article-title":"GLP-1 and ghrelin inversely regulate insulin secretion and action in pancreatic islets, vagal afferents, and hypothalamus for controlling glycemia and feeding","volume":"328","author":"Yada","year":"2025","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.2337\/db05-1665","article-title":"Metabolic sensors mediate hypoglycemic detection at the portal vein","volume":"55","author":"Matveyenko","year":"2006","journal-title":"Diabetes"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0896-6273(03)00063-1","article-title":"The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis","volume":"37","author":"Cowley","year":"2003","journal-title":"Neuron"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.2337\/db10-1088","article-title":"Final answer: Ghrelin can suppress insulin secretion in humans, but is it clinically relevant?","volume":"59","author":"Meyer","year":"2010","journal-title":"Diabetes"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1365-2265.2010.03865.x","article-title":"Ghrelin inhibits autonomic function in healthy controls, but has no effect on obese and vagotomized subjects","volume":"73","author":"Huda","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Yu, Q., Guo, Q., Jin, S., Gao, C., Zheng, P., Li, D.P., and Wu, Y. (2023). Melatonin suppresses sympathetic vasomotor tone through enhancing GABAA receptor activity in the hypothalamus. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1166246"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.3390\/ijms14046981","article-title":"Melatonin and pancreatic islets: Interrelationships between melatonin, insulin and glucagon","volume":"14","author":"Peschke","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cmet.2016.04.009","article-title":"Increased melatonin signaling is a risk factor for type 2 diabetes","volume":"23","author":"Tuomi","year":"2016","journal-title":"Cell Metab."},{"key":"ref_154","first-page":"164","article-title":"Overexpression of Pdx-1 Gene increases Ins1 gene mRNA expression, not Ins2 Gene mRNA expression, in insulionoma cell line RIN-5F","volume":"18","author":"Kiba","year":"2022","journal-title":"Acta Endocrinol."},{"key":"ref_155","first-page":"277","article-title":"Overexpression of PTEN Gene increases Ins2 gene mRNA expression, not Ins1 gene mRNA expression, In insulinoma cell line RIN-5F","volume":"19","author":"Kiba","year":"2023","journal-title":"Acta Endocrinol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2337\/diabetes.50.1.51","article-title":"Amplitude modulation of pulsatile insulin secretion by intrapancreatic ganglion neurons","volume":"50","author":"Sha","year":"2001","journal-title":"Diabetes"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Lee, B., Song, T., Lee, K., Kim, J., Han, S., Berggren, P.O., Ryu, S.H., and Jo, J. (2017). Phase modulation of insulin pulses enhances glucose regulation and enables inter-islet synchronization. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0172901"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.bpj.2009.05.016","article-title":"Synchronization of pancreatic islet oscillations by intrapancreatic ganglia: A modeling study","volume":"97","author":"Fendler","year":"2009","journal-title":"Biophys. J."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1053\/j.gastro.2004.05.002","article-title":"New insights into neurohormonal regulation of pancreatic secretion","volume":"127","author":"Owyang","year":"2004","journal-title":"Gastroenterology"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41392-024-02098-3","article-title":"Pancreatic endocrine and exocrine signaling and crosstalk in physiological and pathological status","volume":"10","author":"Hu","year":"2025","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/17\/1371\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:38:16Z","timestamp":1760035096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/17\/1371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":160,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["cells14171371"],"URL":"https:\/\/doi.org\/10.3390\/cells14171371","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]}}}