{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:25:50Z","timestamp":1790371550724,"version":"4.1.0"},"reference-count":107,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bodossaki Foundation","award":["BDA-1479"],"award-info":[{"award-number":["BDA-1479"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Over recent years, epitranscriptomic research has provided a new layer of gene regulation during hematopoietic development and aberrant hematopoiesis. Among the 170 identified RNA chemical marks, N6-methyladenosine (m6A) is the most abundant in eukaryotic cells and plays a critical role in various biological processes. This dynamic modification is regulated by a series of methyltransferases, demethylases, and m6A binding proteins, known as writers, erasers, and readers, respectively. Emerging evidence suggests that m6A modification and its regulators are involved in every aspect of normal hematopoietic development, from the emergence of hematopoietic stem cells to the generation of mature blood cells. Also, it has been established that abnormal expression of m6A regulators is implicated in the initiation of blood diseases. In this review, we summarize the latest findings regarding the role of m6A in erythropoiesis and highlight its implications in the pathophysiology of hemoglobin disorders.<\/jats:p>","DOI":"10.3390\/cells14171388","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T12:18:18Z","timestamp":1757074698000},"page":"1388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["m6A mRNA Methylation in Hematopoiesis: The Importance of Writing, Erasing, and Reading"],"prefix":"10.3390","volume":"14","author":[{"given":"Antonia-Gerasimina","family":"Vasilopoulou","sequence":"first","affiliation":[{"name":"Laboratory of Cell and Gene Therapy, Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Kalafati","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Gene Therapy, Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6246-3885","authenticated-orcid":false,"given":"Ekati","family":"Drakopoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Gene Therapy, Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.","family":"Anagnou","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Gene Therapy, Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.stem.2008.11.011","article-title":"Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation","volume":"4","author":"Cui","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e11813","DOI":"10.7554\/eLife.11813","article-title":"Epigenetic regulation of hematopoiesis by DNA methylation","volume":"5","author":"Gore","year":"2016","journal-title":"eLife"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.celrep.2019.07.032","article-title":"m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment","volume":"28","author":"Cheng","year":"2019","journal-title":"Cell Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"m6A-dependent regulation of messenger RNA stability","volume":"505","author":"Wang","year":"2013","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1021\/bi00627a023","article-title":"Nucleotide Sequences at the N6-Methyladenosine Sites of HeLa Cell Messenger Ribonucleic Acid","volume":"16","author":"Wei","year":"1977","journal-title":"Biochemistry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","article-title":"Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells","volume":"71","author":"Desrosiers","year":"1974","journal-title":"Proc. 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