{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:24Z","timestamp":1787027844251,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Modern Agricultural Industrial Technology System lnnovation Team of Guangdong Province","award":["2024CXTD22"],"award-info":[{"award-number":["2024CXTD22"]}]},{"name":"the Modern Agricultural Industrial Technology System lnnovation Team of Guangdong Province","award":["NCTIP-XDB14"],"award-info":[{"award-number":["NCTIP-XDB14"]}]},{"name":"the Modern Agricultural Industrial Technology System lnnovation Team of Guangdong Province","award":["2024B03J1305"],"award-info":[{"award-number":["2024B03J1305"]}]},{"name":"the Modern Agricultural Industrial Technology System lnnovation Team of Guangdong Province","award":["2023-4408X1-29060200"],"award-info":[{"award-number":["2023-4408X1-29060200"]}]},{"name":"the National Center of Technology Innovation for Pigs","award":["2024CXTD22"],"award-info":[{"award-number":["2024CXTD22"]}]},{"name":"the National Center of Technology Innovation for Pigs","award":["NCTIP-XDB14"],"award-info":[{"award-number":["NCTIP-XDB14"]}]},{"name":"the National Center of Technology Innovation for Pigs","award":["2024B03J1305"],"award-info":[{"award-number":["2024B03J1305"]}]},{"name":"the National Center of Technology Innovation for Pigs","award":["2023-4408X1-29060200"],"award-info":[{"award-number":["2023-4408X1-29060200"]}]},{"name":"Science and Technology Program of Guangzhou","award":["2024CXTD22"],"award-info":[{"award-number":["2024CXTD22"]}]},{"name":"Science and Technology Program of Guangzhou","award":["NCTIP-XDB14"],"award-info":[{"award-number":["NCTIP-XDB14"]}]},{"name":"Science and Technology Program of Guangzhou","award":["2024B03J1305"],"award-info":[{"award-number":["2024B03J1305"]}]},{"name":"Science and Technology Program of Guangzhou","award":["2023-4408X1-29060200"],"award-info":[{"award-number":["2023-4408X1-29060200"]}]},{"name":"the Breed Industry Innovation Park of Guangdong Xiaoerhua Pig","award":["2024CXTD22"],"award-info":[{"award-number":["2024CXTD22"]}]},{"name":"the Breed Industry Innovation Park of Guangdong Xiaoerhua Pig","award":["NCTIP-XDB14"],"award-info":[{"award-number":["NCTIP-XDB14"]}]},{"name":"the Breed Industry Innovation Park of Guangdong Xiaoerhua Pig","award":["2024B03J1305"],"award-info":[{"award-number":["2024B03J1305"]}]},{"name":"the Breed Industry Innovation Park of Guangdong Xiaoerhua Pig","award":["2023-4408X1-29060200"],"award-info":[{"award-number":["2023-4408X1-29060200"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Long non-coding RNAs (lncRNAs) are essential regulatory molecules involved in various biological processes in mammals. However, their expression patterns across multiple porcine tissues have not been systematically characterized. We analyzed 607 RNA-seq datasets derived from 14 porcine tissues, including backfat, gallbladder, heart, ileum, jejunum, kidney, longissimus dorsi, liver, lung, skeletal muscle, ovary, pituitary, skeletal muscle, and spleen. Additionally, we examined 63 single-cell RNA-seq datasets from porcine primary oocytes at five developmental stages. For comparative analysis, we included 20 human and 17 mouse oocyte RNA-seq datasets. We identified 52,798 porcine lncRNAs, with tissue-specific expression patterns most prominent in oocytes and least in skeletal muscle. Among them, 2169 were classified as housekeeping and 14,469 as tissue-specific lncRNAs. Cross-species analysis revealed that a small subset of oocyte-expressed lncRNAs is conserved in humans and mice, associated with catalytic activity and circadian regulation. Additionally, 44 lncRNAs were differentially expressed during oocyte development, implicating them in neurogenesis, vesicle transport, and protein modification. Our findings not only contribute to the growing body of knowledge regarding lncRNAs in porcine biology but also pave the way for future research aimed at elucidating their functional roles in reproductive biology and other physiological processes.<\/jats:p>","DOI":"10.3390\/cells14181409","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T19:16:17Z","timestamp":1757445377000},"page":"1409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comprehensive Characterization of Long Non-Coding RNAs in Porcine Tissues: Expression Patterns and Functional Insights During Oocyte Development"],"prefix":"10.3390","volume":"14","author":[{"given":"Yao","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory of Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"},{"name":"Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia"},{"name":"School of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA 6150, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yipeng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory of Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingpeng","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory of Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3743-0130","authenticated-orcid":false,"given":"Xiaolong","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory of Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China"},{"name":"Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia"},{"name":"National Center of Technology Innovation for Pigs, Chongqing 402460, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8026-879X","authenticated-orcid":false,"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7053-0355","authenticated-orcid":false,"given":"Bin","family":"Ma","sequence":"additional","affiliation":[{"name":"Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia"},{"name":"School of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA 6150, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1093\/jas\/skz362","article-title":"A critical reflection on intensive pork production with an emphasis on animal health and welfare","volume":"98","author":"Maes","year":"2020","journal-title":"J. Anim. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e20210063","DOI":"10.1590\/1984-3143-ar2021-0063","article-title":"The neuroendocrine pathways and mechanisms for the control of the reproduction in female pigs","volume":"18","author":"Zhao","year":"2021","journal-title":"Anim. Reprod."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Jiang, Y., He, Y., Pan, X., Wang, P., Yuan, X., and Ma, B. (2023). Advances in Oocyte Maturation In Vivo and In Vitro in Mammals. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24109059"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Whitworth, K.M., Green, J.A., Redel, B.K., Geisert, R.D., Lee, K., Telugu, B.P., Wells, K.D., and Prather, R.S. (2022). Improvements in pig agriculture through gene editing. CABI Agric. Biosci., 3.","DOI":"10.1186\/s43170-022-00111-9"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ame2.12223","article-title":"Advances in pig models of human diseases","volume":"5","author":"Hou","year":"2022","journal-title":"Anim. Models Exp. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1177\/03009858231222235","article-title":"Swine models in translational research and medicine","volume":"61","author":"Meyerholz","year":"2024","journal-title":"Vet. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.livres.2024.09.003","article-title":"Genetic engineering drives the breakthrough of pig models in liver disease research","volume":"8","author":"Xu","year":"2024","journal-title":"Liver Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: Definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Chowdhary, A., Satagopam, V., and Schneider, R. (2021). Long Non-coding RNAs: Mechanisms, Experimental, and Computational Approaches in Identification, Characterization, and Their Biomarker Potential in Cancer. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.649619"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Statello, L., Guo, C.-J., Chen, L.-L., and Huarte, M. (2021). Gene regulation by long non-coding RNAs and its biological functions. Nat. Rev. Mol. Cell Biol., 22.","DOI":"10.1038\/s41580-021-00330-4"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Aliperti, V., Skonieczna, J., and Cerase, A. (2021). Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders. Non-Coding RNA, 7.","DOI":"10.3390\/ncrna7020036"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41576-024-00693-2","article-title":"Targeting and engineering long non-coding RNAs for cancer therapy","volume":"25","author":"Coan","year":"2024","journal-title":"Nat. Rev. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41698-022-00283-7","article-title":"Blood-derived lncRNAs as biomarkers for cancer diagnosis: The Good, the Bad and the Beauty","volume":"6","author":"Badowski","year":"2022","journal-title":"npj Precis. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Guh, C.-Y., Hsieh, Y.-H., and Chu, H.-P. (2020). Functions and properties of nuclear lncRNAs-from systematically mapping the interactomes of lncRNAs. J. Biomed. Sci., 27.","DOI":"10.1186\/s12929-020-00640-3"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Samaddar, S., and Banerjee, S. (2021). Far from the nuclear crowd: Cytoplasmic lncRNA and their implications in synaptic plasticity and memory. Neurobiol. Learn. Mem., 185.","DOI":"10.1016\/j.nlm.2021.107522"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/cac2.12108","article-title":"LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer","volume":"41","author":"Tan","year":"2021","journal-title":"Cancer Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ygeno.2020.09.001","article-title":"Identification of differentially expressed long non-coding RNAs and mRNAs in orbital adipose\/connective tissue of thyroid-associated ophthalmopathy","volume":"113","author":"Wu","year":"2021","journal-title":"Genomics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7120","DOI":"10.18632\/oncotarget.6859","article-title":"Identifying and functionally characterizing tissue-specific and ubiquitously expressed human lncRNAs","volume":"7","author":"Jiang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.ymthe.2023.02.008","article-title":"Roles of lncRNAs in brain development and pathogenesis: Emerging therapeutic opportunities","volume":"31","author":"Srinivas","year":"2023","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wang, S., Jin, J., Xu, Z., and Zuo, B. (2019). Functions and Regulatory Mechanisms of lncRNAs in Skeletal Myogenesis, Muscle Disease and Meat Production. Cells, 8.","DOI":"10.3390\/cells8091107"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.5713\/ab.22.0020","article-title":"Identification and functional prediction of long non-coding RNAs related to skeletal muscle development in Duroc pigs","volume":"35","author":"Ma","year":"2022","journal-title":"Anim. Biosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1089\/dna.2021.0220","article-title":"A New lncRNA, lnc-LLMA, Regulates Lipid Metabolism in Pig Hepatocytes","volume":"41","author":"Yu","year":"2022","journal-title":"DNA Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1038\/s41467-021-23560-8","article-title":"A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Gong, Y., He, J., Li, B., Xiao, Y., Zeng, Q., Xu, K., Duan, Y., He, J., and Ma, H. (2021). Integrated Analysis of lncRNA and mRNA in Subcutaneous Adipose Tissue of Ningxiang Pig. Biology, 10.","DOI":"10.3390\/biology10080726"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s00018-023-04873-x","article-title":"Single-cell multi-omics profiling reveals key regulatory mechanisms that poise germinal vesicle oocytes for maturation in pigs","volume":"80","author":"Yuan","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ceb.2012.03.006","article-title":"Small non-coding RNAs mount a silent revolution in gene expression","volume":"24","author":"Aalto","year":"2012","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41588-023-01620-7","article-title":"Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human","volume":"56","author":"Huang","year":"2024","journal-title":"Nat. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40781-018-0183-7","article-title":"Long non-coding RNA: Its evolutionary relics and biological implications in mammals: A review","volume":"60","author":"Dhanoa","year":"2018","journal-title":"J. Anim. Sci. Technol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Tsoi, S., Zhou, C., Grant, J.R., Pasternak, J., Dobrinsky, J., Rigault, P., Nieminen, J., Sirard, M.-A., Robert, C., and Foxcroft, G.R. (2012). Development of a porcine (Sus scofa) embryo-specific microarray: Array annotation and validation. BMC Genom., 13.","DOI":"10.1186\/1471-2164-13-370"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: An ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"304","DOI":"10.12688\/f1000research.23297.1","article-title":"GFF Utilities: GffRead and GffCompare","volume":"9","author":"Pertea","year":"2020","journal-title":"F1000Research"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1093\/nar\/gkt646","article-title":"Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts","volume":"41","author":"Sun","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"W12","DOI":"10.1093\/nar\/gkx428","article-title":"CPC2: A fast and accurate coding potential calculator based on sequence intrinsic features","volume":"45","author":"Kang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: An efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1038\/s41467-019-13056-x","article-title":"The art of using t-SNE for single-cell transcriptomics","volume":"10","author":"Kobak","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/ije\/dyq191","article-title":"The proof and measurement of association between two things","volume":"39","author":"Spearman","year":"2010","journal-title":"Int. J. Epidemiol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"She, X., Rohl, C.A., Castle, J.C., Kulkarni, A.V., Johnson, J.M., and Chen, R. (2009). Definition, conservation and epigenetics of housekeeping and tissue-enriched genes. BMC Genom., 10.","DOI":"10.1186\/1471-2164-10-269"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Gao, Y., Wang, J., and Zhao, F. (2015). CIRI: An efficient and unbiased algorithm for de novo circular RNA identification. Genome Biol., 16.","DOI":"10.1186\/s13059-014-0571-3"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Peng, C., Wang, S., Yu, J., Deng, X., Ye, H., Chen, Z., Yao, H., Cai, H., Li, Y., and Yuan, Y. (2022). lncRNA-mRNA Expression Patterns in Invasive Pituitary Adenomas: A Microarray Analysis. BioMed Res. Int., 2022.","DOI":"10.1155\/2022\/1380485"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: A graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Langfelder, P., and Horvath, S. (2008). WGCNA: An R package for weighted correlation network analysis. BMC Bioinform., 9.","DOI":"10.1186\/1471-2105-9-559"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"D1115","DOI":"10.1093\/nar\/gkab959","article-title":"The UCSC Genome Browser database: 2022 update","volume":"50","author":"Lee","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"111177","DOI":"10.1016\/j.mad.2019.111177","article-title":"Ageing-associated changes in the expression of lncRNAs in human tissues reflect a transcriptional modulation in ageing pathways","volume":"185","author":"Marttila","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Chen, X., and Sun, Z. (2021). Novel lincRNA Discovery and Tissue-Specific Gene Expression across 30 Normal Human Tissues. Genes, 12.","DOI":"10.3390\/genes12050614"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, W., Min, L., Qiu, X., Wu, X., Liu, C., Ma, J., Zhang, D., and Zhu, L. (2021). Biological Function of Long Non-coding RNA (LncRNA) Xist. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.645647"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1101\/gr.188839.114","article-title":"The pig X and Y Chromosomes: Structure, sequence, and evolution","volume":"26","author":"Skinner","year":"2016","journal-title":"Genome Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ernst, C., and Morton, C.C. (2013). Identification and function of long non-coding RNA. Front. Cell. Neurosci., 7.","DOI":"10.3389\/fncel.2013.00168"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","article-title":"Molecular mechanisms of long noncoding RNAs","volume":"43","author":"Wang","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ncrna.2025.01.004","article-title":"Long non-coding RNAs in humans: Classification, genomic organization and function","volume":"11","author":"Chodurska","year":"2025","journal-title":"Non-Coding RNA Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/path.5405","article-title":"Long non-coding RNAs in development and disease: Conservation to mechanisms","volume":"250","author":"Tsagakis","year":"2020","journal-title":"J. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-Colmenero, A., Oktaba, K., and Fernandez-Valverde, S.L. (2020). Evolution of Genome-Organizing Long Non-coding RNAs in Metazoans. Front. Genet., 11.","DOI":"10.3389\/fgene.2020.589697"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Wang, P., Paquet, \u00c9.R., and Robert, C. (2023). Comprehensive transcriptomic analysis of long non-coding RNAs in bovine ovarian follicles and early embryos. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0291761"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.7150\/jca.49067","article-title":"The patterns of antisense long non-coding RNAs regulating corresponding sense genes in human cancers","volume":"12","author":"Zhou","year":"2021","journal-title":"J. Cancer"},{"key":"ref_57","first-page":"337","article-title":"Influence of Long Non-Coding RNAs on Human Oocyte Development","volume":"17","author":"Wang","year":"2024","journal-title":"Pharmacogenom. Pers. Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"He, C., Wang, K., Gao, Y., Wang, C., Li, L., Liao, Y., Hu, K., and Liang, M. (2021). Roles of Noncoding RNA in Reproduction. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.777510"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/18\/1409\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:42:44Z","timestamp":1760035364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/18\/1409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":58,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["cells14181409"],"URL":"https:\/\/doi.org\/10.3390\/cells14181409","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,9]]}}}