{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:24Z","timestamp":1787027844057,"version":"build-2736575974"},"reference-count":240,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Nucleoporin 214 (NUP214) is a component of the nucleopore molecular complex, but in addition to this role in nucleocytoplasmic transport it is also involved in the regulation of gene transcription\/translation, intracellular signaling, cell cycle progression and programmed cell death. Several uncommon translocations associated with acute myeloid leukemia (AML) involve the NUP214 gene, and the corresponding fusion proteins are involved in leukemic transformation. First, the t(6;9) translocation encodes the DEK-NUP214 fusion protein; this translocation is seen in 1\u20132% of AML patients and is associated with an adverse prognosis that is improved by allogeneic stem cell transplantation. Second, the SET-NUP214 fusion gene is less common in AML and is formed either by del(9)(q34.11q34.13) or a balanced t(9;9)(q34;q34). This AML variant shows several biological similarities with the DEK-NUP214 variant, but the possible prognostic impact of this fusion protein is not known. Finally, the NUP214-ABL1 and especially the NUP214-SQSTM1 fusions are very uncommon, and only a few case reports have been published. In this article, we review the functions of the genes\/proteins formed by these fusion genes, the available studies of molecular mechanisms and biological functions for each fusion protein, the characteristics of the corresponding AML cells, the clinical characteristics of these patients and the possible prognostic impact of the fusion genes\/proteins.<\/jats:p>","DOI":"10.3390\/cells14181461","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:54:26Z","timestamp":1758200066000},"page":"1461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["NUP214 in Acute Myeloid Leukemia"],"prefix":"10.3390","volume":"14","author":[{"given":"\u00d8ystein","family":"Bruserud","sequence":"first","affiliation":[{"name":"Acute Leukemia Research Group, Department of Clinical Science, University of Bergen, 5007 Bergen, Norway"},{"name":"Section for Hematology, Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-8411","authenticated-orcid":false,"given":"H\u00e5kon","family":"Reikvam","sequence":"additional","affiliation":[{"name":"Acute Leukemia Research Group, Department of Clinical Science, University of Bergen, 5007 Bergen, Norway"},{"name":"Section for Hematology, Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Petrovic, S., Mobbs, G.W., Bley, C.J., Nie, S., Patke, A., and Hoelz, A. (2022). Structure and Function of the Nuclear Pore Complex. Cold Spring Harb. Perspect. Biol., 14.","DOI":"10.1101\/cshperspect.a041264"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1146\/annurev-biochem-062917-011901","article-title":"The Structure of the Nuclear Pore Complex (An Update)","volume":"88","author":"Lin","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zaitsava, H., Gachowska, M., Bartoszewska, E., Kmiecik, A., and Kulbacka, J. (2024). The Potential of Nuclear Pore Complexes in Cancer Therapy. Molecules, 29.","DOI":"10.3390\/molecules29204832"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Bruserud, \u00d8., Selheim, F., Hernandez-Valladares, M., and Reikvam, H. (2025). XPO1\/Exportin-1 in Acute Myelogenous Leukemia; Biology and Therapeutic Targeting. Biomolecules, 15.","DOI":"10.3390\/biom15020175"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1182\/blood-2016-11-750158","article-title":"A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia","volume":"129","author":"Garzon","year":"2017","journal-title":"Blood"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e566","DOI":"10.1016\/S2352-3026(20)30209-X","article-title":"Safety and activity of selinexor in patients with myelodysplastic syndromes or oligoblastic acute myeloid leukaemia refractory to hypomethylating agents: A single-centre, single-arm, phase 2 trial","volume":"7","author":"Taylor","year":"2020","journal-title":"Lancet Haematol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/s41375-022-01657-3","article-title":"Addition of the nuclear export inhibitor selinexor to standard intensive treatment for elderly patients with acute myeloid leukemia and high risk myelodysplastic syndrome","volume":"36","author":"Janssen","year":"2022","journal-title":"Leukemia"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1196\/annals.1392.019","article-title":"NUP98 dysregulation in myeloid leukemogenesis","volume":"1106","author":"Moore","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.1182\/blood-2011-07-328880","article-title":"NUP98 gene fusions and hematopoietic malignancies: Common themes and new biologic insights","volume":"118","author":"Gough","year":"2011","journal-title":"Blood"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s41375-025-02570-1","article-title":"XPO1-dependency of DEK:NUP214 leukemia","volume":"39","author":"Kloos","year":"2025","journal-title":"Leukemia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4161\/nucl.19674","article-title":"Dynamics and diverse functions of nuclear pore complex proteins","volume":"3","author":"Chatel","year":"2012","journal-title":"Nucleus"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.cellsig.2011.05.023","article-title":"Nucleoporins: Leaving the nuclear pore complex for a successful mitosis","volume":"23","author":"Chatel","year":"2011","journal-title":"Cell. Signal."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mendes, A., and Fahrenkrog, B. (2019). NUP214 in Leukemia: It\u2019s More than Transport. Cells, 8.","DOI":"10.3390\/cells8010076"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jmb.2006.08.021","article-title":"Changes in nucleoporin domain topology in response to chemical effectors","volume":"363","author":"Paulillo","year":"2006","journal-title":"J. Mol. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1083\/jcb.201411003","article-title":"Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold","volume":"208","author":"Gaik","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.cell.2013.10.055","article-title":"Integrated structural analysis of the human nuclear pore complex scaffold","volume":"155","author":"Bui","year":"2013","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.celrep.2015.09.042","article-title":"Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export","volume":"13","author":"Port","year":"2015","journal-title":"Cell Rep."},{"key":"ref_18","first-page":"579","article-title":"Prognostic importance of NUP98-rearrangements in acute myeloid leukemia: A systematic review and meta-analysis","volume":"15","author":"Sheikhi","year":"2024","journal-title":"Casp. J. Intern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e70013","DOI":"10.1002\/hem3.70013","article-title":"NUP98 oncofusions in myeloid malignancies: An update on molecular mechanisms and therapeutic opportunities","volume":"8","author":"Rasouli","year":"2024","journal-title":"Hemasphere"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.cell.2010.01.011","article-title":"Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm","volume":"140","author":"Kalverda","year":"2010","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1128\/MCB.18.3.1236","article-title":"Overexpression of the nucleoporin CAN\/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis","volume":"18","author":"Boer","year":"1998","journal-title":"Mol. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1002\/j.1460-2075.1996.tb00942.x","article-title":"G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN\/Nup214","volume":"15","author":"Boer","year":"1996","journal-title":"EMBO J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1128\/MCB.00124-10","article-title":"Specific nucleoporin requirement for Smad nuclear translocation","volume":"30","author":"Chen","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"22867","DOI":"10.1074\/jbc.M801320200","article-title":"Preferential utilization of Imp7\/8 in nuclear import of Smads","volume":"283","author":"Yao","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1097-2765(02)00586-5","article-title":"Smad2 nucleocytoplasmic shuttling by nucleoporins CAN\/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus","volume":"10","author":"Xu","year":"2002","journal-title":"Mol. Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"42569","DOI":"10.1074\/jbc.M307601200","article-title":"Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import","volume":"278","author":"Xu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.1038\/sj.onc.1208921","article-title":"Autocrine transforming growth factor-beta regulation of hematopoiesis: Many outcomes that depend on the context","volume":"24","author":"Ruscetti","year":"2005","journal-title":"Oncogene"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.1038\/sj.onc.1208923","article-title":"Deregulated TGF-beta signaling in leukemogenesis","volume":"24","author":"Lin","year":"2005","journal-title":"Oncogene"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12943-015-0299-z","article-title":"Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death","volume":"14","author":"Bhattacharjya","year":"2015","journal-title":"Mol. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.1038\/sj.onc.1210760","article-title":"Hox genes in hematopoiesis and leukemogenesis","volume":"26","author":"Argiropoulos","year":"2007","journal-title":"Oncogene"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41408-024-01004-y","article-title":"Regulation of HOX gene expression in AML","volume":"14","author":"Khan","year":"2024","journal-title":"Blood Cancer J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e46667","DOI":"10.7554\/eLife.46667","article-title":"Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells","volume":"8","author":"Oka","year":"2019","journal-title":"eLife"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e09540","DOI":"10.7554\/eLife.09540","article-title":"Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes","volume":"5","author":"Oka","year":"2016","journal-title":"Elife"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41375-024-02438-w","article-title":"NPM1-fusion proteins promote myeloid leukemogenesis through XPO1-dependent HOX activation","volume":"39","author":"Shimosato","year":"2025","journal-title":"Leukemia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1172\/JCI30182","article-title":"The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis","volume":"117","author":"Scholl","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.leukres.2018.07.021","article-title":"The clinical significance of CDX2 in leukemia: A new perspective for leukemia research","volume":"72","author":"Darvishi","year":"2018","journal-title":"Leuk. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.3324\/haematol.2019.223297","article-title":"The microRNA miR-196b acts as a tumor suppressor in Cdx2-driven acute myeloid leukemia","volume":"105","author":"Rawat","year":"2020","journal-title":"Haematologica"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1073\/pnas.0305555101","article-title":"Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia","volume":"101","author":"Rawat","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1182\/blood-2007-04-085407","article-title":"Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia","volume":"111","author":"Rawat","year":"2008","journal-title":"Blood"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.3324\/haematol.2010.023168","article-title":"Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis","volume":"95","author":"Koo","year":"2010","journal-title":"Haematologica"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"16924","DOI":"10.1073\/pnas.0604579103","article-title":"Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model","volume":"103","author":"Bansal","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.4161\/cc.6.18.4656","article-title":"HOX gene regulation in acute myeloid leukemia: CDX marks the spot?","volume":"6","author":"Scholl","year":"2007","journal-title":"Cell Cycle"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1172\/JCI64745","article-title":"CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPAR\u03b3 signaling","volume":"123","author":"Faber","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ccr.2010.04.024","article-title":"GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis","volume":"17","author":"Wang","year":"2010","journal-title":"Cancer Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.exphem.2015.05.012","article-title":"Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond","volume":"43","author":"Chen","year":"2015","journal-title":"Exp. Hematol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/sj.leu.2404233","article-title":"A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare \u2018poor prognosis\u2019 myeloid malignancies","volume":"20","author":"Slovak","year":"2006","journal-title":"Leukemia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.exphem.2023.05.002","article-title":"The impact of the chromatin binding DEK protein in hematopoiesis and acute myeloid leukemia","volume":"123","author":"Wilcher","year":"2023","journal-title":"Exp. Hematol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1038\/leu.2015.72","article-title":"The DEK oncoprotein and its emerging roles in gene regulation","volume":"29","author":"Gullberg","year":"2015","journal-title":"Leukemia"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/MOH.0000000000000344","article-title":"A role for intracellular and extracellular DEK in regulating hematopoiesis","volume":"24","author":"Capitano","year":"2017","journal-title":"Curr. Opin. Hematol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1158\/1078-0432.CCR-09-2330","article-title":"Control of tumorigenesis and chemoresistance by the DEK oncogene","volume":"16","author":"Soengas","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4161\/cc.23121","article-title":"Stacking the DEK: From chromatin topology to cancer stem cells","volume":"12","author":"Kappes","year":"2013","journal-title":"Cell Cycle"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/stem.1443","article-title":"Concise review: Role of DEK in stem\/progenitor cell biology","volume":"31","author":"Broxmeyer","year":"2013","journal-title":"Stem Cells"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6000","DOI":"10.1128\/MCB.24.13.6000-6010.2004","article-title":"Functional domains of the ubiquitous chromatin protein DEK","volume":"24","author":"Kappes","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1128\/MCB.24.13.6011-6020.2004","article-title":"Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK","volume":"24","author":"Kappes","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2004.08.029","article-title":"The DEK protein\u2014An abundant and ubiquitous constituent of mammalian chromatin","volume":"343","author":"Waldmann","year":"2004","journal-title":"Gene"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/s41594-025-01493-w","article-title":"Structural insights into how DEK nucleosome binding facilitates H3K27 trimethylation in chromatin","volume":"32","author":"Kujirai","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_57","first-page":"1739","article-title":"Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements","volume":"10","author":"Fornerod","year":"1995","journal-title":"Oncogene"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e20201974","DOI":"10.1084\/jem.20201974","article-title":"Nuclear DEK preserves hematopoietic stem cells potential via NCoR1\/HDAC3-Akt1\/2-mTOR axis","volume":"218","author":"Chen","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1242\/jcs.115.16.3319","article-title":"Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek","volume":"115","author":"Hollenbach","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1016\/j.febslet.2006.04.081","article-title":"Regulation of histone acetyltransferase activity of p300 and PCAF by proto-oncogene protein DEK","volume":"580","author":"Ko","year":"2006","journal-title":"FEBS Lett."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1093\/nar\/gkr454","article-title":"The human DEK oncogene regulates DNA damage response signaling and repair","volume":"39","author":"Kavanaugh","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Smith, E.A., Gole, B., Willis, N.A., Soria, R., Starnes, L.M., Krumpelbeck, E.F., Jegga, A.G., Ali, A.M., Guo, H., and Meetei, A.R. (2017). DEK is required for homologous recombination repair of DNA breaks. Sci. Rep., 7.","DOI":"10.1038\/srep44662"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1002\/1873-3468.14072","article-title":"Bacterial Growth Inhibition Screen (BGIS): Harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function","volume":"595","author":"Guo","year":"2021","journal-title":"FEBS Lett."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3892\/or.2022.8322","article-title":"DEK modulates both expression and alternative splicing of cancerrelated genes","volume":"47","author":"Liu","year":"2022","journal-title":"Oncol. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.devcel.2020.05.006","article-title":"Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit","volume":"53","author":"Yue","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1083\/jcb.150.2.309","article-title":"The acute myeloid leukemia- associated protein, DEK, forms a splicing-dependent interaction with exon- product complexes","volume":"50","author":"McGarvey","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"31760","DOI":"10.1074\/jbc.M500884200","article-title":"p300\/CBP-associated factor drives DEK into interchromatin granule clusters","volume":"280","author":"Cleary","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5758","DOI":"10.1002\/pmic.200600197","article-title":"Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform","volume":"6","author":"Tabbert","year":"2006","journal-title":"Proteomics"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"43395","DOI":"10.18632\/oncotarget.6028","article-title":"IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival","volume":"6","author":"Adams","year":"2015","journal-title":"Oncotarget"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Pease, N.A., Shephard, M.S., Sertorio, M., Waltz, S.E., and Vinnedge, L.M.P. (2020). DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages. Cancers, 12.","DOI":"10.3390\/cancers12071936"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.exphem.2017.12.009","article-title":"Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors","volume":"59","author":"Nattamai","year":"2018","journal-title":"Exp. Hematol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1038\/s41388-022-02278-x","article-title":"Exosomal DEK removes chemoradiotherapy resistance by triggering quiescence exit of breast cancer stem cells","volume":"41","author":"Yang","year":"2022","journal-title":"Oncogene"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1128\/MCB.00430-06","article-title":"Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions","volume":"26","author":"Allen","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"217446","DOI":"10.1016\/j.canlet.2025.217446","article-title":"FLT3 inhibitors induce p53 instability, driven by STAT5\/MDM2\/p53 competitive interactions in acute myeloid leukemia","volume":"611","author":"Pei","year":"2025","journal-title":"Cancer Lett."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Brenner, A.K., and Bruserud, \u00d8. (2019). Functional Toll-Like Receptors (TLRs) Are Expressed by a Majority of Primary Human Acute Myeloid Leukemia Cells and Inducibility of the TLR Signaling Pathway Is Associated with a More Favorable Phenotype. Cancers, 11.","DOI":"10.3390\/cancers11070973"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Bruserud, \u00d8., Reikvam, H., and Brenner, A.K. (2022). Toll-like Receptor 4, Osteoblasts and Leukemogenesis; the Lesson from Acute Myeloid Leukemia. Molecules, 27.","DOI":"10.3390\/molecules27030735"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1182\/blood.2023023105","article-title":"IL-1 in aging and pathologies of hematopoietic stem cells","volume":"144","author":"Caiado","year":"2024","journal-title":"Blood"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bcmd.2014.07.009","article-title":"DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML)","volume":"54","author":"Logan","year":"2015","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"23740","DOI":"10.18632\/oncotarget.8060","article-title":"The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1\u03b1-dependent and -independent manners","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"14252","DOI":"10.1038\/ncomms14252","article-title":"DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis","volume":"8","author":"Saha","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/art.30138","article-title":"DEK in the synovium of patients with juvenile idiopathic arthritis: Characterization of DEK antibodies and posttranslational modification of the DEK autoantigen","volume":"63","author":"Kappes","year":"2011","journal-title":"Arthritis Rheumatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"9484","DOI":"10.1128\/MCB.01030-06","article-title":"The DEK nuclear autoantigen is a secreted chemotactic factor","volume":"26","author":"Punturieri","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1073\/pnas.1220751110","article-title":"Intercellular trafficking of the nuclear oncoprotein DEK","volume":"110","author":"Saha","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1183\/09031936.03.00070303","article-title":"KL-6 levels are elevated in plasma from patients with acute respiratory distress syndrome","volume":"23","author":"Sato","year":"2004","journal-title":"Eur. Respir. J."},{"key":"ref_85","first-page":"1112","article-title":"Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis","volume":"31","author":"Yanaba","year":"2004","journal-title":"J. Rheumatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1172\/JCI127460","article-title":"Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling","volume":"129","author":"Capitano","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/JLB.3AB1120-740R","article-title":"DEK, a nuclear protein, is chemotactic for hematopoietic stem\/progenitor cells acting through CXCR2 and G\u03b1i signaling","volume":"112","author":"Capitano","year":"2022","journal-title":"J. Leukoc. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2040620720958586","DOI":"10.1177\/2040620720958586","article-title":"High CXCR2 expression predicts poor prognosis in adult patients with acute myeloid leukemia","volume":"11","author":"Tang","year":"2020","journal-title":"Ther. Adv. Hematol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Cao, H., Tadros, V., Hiramoto, B., Leeper, K., Hino, C., Xiao, J., Pham, B., Kim, D.H., Reeves, M.E., and Chen, C.S. (2022). Targeting TKI-Activated NFKB2-MIF\/CXCLs-CXCR2 Signaling Pathways in FLT3 Mutated Acute Myeloid Leukemia Reduced Blast Viability. Biomedicines, 10.","DOI":"10.3390\/biomedicines10051038"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.7717\/peerj.17862","article-title":"Prognostic role of chemokine-related genes in acute myeloid leukemia","volume":"12","author":"Hou","year":"2024","journal-title":"PeerJ"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Lu, C., Zhu, J., Chen, X., Hu, Y., Xie, W., Yao, J., and Huang, S. (2020). Risk Stratification in Acute Myeloid Leukemia Using CXCR Gene Signatures: A Bioinformatics Analysis. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.584766"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1080\/1042819031000119299","article-title":"Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia","volume":"44","author":"Casas","year":"2003","journal-title":"Leuk. Lymphoma"},{"key":"ref_93","first-page":"569","article-title":"Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis","volume":"87","author":"Larramendy","year":"2002","journal-title":"Haematologica"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s00277-022-04905-9","article-title":"Activation of signaling pathways in models of t(6;9)-acute myeloid leukemia","volume":"101","author":"Chiriches","year":"2022","journal-title":"Ann. Hematol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Chiriches, C., Nicolaisen, N., Wieske, M., Elhaddad, H., Mehmetbeyoglu, E., Alvares, C., Becher, D., Hole, P., Ottmann, O.G., and Ruthardt, M. (2022). Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation. PLoS Genet., 18.","DOI":"10.1371\/journal.pgen.1010463"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1038\/s41375-025-02593-8","article-title":"DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes","volume":"39","author":"Kaya","year":"2025","journal-title":"Leukemia"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1128\/MCB.00158-16","article-title":"Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-\u03baB Signaling Pathway","volume":"36","author":"Saito","year":"2016","journal-title":"Mol. Cell Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1046\/j.1365-2141.2001.03224.x","article-title":"Effect of cytokines on growth and differentiation of leukaemic cells with translocation t(6;9)(p23;q34)","volume":"115","author":"Matsushima","year":"2001","journal-title":"Br. J. Haematol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Sand\u00e9n, C., Ageberg, M., Petersson, J., Lennartsson, A., and Gullberg, U. (2013). Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR. BMC Cancer, 13.","DOI":"10.1186\/1471-2407-13-440"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.exphem.2007.01.018","article-title":"Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells","volume":"35","author":"Moore","year":"2007","journal-title":"Exp. Hematol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"9964","DOI":"10.18632\/oncotarget.7128","article-title":"FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia","volume":"7","author":"Chougule","year":"2016","journal-title":"Oncotarget"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1038\/onc.2016.118","article-title":"Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model","volume":"35","author":"Qin","year":"2016","journal-title":"Oncogene"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/s41379-021-00741-w","article-title":"Myelodysplastic syndrome with t(6;9)(p22;q34.1)\/DEK-NUP214 better classified as acute myeloid leukemia? A multicenter study of 107 cases","volume":"34","author":"Fang","year":"2021","journal-title":"Mod. Pathol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41375-023-02118-1","article-title":"Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD\/NPM1 Acute Myeloid Leukemia but with an altered HOX\/MEIS axis","volume":"38","author":"Potluri","year":"2024","journal-title":"Leukemia"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1038\/leu.2010.180","article-title":"The t(6;9) associated DEK\/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation","volume":"24","author":"Oancea","year":"2010","journal-title":"Leukemia"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/gcc.20531","article-title":"Identification of a novel and myeloid specific role of the leukemia-associated fusion protein DEK-NUP214 leading to increased protein synthesis","volume":"47","author":"Ageberg","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"378","DOI":"10.18632\/genesandcancer.39","article-title":"STAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AML","volume":"5","author":"Oancea","year":"2014","journal-title":"Genes Cancer"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1182\/blood-2009-06-227603","article-title":"Modeling the functional heterogeneity of leukemia stem cells: Role of STAT5 in leukemia stem cell self-renewal","volume":"114","author":"Heuser","year":"2009","journal-title":"Blood"},{"key":"ref_109","first-page":"13","article-title":"STAT5-mediated self-renewal of normal hematopoietic and leukemic stem cells","volume":"1","author":"Schepers","year":"2012","journal-title":"JAKSTAT"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41375-017-0005-9","article-title":"Pharmacologic inhibition of STAT5 in acute myeloid leukemia","volume":"32","author":"Wingelhofer","year":"2018","journal-title":"Leukemia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/sj.leu.2403835","article-title":"DEK-CAN molecular monitoring of myeloid malignancies could aid therapeutic stratification","volume":"19","author":"Libura","year":"2005","journal-title":"Leukemia"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.cancergencyto.2010.08.012","article-title":"The t(6;9)(p22;q34) in myeloid neoplasms: A retrospective study of 16 cases","volume":"203","author":"Gupta","year":"2010","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1309\/5DGB59KQA527PD47","article-title":"Acute myeloid leukemia with t(6;9)(p23;q34) is associated with dysplasia and a high frequency of flt3 gene mutations","volume":"122","author":"Oyarzo","year":"2004","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/ajcp\/107.4.430","article-title":"Acute myeloid leukemia with t(6;9) (p23;q34): Association with myelodysplasia, basophilia, and initial CD34 negative immunophenotype","volume":"107","author":"Alsabeh","year":"1997","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/leu.2011.350","article-title":"Prognostic factors for acute myeloid leukemia patients with t(6;9)(p23;q34) who underwent an allogeneic hematopoietic stem cell transplant","volume":"26","author":"Ishiyama","year":"2012","journal-title":"Leukemia"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/leu.2011.229","article-title":"Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with t(6;9)(p23;q34) dramatically improves the patient prognosis: A matched-pair analysis","volume":"26","author":"Ishiyama","year":"2012","journal-title":"Leukemia"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/bjh.12852","article-title":"Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children\u2019s Oncology Group","volume":"166","author":"Tarlock","year":"2014","journal-title":"Br. J. Haematol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3000605251327476","DOI":"10.1177\/03000605251327476","article-title":"Acute myeloid leukemia with DEK::NUP214 fusion resembling acute promyelocytic leukemia, initially presenting as sweet syndrome: A case report and literature review","volume":"53","author":"Liu","year":"2025","journal-title":"J. Int. Med. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1182\/blood.V96.13.4075","article-title":"Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: A Southwest Oncology Group\/Eastern Cooperative Oncology Group Study","volume":"96","author":"Slovak","year":"2000","journal-title":"Blood"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1182\/blood-2009-11-254441","article-title":"Refinement of cytogenetic classification in acute myeloid leukemia: Determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials","volume":"116","author":"Grimwade","year":"2010","journal-title":"Blood"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/bjh.16433","article-title":"Allogeneic stem cell transplantation in AML with t(6;9)(p23;q34);DEK-NUP214 shows a favourable outcome when performed in first complete remission","volume":"189","author":"Labopin","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1200\/JCO.2012.43.4738","article-title":"Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia","volume":"30","author":"Marcucci","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/bjh.16478","article-title":"Outcomes of allogeneic stem cell transplantation for patients with t(6:9) AML- A strong case for allogeneic stem cell transplantation in first complete remission","volume":"189","author":"Stahl","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_124","first-page":"3785","article-title":"FLT3 inhibitors potentially improve response rates in acute myeloid leukemia harboring t(6;9)(DEK::NUP214): The Mayo Clinic experience","volume":"109","author":"Csizmar","year":"2024","journal-title":"Haematologica"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood.2022016867","article-title":"Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN","volume":"140","author":"Wei","year":"2022","journal-title":"Blood"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"721","DOI":"10.6004\/jnccn.2019.0028","article-title":"Acute Myeloid Leukemia, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology","volume":"17","author":"Tallman","year":"2019","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3324\/haematol.2013.098517","article-title":"t(6;9)(p22;q34)\/DEK-NUP214-rearranged pediatric myeloid leukemia: An international study of 62 patients","volume":"99","author":"Sandahl","year":"2014","journal-title":"Haematologica"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0165-4608(89)90089-7","article-title":"Translocation t(6;9) occurring in acute myelofibrosis, myelodysplastic syndrome, and acute nonlymphocytic leukemia suggests multipotent stem cell involvement","volume":"42","author":"Cuneo","year":"1989","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0165-4608(98)00256-8","article-title":"6;9 translocation in myelodysplastic syndrome","volume":"112","author":"Shapira","year":"1999","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0165-4608(87)90040-9","article-title":"Translocation t(6;9)(p22.3;q34) in myelodysplastic syndrome--refractory anemia with excess blasts","volume":"29","author":"Fan","year":"1987","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e29294","DOI":"10.1097\/MD.0000000000029294","article-title":"The characteristics and prognostic significance of the SET-CAN\/NUP214 fusion gene in hematological malignancies: A systematic review","volume":"101","author":"Wang","year":"2022","journal-title":"Medicine"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Song, J., Li, H., and Fan, S. (2023). SET-CAN\/NUP214 fusion gene in leukemia: General features and clinical advances. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1269531"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1182\/blood-2013-08-521518","article-title":"SET-NUP214 is a recurrent \u03b3\u03b4 lineage-specific fusion transcript associated with corticosteroid\/chemotherapy resistance in adult T-ALL","volume":"123","author":"Roggy","year":"2014","journal-title":"Blood"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/mc.23480","article-title":"Blast phase of chronic myeloid leukemia with concurrent BCR::ABL1 and SET::NUP214: A report of two cases","volume":"62","author":"Chen","year":"2023","journal-title":"Mol. Carcinog."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2147\/IJGM.S294715","article-title":"SET-NUP214 Fusion Gene Involved Early T-Cell Precursor Acute Lymphoblastic Leukemia in Adult with B Marker Expression","volume":"14","author":"Xu","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2217\/epi-2019-0181","article-title":"SET protein modulates H4 histone methylation status and regulates miR-137 level in oral squamous cell carcinoma","volume":"12","author":"Sousa","year":"2020","journal-title":"Epigenomics"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.3892\/mmr.2016.5049","article-title":"Construction of SET overexpression vector and its effects on the proliferation and apoptosis of 293T cells","volume":"13","author":"Wang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ng.2696","article-title":"Somatic SETBP1 mutations in myeloid malignancies","volume":"45","author":"Makishima","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/leu.2010.294","article-title":"PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect","volume":"25","author":"Cirauqui","year":"2011","journal-title":"Leukemia"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1182\/blood-2009-06-227363","article-title":"SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia","volume":"115","author":"Blanco","year":"2010","journal-title":"Blood"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.1074\/jbc.271.19.11059","article-title":"The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A","volume":"271","author":"Li","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.1182\/blood-2011-10-388710","article-title":"Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10","volume":"119","author":"Oakley","year":"2012","journal-title":"Blood"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/leu.2014.301","article-title":"SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS","volume":"29","author":"Inoue","year":"2015","journal-title":"Leukemia"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature19759","article-title":"Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode","volume":"538","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1016\/j.febslet.2014.06.053","article-title":"Inhibition of FoxO1 acetylation by INHAT subunit SET\/TAF-I\u03b2 induces p21 transcription","volume":"588","author":"Chae","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molmed.2017.02.001","article-title":"p21: A Two-Faced Genome Guardian","volume":"23","author":"Georgakilas","year":"2017","journal-title":"Trends Mol. Med."},{"key":"ref_147","first-page":"1051","article-title":"High levels of constitutive WAF1\/Cip1 protein are associated with chemoresistance in acute myelogenous leukemia","volume":"1","author":"Zhang","year":"1995","journal-title":"Clin. Cancer Res."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Shamloo, B., and Usluer, S. (2019). p21 in Cancer Research. Cancers, 11.","DOI":"10.3390\/cancers11081178"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrc2657","article-title":"p21 in cancer: Intricate networks and multiple activities","volume":"9","author":"Abbas","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Bruserud, \u00d8., Selheim, F., Hernandez-Valladares, M., and Reikvam, H. (2024). Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25126356"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.leukres.2017.01.028","article-title":"miR-137 downregulates c-kit expression in acute myeloid leukemia","volume":"57","author":"Hu","year":"2017","journal-title":"Leuk. Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1515\/med-2021-0003","article-title":"TRIM25 contributes to the malignancy of acute myeloid leukemia and is negatively regulated by microRNA-137","volume":"16","author":"Wang","year":"2020","journal-title":"Open Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1073\/pnas.0603762104","article-title":"Relationship between the structure of SET\/TAF-Ibeta\/INHAT and its histone chaperone activity","volume":"104","author":"Muto","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s00018-007-7305-6","article-title":"Histone chaperones: 30 years from isolation to elucidation of the mechanisms of nucleosome assembly and disassembly","volume":"65","author":"Eitoku","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1073\/pnas.92.10.4279","article-title":"Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis","volume":"92","author":"Nagata","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"30850","DOI":"10.1074\/jbc.M404969200","article-title":"A signaling role of histone-binding proteins and INHAT subunits pp32 and Set\/TAF-Ib in integrating chro matin hypoacetylation and transcriptional repression","volume":"279","author":"Kutney","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"23859","DOI":"10.1074\/jbc.C400151200","article-title":"Direct binding of INHAT to H3 tails disrupted by modifications","volume":"279","author":"Schneider","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0092-8674(01)00196-9","article-title":"Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein","volume":"104","author":"Seo","year":"2001","journal-title":"Cell"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"8528","DOI":"10.1128\/MCB.23.23.8528-8541.2003","article-title":"Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation onthe DNA-bindingdomain","volume":"23","author":"Miyamoto","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"28758","DOI":"10.1074\/jbc.M302228200","article-title":"Functional interaction of the DNA binding transcription factor Sp1 through its DNA-binding domain with the histone chaperone TAF-I","volume":"278","author":"Suzuki","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1210\/me.2002-0280","article-title":"A novel estrogen receptor a-associated protein, template-activating factor Ib, inhibits acetylation and trans activation","volume":"17","author":"Loven","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.embor.7400309","article-title":"Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET","volume":"6","author":"Telese","year":"2005","journal-title":"EMBO Rep."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cancergencyto.2010.05.010","article-title":"Molecular characterization of alternative SET-NUP214 fusion transcripts in a case of acute undifferentiated leukemia","volume":"201","author":"Kim","year":"2010","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1182\/blood-2007-09-111872","article-title":"The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia","volume":"111","author":"Tchinda","year":"2008","journal-title":"Blood"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1756-8722-2-3","article-title":"SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines","volume":"2","author":"Quentmeier","year":"2009","journal-title":"J. Hematol. Oncol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1073\/pnas.91.4.1519","article-title":"The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm","volume":"91","author":"Kraemer","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_167","first-page":"3346","article-title":"Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3\u2019 half to different genes: Characterization of the set gene","volume":"12","author":"Wiegant","year":"1992","journal-title":"Mol. Cell Biol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"23068","DOI":"10.1074\/jbc.M116.735340","article-title":"The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export","volume":"291","author":"Port","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Mendes, A., J\u00fchlen, R., Bousbata, S., and Fahrenkrog, B. (2020). Disclosing the Interactome of Leukemogenic NUP98-HOXA9 and SET-NUP214 Fusion Proteins Using a Proteomic Approach. Cells, 9.","DOI":"10.3390\/cells9071666"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.18632\/oncotarget.27711","article-title":"Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements","volume":"11","author":"Mendes","year":"2020","journal-title":"Oncotarget"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3324\/haematol.10148","article-title":"Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cells","volume":"92","author":"Bruserud","year":"2007","journal-title":"Haematologica"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/gtc.12886","article-title":"SET-NUP214 and MLL cooperatively regulate the promoter activity of the HoxA10 gene","volume":"26","author":"Cigdem","year":"2021","journal-title":"Genes Cells"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Antunes, E.T.B., and Ottersbach, K. (2020). The MLL\/SET family and haematopoiesis. Biochim. Biophys. Acta Gene Regul. Mech., 1863.","DOI":"10.1016\/j.bbagrm.2020.194579"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e191355","DOI":"10.1172\/JCI191355","article-title":"HoxBlinc: A key driver of chromatin dynamics in NUP98 fusion-driven leukemia","volume":"135","author":"Xu","year":"2025","journal-title":"J. Clin. Investig."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/jcp.21199","article-title":"Impairment of erythroid and megakaryocytic differentiation by a leukemia-associated and t(9;9)-derived fusion gene product, SET\/TAF-Ibeta-CAN\/Nup214","volume":"214","author":"Saito","year":"2008","journal-title":"J. Cell Physiol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"654","DOI":"10.2353\/ajpath.2007.060934","article-title":"SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice","volume":"171","author":"Ozbek","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/sj.leu.2403227","article-title":"Effects of SET and SET-CAN on the differentiation of the human promonocytic cell line U937","volume":"18","author":"Kandilci","year":"2004","journal-title":"Leukemia"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"112884","DOI":"10.1016\/j.celrep.2023.112884","article-title":"Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1\/CRM1 and rearrangement of 3D genome structure","volume":"42","author":"Oka","year":"2023","journal-title":"Cell Rep"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"14451","DOI":"10.3390\/ijms241914451","article-title":"Unusual Presentation of SET::NUP214-Associated Concomitant Hematological Neoplasm in a Child-Diagnostic and Treatment Struggle","volume":"24","author":"Menchits","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3343\/alm.2019.39.4.403","article-title":"A Rare Case of Acute Myeloid Leukemia With SET-NUP214 Fusion and Massive Hyperdiploidy","volume":"39","author":"Jeong","year":"2019","journal-title":"Ann. Lab. Med."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/jcb.22101","article-title":"Oncogenic nucleoporin CAN\/Nup214 interacts with vitamin D receptor and modulates its function","volume":"106","author":"Miyauchi","year":"2009","journal-title":"J. Cell Biochem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.celrep.2019.12.055","article-title":"Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow","volume":"30","author":"Paubelle","year":"2020","journal-title":"Cell Rep."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Shen, Y., Yang, D., Zhang, R., Chen, X., Ma, Q., Wei, J., Zhai, W., Pang, A., He, Y., and Jiang, E. (2023). The outcome of acute leukemia patients with SET-NUP214 fusion after allogeneic stem cell transplantation. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1256043"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/1061186X.2016.1245307","article-title":"SET protein overexpression contributes to paclitaxel resistance in MCF-7\/S cells through PI3K\/Akt pathway","volume":"25","author":"Zhang","year":"2017","journal-title":"J. Drug Target."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/10428194.2023.2277672","article-title":"Comprehensive genomic profiling reveals molecular subsets of ASXL1-mutated myeloid neoplasms","volume":"65","author":"Johnson","year":"2024","journal-title":"Leuk Lymphoma"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1182\/bloodadvances.2020003443","article-title":"SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD-mutant AML","volume":"5","author":"Pacharne","year":"2021","journal-title":"Blood Adv."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Arriazu, E., Pippa, R., and Odero, M.D. (2016). Protein Phosphatase 2A as a Therapeutic Target in Acute Myeloid Leukemia. Front. Oncol., 6.","DOI":"10.3389\/fonc.2016.00078"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1038\/leu.2008.242","article-title":"Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases","volume":"22","author":"Versele","year":"2008","journal-title":"Leukemia"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1128\/MCB.01454-13","article-title":"The capable ABL: What is its biological function?","volume":"34","author":"Wang","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nrm3207","article-title":"Thenucleoskeletonasagenome-associated dynamic \u2018network of networks","volume":"12","author":"Simon","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"15174","DOI":"10.1073\/pnas.93.26.15174","article-title":"Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic nuclear transport","volume":"93","author":"Lewis","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"re6","DOI":"10.1126\/scisignal.3139re6","article-title":"ABL tyrosine kinases: Evolution of function, regulation, and specificity","volume":"3","author":"Colicelli","year":"2010","journal-title":"Sci. Signal."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"27104","DOI":"10.1074\/jbc.M100559200","article-title":"2001. Inhibition of c-Abl tyrosine kinase activity by filamentous actin","volume":"276","author":"Woodring","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ncb0104-3","article-title":"Controlling Abl: Auto-inhibition and co-inhibition?","volume":"6","author":"Wang","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0092-8674(93)90497-E","article-title":"A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle","volume":"75","author":"Welch","year":"1993","journal-title":"Cell"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/sj.cr.7290261","article-title":"Roleof c-Abl in the DNAdamagestress response","volume":"15","author":"Shaul","year":"2005","journal-title":"Cell Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0092-8674(03)00194-6","article-title":"Structural basis for the autoinhibition of c-Abl tyrosine kinase","volume":"112","author":"Nagar","year":"2003","journal-title":"Cell"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"22823","DOI":"10.1074\/jbc.271.37.22823","article-title":"Binding of A\/T-rich DNA by three high mobility group-like domains in c-Abl tyrosine kinase","volume":"271","author":"Miao","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nsb0903-679","article-title":"The CTD code","volume":"10","author":"Buratowski","year":"2003","journal-title":"Nat. Struct. Biol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nature12201","article-title":"KAT5 tyrosine phosphorylation couples chro matin sensing to ATM signalling","volume":"498","author":"Kaidi","year":"2013","journal-title":"Nature"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0609.2011.01586.x","article-title":"ABL1 fusion genes in hematological malignancies: A review","volume":"86","author":"Rowe","year":"2011","journal-title":"Eur. J. Haematol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3892\/ol.2014.2263","article-title":"NUP214 fusion genes in acute leukemia (Review)","volume":"8","author":"Zhou","year":"2014","journal-title":"Oncol. Lett."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"e30203","DOI":"10.1002\/pbc.30203","article-title":"NUP214::ABL1: A Ph-like fusion found in a pediatric acute myeloid leukemia patient with normal karyotype","volume":"70","author":"Gamba","year":"2023","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Wang, H.P., He, J.J., Zhu, Q.Y., Wang, L., Li, J.H., Huang, J.S., Xie, W.Z., Zhu, H.H., and Jin, J. (2021). Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.706798"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Ikeda, D., Chi, S., Uchiyama, S., Nakamura, H., Guo, Y.M., Yamauchi, N., Yuda, J., and Minami, Y. (2022). Molecular Classification and Overcoming Therapy Resistance for Acute Myeloid Leukemia with Adverse Genetic Factors. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115950"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.pathol.2021.02.001","article-title":"Diagnosis of rare subtypes of acute myeloid leukaemia and related neoplasms","volume":"53","author":"George","year":"2021","journal-title":"Pathology"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"250","DOI":"10.14740\/jmc4286","article-title":"Clinical, Phenotypic and Molecular Characterization of NUP214-ABL1 Fusion Positive Myeloid Malignancies","volume":"15","author":"Wakefield","year":"2024","journal-title":"J. Med. Cases"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/EBC20170035","article-title":"Regulation of selective autophagy: The p62\/SQSTM1 paradigm","volume":"61","author":"Lamark","year":"2017","journal-title":"Essays Biochem."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Kumar, A.V., Mills, J., and Lapierre, L.R. (2022). Selective Autophagy Receptor p62\/SQSTM1, a Pivotal Player in Stress and Aging. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.793328"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/febs.14712","article-title":"p62\/SQSTM1: \u2018Jack of all trades\u2019 in health and cancer","volume":"286","author":"Saito","year":"2019","journal-title":"FEBS J."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1038\/cdd.2014.102","article-title":"p62\/SQSTM1 upregulation constitutes a survival mechanism that occurs during granulocytic differentiation of acute myeloid leukemia cells","volume":"21","author":"Trocoli","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.canlet.2021.04.003","article-title":"A mitophagy inhibitor targeting p62 attenuates the leukemia-initiation potential of acute myeloid leukemia cells","volume":"510","author":"Li","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2009.03.048","article-title":"Autophagy suppresses tumorigenesis through elimination of p62","volume":"137","author":"Mathew","year":"2009","journal-title":"Cell"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1074\/jbc.M702824200","article-title":"p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy","volume":"282","author":"Pankiv","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41467-020-15119-w","article-title":"Microglia clear neuron-released \u03b1-synuclein via selective autophagy and prevent neurodegeneration","volume":"11","author":"Choi","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2015.12.057","article-title":"NF-\u03baB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria","volume":"164","author":"Zhong","year":"2016","journal-title":"Cell"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1080\/15548627.2022.2047384","article-title":"TRAF6 autophagic degradation by avibirnavirus VP3 inhibits antiviral innate immunity via blocking NFKB\/NF-\u03baB activation","volume":"18","author":"Deng","year":"2022","journal-title":"Autophagy"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1074\/mcp.M112.024877","article-title":"Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry","volume":"12","author":"Thakar","year":"2013","journal-title":"Mol. Cell Proteom."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"e4840","DOI":"10.1002\/pro.4840","article-title":"The PB1 and the ZZ domain of the autophagy receptor p62\/SQSTM1 regulate the interaction of p62\/SQSTM1 with the autophagosome protein LC3B","volume":"33","author":"Zang","year":"2024","journal-title":"Protein Sci."},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Lavau, C.P., Aumann, W.K., Sze, S.K., Gupta, V., Ripple, K., Port, S.A., Kehlenbach, R.H., and Wechsler, D.S. (2020). The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0232036"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.3324\/haematol.2010.029769","article-title":"SQSTM1-NUP214: A new gene fusion in adult T-cell acute lymphoblastic leukemia","volume":"95","author":"Gorello","year":"2010","journal-title":"Haematologica"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/bjh.14413","article-title":"Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia","volume":"176","author":"Brown","year":"2017","journal-title":"Br. J. Haematol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000441464","article-title":"NUP214-RAC1 and RAC1-COL12A1 Fusion in Complex Variant Translocations Involving Chromosomes 6, 7 and 9 in an Acute Myeloid Leukemia Case with DEK- NUP214","volume":"146","author":"Abe","year":"2015","journal-title":"Cytogenet. Genome Res."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"98509","DOI":"10.18632\/oncotarget.21533","article-title":"Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines","volume":"8","author":"Cabrera","year":"2017","journal-title":"Oncotarget"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12032-023-02075-w","article-title":"RUNX1\/ETO regulates reactive oxygen species (ROS) levels in t(8,21) acute myeloid leukaemia via FLT3 and RAC1","volume":"40","author":"Azlan","year":"2023","journal-title":"Med. Oncol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/leu.2017.324","article-title":"Bruton\u2019s tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia","volume":"32","author":"Nimmagadda","year":"2018","journal-title":"Leukemia"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.bbrc.2009.06.125","article-title":"Overexpression of Rac1 in leukemia patients and its role in leukemia cell migration and growth","volume":"386","author":"Wang","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00277-024-05680-5","article-title":"Acute myeloid leukemia with rare recurring translocations-an overview of the entities included in the international consensus classification","volume":"103","author":"Torkildsen","year":"2024","journal-title":"Ann. Hematol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/gcc.22064","article-title":"NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia","volume":"52","author":"Shiba","year":"2013","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_230","first-page":"01324","article-title":"NUP98 Rearrangement Dynamics Predict Outcomes in Adult Patients With Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Multicenter Real-World Study","volume":"S2666\u20136367","author":"Yuan","year":"2025","journal-title":"Transplant. Cell Ther."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1182\/blood-2012-08-447581","article-title":"Prognostic impact and targeting of CRM1 in acute myeloid leukemia","volume":"121","author":"Kojima","year":"2013","journal-title":"Blood"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cmet.2022.01.007","article-title":"The hallmarks of cancer metabolism: Still emerging","volume":"34","author":"Pavlova","year":"2022","journal-title":"Cell Metab."},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Senga, S.S., and Grose, R.P. (2021). Hallmarks of cancer-the new testament. Open Biol., 11.","DOI":"10.1098\/rsob.200358"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1080\/15548627.2020.1822628","article-title":"The role of autophagy in targeted therapy for acute myeloid leukemia","volume":"17","author":"Du","year":"2021","journal-title":"Autophagy"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/14737140.2023.2161518","article-title":"The role of autophagy in acute myeloid leukemia development","volume":"23","author":"Bednarczyk","year":"2023","journal-title":"Expert Rev. Anticancer Ther."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s12094-022-02804-z","article-title":"Autophagy in acute myeloid leukemia: A paradoxical role in chemoresistance","volume":"24","author":"Khan","year":"2022","journal-title":"Clin. Transl. Oncol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"115990","DOI":"10.1016\/j.taap.2022.115990","article-title":"Rac GTPases in acute myeloid leukemia cells: Expression profile and biological effects of pharmacological inhibition","volume":"442","author":"Ramos","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/cac2.12010","article-title":"CXCL5\/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target","volume":"40","author":"Zhang","year":"2020","journal-title":"Cancer Commun."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"108257","DOI":"10.1016\/j.pharmthera.2022.108257","article-title":"Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases","volume":"237","author":"Dhayni","year":"2022","journal-title":"Pharmacol. Ther."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/18\/1461\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:48:04Z","timestamp":1760035684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/18\/1461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":240,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["cells14181461"],"URL":"https:\/\/doi.org\/10.3390\/cells14181461","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,18]]}}}