{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:50:37Z","timestamp":1787496637757,"version":"build-2736575974"},"reference-count":64,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"unrestricted award from Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]},{"name":"unrestricted award from Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"name":"unrestricted award from Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences","award":["EY034646"],"award-info":[{"award-number":["EY034646"]}]},{"name":"unrestricted award from Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences","award":["EY030076"],"award-info":[{"award-number":["EY030076"]}]},{"name":"Prevent Blindness Steine Innovation Award","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]},{"name":"Prevent Blindness Steine Innovation Award","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"name":"Prevent Blindness Steine Innovation Award","award":["EY034646"],"award-info":[{"award-number":["EY034646"]}]},{"name":"Prevent Blindness Steine Innovation Award","award":["EY030076"],"award-info":[{"award-number":["EY030076"]}]},{"name":"Retina Research Foundation","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]},{"name":"Retina Research Foundation","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"name":"Retina Research Foundation","award":["EY034646"],"award-info":[{"award-number":["EY034646"]}]},{"name":"Retina Research Foundation","award":["EY030076"],"award-info":[{"award-number":["EY030076"]}]},{"name":"RRF\/Daniel M. Albert chair","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]},{"name":"RRF\/Daniel M. Albert chair","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"name":"RRF\/Daniel M. Albert chair","award":["EY034646"],"award-info":[{"award-number":["EY034646"]}]},{"name":"RRF\/Daniel M. Albert chair","award":["EY030076"],"award-info":[{"award-number":["EY030076"]}]},{"name":"National Institutes of Health","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]},{"name":"National Institutes of Health","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"name":"National Institutes of Health","award":["EY034646"],"award-info":[{"award-number":["EY034646"]}]},{"name":"National Institutes of Health","award":["EY030076"],"award-info":[{"award-number":["EY030076"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Pericytes produce vascular endothelial growth factor-A (VEGF-A; hereafter referred to as VEGF). VEGF inhibits pericyte proliferation and migration through enhanced VEGFR2 and PDGFR\u03b2 heterodimerization. Heterodimerization of these receptors on perivascular supporting cells, mediated by VEGF in culture, mitigates signaling through these receptors and promotes a quiescent phenotype. However, the detailed cellular mechanisms and the significance of these interactions in vivo require further investigation. The cell-autonomous activities of pericyte VEGF expression during vascular development and neovascularization remain unknown. Here we utilized mice conditionally lacking Vegfa in pericytes (VegfaPC) to examine its impact on retinal vascular development and pathological ocular neovascularization. Vascular integrity was also assessed in older mice using fundus imaging and fluorescein angiography. The lack of Vegfa pericyte expression delayed the initial spreading of the superficial layer of the retinal vasculature. Mice lacking Vegfa pericyte expression had similar numbers of retinal endothelial cells and arteries to their wild-type littermates. However, the number of pericytes was significantly reduced in younger VegfaPC mice but increased in more mature mice. In addition, pericyte Vegfa deficiency did not impact responses during oxygen-induced ischemic retinopathy and laser-induced choroidal neovascularization. Thus, pericyte VEGF expression plays a role during early stages of retinal vascular development with limited influence on mature retinal vascularization, its integrity, and neovascularization.<\/jats:p>","DOI":"10.3390\/cells14181473","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T08:37:39Z","timestamp":1758530259000},"page":"1473","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pericyte Expression of VEGF-A Minimally Impacts Ocular Vascular Development and Neovascularization"],"prefix":"10.3390","volume":"14","author":[{"given":"Yong-Seok","family":"Song","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"},{"name":"McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoujian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samay","family":"Inampudi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope","family":"Risa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Sorenson","sequence":"additional","affiliation":[{"name":"McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"},{"name":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2723-9217","authenticated-orcid":false,"given":"Nader","family":"Sheibani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"},{"name":"McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"},{"name":"Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1242\/dev.126.6.1149","article-title":"VEGF is required for growth and survival in neonatal mice","volume":"126","author":"Gerber","year":"1999","journal-title":"Development"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/380439a0","article-title":"Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene","volume":"380","author":"Ferrara","year":"1996","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100921","DOI":"10.1016\/j.preteyeres.2020.100921","article-title":"Sustained suppression of VEGF for treatment of retinal\/choroidal vascular diseases","volume":"83","author":"Campochiaro","year":"2021","journal-title":"Prog. 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