{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:51Z","timestamp":1787027871340,"version":"build-2736575974"},"reference-count":316,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH-NINDS R01","award":["NS111969"],"award-info":[{"award-number":["NS111969"]}]},{"name":"NIH-NINDS F31","award":["NS130993"],"award-info":[{"award-number":["NS130993"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Cells"],"abstract":"<jats:p>Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is a receptor found in microglia within the central nervous system (CNS) as well as in several other cell types throughout the body. TREM2 has been highlighted as a \u201cdouble-edged sword\u201d due to its contribution to anti- or pro-inflammatory signaling responses in a spatial, temporal, and disease-specific fashion. Many of the functions of TREM2 in relation to neurological disease have been elucidated in a variety of CNS pathologies, including neurodegenerative, traumatic, and vascular injuries, as well as autoimmune diseases. Less is known about the function of TREM2 in motoneurons and sensory neurons, whose cell bodies and axons span both the CNS and peripheral nervous system (PNS) and are exposed to a variety of TREM2-expressing cells and mechanisms. In this review, we provide a brief overview of TREM2 and then highlight the literature detailing the involvement of TREM2 along the spinal cord, peripheral nerves and muscles, and sensory, motor, and autonomic functions in health, aging, disease, and injury. We further discuss the current feasibility of TREM2 as a potential therapeutic target to ameliorate damage in the sensorimotor circuits of the spinal cord.<\/jats:p>","DOI":"10.3390\/cells14191520","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:49:34Z","timestamp":1759142974000},"page":"1520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is TREM2 a Stretch: Implications of TREM2 Along Spinal Cord Circuits in Health, Aging, Injury, and Disease"],"prefix":"10.3390","volume":"14","author":[{"given":"Tana S.","family":"Pottorf","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Emory University, Atlanta, GA 30322, USA"},{"name":"Department of Neuroscience, Ohio State University, Columbus, OH 43085, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5881-0334","authenticated-orcid":false,"given":"Elizabeth L.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-3244","authenticated-orcid":false,"given":"Francisco J.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(11)70015-1","article-title":"Neuroinflammation in amyotrophic lateral sclerosis: Role of glial activation in motor neuron disease","volume":"10","author":"Philips","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Liu, J., and Wang, F. (2017). Role of neuroinflammation in amyotrophic lateral sclerosis: Cellular mechanisms and therapeutic implications. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01005"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s13311-014-0329-3","article-title":"Protective and toxic neuroinflammation in amyotrophic lateral sclerosis","volume":"12","author":"Hooten","year":"2015","journal-title":"Neurotherapeutics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"eadi3259","DOI":"10.1126\/scitranslmed.adi3259","article-title":"Microglia promote maladaptive plasticity in autonomic circuitry after spinal cord injury in mice","volume":"16","author":"Brennan","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"ref_5","unstructured":"Rajendram, R., Preedy, V.R., and Martin, C.R. (2022). Chapter 30\u2014Features and physiology of spinal stretch reflexes in people with chronic spinal cord injury. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury, Academic Press."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00018-022-04644-0","article-title":"Role of peripheral immune cells in spinal cord injury","volume":"80","author":"Li","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2250274","DOI":"10.1002\/eji.202250274","article-title":"System failure: Systemic inflammation following spinal cord injury","volume":"54","author":"DiSabato","year":"2024","journal-title":"Eur. J. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.expneurol.2014.04.023","article-title":"The paradox of chronic neuroinflammation, systemic immune suppression, autoimmunity after traumatic chronic spinal cord injury","volume":"258","author":"Schwab","year":"2014","journal-title":"Exp. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Pottorf, T.S., Rotterman, T.M., McCallum, W.M., Haley-Johnson, Z.A., and Alvarez, F.J. (2022). The Role of Microglia in Neuroinflammation of the Spinal Cord after Peripheral Nerve Injury. Cells, 11.","DOI":"10.3390\/cells11132083"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Konishi, H., and Kiyama, H. (2018). Microglial TREM2\/DAP12 Signaling: A Double-Edged Sword in Neural Diseases. Front. Cell. Neurosci., 12.","DOI":"10.3389\/fncel.2018.00206"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/s41577-023-00837-1","article-title":"The biology of TREM receptors","volume":"23","author":"Colonna","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nri1106","article-title":"TREMs in the immune system and beyond","volume":"3","author":"Colonna","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12974-020-01878-2","article-title":"TREM2 ectodomain and its soluble form in Alzheimer\u2019s disease","volume":"17","author":"Yang","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1600-065X.2008.00720.x","article-title":"DAP10-and DAP12-associated receptors in innate immunity","volume":"227","author":"Lanier","year":"2009","journal-title":"Immunol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/immu.200310033","article-title":"The human TREM gene cluster at 6p21. 1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44","volume":"33","author":"Allcock","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kasamatsu, J., Deng, M., Azuma, M., Funami, K., Shime, H., Oshiumi, H., Matsumoto, M., Kasahara, M., and Seya, T. (2016). Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells. BMC Immunol., 17.","DOI":"10.1186\/s12865-016-0147-y"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00251-005-0771-9","article-title":"Novel immunoglobulin-like transcripts in teleost fish encode polymorphic receptors with cytoplasmic ITAM or ITIM and a new structural Ig domain similar to the natural cytotoxicity receptor NKp44","volume":"57","author":"Stet","year":"2005","journal-title":"Immunogenetics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s00251-006-0091-8","article-title":"The chicken immunoregulatory receptor families SIRP, TREM, and CMRF35\/CD300L","volume":"58","author":"Viertlboeck","year":"2006","journal-title":"Immunogenetics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1093\/hmg\/ddu277","article-title":"Coding variants in TREM2 increase risk for Alzheimer\u2019s disease","volume":"23","author":"Jin","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13024-017-0197-5","article-title":"TREM2 in neurodegenerative diseases","volume":"12","author":"Jay","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.3233\/JAD-215602","article-title":"An Alternatively Spliced TREM2 Isoform Lacking the Ligand Binding Domain is Expressed in Human Brain","volume":"87","author":"Shaw","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"ra38","DOI":"10.1126\/scisignal.2000500","article-title":"TREM2-and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1","volume":"3","author":"Peng","year":"2010","journal-title":"Sci. Signal."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"33027","DOI":"10.1074\/jbc.M113.517540","article-title":"Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and \u03b3-secretase-dependent intramembranous cleavage","volume":"288","author":"Wunderlich","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.14283\/jpad.2024.164","article-title":"Roles of TREM2 in the Pathological Mechanism and the Therapeutic Strategies of Alzheimer\u2019s Disease","volume":"11","author":"Lin","year":"2024","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41419-024-06579-9","article-title":"TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits","volume":"15","author":"Zhang","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Sun, H., Feng, J., and Tang, L. (2020). Function of TREM1 and TREM2 in liver-related diseases. Cells, 9.","DOI":"10.3390\/cells9122626"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41413-020-00134-w","article-title":"Two macrophages, osteoclasts and microglia: From development to pleiotropy","volume":"9","author":"Lee","year":"2021","journal-title":"Bone Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Wang, X., Wang, Y., Yang, L., Zhang, Y., and Yang, L. (2025). TREM2+ macrophages: A key role in disease development. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1550893"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41582-018-0072-1","article-title":"TREM2\u2014A key player in microglial biology and Alzheimer disease","volume":"14","author":"Ulland","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn.2016.7","article-title":"TREM2 variants: New keys to decipher Alzheimer disease pathogenesis","volume":"17","author":"Colonna","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer\u2019s disease","volume":"217","author":"Hansen","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-015-0040-9","article-title":"TREM2 in CNS homeostasis and neurodegenerative disease","volume":"10","author":"Painter","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: Signal 0s that spur autophagy and immunity","volume":"249","author":"Tang","year":"2012","journal-title":"Immunol. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1158\/1541-7786.MCR-08-0401","article-title":"Host deficiency in Vav2\/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo","volume":"7","author":"Zhuang","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3233\/JAD-180054","article-title":"Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn","volume":"64","author":"Li","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1182\/blood.V96.6.2181","article-title":"Signaling via LAT (linker for T-cell activation) and Syk\/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation","volume":"96","author":"Martelli","year":"2000","journal-title":"Blood"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.molmed.2013.06.004","article-title":"Bridging integrator 1 (BIN1): Form, function, and Alzheimer\u2019s disease","volume":"19","author":"Tan","year":"2013","journal-title":"Trends Mol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2019.06.010","article-title":"TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer\u2019s Disease","volume":"103","author":"Griciuc","year":"2019","journal-title":"Neuron"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Cheng, B., Li, X., Dai, K., Duan, S., Rong, Z., Chen, Y., L\u00fc, L., Liu, Z., Huang, X., and Xu, H. (2021). Triggering receptor expressed on myeloid cells-2 (TREM2) interacts with colony-stimulating factor 1 receptor (CSF1R) but is not necessary for CSF1\/CSF1R-mediated microglial survival. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.633796"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-025-00834-z","article-title":"TREM2 and sTREM2 in Alzheimer\u2019s disease: From mechanisms to therapies","volume":"20","author":"Zhang","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nri2765","article-title":"The SYK tyrosine kinase: A crucial player in diverse biological functions","volume":"10","author":"Ruland","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer\u2019s disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Shirotani, K., Hori, Y., Yoshizaki, R., Higuchi, E., Colonna, M., Saito, T., Hashimoto, S., Saito, T., Saido, T.C., and Iwata, N. (2019). Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-43535-6"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/alz.12194","article-title":"Functional insights from biophysical study of TREM2 interactions with apoE and A\u03b21-42","volume":"17","author":"Kober","year":"2021","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00251-011-0562-4","article-title":"Specific lipid recognition is a general feature of CD300 and TREM molecules","volume":"64","author":"Cannon","year":"2012","journal-title":"Immunogenetics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jalz.2016.07.004","article-title":"Alzheimer\u2019s disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation","volume":"13","author":"Song","year":"2017","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"26043","DOI":"10.1074\/jbc.M115.679043","article-title":"Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)","volume":"290","author":"Atagi","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"26033","DOI":"10.1074\/jbc.M115.677286","article-title":"The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E","volume":"290","author":"Bailey","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1523\/JNEUROSCI.2620-14.2015","article-title":"Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke","volume":"35","author":"Kawabori","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4049\/jimmunol.171.2.594","article-title":"Pattern recognition by TREM-2: Binding of anionic ligands","volume":"171","author":"Daws","year":"2003","journal-title":"J. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1038\/s41467-021-22620-3","article-title":"TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation","volume":"12","author":"Iizasa","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.neuron.2018.01.031","article-title":"TREM2 is a receptor for \u03b2-amyloid that mediates microglial function","volume":"97","author":"Zhao","year":"2018","journal-title":"Neuron"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41593-021-00975-6","article-title":"TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration","volume":"25","author":"Xie","year":"2022","journal-title":"Nat. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12264-022-00944-4","article-title":"TREMble before TREM2: The mighty microglial receptor conferring neuroprotective properties in TDP-43 mediated neurodegeneration","volume":"39","author":"Eyo","year":"2023","journal-title":"Neurosci. Bull."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.4049\/jimmunol.176.11.6615","article-title":"Regulation of Ly49D\/DAP12 Signal Transduction by Src-Family Kinases and CD4512","volume":"176","author":"Mason","year":"2006","journal-title":"J. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"9840","DOI":"10.1074\/jbc.270.17.9840","article-title":"Sequence Requirements for Binding of Src Family Tyrosine Kinases to Activated Growth Factor Receptors","volume":"270","author":"Alonso","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1084\/jem.20120412","article-title":"Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival","volume":"210","author":"Luo","year":"2013","journal-title":"J. Exp. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jlb.62.2.145","article-title":"CSF-1 signal transduction","volume":"62","author":"Hamilton","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tcb.2004.09.016","article-title":"CSF-1 regulation of the wandering macrophage: Complexity in action","volume":"14","author":"Pixley","year":"2004","journal-title":"Trends Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nn.4189","article-title":"Injured sensory neuron\u2013derived CSF1 induces microglial proliferation and DAP12-dependent pain","volume":"19","author":"Guan","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/ni.1744","article-title":"Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and \u03b2-catenin","volume":"10","author":"Otero","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.15252\/emmm.201707673","article-title":"TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer\u2019s disease-associated H157Y variant","volume":"9","author":"Thornton","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.15252\/emmm.201707672","article-title":"An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function","volume":"9","author":"Schlepckow","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12974-016-0479-9","article-title":"Functional involvement of \u03b3-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)","volume":"13","author":"Glebov","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neulet.2017.09.034","article-title":"ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157","volume":"660","author":"Feuerbach","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Filipello, F., Goldsbury, C., You, S.F., Locca, A., Karch, C.M., and Piccio, L. (2022). Soluble TREM2: Innocent bystander or active player in neurological diseases?. Neurobiol. Dis., 165.","DOI":"10.1016\/j.nbd.2022.105630"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13073-023-01160-z","article-title":"TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation","volume":"15","author":"Moutinho","year":"2023","journal-title":"Genome Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/JLB.2CE0521-264R","article-title":"TREM2 splicing emerges as crucial aspect to understand TREM2 biology","volume":"110","author":"Moutinho","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1093\/brain\/awn217","article-title":"Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation","volume":"131","author":"Piccio","year":"2008","journal-title":"Brain J. Neurol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbi.2023.01.013","article-title":"Profiling TREM2 expression in amyotrophic lateral sclerosis","volume":"109","author":"Macias","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.20160844","article-title":"Soluble TREM2 induces inflammatory responses and enhances microglial survival","volume":"214","author":"Zhong","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1084\/jem.20171529","article-title":"Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism","volume":"215","author":"Song","year":"2018","journal-title":"J. Exp. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1084\/jem.20141732","article-title":"TREM-2 promotes macrophage survival and lung disease after respiratory viral infection","volume":"212","author":"Wu","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Park, S.H., Lee, E.H., Kim, H.J., Jo, S., Lee, S., Seo, S.W., Park, H.H., Koh, S.H., and Lee, J.H. (2021). The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer\u2019s disease. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-92101-6"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Nabizadeh, F., Seyedmirzaei, H., and Karami, S. (2024). Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer\u2019s disease: A longitudinal study. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-66211-w"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Wang, R., Zhan, Y., Zhu, W., Yang, Q., and Pei, J. (2024). Association of soluble TREM2 with Alzheimer\u2019s disease and mild cognitive impairment: A systematic review and meta-analysis. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1407980"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Jiao, L., Yang, J., Wang, W., Liu, X., Fu, Y., and Fan, D. (2024). sTREM2 cerebrospinal fluid levels are a potential biomarker in amyotrophic lateral sclerosis and associate with UMN burden. Front. Neurol., 15.","DOI":"10.3389\/fneur.2024.1515252"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40478-017-0424-x","article-title":"A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis","volume":"5","author":"Green","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"112629","DOI":"10.1016\/j.celrep.2023.112629","article-title":"Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders","volume":"42","author":"Gao","year":"2023","journal-title":"Cell Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1086\/342259","article-title":"Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype","volume":"71","author":"Paloneva","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.20030027","article-title":"DAP12\/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features","volume":"198","author":"Paloneva","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41590-022-01403-y","article-title":"Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia","volume":"24","author":"Zhou","year":"2023","journal-title":"Nat. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e20391","DOI":"10.7554\/eLife.20391","article-title":"Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms","volume":"5","author":"Kober","year":"2016","journal-title":"eLife"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer\u2019s disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Borroni, B., Ferrari, F., Galimberti, D., Nacmias, B., Barone, C., Bagnoli, S., Fenoglio, C., Piaceri, I., Archetti, S., and Bonvicini, C. (2014). Heterozygous TREM2 mutations in frontotemporal dementia. Neurobiol. Aging, 35.","DOI":"10.1016\/j.neurobiolaging.2013.09.017"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1136\/jmg-2022-108627","article-title":"Frontotemporal dementia presentation in patients with heterozygous p. H157Y variant of TREM2","volume":"60","author":"Ogonowski","year":"2023","journal-title":"J. Med. Genet."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u2019s disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13024-022-00562-8","article-title":"Trem2 deletion enhances tau dispersion and pathology through microglia exosomes","volume":"17","author":"Zhu","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/glia.24318","article-title":"Alzheimer\u2019s disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss","volume":"71","author":"Popescu","year":"2023","journal-title":"Glia"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3233\/JAD-181038","article-title":"TREM2 Variants and Neurodegenerative Diseases: A Systematic Review and Meta-Analysis","volume":"68","author":"Zhou","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13024-018-0298-9","article-title":"New insights into the role of TREM2 in Alzheimer\u2019s disease","volume":"13","author":"Gratuze","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1750-1326-8-19","article-title":"TREM2 in neurodegeneration: Evidence for association of the p. R47H variant with frontotemporal dementia and Parkinson\u2019s disease","volume":"8","author":"Rayaprolu","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/jamaneurol.2013.6237","article-title":"TREM2 variant p. R47H as a risk factor for sporadic amyotrophic lateral sclerosis","volume":"71","author":"Cady","year":"2014","journal-title":"JAMA Neurol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/21678421.2018.1451894","article-title":"TREM2 variants in neurodegenerative disorders in the Polish population. Homozygosity and compound heterozygosity in FTD patients","volume":"19","author":"Peplonska","year":"2018","journal-title":"Amyotroph. Lateral Scler. Front. Degener."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s10072-015-2274-2","article-title":"TREM2 variants and risk of Alzheimer\u2019s disease: A meta-analysis","volume":"36","author":"Lu","year":"2015","journal-title":"Neurol. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1001\/jamaneurol.2013.579","article-title":"Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia\u2013like syndrome without bone involvement","volume":"70","author":"Guerreiro","year":"2013","journal-title":"JAMA Neurol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jns.2013.01.021","article-title":"Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL): A new report of an Italian woman and review of the literature","volume":"326","author":"Bock","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1212\/01.WNL.0000160304.00003.CA","article-title":"The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2","volume":"64","author":"Klunemann","year":"2005","journal-title":"Neurology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/jnnp.74.6.825-a","article-title":"An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene","volume":"74","author":"Soragna","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1111\/ene.14908","article-title":"TREM2 variants as a possible cause of frontotemporal dementia with distinct neuroimaging features","volume":"28","author":"Samanci","year":"2021","journal-title":"Eur. J. Neurol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1468-1331.2010.03311.x","article-title":"Nasu\u2013Hakola disease with a splicing mutation of TREM2 in a Japanese family","volume":"18","author":"Numasawa","year":"2011","journal-title":"Eur. J. Neurol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13195-025-01700-2","article-title":"TREM2 risk variants and associated endophenotypes in alzheimer\u2019s disease","volume":"17","author":"Dijkstra","year":"2025","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Dardiotis, E., Siokas, V., Pantazi, E., Dardioti, M., Rikos, D., Xiromerisiou, G., Markou, A., Papadimitriou, D., Speletas, M., and Hadjigeorgiou, G.M. (2017). A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature. Neurobiol. Aging, 53.","DOI":"10.1016\/j.neurobiolaging.2017.01.015"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.jalz.2014.10.013","article-title":"The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer\u2019s dementia","volume":"11","author":"Roussos","year":"2015","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Le Ber, I., De Septenville, A., Guerreiro, R., Bras, J., Camuzat, A., Caroppo, P., Lattante, S., Couarch, P., Kabashi, E., and Bouya-Ahmed, K. (2014). Homozygous TREM2 mutation in a family with atypical frontotemporal dementia. Neurobiol. Aging, 35.","DOI":"10.1016\/j.neurobiolaging.2014.04.010"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Giraldo, M., Lopera, F., Siniard, A.L., Corneveaux, J.J., Schrauwen, I., Carvajal, J., Mu\u00f1oz, C., Ramirez-Restrepo, M., Gaiteri, C., and Myers, A.J. (2013). Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer\u2019s disease. Neurobiol. Aging, 34.","DOI":"10.1016\/j.neurobiolaging.2013.02.016"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Guerreiro, R., Bilgic, B., Guven, G., Br\u00e1s, J., Rohrer, J., Lohmann, E., Hanagasi, H., Gurvit, H., and Emre, M. (2013). A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family. Neurobiol. Aging, 34.","DOI":"10.1016\/j.neurobiolaging.2013.06.005"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Thelen, M., Razquin, C., Hern\u00e1ndez, I., Gorostidi, A., Sanchez-Valle, R., Ortega-Cubero, S., Wolfsgruber, S., Drichel, D., Fliessbach, K., and Duenkel, T. (2014). Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes. Neurobiol. Aging, 35.","DOI":"10.1016\/j.neurobiolaging.2014.06.018"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Jiang, T., Tan, L., Chen, Q., Tan, M.S., Zhou, J.S., Zhu, X.C., Lu, H., Wang, H.F., Zhang, Y.D., and Yu, J.T. (2016). A rare coding variant in TREM2 increases risk for Alzheimer\u2019s disease in Han Chinese. Neurobiol. Aging, 42.","DOI":"10.1016\/j.neurobiolaging.2016.02.023"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-015-0016-9","article-title":"TREM2 is associated with increased risk for Alzheimer\u2019s disease in African Americans","volume":"10","author":"Jin","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/hmg\/ddx366","article-title":"Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal","volume":"27","author":"Kang","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.immuni.2018.04.016","article-title":"The microglial innate immune receptor TREM2 is required for synapse elimination and normal brain connectivity","volume":"48","author":"Filipello","year":"2018","journal-title":"Immunity"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.immuni.2023.12.002","article-title":"Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development","volume":"57","author":"Tagliatti","year":"2024","journal-title":"Immunity"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1046\/j.1471-4159.2002.01243.x","article-title":"Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia","volume":"83","author":"Schmid","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1016\/j.neurobiolaging.2013.05.001","article-title":"Insights into TREM2 biology by network analysis of human brain gene expression data","volume":"34","author":"Forabosco","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"11524","DOI":"10.1073\/pnas.1710311114","article-title":"TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy","volume":"114","author":"Leyns","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/s41593-019-0433-0","article-title":"TREM2 function impedes tau seeding in neuritic plaques","volume":"22","author":"Leyns","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10163","article-title":"A conditional knockout resource for the genome-wide study of mouse gene function","volume":"474","author":"Skarnes","year":"2011","journal-title":"Nature"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/jnnp.13.3.203","article-title":"The penetration of particulate matter from the cerebrospinal fluid into the spinal ganglia, peripheral nerves, and perivascular spaces of the central nervous system","volume":"13","author":"Brierley","year":"1950","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/S0304-3959(99)00135-9","article-title":"Unexplained peculiarities of the dorsal root ganglion","volume":"82","author":"Devor","year":"1999","journal-title":"PAIN"},{"key":"ref_122","first-page":"333","article-title":"A Histopathological Study of the Human Spinal Ganglia. Normal Variations in Aging","volume":"24","author":"Nagashima","year":"1974","journal-title":"Acta Patholigica Jpn."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1023\/B:NEUR.0000030693.91881.53","article-title":"Unbiased estimates of number and size of rat dorsal root ganglion cells in studies of structure and cell survival","volume":"33","author":"Tandrup","year":"2004","journal-title":"J. Neurocytol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1227\/NEU.0b013e318241ace1","article-title":"Sensory neurons of the human brachial plexus: A quantitative study employing optical fractionation and in vivo volumetric magnetic resonance imaging","volume":"70","author":"West","year":"2012","journal-title":"Neurosurgery"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00441-023-03770-w","article-title":"Ultrastructure of dorsal root ganglia","volume":"393","author":"Haberberger","year":"2023","journal-title":"Cell Tissue Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e68457","DOI":"10.7554\/eLife.68457","article-title":"Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair","volume":"10","author":"Avraham","year":"2021","journal-title":"eLife"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0014-4886(85)90225-0","article-title":"Cell death in the adult rat dorsal root ganglion after hind limb amputation, spinal cord transection, or both operations","volume":"87","author":"Feringa","year":"1985","journal-title":"Exp. Neurol."},{"key":"ref_128","unstructured":"Lu, S. (2023). Single-Cell Transcriptome Analyses of Dorsal Root Ganglia in Aged Hyperlipidemic Mice. [Ph.D. Thesis, Faculty of Medicine]."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Li, X., Zhuang, Z., Hao, Y., Lin, S., Gu, J., Chang, S., Lan, L., Zhao, G., and Zhang, D. (2025). Paeonol Relieves Chronic Neuropathic Pain by Reducing Communication Between Schwann Cells and Macrophages in the Dorsal Root Ganglia After Injury. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26093964"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e31481","DOI":"10.1016\/j.heliyon.2024.e31481","article-title":"Neuroinflammation signatures in dorsal root ganglia following chronic constriction injury","volume":"10","author":"Qu","year":"2024","journal-title":"Heliyon"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41467-019-13839-2","article-title":"Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e2215906120","DOI":"10.1073\/pnas.2215906120","article-title":"Self-renewing macrophages in dorsal root ganglia contribute to promote nerve regeneration","volume":"120","author":"Feng","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_133","unstructured":"Brown, A.G. (2012). Organization in the Spinal Cord: The Anatomy and Physiology of Identified Neurones, Springer Science & Business Media."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn2401","article-title":"The neural control of micturition","volume":"9","author":"Fowler","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1152\/physrev.1965.45.3.425","article-title":"Nervous control of micturition","volume":"45","author":"Kuru","year":"1965","journal-title":"Physiol. Rev."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/BF02239440","article-title":"Sacral reflexes: Physiology and clinical application","volume":"41","author":"Uher","year":"1998","journal-title":"Dis. Colon Rectum"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1053\/j.sult.2016.05.002","article-title":"Spinal Cord Anatomy and Clinical Syndromes","volume":"37","author":"Diaz","year":"2016","journal-title":"Semin. Ultrasound CT MRI"},{"key":"ref_138","unstructured":"Cramer, G.D., and Darby, S.A. (2013). Clinical Anatomy of the Spine, Spinal Cord, and ANS, Elsevier."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/cei\/uxae023","article-title":"Quantifying microglial morphology: An insight into function","volume":"216","author":"Green","year":"2024","journal-title":"Clin. Exp. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Vidal-Itriago, A., Radford, R.A., Aramideh, J.A., Maurel, C., Scherer, N.M., Don, E.K., Lee, A., Chung, R.S., Graeber, M.B., and Morsch, M. (2022). Microglia morphophysiological diversity and its implications for the CNS. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.997786"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Edler, M.K., Mhatre-Winters, I., and Richardson, J.R. (2021). Microglia in Aging and Alzheimer\u2019s Disease: A Comparative Species Review. Cells, 10.","DOI":"10.3390\/cells10051138"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Pottorf, T.S., Lane, E.L., Haley-Johnson, Z., Amores-Sanchez, V., Ukmar, D.N., Correa-Torres, P.M., and Alvarez, F.J. (2025). Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration After Axotomy. bioRxiv.","DOI":"10.1101\/2025.08.06.668924"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"8441","DOI":"10.1523\/JNEUROSCI.0860-21.2021","article-title":"Spinal Cord Injury Induces Permanent Reprogramming of Microglia into a Disease-Associated State Which Contributes to Functional Recovery","volume":"41","author":"Hakim","year":"2021","journal-title":"J. Neurosci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer\u2019s disease","volume":"169","author":"Spinrad","year":"2017","journal-title":"Cell"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Samant, R.R., Standaert, D.G., and Harms, A.S. (2024). The emerging role of disease-associated microglia in Parkinson\u2019s disease. Front. Cell. Neurosci., 18.","DOI":"10.3389\/fncel.2024.1476461"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/dneu.22864","article-title":"Microglial TREM2 in amyotrophic lateral sclerosis","volume":"82","author":"Xie","year":"2022","journal-title":"Dev. Neurobiol."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Wang, H. (2021). Microglia heterogeneity in Alzheimer\u2019s disease: Insights from single-cell technologies. Front. Synaptic Neurosci., 13.","DOI":"10.3389\/fnsyn.2021.773590"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.cell.2018.05.003","article-title":"Disease-associated microglia: A universal immune sensor of neurodegeneration","volume":"173","author":"Deczkowska","year":"2018","journal-title":"Cell"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41591-019-0695-9","article-title":"Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer\u2019s disease","volume":"26","author":"Zhou","year":"2020","journal-title":"Nat. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/s41590-018-0212-1","article-title":"The identity and function of microglia in neurodegeneration","volume":"19","author":"Song","year":"2018","journal-title":"Nat. Immunol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1038\/s41467-020-19227-5","article-title":"Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer\u2019s disease","volume":"11","author":"McQuade","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1016\/j.cell.2022.09.030","article-title":"SYK coordinates neuroprotective microglial responses in neurodegenerative disease","volume":"185","author":"Ennerfelt","year":"2022","journal-title":"Cell"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/glia.24574","article-title":"The role of microglial TREM2 in development: A path toward neurodegeneration?","volume":"72","author":"Matteoli","year":"2024","journal-title":"Glia"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/glia.23664","article-title":"TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment","volume":"67","author":"Jay","year":"2019","journal-title":"Glia"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Vecchiarelli, H.A., Bisht, K., Sharma, K., Weiser Novak, S., Traetta, M.E., Garcia-Segura, M.E., St-Pierre, M.K., Savage, J.C., Willis, C., and Picard, K. (2024). Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2. bioRxiv.","DOI":"10.1101\/2024.10.15.618087"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1759091420925335","DOI":"10.1177\/1759091420925335","article-title":"Shedding light on the dark side of the microglia","volume":"12","author":"Tremblay","year":"2020","journal-title":"ASN Neuro"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-neuro-061010-113810","article-title":"The complement system: An unexpected role in synaptic pruning during development and disease","volume":"35","author":"Stephan","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/glia.24650","article-title":"Microglia and Astrocytes in Postnatal Neural Circuit Formation","volume":"73","author":"Duffy","year":"2025","journal-title":"Glia"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"e105380","DOI":"10.15252\/embj.2020105380","article-title":"Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia","volume":"39","author":"Perrucci","year":"2020","journal-title":"EMBO J."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0304-3940(01)01842-0","article-title":"Complement activation by neurofibrillary tangles in Alzheimer\u2019s disease","volume":"305","author":"Shen","year":"2001","journal-title":"Neurosci. Lett."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.4049\/jimmunol.152.10.5050","article-title":"beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain","volume":"152","author":"Jiang","year":"1994","journal-title":"J. Immunol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"10016","DOI":"10.1073\/pnas.89.21.10016","article-title":"Complement activation by beta-amyloid in Alzheimer disease","volume":"89","author":"Rogers","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/j.immuni.2023.06.016","article-title":"TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration","volume":"56","author":"Zhong","year":"2023","journal-title":"Immunity"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"e113246","DOI":"10.15252\/embj.2022113246","article-title":"Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer\u2019s disease models","volume":"42","author":"Sokolova","year":"2023","journal-title":"EMBO J."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"e13108","DOI":"10.1111\/bpa.13108","article-title":"TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer\u2019s neuropathology","volume":"33","author":"Fracassi","year":"2023","journal-title":"Brain Pathol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/s43587-022-00281-1","article-title":"Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer\u2019s disease mouse models","volume":"2","author":"Dejanovic","year":"2022","journal-title":"Nat. Aging"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Das, M., Mao, W., Voskobiynyk, Y., Necula, D., Lew, I., Petersen, C., Zahn, A., Yu, G.Q., Yu, X., and Smith, N. (2023). Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models. Neurobiol. Dis., 186.","DOI":"10.1016\/j.nbd.2023.106263"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"9103","DOI":"10.1523\/JNEUROSCI.0131-20.2020","article-title":"Serial Systemic Injections of Endotoxin (LPS) Elicit Neuroprotective Spinal Cord Microglia through IL-1-Dependent Cross Talk with Endothelial Cells","volume":"40","author":"Freria","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1126\/science.aax6752","article-title":"Microglia monitor and protect neuronal function through specialized somatic purinergic junctions","volume":"367","author":"Fekete","year":"2020","journal-title":"Science"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrn.2018.2","article-title":"Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential","volume":"19","author":"Inoue","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Tozaki-Saitoh, H., Takeda, H., and Inoue, K. (2022). The Role of Microglial Purinergic Receptors in Pain Signaling. Molecules, 27.","DOI":"10.3390\/molecules27061919"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1523\/JNEUROSCI.0323-08.2008","article-title":"P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury","volume":"28","author":"Tsuda","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"8032","DOI":"10.1073\/pnas.0810420106","article-title":"IFN-\u03b3 receptor signaling mediates spinal microglia activation driving neuropathic pain","volume":"106","author":"Tsuda","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"12529","DOI":"10.1038\/ncomms12529","article-title":"Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain","volume":"7","author":"Masuda","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Boakye, P.A., Tang, S.J., and Smith, P.A. (2021). Mediators of Neuropathic Pain; Focus on Spinal Microglia, CSF-1, BDNF, CCL21, TNF-\u03b1, Wnt Ligands, and Interleukin 1\u03b2. Front. Pain Res., 2.","DOI":"10.3389\/fpain.2021.698157"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbi.2021.06.005","article-title":"Microglial heterogeneity in chronic pain","volume":"96","author":"Malcangio","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"e883","DOI":"10.1097\/PR9.0000000000000883","article-title":"Contribution of colony-stimulating factor 1 to neuropathic pain","volume":"6","author":"Yu","year":"2021","journal-title":"Pain Rep."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"e864","DOI":"10.1097\/PR9.0000000000000864","article-title":"Role of microglia and P2X4 receptors in chronic pain","volume":"6","author":"Kohno","year":"2021","journal-title":"Pain Rep."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s13311-020-00905-7","article-title":"Central nervous system targets: Glial cell mechanisms in chronic pain","volume":"17","author":"Donnelly","year":"2020","journal-title":"Neurotherapeutics"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2014.06.008","article-title":"Sublime microglia: Expanding roles for the guardians of the CNS","volume":"158","author":"Salter","year":"2014","journal-title":"Cell"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"429815","DOI":"10.1155\/2013\/429815","article-title":"Microglia control neuronal network excitability via BDNF signalling","volume":"2013","author":"Ferrini","year":"2013","journal-title":"Neural Plast."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41583-025-00914-5","article-title":"How microglia contribute to the induction and maintenance of neuropathic pain","volume":"26","author":"Malcangio","year":"2025","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"111410","DOI":"10.1016\/j.brainresbull.2025.111410","article-title":"The role of microglia in neuropathic pain: A systematic review of animal experiments","volume":"28","author":"Long","year":"2025","journal-title":"Brain Res. Bull."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"11138","DOI":"10.1523\/JNEUROSCI.1238-16.2016","article-title":"TREM2\/DAP12 signal elicits proinflammatory response in microglia and exacerbates neuropathic pain","volume":"36","author":"Kobayashi","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/s12974-020-01991-2","article-title":"Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"112010","DOI":"10.1016\/j.celrep.2023.112010","article-title":"Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain","volume":"42","author":"Yousefpour","year":"2023","journal-title":"Cell Rep."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.abf6805","article-title":"A spinal microglia population involved in remitting and relapsing neuropathic pain","volume":"376","author":"Kohno","year":"2022","journal-title":"Science"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.tins.2023.05.001","article-title":"Microglial diversity in neuropathic pain","volume":"46","author":"Tsuda","year":"2023","journal-title":"Trends Neurosci."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.bbadis.2016.07.007","article-title":"Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer\u2019s disease","volume":"1862","author":"Kamphuis","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/glia.24133","article-title":"Sex-specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury","volume":"70","author":"Fiore","year":"2021","journal-title":"Glia"},{"key":"ref_193","unstructured":"Le, Y., Tang, S.Q., He, W.Y., He, J., Wang, Y.H., and Wang, H. (2021). Contribution of Trem2 signaling to the development of painful diabetic neuropathy by mediating microglial polarization in mice. Res. Sq."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1007\/s10753-014-0067-z","article-title":"Artesunate ameliorates functional limitations in Freund\u2019s complete adjuvant-induced monoarthritis in rat by maintaining oxidative homeostasis and inhibiting COX-2 expression","volume":"38","author":"Guruprasad","year":"2015","journal-title":"Inflammation"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuroscience.2022.01.003","article-title":"Artesunate reduces remifentanil-induced hyperalgesia and peroxiredoxin-3 hyperacetylation via modulating spinal metabotropic glutamate receptor 5 in rats","volume":"487","author":"Zhang","year":"2022","journal-title":"Neuroscience"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Zhang, L., Li, N., Zhang, H., Wang, Y., Gao, T., Zhao, Y., Wang, G., Yu, Y., Wang, C., and Li, Y. (2022). Artesunate therapy alleviates fracture-associated chronic pain after orthopedic surgery by suppressing CCL21-dependent TREM2\/DAP12 inflammatory signaling in mice. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.894963"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Uzun, T., Toptas, O., Saylan, A., Carver, H., and Turkoglu, S.A. (2019). Evaluation and Comparison of the Effects of Artesunate, Dexamethasone, and Tacrolimus on Sciatic Nerve Regeneration. J. Oral Maxillofac. Surg., 77.","DOI":"10.1016\/j.joms.2018.12.019"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Ji, X.T., Qian, N.S., Zhang, T., Li, J.M., Li, X.K., Wang, P., Zhao, D.S., Huang, G., Zhang, L., and Fei, Z. (2013). Spinal astrocytic activation contributes to mechanical allodynia in a rat chemotherapy-induced neuropathic pain model. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0060733"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbi.2017.10.011","article-title":"Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice","volume":"68","author":"Hu","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.expneurol.2014.06.016","article-title":"Glial role in oxaliplatin-induced neuropathic pain","volume":"261","author":"Mannelli","year":"2014","journal-title":"Exp. Neurol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.brainresbull.2013.03.005","article-title":"Spinal CCL2 and microglial activation are involved in paclitaxel-evoked cold hyperalgesia","volume":"95","author":"Pevida","year":"2013","journal-title":"Brain Res. Bull."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuroscience.2010.12.052","article-title":"The response of spinal microglia to chemotherapy-evoked painful peripheral neuropathies is distinct from that evoked by traumatic nerve injuries","volume":"176","author":"Zheng","year":"2011","journal-title":"Neuroscience"},{"key":"ref_203","first-page":"3412","article-title":"Motor circuit synaptic plasticity after peripheral nerve injury depends on a central neuroinflammatory response and a CCR2 mechanism","volume":"39","author":"Rotterman","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"113776","DOI":"10.1016\/j.celrep.2024.113776","article-title":"Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia","volume":"43","author":"Rotterman","year":"2024","journal-title":"Cell Rep."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1523\/JNEUROSCI.0103-23.2023","article-title":"Structural preservation does not ensure function at sensory Ia\u2013motoneuron synapses following peripheral nerve injury and repair","volume":"43","author":"Rotterman","year":"2023","journal-title":"J. Neurosci."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Rotterman, T.M., and Alvarez, F.J. (2020). Microglia dynamics and interactions with motoneurons axotomized after nerve injuries revealed by two-photon imaging. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-65363-9"},{"key":"ref_207","first-page":"3412","article-title":"Spinal Motor Circuit Synaptic Plasticity after Peripheral Nerve Injury Depends on Microglia Activation and a CCR2 Mechanism","volume":"39","author":"Rotterman","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Manich, G., G\u00f3mez-L\u00f3pez, A.R., Almolda, B., Villacampa, N., Recasens, M., Shrivastava, K., Gonz\u00e1lez, B., and Castellano, B. (2020). Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.567404"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/glia.22802","article-title":"A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons","volume":"63","author":"Kobayashi","year":"2015","journal-title":"Glia"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0074-7742(08)60183-X","article-title":"The axon reaction: A review of the principal features of perikaryal responses to axon injury","volume":"14","author":"Lieberman","year":"1971","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02740621","article-title":"The cellular and molecular basis of peripheral nerve regeneration","volume":"14","author":"Fu","year":"1997","journal-title":"Mol. Neurobiol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/glia.24470","article-title":"Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses","volume":"72","author":"Castro","year":"2024","journal-title":"Glia"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Dom\u00ednguez, M. (2025). Pathological and Inflammatory Consequences of Aging. Biomolecules, 15.","DOI":"10.3390\/biom15030404"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"e168448","DOI":"10.1172\/jci.insight.168448","article-title":"Aging alters mechanisms underlying voluntary movements in spinal motor neurons of mice, primates, and humans","volume":"8","author":"Castro","year":"2023","journal-title":"JCI Insight"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"You, J., Youssef, M.M., Santos, J.R., Lee, J., and Park, J. (2023). Microglia and astrocytes in amyotrophic lateral sclerosis: Disease-associated states, pathological roles, and therapeutic potential. Biology, 12.","DOI":"10.3390\/biology12101307"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1093\/brain\/awaa309","article-title":"The microglial component of amyotrophic lateral sclerosis","volume":"143","author":"Clarke","year":"2020","journal-title":"Brain J. Neurol."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Brites, D., and Vaz, A.R. (2014). Microglia centered pathogenesis in ALS: Insights in cell interconnectivity. Front. Cell. Neurosci., 8.","DOI":"10.3389\/fncel.2014.00117"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11481-009-9171-5","article-title":"Microglia in ALS: The good, the bad, and the resting","volume":"4","author":"Henkel","year":"2009","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"e829","DOI":"10.1212\/NXI.0000000000000829","article-title":"Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosis","volume":"7","author":"Montal","year":"2020","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"0548","DOI":"10.34133\/research.0548","article-title":"Single-Nucleus RNA Sequencing Reveals the Spatiotemporal Dynamics of Disease-Associated Microglia in Amyotrophic Lateral Sclerosis","volume":"7","author":"Chen","year":"2024","journal-title":"Research"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.celrep.2019.09.066","article-title":"Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia","volume":"29","author":"Tam","year":"2019","journal-title":"Cell Rep."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Jauregui, C., Blanco-Luquin, I., Mac\u00edas, M., Roldan, M., Caballero, C., Pagola, I., Mendioroz, M., and Jeric\u00f3, I. (2023). Exploring the Disease-Associated microglia state in amyotrophic lateral sclerosis. Biomedicines, 11.","DOI":"10.3390\/biomedicines11112994"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.aav9776","article-title":"Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis","volume":"364","author":"Maniatis","year":"2019","journal-title":"Science"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science"},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Prasad, A., Bharathi, V., Sivalingam, V., Girdhar, A., and Patel, B.K. (2019). Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis. Front. Mol. Neurosci., 12.","DOI":"10.3389\/fnmol.2019.00025"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s13311-015-0338-x","article-title":"TDP-43 proteinopathy and ALS: Insights into disease mechanisms and therapeutic targets","volume":"12","author":"Scotter","year":"2015","journal-title":"Neurotherapeutics"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/sc.1991.85","article-title":"Definition of complete spinal cord injury","volume":"29","author":"Waters","year":"1991","journal-title":"Spinal Cord."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00003086-197510000-00003","article-title":"Diagnosis and prognosis of acute cervical spinal cord injury","volume":"112","author":"Stauffer","year":"1975","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_229","first-page":"331","article-title":"University of Miami Neuro-Spinal Index (UMNI): A quantitative method for determining spinal cord function","volume":"18","author":"Klose","year":"1980","journal-title":"Paraplegia"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/sj.sc.3100432","article-title":"International standards for neurological and functional classification of spinal cord injury","volume":"35","author":"Maynard","year":"1997","journal-title":"Spinal Cord"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/sc.2014.91","article-title":"Spinal cord injury models: A review","volume":"52","author":"Cheriyan","year":"2014","journal-title":"Spinal Cord"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/095952874002300111","article-title":"Second Memoir on some principles of the pathology of the nervous system","volume":"23","author":"Hall","year":"1840","journal-title":"Med. Chir. Trans."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"47","DOI":"10.13004\/kjnt.2018.14.2.47","article-title":"Revisit Spinal Shock: Pattern of Reflex Evolution during Spinal Shock","volume":"14","author":"Ko","year":"2018","journal-title":"Korean J. Neurotrauma"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/095952879007300113","article-title":"On the symptomatology of total transverse lesions of the spinal cord; with special reference to the condition of the various reflexes","volume":"73","author":"Bastian","year":"1890","journal-title":"Med. Chir. Trans."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pneurobio.2013.11.002","article-title":"From basics to clinical: A comprehensive review on spinal cord injury","volume":"114","author":"Silva","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/sc.1980.51","article-title":"Incidence and clinical features of autonomic dysreflexia in patients with spinal cord injury","volume":"18","author":"Lindan","year":"1980","journal-title":"Spinal Cord"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1053\/apmr.2001.25077","article-title":"Relationships among clinical characteristics of chronic pain after spinal cord injury","volume":"82","author":"Yezierski","year":"2001","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"281","DOI":"10.55782\/ane-2011-1848","article-title":"Secondary injury mechanisms in traumatic spinal cord injury: A nugget of this multiply cascade","volume":"71","author":"Oyinbo","year":"2011","journal-title":"Acta Neurobiol. Exp."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","article-title":"Traumatic spinal cord injury","volume":"3","author":"Ahuja","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3171\/jns.1991.75.1.0015","article-title":"Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms","volume":"75","author":"Tator","year":"1991","journal-title":"J. Neurosurg."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1038\/s41467-022-31797-0","article-title":"Microglia coordinate cellular interactions during spinal cord repair in mice","volume":"13","author":"Brennan","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Swarts, E.A., and Brennan, F.H. (2025). Evolving insights on the role of microglia in neuroinflammation, plasticity, and regeneration of the injured spinal cord. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1621789"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"134370","DOI":"10.1016\/j.neulet.2019.134370","article-title":"Role of microglia in spinal cord injury","volume":"709","author":"Kroner","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.4103\/1673-5374.143423","article-title":"Function of microglia and macrophages in secondary damage after spinal cord injury","volume":"9","author":"Zhou","year":"2014","journal-title":"Neural Regen. Res."},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Brockie, S., Hong, J., and Fehlings, M.G. (2021). The role of microglia in modulating neuroinflammation after spinal cord injury. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189706"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nrn3053","article-title":"Repertoire of microglial and macrophage responses after spinal cord injury","volume":"12","author":"David","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Xu, L., Wang, J., Ding, Y., Wang, L., and Zhu, Y.J. (2022). Current knowledge of microglia in traumatic spinal cord injury. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.796704"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.4103\/1673-5374.389630","article-title":"Resident immune responses to spinal cord injury: Role of astrocytes and microglia","volume":"19","author":"Brockie","year":"2024","journal-title":"Neural Regen. Res."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4103\/NRR.NRR-D-23-02044","article-title":"Microglia: A promising therapeutic target in spinal cord injury","volume":"20","author":"Zha","year":"2025","journal-title":"Neural Regen. Res."},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Zhao, T., Di, J., Kang, Y., Zhang, H., Yao, S., Liu, B., and Rong, L. (2025). TREM2 Impedes Recovery After Spinal Cord Injury by Regulating Microglial Lysosomal Membrane Permeabilization-Mediated Autophagy, Wiley.","DOI":"10.1111\/cpr.70047"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4049\/immunohorizons.1900038","article-title":"Cx3CR1 expression identifies distinct macrophage populations that contribute differentially to inflammation and repair","volume":"3","author":"Burgess","year":"2019","journal-title":"Immunohorizons"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.4110\/in.2018.18.e5","article-title":"Tissue-specific role of CX3CR1 expressing immune cells and their relationships with human disease","volume":"18","author":"Lee","year":"2018","journal-title":"Immune Netw."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"ref_254","first-page":"167","article-title":"Anatomy and physiology of peripheral nerve injury and repair","volume":"29","author":"Flores","year":"2000","journal-title":"Am. J. Orthop. Belle Mead"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0074-7742(09)87003-7","article-title":"Histology of the peripheral nerve and changes occurring during nerve regeneration","volume":"87","author":"Geuna","year":"2009","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_256","unstructured":"Tubbs, R.S., Rizk, E., Shoja, M.M., Loukas, M., Barbaro, N., and Spinner, R.J. (2015). Chapter 37\u2014The Microcirculation of Peripheral Nerves: The Vasa Nervorum. Nerves and Nerve Injuries, Academic Press."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0006-8993(84)90344-5","article-title":"The nerves to blood vessels supplying blood to nerves: The innervation of vasa nervorum","volume":"304","author":"Appenzeller","year":"1984","journal-title":"Brain Res."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00276-008-0386-6","article-title":"Microanatomical structure of the human sciatic nerve","volume":"30","author":"Sladjana","year":"2008","journal-title":"Surg. Radiol. Anat."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12974-022-02462-6","article-title":"An RNA-sequencing transcriptome of the rodent Schwann cell response to peripheral nerve injury","volume":"19","author":"Lucas","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"e58591","DOI":"10.7554\/eLife.58591","article-title":"Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)","volume":"10","author":"Gerber","year":"2021","journal-title":"eLife"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1038\/s41467-020-16355-w","article-title":"Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_262","unstructured":"Wang, P.L. (2021). Peripheral Nerve Macrophages and Their Implications in Neuroimmunity, Washington University in St. Louis."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40478-025-01937-w","article-title":"Current molecular understanding of central nervous system schwannomas","volume":"13","author":"Tsuchiya","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1038\/s41416-024-02646-2","article-title":"Single-cell RNA sequencing analysis of vestibular schwannoma reveals functionally distinct macrophage subsets","volume":"130","author":"Baruah","year":"2024","journal-title":"Br. J. Cancer"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.cell.2020.06.032","article-title":"Coupled scRNA-Seq and intracellular protein activity reveal an immunosuppressive role of TREM2 in cancer","volume":"182","author":"Katzenelenbogen","year":"2020","journal-title":"Cell"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41392-020-00356-8","article-title":"TREM2 marks tumor-associated macrophages","volume":"5","author":"Nakamura","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"e33470","DOI":"10.1097\/MD.0000000000033470","article-title":"Identification of key genes and immune infiltration based on weighted gene co-expression network analysis in vestibular schwannoma","volume":"102","author":"Fu","year":"2023","journal-title":"Medicine"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0014-4886(69)90037-5","article-title":"Origin of macrophages in Wallerian degeneration of peripheral nerves demonstrated autoradiographically","volume":"23","author":"Olsson","year":"1969","journal-title":"Exp. Neurol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/BF01191724","article-title":"MHC-positive, ramified macrophages in the normal and injured rat peripheral nervous system","volume":"21","author":"Monaco","year":"1992","journal-title":"J. Neurocytol."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00401-015-1482-4","article-title":"Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury","volume":"130","author":"Chen","year":"2015","journal-title":"Acta Neuropathol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cell.2015.07.021","article-title":"Macrophage-induced blood vessels guide Schwann cell-mediated regeneration of peripheral nerves","volume":"162","author":"Cattin","year":"2015","journal-title":"Cell"},{"key":"ref_272","doi-asserted-by":"crossref","unstructured":"Gordon, T. (2020). Peripheral Nerve Regeneration and Muscle Reinnervation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228652"},{"key":"ref_273","doi-asserted-by":"crossref","unstructured":"Chen, B., Chen, Q., Parkinson, D.B., and Dun, X.P. (2019). Analysis of Schwann cell migration and axon regeneration following nerve injury in the sciatic nerve bridge. Front. Mol. Neurosci., 12.","DOI":"10.3389\/fnmol.2019.00308"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/cne.20436","article-title":"Pathway sampling by regenerating peripheral axons","volume":"485","author":"Witzel","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12974-018-1219-0","article-title":"Temporal changes in macrophage phenotype after peripheral nerve injury","volume":"15","author":"Tomlinson","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"103590","DOI":"10.1016\/j.mcn.2021.103590","article-title":"Macrophage roles in peripheral nervous system injury and pathology: Allies in neuromuscular junction recovery","volume":"111","author":"Rios","year":"2021","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/1742-2094-9-176","article-title":"Acute injury in the peripheral nervous system triggers an alternative macrophage response","volume":"9","author":"Ydens","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"ref_278","doi-asserted-by":"crossref","unstructured":"Shiraishi, W., Yamasaki, R., Hashimoto, Y., Ko, S., Kobayakawa, Y., Isobe, N., Matsushita, T., and Kira, J.I. (2021). Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-96064-6"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-2094-7-8","article-title":"Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis","volume":"7","author":"Graber","year":"2010","journal-title":"J. Neuroinflamm."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1212\/WNL.0b013e318249f776","article-title":"Peripheral nerve inflammation in ALS mice: Cause or consequence","volume":"78","author":"Kano","year":"2012","journal-title":"Neurology"},{"key":"ref_281","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Muriana, A., Mancuso, R., Francos-Quijorna, I., Olmos-Alonso, A., Osta, R., Perry, V.H., Navarro, X., Gomez-Nicola, D., and L\u00f3pez-Vales, R. (2016). CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves. Sci. Rep., 6.","DOI":"10.1038\/srep25663"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/s41593-020-00718-z","article-title":"Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival","volume":"23","author":"Chiot","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12974-022-02454-6","article-title":"The macrophage: A key player in the pathophysiology of peripheral neuropathies","volume":"19","author":"Msheik","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_284","doi-asserted-by":"crossref","unstructured":"MacIntosh, B.R., Gardiner, P.F., and McComas, A.J. (2006). Skeletal Muscle: Form and Function, Human Kinetics.","DOI":"10.5040\/9781492596912"},{"key":"ref_285","unstructured":"Lieber, R.L. (2002). Skeletal Muscle Structure, Function, and Plasticity, Lippincott Williams & Wilkins."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1098\/rspb.1924.0023","article-title":"Reflexes in response to stretch (myotatic reflexes)","volume":"96","author":"Liddel","year":"1924","journal-title":"Proc. R. Soc. Lond. Ser. B"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1113\/jphysiol.1957.sp005849","article-title":"Synaptic actions on motoneurones caused by impulses in Golgi tendon organ afferents","volume":"138","author":"Eccles","year":"1957","journal-title":"J. Physiol."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1152\/jn.1971.34.1.171","article-title":"Terminals of single Ia fibers: Location, density, and distribution within a pool of 300 homonymous motoneurons","volume":"34","author":"Mendell","year":"1971","journal-title":"J. Neurophysiol."},{"key":"ref_289","doi-asserted-by":"crossref","unstructured":"B\u0105czyk, M., Manuel, M., Roselli, F., and Zytnicki, D. (2022). Diversity of Mammalian Motoneurons and Motor Units. Vertebrate Motoneurons, Springer.","DOI":"10.1007\/978-3-031-07167-6_6"},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Kernell, D. (2006). The Motoneurone and its Muscle Fibres, Oxford University Press UK.","DOI":"10.1093\/acprof:oso\/9780198526551.001.0001"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1142\/S0219635211002786","article-title":"Alpha, beta and gamma motoneurons: Functional diversity in the motor system\u2019s final pathway","volume":"10","author":"Manuel","year":"2011","journal-title":"J. Integr. Neurosci."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"fcab081","DOI":"10.1093\/braincomms\/fcab081","article-title":"Terminal Schwann cells at the human neuromuscular junction","volume":"3","author":"Alhindi","year":"2021","journal-title":"Brain Commun."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0960-9822(02)70662-3","article-title":"Schwann cells: Dynamic roles at the neuromuscular junction","volume":"6","year":"1996","journal-title":"Curr. Biol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.tins.2024.03.007","article-title":"Origin, identity, and function of terminal Schwann cells","volume":"47","author":"Hastings","year":"2024","journal-title":"Trends Neurosci."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Hastings, R.L., Mikesh, M., Lee, Y.i., and Thompson, W.J. (2020). Morphological remodeling during recovery of the neuromuscular junction from terminal Schwann cell ablation in adult mice. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-67630-1"},{"key":"ref_296","first-page":"435","article-title":"The structure of the satellite cells in skeletal muscle","volume":"99","author":"Muir","year":"1965","journal-title":"J. Anat."},{"key":"ref_297","doi-asserted-by":"crossref","unstructured":"Mauro, A. (1961). Satellite cell of skeletal muscle fibers. J. Biophys. Biochem. Cytol., 9.","DOI":"10.1083\/jcb.9.2.493"},{"key":"ref_298","doi-asserted-by":"crossref","unstructured":"Rubenstein, A.B., Smith, G.R., Raue, U., Begue, G., Minchev, K., Ruf-Zamojski, F., Nair, V.D., Wang, X., Zhou, L., and Zaslavsky, E. (2020). Single-cell transcriptional profiles in human skeletal muscle. Sci. Rep., 10.","DOI":"10.1038\/s41598-019-57110-6"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13395-020-00236-3","article-title":"A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations","volume":"10","author":"Spector","year":"2020","journal-title":"Skelet. Muscle"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.1523\/JNEUROSCI.4673-13.2014","article-title":"Terminal Schwann Cells Participate in Neuromuscular Synapse Remodeling during Reinnervation following Nerve Injury","volume":"34","author":"Kang","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/BF01206897","article-title":"Terminal Schwann cells elaborate extensive processes following denervation of the motor endplate","volume":"21","author":"Reynolds","year":"1992","journal-title":"J. Neurocytol."},{"key":"ref_302","doi-asserted-by":"crossref","unstructured":"Bermedo-Garc\u00eda, F., Zelada, D., Mart\u00ednez, E., Tabares, L., and Henr\u00edquez, J.P. (2022). Functional regeneration of the murine neuromuscular synapse relies on long-lasting morphological adaptations. BMC Biol., 20.","DOI":"10.1186\/s12915-022-01358-4"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0896-6273(95)90246-5","article-title":"Schwann cell processes guide regeneration of peripheral axons","volume":"14","author":"Son","year":"1995","journal-title":"Neuron"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"2304084","DOI":"10.1002\/advs.202304084","article-title":"Deciphering immune landscape remodeling unravels the underlying mechanism for synchronized muscle and bone aging","volume":"11","author":"Yin","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"e162835","DOI":"10.1172\/jci.insight.162835","article-title":"Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss","volume":"8","author":"Larouche","year":"2023","journal-title":"JCI Insight"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"e2410095122","DOI":"10.1073\/pnas.2410095122","article-title":"Expansion and pathogenic activation of skeletal muscle\u2013resident macrophages in mdx5cv\/Ccr2\u2212\/\u2212 mice","volume":"122","author":"Wang","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/jbmr.4572","article-title":"Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice","volume":"37","author":"Essex","year":"2022","journal-title":"J. Bone Min. Res."},{"key":"ref_308","doi-asserted-by":"crossref","unstructured":"Tacconi, S., Giudetti, A.M., Blangero, F., Meugnier, E., El-jaafari, A., Longo, S., Angil\u00e9, F., Fanizzi, F.P., Canaple, L., and Jalabert, A. (2025). LAM\/TREM2+ macrophages release extracellular vesicles and extracellular lipid droplets which modulate the phenotype of recipient macrophages and homeostasis of skeletal muscle cells. bioRxiv.","DOI":"10.1101\/2025.01.26.634912"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"9602","DOI":"10.1523\/JNEUROSCI.1736-20.2020","article-title":"Macrophage-derived vascular endothelial growth factor-A is integral to neuromuscular junction reinnervation after nerve injury","volume":"40","author":"Lu","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.expneurol.2016.01.008","article-title":"Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS)","volume":"277","author":"Macrander","year":"2016","journal-title":"Exp. Neurol."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"20960","DOI":"10.1073\/pnas.0911405106","article-title":"Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice","volume":"106","author":"Chiu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/NEN.0b013e31821cbd8b","article-title":"Defective neuromuscular junction organization and postnatal myogenesis in mice with severe spinal muscular atrophy","volume":"70","author":"Dachs","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.cell.2020.05.003","article-title":"The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway","volume":"181","author":"Deczkowska","year":"2020","journal-title":"Cell"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"16027","DOI":"10.1038\/mtm.2016.27","article-title":"A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses","volume":"3","author":"Chtarto","year":"2016","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s12974-024-03232-2","article-title":"A comprehensive review of AAV-mediated strategies targeting microglia for therapeutic intervention of neurodegenerative diseases","volume":"21","author":"Zhou","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1212\/WNL.0000000000204897","article-title":"Microglial-targeted Gene Therapy: Developing a Disease Modifying Treatment for ALSP Associated with CSF1R Mutations (ALSP-CSF1R) (P11-4.012)","volume":"102","author":"Masoudi","year":"2024","journal-title":"Neurology"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/19\/1520\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:12:34Z","timestamp":1759144354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/19\/1520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":316,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["cells14191520"],"URL":"https:\/\/doi.org\/10.3390\/cells14191520","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]}}}