{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T18:55:01Z","timestamp":1785264901047,"version":"3.55.0"},"reference-count":113,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disorder with a complex etiology whose exact mechanisms are not fully understood. In recent years, there has been growing interest in the role of the gastrointestinal microbiota in the pathogenesis of AD, particularly in the context of the gut\u2013brain axis. The purpose of this review is to discuss the current state of knowledge regarding potential relationships between the composition of the gut microbiota and the development and progression of AD. Preclinical and clinical studies indicating that microbiota imbalances (dysbiosis) may contribute to increased inflammation, increased permeability of the intestinal and blood\u2013brain barriers, and accumulation of pathological proteins such as beta-amyloid and tau are analyzed. The effects of diet, probiotics and microbiota interventions on cognitive function were also discussed. An attempt was also made to evaluate microbiota disruption as a potential early marker of AD development. Although the mechanisms require further study, the role of the gut microbiota appears to be an important and promising direction in understanding the pathophysiology of AD and developing potential therapeutic and diagnostic strategies.<\/jats:p>","DOI":"10.3390\/cells14201578","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:13:27Z","timestamp":1760361207000},"page":"1578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of the Gut Microbiota on the Pathogenesis of Alzheimer\u2019s Disease: A Literature Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-038X","authenticated-orcid":false,"given":"Joanna","family":"Koga-Batko","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5026-0344","authenticated-orcid":false,"given":"Katarzyna","family":"Antosz-Popio\u0142ek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Suchecki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4781-4151","authenticated-orcid":false,"given":"Hubert","family":"Szyller","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7710-3680","authenticated-orcid":false,"given":"Martyna","family":"Wrze\u015bniewska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-7628","authenticated-orcid":false,"given":"Maciej","family":"Dyda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Leszek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, Ludwika Pasteura 1, 50-367 Wroc\u0142aw, Poland"},{"name":"Clinic of Psychiatry, Department of Psychiatry, Wroclaw Medical University, Ludwika Pasteura 10, 50-367 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"ref_1","unstructured":"(2021). 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