{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:24Z","timestamp":1787027844808,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01-HL148598"],"award-info":[{"award-number":["R01-HL148598"]}]},{"name":"NIH","award":["R01-AI159078"],"award-info":[{"award-number":["R01-AI159078"]}]},{"name":"American Heart Association Career Development Award","award":["CDA34110117"],"award-info":[{"award-number":["CDA34110117"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Angiotensin II (AngII), the primary effector of the renin-angiotensin system, is essential for maintaining blood pressure and fluid-electrolyte homeostasis. However, elevated AngII levels are a feature of disease conditions such as heart failure and chronic kidney disease, where it is associated with pathological tissue remodeling and fibrosis. AngII-mediated fibrosis has been documented in multiple organs and is characterized by fibroblast expansion, myofibroblast differentiation, and excessive extracellular matrix deposition. Periostin has recently emerged as a marker of fibroblast activation. Notably, periostin expression is highly upregulated during fibrotic remodeling in the kidney and lung, which is strongly linked with impaired organ function. While AngII-induced activation of periostin-lineage (PostnLin) cells is well established in the heart, the temporal dynamics of PostnLin activation in response to AngII infusion in the lung and kidney remain unexplored. Here, we used a Postn-MerCreMer lineage-tracing approach, combined with continuous AngII infusion over an experimental period of one week and two weeks to assess PostnLin responses in lung and kidney. Our findings reveal a progressive activation of PostnLin cells in both organs, characterized by myofibroblast phenotype, together with increased collagen deposition and macrophage infiltration. These results highlight the potential of PostnLin fibroblasts as a key effector of AngII-mediated tissue remodeling and fibrosis in the lung and kidney.<\/jats:p>","DOI":"10.3390\/cells14201584","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:13:27Z","timestamp":1760361207000},"page":"1584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Angiotensin II Promotes Progressive Activation of Fibrogenic Periostin-Lineage Cells in Lung and Kidney"],"prefix":"10.3390","volume":"14","author":[{"given":"Mustafa","family":"Ozdemir","sequence":"first","affiliation":[{"name":"Pathobiology and Molecular Medicine Program, Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA"},{"name":"Division of Basic and Translational Science, Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8417-9014","authenticated-orcid":false,"given":"Jos\u00e9 P.","family":"Guirao-Abad","sequence":"additional","affiliation":[{"name":"Division of Basic and Translational Science, Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Kasprovic","sequence":"additional","affiliation":[{"name":"Division of Basic and Translational Science, Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"},{"name":"Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Jaggers","sequence":"additional","affiliation":[{"name":"Division of Basic and Translational Science, Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"},{"name":"Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-4874","authenticated-orcid":false,"given":"Onur","family":"Kanisicak","sequence":"additional","affiliation":[{"name":"Pathobiology and Molecular Medicine Program, Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA"},{"name":"Division of Basic and Translational Science, Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"},{"name":"Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1053\/euhj.1999.1740","article-title":"Clinical implications of increased plasma angiotensin II despite ACE inhibitor therapy in patients with congestive heart failure","volume":"21","author":"Roig","year":"2000","journal-title":"Eur. 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