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Alcohol consumption is linked to an increased risk of several cancers and is a controversial risk factor for developing cervical cancer. This review updates existing information on the correlation between alcohol consumption and the risk of developing cervical cancer. Several comprehensive studies from different geographical regions have shown that moderate and heavy drinking is positively correlated with the development of cervical cancer. There is a synergistic relationship between human papillomavirus (HPV) viral load and alcohol use among drinkers with a high HPV viral load. Excessive alcohol consumption and exposure to second-hand smoke may elevate the risk of persistent HPV infection. Furthermore, high-risk behaviors associated with Human immunodeficiency virus (HIV)\/HPV co-infection are more common among binge drinkers. However, several observations failed to establish a relationship between these factors. Despite some inconsistency in the literature, evidence suggests a modest association between alcohol consumption and increased risk of persistent HPV infection, causing cervical cancer.<\/jats:p>","DOI":"10.3390\/cells14201639","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:42:03Z","timestamp":1761054123000},"page":"1639","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Alcohol Consumption and Cervical Carcinogenesis: Time to Draw Conclusions"],"prefix":"10.3390","volume":"14","author":[{"given":"Vivek K.","family":"Kashyap","sequence":"first","affiliation":[{"name":"Division of Cancer Immunology and Microbiology, Medicine and Oncology Integrated Service Unit, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"},{"name":"South Texas Center of Excellence in Cancer Research (ST-CECR), McAllen, TX 78504, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya B.","family":"Kenchappa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatric-Pulmonology, University of Tennessee Health Science Center, Le Bonheur Children\u2019s Hospital, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupesh","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Applied Sciences, OM Sterling Global University, Hisar 125001, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-8828","authenticated-orcid":false,"given":"Murali M.","family":"Yallapu","sequence":"additional","affiliation":[{"name":"Division of Cancer Immunology and Microbiology, Medicine and Oncology Integrated Service Unit, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"},{"name":"South Texas Center of Excellence in Cancer Research (ST-CECR), McAllen, TX 78504, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everardo","family":"Cobos","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash C.","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Division of Cancer Immunology and Microbiology, Medicine and Oncology Integrated Service Unit, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA"},{"name":"South Texas Center of Excellence in Cancer Research (ST-CECR), McAllen, TX 78504, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"ref_1","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. 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