{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:24:26Z","timestamp":1787509466374,"version":"build-2736575974"},"reference-count":105,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["25-24-00040"],"award-info":[{"award-number":["25-24-00040"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Liver diseases are leading causes of death and disability worldwide. Therefore, the development of new treatments for liver disease is urgent. An integral part of the treatment of any liver disease is the process of regeneration of its parenchyma. However, the current approach to studying mammalian liver regeneration is one-sided, focusing solely on the liver itself and neglecting its interactions with other organs. This includes organs of the functional excretory system, such as the lungs and kidneys, which can secrete factors, including HGF, EGF, TGF\u03b2, IL6, and others, into the bloodstream, which influence reparative processes in the liver. Only a few studies exist in this area. However, without a systematic approach to studying liver regeneration, it is impossible to develop new and effective methods to stimulate its regeneration. This review presents data on the interaction of the regenerating liver with the nervous, endocrine, and immune systems, as well as with the lungs, kidneys, and intestines.<\/jats:p>","DOI":"10.3390\/cells14211691","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:59:36Z","timestamp":1761659976000},"page":"1691","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Crosstalk Between Liver and Extra-Liver Organs During Liver Regeneration in Mammals"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-4439","authenticated-orcid":false,"given":"Andrey","family":"Elchaninov","sequence":"first","affiliation":[{"name":"Laboratory of Growth and Development, Avtsyn Research Institute of Human Morphology of FSBI \u201cPetrovsky National Research Centre of Surgery\u201d, 3 Tsurupa Street, 117418 Moscow, Russia"},{"name":"Research Institute of Molecular and Cellular Medicine, Peoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5639-0835","authenticated-orcid":false,"given":"Daria","family":"Bykova","sequence":"additional","affiliation":[{"name":"Laboratory of Growth and Development, Avtsyn Research Institute of Human Morphology of FSBI \u201cPetrovsky National Research Centre of Surgery\u201d, 3 Tsurupa Street, 117418 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-8005","authenticated-orcid":false,"given":"Elena","family":"Gantsova","sequence":"additional","affiliation":[{"name":"Laboratory of Growth and Development, Avtsyn Research Institute of Human Morphology of FSBI \u201cPetrovsky National Research Centre of Surgery\u201d, 3 Tsurupa Street, 117418 Moscow, Russia"},{"name":"Research Institute of Molecular and Cellular Medicine, Peoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8650-8240","authenticated-orcid":false,"given":"Polina","family":"Vishnyakova","sequence":"additional","affiliation":[{"name":"Research Institute of Molecular and Cellular Medicine, Peoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"},{"name":"Laboratory of Regenerative Medicine, Institute of Translational Medicine, National Medical Research Centre for Obstetrics, Gynecology and Perinatology Named After Academician V.I. 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Cells, 14.","DOI":"10.3390\/cells14151129"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver Regeneration: Biological and Pathological Mechanisms and Implications","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.21037\/atm-21-5234","article-title":"A Narrative Review of Liver Regeneration\u2014From Models to Molecular Basis","volume":"9","author":"Huang","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1440-1746.2010.06539.x","article-title":"New Concepts in Liver Regeneration","volume":"26","author":"Riehle","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.276.5309.60","article-title":"Liver Regeneration","volume":"276","author":"Michalopoulos","year":"1997","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.hpb.2019.06.016","article-title":"Acute Kidney Injury after Liver Surgery: Does Postoperative Urine Output Correlate with Postoperative Serum Creatinine?","volume":"22","author":"Joliat","year":"2020","journal-title":"HPB"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1136\/thoraxjnl-2020-216128","article-title":"Inhaled Nitric Oxide Improves the Hepatopulmonary Syndrome: A Physiologic Analysis","volume":"76","author":"Gupta","year":"2021","journal-title":"Thorax"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1183\/09059180.00007211","article-title":"Portopulmonary Hypertension and Hepatopulmonary Syndrome: A Clinician-Oriented Overview","volume":"21","author":"Altamirano","year":"2012","journal-title":"Eur. Respir. Rev."},{"key":"ref_11","first-page":"e65204","article-title":"Hepatopulmonary Syndrome: A Comprehensive Review","volume":"16","author":"Qasim","year":"2024","journal-title":"Cureus"},{"key":"ref_12","unstructured":"Anokhin, P. (1980). Key Issues of the Theory of Functional Systems, Nauka."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.7150\/ijbs.41293","article-title":"Potential Crosstalk between Liver and Extra-Liver Organs in Mouse Models of Acute Liver Injury","volume":"16","author":"Zheng","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Yang Zhou, J. (2023). Innate Immunity and Early Liver Inflammation. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1175147"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/s41423-025-01313-7","article-title":"Inflammation and Immunity in Liver Homeostasis and Disease: A Nexus of Hepatocytes, Nonparenchymal Cells and Immune Cells","volume":"22","author":"Kostallari","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s11684-017-0584-x","article-title":"\u0393\u03b4 T Cells in Liver Diseases","volume":"12","author":"Wang","year":"2018","journal-title":"Front. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2016.07.009","article-title":"Liver Sinusoidal Endothelial Cells: Physiology and Role in Liver Diseases","volume":"66","author":"Poisson","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Elchaninov, A., Vishnyakova, P., Menyailo, E., Sukhikh, G., and Fatkhudinov, T. (2022). An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23179868"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00424-012-1209-5","article-title":"Hepatic Stellate Cells--the Pericytes in the Liver","volume":"465","author":"Hellerbrand","year":"2013","journal-title":"Pflugers Arch."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1172\/JCI66027","article-title":"Hepatic Stem Cell Niches","volume":"123","author":"Kordes","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/livers3030029","article-title":"The Role of Immune Cells in Liver Regeneration","volume":"3","author":"Wen","year":"2023","journal-title":"Livers"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/hep.27084","article-title":"Clonal Tracing of Sox9+ Liver Progenitors in Mouse Oval Cell Injury","volume":"60","author":"Tarlow","year":"2014","journal-title":"Hepatology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2016.97","article-title":"Liver Regeneration\u2014Mechanisms and Models to Clinical Application","volume":"13","author":"Forbes","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Du, Y., Zhang, W., Qiu, H., Xiao, C., Shi, J., Reid, L.M., and He, Z. (2022). Mouse Models of Liver Parenchyma Injuries and Regeneration. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.903740"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41575-021-00454-0","article-title":"Novel Insights into Liver Homeostasis and Regeneration","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2353\/ajpath.2010.090675","article-title":"Liver Regeneration after Partial Hepatectomy","volume":"176","author":"Michalopoulos","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/ajpgi.1998.274.4.G767","article-title":"Heterogeneity of the Proliferative Capacity of Rat Cholangiocytes after Bile Duct Ligation","volume":"274","author":"Alpini","year":"1998","journal-title":"Am. J. Physiol. -Gastrointest. Liver Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0016-5085(99)70242-8","article-title":"Bile Acid Feeding Induces Cholangiocyte Proliferation and Secretion: Evidence for Bile Acid-Regulated Ductal Secretion","volume":"116","author":"Alpini","year":"1999","journal-title":"Gastroenterology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.510290242","article-title":"Acute Carbon Tetrachloride Feeding Selectively Damages Large, but Not Small, Cholangiocytes from Normal Rat Liver","volume":"29","author":"LeSage","year":"1999","journal-title":"Hepatology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/S0016-5085(96)70027-6","article-title":"Regrowth of the Rat Biliary Tree after 70% Partial Hepatectomy Is Coupled to Increased Secretin-Induced Ductal Secretion","volume":"111","author":"Lesage","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0016-5085(96)70081-1","article-title":"Hepatic Microcirculation and Peribiliary Plexus in Experimental Biliary Cirrhosis: A Morphological Study","volume":"111","author":"Gaudio","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0002-9440(10)65209-1","article-title":"Hepatocellular Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Angiogenesis in Experimental Biliary Cirrhosis","volume":"155","author":"Rosmorduc","year":"1999","journal-title":"Am. J. Pathol."},{"key":"ref_33","first-page":"1574","article-title":"Somatostatin Analogue (Octreotide) Inhibits Bile Duct Epithelial Cell Proliferation and Fibrosis after Extrahepatic Biliary Obstruction","volume":"143","author":"Tracy","year":"1993","journal-title":"Am. J. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1053\/jhep.2000.8265","article-title":"Gastrin Inhibits Cholangiocyte Growth in Bile Duct-Ligated Rats by Interaction with Cholecystokinin-B\/Gastrin Receptors via D-Myo-Inositol 1,4,5-Triphosphate-, Ca2+-, and Protein Kinase C \u03b1-Dependent Mechanisms","volume":"32","author":"Glaser","year":"2000","journal-title":"Hepatology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI89429","article-title":"Accelerated Resolution of Inflammation Underlies Sex Differences in Inflammatory Responses in Humans","volume":"127","author":"Rathod","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0037-1601351","article-title":"Update on the Mechanisms of Liver Regeneration","volume":"37","author":"Preziosi","year":"2017","journal-title":"Semin. Liver Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/liv.12164","article-title":"Gliotoxin-Induced Changes in Rat Liver Regeneration after Partial Hepatectomy","volume":"33","author":"Orr","year":"2013","journal-title":"Liver Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic Stellate Cells as Key Target in Liver Fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/cvr\/cvt101","article-title":"The Atherosusceptible Endothelium: Endothelial Phenotypes in Complex Haemodynamic Shear Stress Regions in Vivo","volume":"99","author":"Davies","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"DeLeve, L.D. (2013). Liver Sinusoidal Endothelial Cells and Liver Injury. Drug-Induced Liver Disease, Elsevier Inc.","DOI":"10.1016\/B978-0-12-387817-5.00008-X"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1172\/JCI58789","article-title":"Liver Sinusoidal Endothelial Cell Progenitor Cells Promote Liver Regeneration in Rats","volume":"122","author":"Wang","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.bcp.2013.07.006","article-title":"Role of Hepatic Resident and Infiltrating Macrophages in Liver Repair after Acute Injury","volume":"86","author":"You","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4049\/jimmunol.1400574","article-title":"Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury","volume":"193","author":"Zigmond","year":"2014","journal-title":"J. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1034\/j.1600-0676.2000.020001066.x","article-title":"Kupffer Cell Depletion by CI2MDP-Liposomes Alters Hepatic Cytokine Expression and Delays Liver Regeneration after Partial Hepatectomy","volume":"20","author":"Meijer","year":"2000","journal-title":"Liver"},{"key":"ref_46","unstructured":"Constandinou, C.M., Vuthoori, S., Iredale, J.P., Partolina, M., Lang, R., Clay, S., Duffield, J.S., Wu, S., and Forbes, S.J. (2008). Selective Depletion of Macrophages Reveals Distinct, Opposing Roles during Liver Injury and Repair. J. Clin. Investig."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.biocel.2009.09.014","article-title":"Liver Regeneration: Alternative Epithelial Pathways","volume":"43","author":"Michalopoulos","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Nishiyama, K., Nakashima, H., Ikarashi, M., Kinoshita, M., Nakashima, M., Aosasa, S., Seki, S., and Yamamoto, J. (2015). Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136774"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Elchaninov, A., Vishnyakova, P., Gantsova, E., Chirkova, M., Karyagina, V., Anatoliy, L., Kananykhina, E., Kuznetsova, M., Atabekov, I., and Karpulevich, E. (2025). Cellular Effects of Splenectomy on Liver Regeneration after 70% Resection. Front. Cell Dev. Biol., 13.","DOI":"10.3389\/fcell.2025.1561815"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Elchaninov, A., Vishnyakova, P., Kuznetsova, M., Gantsova, E., Kiseleva, V., Lokhonina, A., Antonova, M., Mamedov, A., Soboleva, A., and Trofimov, D. (2023). The Spleen as a Possible Source of Serine Protease Inhibitors and Migrating Monocytes Required for Liver Regeneration after 70% Resection in Mice. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1241819"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Elchaninov, A., Nikitina, M., Vishnyakova, P., Lokhonina, A., Makarov, A., Sukhikh, G., and Fatkhudinov, T. (2021). Macro- and Microtranscriptomic Evidence of the Monocyte Recruitment to Regenerating Liver after Partial Hepatectomy in Mouse Model. Biomed. Pharmacother., 138.","DOI":"10.1016\/j.biopha.2021.111516"},{"key":"ref_52","unstructured":"Sidorova, V.F., Ryabinina, Z.A., and Leikina, E.M. (1966). Mammas Liver Regeneration, Meditsina."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000065594","article-title":"The Role of the Autonomic Nervous System in Liver Regeneration and Apoptosis\u2014Recent Developments","volume":"66","author":"Kiba","year":"2002","journal-title":"Digestion"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1002\/hep.32055","article-title":"Hepatic Nervous System in Development, Regeneration, and Disease","volume":"74","author":"Miller","year":"2021","journal-title":"Hepatology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/j.2040-4603.2013.tb00506.x","article-title":"Hepatic Nervous System and Neurobiology of the Liver","volume":"3","author":"Jensen","year":"2013","journal-title":"Compr. Physiol."},{"key":"ref_56","unstructured":"Dubovaya, T., and Eletsky, U.K. (1989). Morphofunctional Analysis of the State and Reactivity of Liver Parenchyma under Conditions of Disorders of Organ Innervation. Folia Morphol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jss.2007.01.007","article-title":"The Effect of Denervation on Liver Regeneration in Partially Hepatectomized Rats","volume":"142","author":"Hamada","year":"2007","journal-title":"J. Surg. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.3748\/wjg.v24.i15.1616","article-title":"Autonomic Nervous System Network and Liver Regeneration","volume":"24","author":"Kamimura","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Amir, M., Yu, M., He, P., and Srinivasan, S. (2020). Hepatic Autonomic Nervous System and Neurotrophic Factors Regulate the Pathogenesis and Progression of Non-Alcoholic Fatty Liver Disease. Front. Med., 7.","DOI":"10.3389\/fmed.2020.00062"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.4240\/wjgs.v15.i12.2866","article-title":"Hepatic Vagotomy Blunts Liver Regeneration after Hepatectomy by Downregulating the Expression of Interleukin-22","volume":"15","author":"Zhou","year":"2023","journal-title":"World J. Gastrointest. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"110227","DOI":"10.1016\/j.cellsig.2021.110227","article-title":"Netrin-1 Promotes Liver Regeneration Possibly by Facilitating Vagal Nerve Repair after Partial Hepatectomy in Mice","volume":"91","author":"Wang","year":"2022","journal-title":"Cell. Signal."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1038\/s41467-018-07747-0","article-title":"Vagus-Macrophage-Hepatocyte Link Promotes Post-Injury Liver Regeneration and Whole-Body Survival through Hepatic FoxM1 Activation","volume":"9","author":"Izumi","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"dmm048922","DOI":"10.1242\/dmm.048922","article-title":"Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver","volume":"14","author":"Ko","year":"2021","journal-title":"Dis. Model Mech."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jns.2006.12.003","article-title":"Increased 5-HT2C Receptor Binding in the Brain Stem and Cerebral Cortex during Liver Regeneration and Hepatic Neoplasia in Rats","volume":"254","author":"Pyroja","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/jcp.1041400202","article-title":"Regulation of Hepatocyte Growth: Alpha-1 Adrenergic Receptor and Ras P21 Changes in Liver Regeneration","volume":"140","author":"Cruise","year":"1989","journal-title":"J. Cell. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1126\/science.2982212","article-title":"Induction of DNA Synthesis in Cultured Rat Hepatocytes through Stimulation of Alpha 1 Adrenoreceptor by Norepinephrine","volume":"227","author":"Cruise","year":"1985","journal-title":"Science"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.mayocpiqo.2020.02.001","article-title":"Hormonal Contribution to Liver Regeneration","volume":"4","author":"Zhou","year":"2020","journal-title":"Mayo Clin. Proc. Innov. Qual. Outcomes"},{"key":"ref_68","first-page":"529","article-title":"Effects of Growth Hormone on Hepatic Regeneration","volume":"30","author":"Balik","year":"2000","journal-title":"Turkish J. Med. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1677\/joe.0.1350059","article-title":"Growth Hormone Promotes Early Initiation of Hepatocyte Growth Factor Gene Expression in the Liver of Hypophysectomized Rats after Partial Hepatectomy","volume":"135","author":"Ekberg","year":"1992","journal-title":"J. Endocrinol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/hep.26609","article-title":"The Insulin Receptor Translocates to the Nucleus to Regulate Cell Proliferation in Liver","volume":"59","author":"Amaya","year":"2014","journal-title":"Hepatology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1096\/fsb2fj000416com","article-title":"Cyclin D1 Is an Early Target in Hepatocyte Proliferation Induced by Thyroid Hormone (T3)","volume":"15","author":"Pibiri","year":"2001","journal-title":"FASEB J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000083639","article-title":"Thyroid Status Affects Rat Liver Regeneration After Partial Hepatectomy by Regulating Cell Cycle and Apoptosis","volume":"15","author":"Alisi","year":"2005","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.3748\/wjg.v19.i23.3534","article-title":"Liver-Spleen Axis: Intersection between Immunity, Infections and Metabolism","volume":"19","author":"Tarantino","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Elchaninov, A., Vishnyakova, P., Sukhikh, G., and Fatkhudinov, T. (2022). Spleen: Reparative Regeneration and Influence on Liver. Life, 12.","DOI":"10.3390\/life12050626"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/hepr.12267","article-title":"Cytokine Expression in Spleen Affects Progression of Liver Cirrhosis through Liver-Spleen Cross-Talk","volume":"44","author":"Asanoma","year":"2014","journal-title":"Hepatol. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s12276-021-00574-2","article-title":"Splenectomy Improves Liver Fibrosis via Tumor Necrosis Factor Superfamily 14 (LIGHT) through the JNK\/TGF-\u03921 Signaling Pathway","volume":"53","author":"Liang","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"441","DOI":"10.22363\/2313-0245-2023-27-4-441-448","article-title":"Macrophage Population State and Proliferative Activity of Spleen Cells under Liver Regeneration Conditions","volume":"27","author":"Mamedov","year":"2023","journal-title":"Rudn J. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s12276-024-01371-3","article-title":"CD300E+ Macrophages Facilitate Liver Regeneration after Splenectomy in Decompensated Cirrhotic Patients","volume":"57","author":"Yang","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"E100","DOI":"10.1111\/hepr.12234","article-title":"Influence of Splenectomy in Patients with Liver Cirrhosis and Hypersplenism","volume":"44","author":"Nomura","year":"2014","journal-title":"Hepatol. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.ajpath.2011.01.001","article-title":"Enhanced Liver Regeneration in IL-10-Deficient Mice after Partial Hepatectomy via Stimulating Inflammatory Response and Activating Hepatocyte STAT3","volume":"178","author":"Yin","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Elchaninov, A.V., Fatkhudinov, T.K., Vishnyakova, P.A., Nikitina, M.P., Lokhonina, A.V., Makarov, A.V., Arutyunyan, I.V., Kananykhina, E.Y., Poltavets, A.S., and Butov, K.R. (2020). Molecular Mechanisms of Splenectomy-Induced Hepatocyte Proliferation. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0233767"},{"key":"ref_82","first-page":"453","article-title":"Cellular and Humoral Immunity Factors as Regulators of Regenerative Morphogenesis","volume":"20","author":"Babaeva","year":"1989","journal-title":"Ontogenez"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jcp.21172","article-title":"Liver Regeneration","volume":"213","author":"Michalopoulos","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0006-291X(92)90844-B","article-title":"Marked Induction of Hepatocyte Growth Factor MRNA in Intact Kidney and Spleen in Response to Injury of Distant Organs","volume":"186","author":"Kono","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.jss.2013.03.033","article-title":"Interleukin-17A Plays a Pivotal Role after Partial Hepatectomy in Mice","volume":"184","author":"Furuya","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e220073","DOI":"10.1530\/JOE-22-0073","article-title":"SerpinA3N Deficiency Attenuates Steatosis and Enhances Insulin Signaling in Male Mice","volume":"256","author":"Tran","year":"2023","journal-title":"J. Endocrinol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/cns.13776","article-title":"SerpinA3N Attenuates Ischemic Stroke Injury by Reducing Apoptosis and Neuroinflammation","volume":"28","author":"Zhang","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"ref_88","unstructured":"Babaeva, A.G., and Zotikov, E.A. (1987). Immunology of Processes of Adaptive Growth, Proliferation and Their Disorders, Medicine."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1053\/j.gastro.2008.09.015","article-title":"T Cell-Derived Lymphotoxin Regulates Liver Regeneration","volume":"136","author":"Tumanov","year":"2009","journal-title":"Gastroenterology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1053\/j.gastro.2006.08.028","article-title":"Activation of Mouse Natural Killer T Cells Accelerates Liver Regeneration after Partial Hepatectomy","volume":"131","author":"Nakashima","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/2011097a0","article-title":"Regeneration in Relation to the Lymphoid System","volume":"201","author":"Davies","year":"1964","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Peters, S. (2017). Excretory System. Encyclopedia of Animal Cognition and Behavior, Springer.","DOI":"10.1007\/978-3-319-47829-6_1287-1"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1121435","article-title":"Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration","volume":"312","author":"Huang","year":"2006","journal-title":"Science"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.devcel.2018.12.021","article-title":"FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis","volume":"48","author":"Ji","year":"2019","journal-title":"Dev. Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1590\/0100-69912017005009","article-title":"Influence of the Colon in Liver Regeneration of Rats Submitted to Hepatectomy and Colectomy","volume":"44","author":"Moreira","year":"2017","journal-title":"Rev. Col. Bras. Cir."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Wang, X., Zhang, H., Zong, R., Yu, W., Wu, F., and Li, Y. (2023). Novel Models for Early Prediction and Prevention of Acute Respiratory Distress Syndrome in Patients Following Hepatectomy: A Clinical Translational Study Based on 1,032 Patients. Front. Med., 9.","DOI":"10.3389\/fmed.2022.1025764"},{"key":"ref_97","first-page":"586425","article-title":"Rapid-Onset Acute Respiratory Distress Syndrome (ARDS) in a Patient Undergoing Metastatic Liver Resection: A Case Report and Review of the Literature","volume":"2010","author":"Brenner","year":"2010","journal-title":"Anesthesiol. Res. Pract."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Wang, B., Liang, H., Zhao, H., Shen, J., An, Y., and Feng, Y. (2023). Risk Factors and Predictive Model for Pulmonary Complications in Patients Transferred to ICU after Hepatectomy. BMC Surg., 23.","DOI":"10.1186\/s12893-023-02019-1"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"101733","DOI":"10.1016\/j.clinre.2021.101733","article-title":"Pulmonary Infection after Hepatic Resection: Associated Factors and Impact on Outcomes","volume":"46","author":"Loncar","year":"2022","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/0006-291X(92)91803-X","article-title":"Lung May Have an Endocrine Function Producing Hepatocyte Growth Factor in Response to Injury of Distal Organs","volume":"182","author":"Yanagita","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Coudriet, G.M., He, J., Trucco, M., Mars, W.M., and Piganelli, J.D. (2010). Hepatocyte Growth Factor Modulates Interleukin-6 Production in Bone Marrow Derived Macrophages: Implications for Inflammatory Mediated Diseases. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015384"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s10517-018-4115-9","article-title":"Dynamics of Expression of Cytokine Genes and Macrophage Content in the Lungs and Kidneys after Subtotal Hepatectomy in Rats","volume":"165","author":"Fatkhudinov","year":"2018","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s10517-016-3423-1","article-title":"Expression of Cytokine Genes and Growth Factors in Rat Lungs and Kidneys after Subtotal Hepatectomy","volume":"161","author":"Elchaninov","year":"2016","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Elchaninov, A., Fatkhudinov, T., Usman, N., Kananykhina, E., Arutyunyan, I., Makarov, A., Bolshakova, G., Goldshtein, D., and Sukhikh, G. (2016). Molecular Survey of Cell Source Usage during Subtotal Hepatectomy-Induced Liver Regeneration in Rats. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162613"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"21212","DOI":"10.1016\/S0021-9258(19)36912-1","article-title":"Hepatocyte Growth Factor May Act as a Pulmotrophic Factor on Lung Regeneration after Acute Lung Injury","volume":"268","author":"Yanagita","year":"1993","journal-title":"J. Biol. Chem."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/21\/1691\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:42:01Z","timestamp":1761705721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/21\/1691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":105,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["cells14211691"],"URL":"https:\/\/doi.org\/10.3390\/cells14211691","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,28]]}}}