{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:56:40Z","timestamp":1793152600573,"version":"4.5.0"},"reference-count":36,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNR institutional funding"},{"name":"the internal funding of UCSC"},{"name":"Ministero dell\u2019Universit\u00e0 e della Ricerca under PRIN2022","award":["2022XTSLAP"],"award-info":[{"award-number":["2022XTSLAP"]}]},{"name":"Fondazione Policlinico Universitario \u2018A. Gemelli\u2019 IRCCS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>UVA radiation induces oxidative stress, mitochondrial dysfunction, and cell death in human dermal fibroblasts, contributing to skin aging and damage. In this study, we investigated the protective effects of polydatin, a natural polyphenol, against UVA-induced cell damage. Our results show that polydatin preserves cell viability and reduces intracellular reactive oxygen species (ROS) levels after UVA exposure. In addition, polydatin maintains mitochondrial integrity by preserving mitochondrial membrane potential and improving mitochondrial respiration. From a molecular perspective, polydatin regulates the expression of Nrf2, a key regulator of the cellular antioxidant response, thereby promoting cellular defense mechanisms. Additionally, polydatin attenuates UVA-induced mitochondrial fission, supporting a balanced mitochondrial dynamic profile. These results suggest that polydatin exerts a protective effect on UVA-irradiated fibroblasts, highlighting its potential for cosmetic and dermatological applications aimed at preventing photoaging and oxidative skin damage.<\/jats:p>","DOI":"10.3390\/cells14211702","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T02:48:28Z","timestamp":1761878908000},"page":"1702","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Polydatin Prevents UVA-Induced Damage in Human Dermal Fibroblasts by Maintaining Mitochondrial Integrity"],"prefix":"10.3390","volume":"14","author":[{"given":"Benedetta","family":"Niccolini","sequence":"first","affiliation":[{"name":"UOC Genetica Medica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Dipartimento di Sanit\u00e0 Pubblica e Scienze della Vita, Sezione di Medicina Genomica, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Riente","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Dipartimento di Neuroscienze, Sezione di Fisica, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5992-0201","authenticated-orcid":false,"given":"Duaa","family":"Hatem","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Dipartimento di Neuroscienze, Sezione di Fisica, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-8903","authenticated-orcid":false,"given":"Patrizia","family":"Bottoni","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Pizzoferrato","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Pharmacology Section, Department of Health Care Surveillance and Bioethics, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1030-9429","authenticated-orcid":false,"given":"Giuseppe","family":"Tringali","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Pharmacology Section, Department of Health Care Surveillance and Bioethics, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-2242","authenticated-orcid":false,"given":"Elisabetta","family":"Tabolacci","sequence":"additional","affiliation":[{"name":"UOC Genetica Medica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Dipartimento di Sanit\u00e0 Pubblica e Scienze della Vita, Sezione di Medicina Genomica, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-319X","authenticated-orcid":false,"given":"Giuseppe","family":"Maulucci","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Dipartimento di Neuroscienze, Sezione di Fisica, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1299-6696","authenticated-orcid":false,"given":"Stefano","family":"Marini","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome \u2018Tor Vergata\u2019, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1119-2303","authenticated-orcid":false,"given":"Chiara","family":"Ciaccio","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome \u2018Tor Vergata\u2019, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4615-7826","authenticated-orcid":false,"given":"Maria Elisabetta","family":"Clementi","sequence":"additional","affiliation":[{"name":"Istituto di Scienze e Tecnologie Chimiche \u201cGiulio Natta\u201d SCITEC-CNR, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3109\/13880209.2013.792849","article-title":"Polydatin: A review of pharmacology and pharmacokinetics","volume":"51","author":"Du","year":"2013","journal-title":"Pharm. 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