{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:25:42Z","timestamp":1793960742434,"version":"4.8.0"},"reference-count":157,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016112","name":"University of Foggia","doi-asserted-by":"publisher","award":["PRA 2019"],"award-info":[{"award-number":["PRA 2019"]}],"id":[{"id":"10.13039\/100016112","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016112","name":"University of Foggia","doi-asserted-by":"publisher","award":["PRA 2021"],"award-info":[{"award-number":["PRA 2021"]}],"id":[{"id":"10.13039\/100016112","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016112","name":"University of Foggia","doi-asserted-by":"publisher","award":["PRA 2025"],"award-info":[{"award-number":["PRA 2025"]}],"id":[{"id":"10.13039\/100016112","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Aging is characterized by a chronic, low-grade inflammatory state known as inflammaging, which closely interacts with immunosenescence\u2014the gradual deterioration of immune function. Together, these processes contribute to tissue dysfunction and the development of age-related diseases. This review explores the cellular and molecular mechanisms underlying inflammaging, including mitochondrial dysfunction, telomere attrition, impaired autophagy, and gut microbiota dysbiosis. A particular emphasis is given to the senescence-associated secretory phenotype (SASP), which sustains a pro-inflammatory microenvironment and exacerbates tissue damage. We further discuss the impact of inflammaging on major age-related pathologies, with a focus on the kidney as a paradigmatic model of age-related decline, where inflammaging and cellular senescence contribute to chronic kidney disease (CKD) and impaired regeneration. Finally, we summarize emerging therapeutic strategies such as senolytics, senomorphics, immunomodulation, and lifestyle interventions, aimed at reducing the burden of senescent cells, mitigating inflammaging and extending healthspan.<\/jats:p>","DOI":"10.3390\/cells14221831","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T15:00:17Z","timestamp":1763650817000},"page":"1831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6529-7972","authenticated-orcid":false,"given":"Federica","family":"De Luca","sequence":"first","affiliation":[{"name":"Unit of Clinical Pathology, Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Leccese","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pathology, Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"},{"name":"Center for Research and Innovation in Medicine (CREATE), Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-2114","authenticated-orcid":false,"given":"Roberto","family":"Cuttano","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pathology, Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"},{"name":"Center for Research and Innovation in Medicine (CREATE), Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2648-6021","authenticated-orcid":false,"given":"Dario","family":"Troise","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Medicine (CREATE), Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"},{"name":"Unit of Nephrology, Dialysis and Transplantation, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Infante","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Medicine (CREATE), Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"},{"name":"Unit of Nephrology, Dialysis and Transplantation, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Stallone","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Medicine (CREATE), Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"},{"name":"Unit of Nephrology, Dialysis and Transplantation, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3495-2707","authenticated-orcid":false,"given":"Giuseppe","family":"Netti","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pathology, Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"},{"name":"Center for Research and Innovation in Medicine (CREATE), Department of Medical and Surgical Sciences, University of Foggia\u2014University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, 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