{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:08:29Z","timestamp":1792591709537,"version":"4.5.0"},"reference-count":68,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Male infertility affects a significant proportion of couples struggling to conceive and re-quire a comprehensive investigation into the underlying causes and potential diagnostic markers. Seminal biomarkers and multi-omic approaches, particularly metabolomics, have provided valuable insights into the alterations of molecular pathways associated with male infertility. This review systematically integrates literature, focusing on studies which examine the interaction between seminal biomarkers, metabolomics, and various omics technologies in the evaluation of sperm quality, and then male infertility. We high-light the importance of a multi-dimensional approach to decipher the complex etiology of male infertility and identify potential diagnostic markers.<\/jats:p>","DOI":"10.3390\/cells14231886","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:31:52Z","timestamp":1764261112000},"page":"1886","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["New Evidence in Male Infertility Diagnosis: The Role of Metabolomics"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8102-2126","authenticated-orcid":false,"given":"Giuseppina","family":"Peluso","sequence":"first","affiliation":[{"name":"Sperm Bank, Department of Maternal Infant, A.O. of Cosenza, 87100 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Serrao","sequence":"additional","affiliation":[{"name":"Department of Urology, Tirrenia Hospital, 87021 Belvedere Marittimo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Urlandini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Health and Nutrition Sciences, University of Calabria, 87030 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-7378","authenticated-orcid":false,"given":"Vittoria","family":"Rago","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Health and Nutrition Sciences, University of Calabria, 87030 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4738-6927","authenticated-orcid":false,"given":"Saveria","family":"Aquila","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Health and Nutrition Sciences, University of Calabria, 87030 Rende, Italy"},{"name":"Health Center (Cube 34B), University of Calabria, 87030 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-8396","authenticated-orcid":false,"given":"Adele","family":"Vivacqua","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Health and Nutrition Sciences, University of Calabria, 87030 Rende, Italy"},{"name":"Health Center (Cube 34B), University of Calabria, 87030 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.fertnstert.2013.01.111","article-title":"The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility","volume":"99","author":"Kovac","year":"2013","journal-title":"Fertil. 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