{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:44:47Z","timestamp":1791870287342,"version":"4.3.4"},"reference-count":123,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["AI007281"],"award-info":[{"award-number":["AI007281"]}]},{"name":"National Institute of Health","award":["GM144927"],"award-info":[{"award-number":["GM144927"]}]},{"name":"National Institute of Health","award":["GM151274"],"award-info":[{"award-number":["GM151274"]}]},{"name":"National Institute of Health","award":["GM152837"],"award-info":[{"award-number":["GM152837"]}]},{"name":"National Institute of Health","award":["HL007737"],"award-info":[{"award-number":["HL007737"]}]},{"name":"National Institute of Health","award":["HL173273"],"award-info":[{"award-number":["HL173273"]}]},{"name":"National Institute of Health","award":["UC2MD019626"],"award-info":[{"award-number":["UC2MD019626"]}]},{"name":"Veterans Affairs Office of Research and Development","award":["BX00584"],"award-info":[{"award-number":["BX00584"]}]},{"name":"Veterans Affairs Office of Research and Development","award":["CX002780"],"award-info":[{"award-number":["CX002780"]}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chan Zuckerberg Initiative\u2019s Foundation to Accelerate Precision Health Program and Advance Genomics Research at Meharry Medical College","award":["CZIF2022-007043"],"award-info":[{"award-number":["CZIF2022-007043"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cientifica y Tecnologica de Argentina","award":["PICT 2019-02987"],"award-info":[{"award-number":["PICT 2019-02987"]}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas de Argentina","award":["PIP 938"],"award-info":[{"award-number":["PIP 938"]}]},{"name":"NIH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>When blood flow to a part of the myocardial muscle is reduced or blocked, it leads to tissue ischemia in that region. Myocardial infarction (MI) occurs when the ischemic insult is of sufficient duration in time to induce cardiomyocyte death and subsequent activation of the innate immune response. MI initiates a complex cascade of cellular and molecular events within the left ventricle. Inflammatory cells rapidly infiltrate the infarcted area to remove necrotic tissue, setting the stage for reparative wound healing processes. Over the ensuing days, various cell populations\u2014including leukocytes, fibroblasts, and endothelial cells\u2014are attracted to the infarcted site by inflammatory cytokines and chemokines. The activated cells at the site of injury contribute to tissue remodeling and scar formation through the deposition of extracellular matrix components, particularly collagen. While scar formation is essential for structural stabilization of the infarct region to replace the loss of cardiomyocytes, scar tissue also increases myocardial stiffness and impairs cardiac contractile function. This review summarizes our knowledge regarding cellular dynamics, inflammatory signaling, and cardiac remodeling that govern MI healing. We identify the current gaps in the field and provide a foundational resource for those seeking to understand the biological underpinnings of cardiac repair following MI.<\/jats:p>","DOI":"10.3390\/cells14231903","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:39:43Z","timestamp":1764679183000},"page":"1903","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cellular Interactions of Cardiac Repair After Myocardial Infarction"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-0391","authenticated-orcid":false,"given":"Merry L.","family":"Lindsey","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208, USA"},{"name":"Department of Applied Education, Meharry Medical College, Nashville, TN 37208, USA"},{"name":"Research Service, Nashville VA Medical Center, Nashville, TN 37212, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9874-2621","authenticated-orcid":false,"given":"Ashton F.","family":"Oliver","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208, USA"},{"name":"Department of Integrative Genomics and Epidemiology, Meharry Medical College, Nashville, TN 37208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1180-2792","authenticated-orcid":false,"given":"Amadou","family":"Gaye","sequence":"additional","affiliation":[{"name":"Department of Integrative Genomics and Epidemiology, Meharry Medical College, Nashville, TN 37208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-7721","authenticated-orcid":false,"given":"Pius N.","family":"Nde","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9647-6112","authenticated-orcid":false,"given":"Kristine Y.","family":"DeLeon-Pennell","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, School of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA"},{"name":"Research Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-9837","authenticated-orcid":false,"given":"Germ\u00e1n E.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda Cardiovascular Experimental e Hipertensi\u00f3n Arterial, Instituto de Investigaciones Biom\u00e9dicas (UCA-CONICET), Facultad de Ciencias M\u00e9dicas, Universidad Cat\u00f3lica Argentina, Buenos Aires C1107, Argentina"},{"name":"Departamento de Patolog\u00eda, Instituto de Salud Comunitaria, Universidad Nacional de Hurlingham, Villa Tesei B1688, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1584","DOI":"10.1002\/wsbm.1584","article-title":"The cardiac wound healing response to myocardial infarction","volume":"15","author":"Chalise","year":"2023","journal-title":"WIREs Mech. 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