{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:27:08Z","timestamp":1790141228316,"version":"4.0.1"},"reference-count":146,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["101078827"],"award-info":[{"award-number":["101078827"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Lymphoedema is a physically and psychologically stressful, chronic progressive disease caused by long lasting damage or malfunction of the lymphatic drainage system. It is classified as primary when caused by a genetic predisposition (inherited or congenital) directly affecting any part of the lymphatic vascular system, or, much more often, as secondary (acquired) when caused by factors outside the lymphatic system, such as tumours or their treatment. As part of the development of an S3 guideline for the diagnosis and treatment of lymphoedema in German-speaking countries, we present here the definition of lymphoedema, its epidemiology, staging, pathophysiology, aggravating comorbidities, and differentiation from other forms of oedema or volume-increasing diseases. We refer to molecular links with obesity, present a diagram of possible pathomechanistic interactions, and finally discuss approaches for potential drug therapies. More intensive molecular genetic diagnostics of primary lymphedema seem to be gaining ground in Germany currently. We recommend further strengthening these diagnostics, as this is the only way to expand therapeutic options in the future and use existing therapies more efficiently.<\/jats:p>","DOI":"10.3390\/cells14241955","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T13:51:46Z","timestamp":1765288306000},"page":"1955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Definition, Epidemiology and Pathophysiology of Lymphoedema"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-1198","authenticated-orcid":false,"given":"Erich","family":"Brenner","sequence":"first","affiliation":[{"name":"Institute for Clinical and Functional Anatomy, Medical University of Innsbruck, M\u00fcllerstrasse 59, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6830-2043","authenticated-orcid":false,"given":"Ren\u00e9","family":"H\u00e4gerling","sequence":"additional","affiliation":[{"name":"Research Group \u2018Lymphovascular Medicine and Translational 3D-Histopathology\u2019, Institute of Medical and Human Genetics, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Berlin Institute of Health at Charit\u00e9-Universit\u00e4tsmedizin Berlin, BIH Center for Regenerative Therapies, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Schacht","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Allergology and Venerology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schrader","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Gef\u00e4\u00dfkrankheiten, Lilienthalstrasse 2, 95032 Hof, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8337-2296","authenticated-orcid":false,"given":"J\u00f6rg","family":"Wilting","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, University Medical Center G\u00f6ttingen, Kreuzbergring 36, 37075 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Executive Committee of the International Society of Lymphology (2023). The Diagnosis and Treatment of Peripheral Lymphedema: 2023 Consensus Document of The International Society of Lymphology. Lymphology, 56, 133\u2013151.","DOI":"10.2458\/lymph.6372"},{"key":"ref_2","first-page":"9","article-title":"Das Lymphsystem und das Starlingsche Gleichgewicht","volume":"22","author":"Brenner","year":"2018","journal-title":"Lymphol. Forsch. Und Prax."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/cvr\/cvq062","article-title":"Microvascular fluid exchange and the revised Starling principle","volume":"87","author":"Levick","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"ref_4","first-page":"71","article-title":"Gilt die Starling\u2019sche Hypothese noch?","volume":"13","author":"Schad","year":"2009","journal-title":"LymphForsch"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1983.sp014961","article-title":"The effect of the canine popliteal node on the composition of lymph","volume":"345","author":"Knox","year":"1983","journal-title":"J. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13578-022-00898-0","article-title":"The lymphatic vascular system: Much more than just a sewer","volume":"12","author":"Wilting","year":"2022","journal-title":"Cell Biosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1055\/s-2001-9917","article-title":"The effect of cardiopulmonary lymphatic obstruction on heart and lung function","volume":"49","author":"Cui","year":"2001","journal-title":"Thorac. Cardiovasc. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10555-006-8496-2","article-title":"Structure function relationships in the lymphatic system and implications for cancer biology","volume":"25","author":"Witte","year":"2006","journal-title":"Cancer Metastasis Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jpeds.2014.12.069","article-title":"Lymphatic and other vascular malformative\/overgrowth disorders are caused by somatic mutations in PIK3CA","volume":"166","author":"Luks","year":"2015","journal-title":"J. Pediatr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/cge.14364","article-title":"Lymphedema is associated with CELSR1 in Phelan-McDermid syndrome","volume":"104","author":"Smith","year":"2023","journal-title":"Clin. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ng.923","article-title":"Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)","volume":"43","author":"Ostergaard","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ajhg.2011.12.018","article-title":"Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy","volume":"90","author":"Ostergaard","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/cge.12158","article-title":"A novel mutation in GJA1 causing oculodentodigital syndrome and primary lymphoedema in a three generation family","volume":"84","author":"Brice","year":"2013","journal-title":"Clin. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/ng.484","article-title":"Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans","volume":"41","author":"Alders","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00439-014-1456-y","article-title":"Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome","volume":"133","author":"Alders","year":"2014","journal-title":"Hum. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8085","DOI":"10.1038\/ncomms9085","article-title":"Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis","volume":"6","author":"Fotiou","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1002\/ajmg.a.62416","article-title":"EPHB4 mutation causes adult and adolescent-onset primary lymphedema","volume":"185","author":"Greene","year":"2021","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1086\/375614","article-title":"Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia","volume":"72","author":"Irrthum","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1177\/000348949110000812","article-title":"Choanal atresia and lymphedema","volume":"100","author":"Borderon","year":"1991","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/ATVBAHA.117.309818","article-title":"Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report","volume":"37","author":"Pujol","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/nm.2545","article-title":"The lymphatic vasculature in disease","volume":"17","author":"Alitalo","year":"2011","journal-title":"Nat. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1136\/jmg.2004.024802","article-title":"Milroy disease and the VEGFR-3 mutation phenotype","volume":"42","author":"Brice","year":"2005","journal-title":"J. Med. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1086\/316915","article-title":"Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome","volume":"67","author":"Fang","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/hmg\/10.11.1185","article-title":"Truncating mutations in FOXC2 cause multiple lymphedema syndromes","volume":"10","author":"Finegold","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.ajhg.2010.04.010","article-title":"GJC2 missense mutations cause human lymphedema","volume":"86","author":"Ferrell","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/hmg\/ddae060","article-title":"Pathogenic variants in HGF give rise to childhood-to-late onset primary lymphoedema by loss of function","volume":"33","author":"Alpaslan","year":"2024","journal-title":"Hum. Mol. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Michelini, S., Ricci, M., Veselenyiova, D., Kenanoglu, S., Kurti, D., Baglivo, M., Fiorentino, A., Basha, S.H., Priya, S., and Serrani, R. (2020). TIE1 as a Candidate Gene for Lymphatic Malformations with or without Lymphedema. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186780"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41591-023-02211-z","article-title":"Genetic association analysis of 77,539 genomes reveals rare disease etiologies","volume":"29","author":"Greene","year":"2023","journal-title":"Nat. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1745-7599.2010.00542.x","article-title":"Recognizing and treating upper extremity lymphedema in postmastectomy\/lumpectomy patients: A guide for primary care providers","volume":"22","author":"Quirion","year":"2010","journal-title":"J. Am. Acad. Nurse Pract."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.ejso.2006.05.003","article-title":"Morbidity after inguinal sentinel lymph node biopsy and completion lymph node dissection in patients with cutaneous melanoma","volume":"32","author":"Vonkeman","year":"2006","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00066-008-1728-3","article-title":"Lymph edema of the lower extremities after lymphadenectomy and radiotherapy for cervical cancer","volume":"184","author":"Fuller","year":"2008","journal-title":"Strahlenther. Onkol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1002\/cncr.25458","article-title":"Lymphedema beyond breast cancer: A systematic review and meta-analysis of cancer-related secondary lymphedema","volume":"116","author":"Cormier","year":"2010","journal-title":"Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1245\/s10434-017-5960-x","article-title":"Breast Cancer-Related Lymphedema Risk is Related to Multidisciplinary Treatment and Not Surgery Alone: Results from a Large Cohort Study","volume":"24","author":"Nguyen","year":"2017","journal-title":"Ann. Surg. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.critrevonc.2014.06.004","article-title":"Lymphedema following breast cancer treatment and impact on quality of life: A review","volume":"92","author":"Taghian","year":"2014","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10549-016-4089-0","article-title":"Radiation therapy targets and the risk of breast cancer-related lymphedema: A systematic review and network meta-analysis","volume":"162","author":"Shaitelman","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S234","DOI":"10.1097\/SAP.0000000000001864","article-title":"Lymphedema Incidence After Axillary Lymph Node Dissection: Quantifying the Impact of Radiation and the Lymphatic Microsurgical Preventive Healing Approach","volume":"82","author":"Johnson","year":"2019","journal-title":"Ann. Plast. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/pmic.200300573","article-title":"Proteomic analysis of lymph","volume":"4","author":"Leak","year":"2004","journal-title":"Proteomics"},{"key":"ref_38","first-page":"173","article-title":"Changes of tissue fluid hyaluronan (hyaluronic acid) in peripheral lymphedema","volume":"31","author":"Liu","year":"1998","journal-title":"Lymphology"},{"key":"ref_39","unstructured":"F\u00f6ldi, M., F\u00f6ldi, E., and Kubik, S. (2010). Morphologische Befunde beim Lymph\u00f6dem. Lehrbuch Lymphologie, Urban and Fischer. [7th ed.]."},{"key":"ref_40","unstructured":"Clodius, L., Baumeister, R.G.H., Foldi, E., Kubik, S., Partsch, H., Str\u00f6berl, C., and Weisleder, H. (1988). Lymphostatische Venopathie im Tierexperiment und beim Menschen. Lymphologica Jahresband 1989. Ausgew\u00e4hlte Vortr\u00e4ge der Lymphologica Z\u00fcrich 1988, Medikon."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Becker, J., Schwoch, S., Zelent, C., Sitte, M., Salinas, G., and Wilting, J. (2021). Transcriptome Analysis of Hypoxic Lymphatic Endothelial Cells Indicates Their Potential to Contribute to Extracellular Matrix Rearrangement. Cells, 10.","DOI":"10.3390\/cells10051008"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/dvdy.460","article-title":"Control of the extracellular matrix by hypoxic lymphatic endothelial cells: Impact on the progression of lymphedema?","volume":"252","author":"Wilting","year":"2023","journal-title":"Dev. Dyn."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000096913","article-title":"Recurrent erysipelas: 47 cases","volume":"214","author":"Leclerc","year":"2007","journal-title":"Dermatology"},{"key":"ref_44","first-page":"121","article-title":"The effects of reduction operation with genital lymphedema on the frequency of erysipelas and the quality of life","volume":"44","author":"Zvonik","year":"2011","journal-title":"Lymphology"},{"key":"ref_45","unstructured":"Letzel, S., Schmitz-Spanke, S., Lang, J., and Nowak, D. (2022). \u00d6dem. Klinische Symptomie in der Arbeitsmedizin, Ecomed."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1089\/lrb.2022.0109","article-title":"Prevalence and Prognostic Role of Lymphedema in Patients with Deep Venous Thrombosis and Thrombophlebitis","volume":"22","author":"Grigorean","year":"2024","journal-title":"Lymphat. Res. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Cornely, M.E., Marsch, W.C., and Brenner, E. (2023). \u00d6dematologie. Angewandte Lymphologie, Springer.","DOI":"10.1007\/978-3-662-61452-5"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1136\/jmg.22.4.274","article-title":"The inheritance of primary lymphoedema","volume":"22","author":"Dale","year":"1985","journal-title":"J. Med. Genet."},{"key":"ref_49","first-page":"206","article-title":"Primary lymphedema in children and adolescents: A follow-up study and review","volume":"76","author":"Smeltzer","year":"1985","journal-title":"Pediatrics"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/qjmed\/hcg126","article-title":"Lymphoedema: An underestimated health problem","volume":"96","author":"Moffatt","year":"2003","journal-title":"QJM"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1055\/s-0037-1622142","article-title":"Beitrag zur Epidemiologie des Lymph\u00f6dems","volume":"35","author":"Brenner","year":"2006","journal-title":"Phlebologie"},{"key":"ref_52","first-page":"59","article-title":"Klinische Diagnostik des prim\u00e4ren Lymph\u00f6dems der Beine","volume":"3","author":"Brunner","year":"1981","journal-title":"Swiss Med."},{"key":"ref_53","unstructured":"(2006). Lymphoedema Framework. Best Practice for the Management of Lymphoedema. International Consensus, MEP Ltd."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S1470-2045(13)70076-7","article-title":"Incidence of unilateral arm lymphoedema after breast cancer: A systematic review and meta-analysis","volume":"14","author":"DiSipio","year":"2013","journal-title":"Lancet Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e438776","DOI":"10.1200\/EDBK_438776","article-title":"Personalizing Locoregional Therapy in Patients with Breast Cancer in 2024: Tailoring Axillary Surgery, Escalating Lymphatic Surgery, and Implementing Evidence-Based Hypofractionated Radiotherapy","volume":"44","author":"Weber","year":"2024","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ygyno.2015.07.003","article-title":"Close relationship between removal of circumflex iliac nodes to distal external iliac nodes and postoperative lower-extremity lymphedema in uterine corpus malignant tumors","volume":"139","author":"Todo","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ygyno.2015.09.007","article-title":"Relationship between removal of circumflex iliac nodes distal to the external iliac nodes and postoperative lower-extremity lymphedema in uterine cervical cancer","volume":"139","author":"Yamazaki","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1046\/j.0004-8666.2003.00040.x","article-title":"Aetiology and prevalence of lower limb lymphoedema following treatment for gynaecological cancer","volume":"43","author":"Ryan","year":"2003","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ygyno.2008.03.005","article-title":"A randomized phase III trial of VH fibrin sealant to reduce lymphedema after inguinal lymph node dissection: A Gynecologic Oncology Group study","volume":"110","author":"Carlson","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Blum, K.S., Karaman, S., Proulx, S.T., Ochsenbein, A.M., Luciani, P., Leroux, J.C., Wolfrum, C., and Detmar, M. (2014). Chronic high-fat diet impairs collecting lymphatic vessel function in mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094713"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1097\/PRS.0000000000001271","article-title":"Obesity-induced lymphedema: Clinical and lymphoscintigraphic features","volume":"135","author":"Greene","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10549-023-07161-1","article-title":"Breast lymphedema following breast-conserving treatment for breast cancer: Current status and future directions","volume":"204","author":"Brunelle","year":"2024","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/jmri.29456","article-title":"Prognostic Value of MRI Assessment of Residual Peritumoral Edema in Breast Cancer Treated with Neoadjuvant Chemotherapy","volume":"61","author":"Shigematsu","year":"2025","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Cornely, M.E., Marsch, W.C., and Brenner, E. (2023). Begutachtung. Angewandte Lymphologie, Springer.","DOI":"10.1007\/978-3-662-61452-5"},{"key":"ref_65","first-page":"56","article-title":"Magnetic resonance lymphography demonstrates spontaneous lymphatic disruption and regeneration in obstructive lymphedema","volume":"46","author":"Liu","year":"2013","journal-title":"Lymphology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/iwj.12694","article-title":"Chronic oedema: A prevalent health care problem for UK health services","volume":"14","author":"Moffatt","year":"2017","journal-title":"Int. Wound J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.12968\/bjcn.2022.27.Sup10.S22","article-title":"The All-Ireland Guidelines for the diagnosis, assessment and management of lymphoedema","volume":"27","author":"Rankin","year":"2022","journal-title":"Br. J. Community Nurs."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/cs0850737","article-title":"Change in Macro Molecular Composition of Interstitial Fluid from Swollen Arms after Breast Cancer Treatment, and Its Implications","volume":"85","author":"Bates","year":"1993","journal-title":"Clin. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Cornely, M.E., Marsch, W.C., and Brenner, E. (2023). Das Interstitium. Angewandte Lymphologie, Springer.","DOI":"10.1007\/978-3-662-61452-5"},{"key":"ref_70","unstructured":"F\u00f6ldi, M., F\u00f6ldi, E., and Kubik, S. (2010). Physiologie und Pathophysiologie des Lymphgef\u00e4\u00dfsystems. Lehrbuch Lymphologie, Elsevier\u2014Urban & Fischer. [7th ed.]."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0140-6736(56)90053-8","article-title":"The protein levels of oedema fluids","volume":"271","author":"Crockett","year":"1956","journal-title":"Lancet"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1136\/bmj.1.5080.1159","article-title":"Protein content of oedema fluid in lymphoedema","volume":"1","author":"Taylor","year":"1958","journal-title":"Br. Med. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1113\/jphysiol.2006.108308","article-title":"Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema","volume":"574","author":"Karlsen","year":"2006","journal-title":"J. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2796.1997.00170.x","article-title":"Hyaluronan: Its nature, distribution, functions and turnover","volume":"242","author":"Fraser","year":"1997","journal-title":"J. Intern. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1050-1738(02)00189-5","article-title":"The lymphatics revisited: New perspectives from the hyaluronan receptor LYVE-1","volume":"13","author":"Jackson","year":"2003","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/archinte.1955.00250110032004","article-title":"Use of hyaluronidase by iontophoresis in treatment of lymphedema","volume":"95","author":"Schwartz","year":"1955","journal-title":"AMA Arch. Intern. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/182377a0","article-title":"Effect of hyaluronidase on capillary permeability, lymph flow and passage of dye-labelled protein from plasma to lymph","volume":"182","author":"Magyar","year":"1958","journal-title":"Nature"},{"key":"ref_78","unstructured":"Daroczy, J., Wolfe, J., and Mentzel, T. (2003). Diseases of the Lymphatics. Pathology, Oxford University Press."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/oby.2011.268","article-title":"ITIH-5 expression in human adipose tissue is increased in obesity","volume":"20","author":"Anveden","year":"2012","journal-title":"Obesity"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Neligan, P., Masia, J., and Piller, N. (2016). Dermatologic implications of secondary lymphedema of the lower leg. Lymphedema: Complete Medical and Surgical Management, CRC Press.","DOI":"10.1055\/b-0037-143456"},{"key":"ref_81","first-page":"100753","article-title":"Differentially expressed mRNAs and lncRNAs shared between activated human hepatic stellate cells and nash fibrosis","volume":"22","author":"Gerhard","year":"2020","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.matbio.2015.05.006","article-title":"The extracellular matrix and transforming growth factor-beta1: Tale of a strained relationship","volume":"47","author":"Hinz","year":"2015","journal-title":"Matrix Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"H2113","DOI":"10.1152\/ajpheart.00879.2008","article-title":"TGF-beta1 is a negative regulator of lymphatic regeneration during wound repair","volume":"295","author":"Clavin","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"16069","DOI":"10.1073\/pnas.242401399","article-title":"Molecular characterization of lymphatic endothelial cells","volume":"99","author":"Podgrabinska","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e2268","DOI":"10.1097\/GOX.0000000000002268","article-title":"Lymphatic Vessel Thrombosis in a Patient with Secondary Lymphedema","volume":"7","author":"Hara","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1089\/lrb.2019.0074","article-title":"Axillary Web Syndrome: Evidence for Lymphatic Origin with Thrombosis","volume":"18","author":"Johansson","year":"2020","journal-title":"Lymphat. Res. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2535\/ofaj1936.65.6_391","article-title":"Enzyme-histochemical visualization of lymphatic capillaries in the mouse tongue: Light and electron microscopic study","volume":"65","author":"Kato","year":"1989","journal-title":"Okajimas Folia Anat. Jpn."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.pharep.2015.05.002","article-title":"The role of ecto-5\u2032-nucleotidase in endothelial dysfunction and vascular pathologies","volume":"67","author":"Zukowska","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Hasselhof, V., Sperling, A., Buttler, K., Str\u00f6bel, P., Becker, J., Aung, T., Felmerer, G., and Wilting, J. (2016). Morphological and Molecular Characterization of Human Dermal Lymphatic Collectors. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164964"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12026-012-8283-9","article-title":"IL-33\/ST2 axis in inflammation and immunopathology","volume":"52","author":"Milovanovic","year":"2012","journal-title":"Immunol. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"112455","DOI":"10.1016\/j.diabres.2025.112455","article-title":"Dynamic regulation of IL-33 in the obesity pathogenesis: Spatiotemporal specificity and functional paradoxes","volume":"229","author":"Cui","year":"2025","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Cornely, M.E., and Tietz, H.-J. (2025). Fungal Diseases and Lymphedema. Applied Lymphology: Basics|Daily Practice|Perspectives, Springer.","DOI":"10.1007\/978-3-031-77734-9"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1079\/PNS200198","article-title":"Long-term changes in adipose tissue in human disease","volume":"60","author":"Pond","year":"2001","journal-title":"Proc. Nutr. Soc."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1084\/jem.20091619","article-title":"Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning","volume":"207","author":"Pham","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-immunol-020711-075011","article-title":"Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs","volume":"30","author":"Cyster","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/jcp.24795","article-title":"Sphingosine-1-phosphate mediates COX-2 expression and PGE2 \/IL-6 secretion via c-Src-dependent AP-1 activation","volume":"230","author":"Hsu","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Kowalski, G.M., Carey, A.L., Selathurai, A., Kingwell, B.A., and Bruce, C.R. (2013). Plasma sphingosine-1-phosphate is elevated in obesity. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072449"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/ng1642","article-title":"Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity","volume":"37","author":"Harvey","year":"2005","journal-title":"Nat. Genet."},{"key":"ref_99","first-page":"130","article-title":"Tissue changes in chronic experimental lymphoedema in dogs","volume":"13","author":"Clodius","year":"1980","journal-title":"Lymphology"},{"key":"ref_100","unstructured":"Frick, A., Wibecke, B., and Baumeister, R.G. (1990). Histologische Befunde von Lymphgef\u00e4\u00dfen, Gewonnen bei Lymphgef\u00e4\u00dftransplantationen. Lymphologica Jahresband 1990, Medicon."},{"key":"ref_101","unstructured":"Weissleder, H., and Schuchardt, C. (2015). Die genetischen Ursachen des prim\u00e4ren Lymph\u00f6dems. Erkrankungen des Lymphgef\u00e4\u00dfsystems, Viavital Verlag."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1196\/annals.1413.015","article-title":"The clinical spectrum of lymphatic disease","volume":"1131","author":"Radhakrishnan","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jemt.1163","article-title":"Lymphangiogenesis and lymphangiodysplasia: From molecular to clinical lymphology","volume":"55","author":"Witte","year":"2001","journal-title":"Microsc. Res. Tech."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/jmedgenet-2019-106084","article-title":"Update and audit of the St George\u2019s classification algorithm of primary lymphatic anomalies: A clinical and molecular approach to diagnosis","volume":"57","author":"Gordon","year":"2020","journal-title":"J. Med. Genet."},{"key":"ref_105","first-page":"237","article-title":"Surdi-mutite, lymphoedeme des membres inferieurs et anomalies hematologiques (leucose aigue, cytopenies) a transmission autosomique dominante","volume":"27","author":"Emberger","year":"1979","journal-title":"J. Genet. Hum."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0092-8674(95)90142-6","article-title":"Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo","volume":"83","author":"Blangy","year":"1995","journal-title":"Cell"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.18632\/oncotarget.1490","article-title":"Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5","volume":"4","author":"Exertier","year":"2013","journal-title":"Oncotarget"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.bbrc.2008.04.177","article-title":"Disruption of the mitotic kinesin Eg5 gene (Knsl1) results in early embryonic lethality","volume":"372","author":"Chauviere","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s00105-023-05183-w","article-title":"Genetik, Diagnostik und Klinik des pim\u00e4ren Lymph\u00f6dems","volume":"74","year":"2023","journal-title":"Dermatologie"},{"key":"ref_110","first-page":"515","article-title":"Hypotrichosis, lymphedema of the legs and acral telangiectasias\u2014New syndrome?","volume":"11","author":"Glade","year":"2001","journal-title":"Eur. J. Dermatol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ajhg.2010.08.008","article-title":"Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans","volume":"87","author":"Au","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1136\/jmg.40.9.697","article-title":"Identification of eight novel VEGFR-3 mutations in families with primary congenital lymphoedema","volume":"40","author":"Evans","year":"2003","journal-title":"J. Med. Genet."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/75997","article-title":"Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema","volume":"25","author":"Karkkainen","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00439-008-0586-5","article-title":"Analysis of the coding regions of VEGFR3 and VEGFC in Milroy disease and other primary lymphoedemas","volume":"124","author":"Connell","year":"2009","journal-title":"Hum. Genet."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","article-title":"Lymphangiogenesis: Molecular mechanisms and future promise","volume":"140","author":"Tammela","year":"2010","journal-title":"Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/jmedgenet-2013-102020","article-title":"A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease","volume":"51","author":"Lago","year":"2014","journal-title":"J. Med. Genet."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00018-012-1110-6","article-title":"Flow control in our vessels: Vascular valves make sure there is no way back","volume":"70","author":"Bazigou","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/jmg.2010.085563","article-title":"Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype","volume":"48","author":"Ostergaard","year":"2011","journal-title":"J. Med. Genet."},{"key":"ref_119","unstructured":"Herpertz, U. (2010). \u00d6deme und Lymphdrainage: Diagnose und Therapie von \u00d6demkrankheiten; mit 36 Tabellen, Schattauer Verlag. [4th ed.]."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1089\/lrb.2022.0003","article-title":"Adipose Tissue in Lymphedema: A Central Feature of Pathology and Target for Pharmacologic Therapy","volume":"21","author":"Burton","year":"2023","journal-title":"Lymphat. Res. Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1210\/jc.2009-1584","article-title":"The predictive value of different measures of obesity for incident cardiovascular events and mortality","volume":"95","author":"Schneider","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ijo.2010.273","article-title":"Oedema in obesity; role of structural lymphatic abnormalities","volume":"35","author":"Vasileiou","year":"2011","journal-title":"Int. J. Obes."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"111e","DOI":"10.1097\/PRS.0000000000002258","article-title":"Diagnosis and Management of Obesity-Induced Lymphedema","volume":"138","author":"Greene","year":"2016","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1089\/wound.2020.1337","article-title":"Current Overview of Obesity-Induced Lymphedema","volume":"11","author":"Sudduth","year":"2022","journal-title":"Adv. Wound Care"},{"key":"ref_125","first-page":"184","article-title":"Lipedema of the legs: A syndrom characterized by fat legs and orthostatic edema","volume":"15","author":"Allen","year":"1940","journal-title":"Proc. Staff Mayo Clin."},{"key":"ref_126","unstructured":"Deutsche Gesellschaft f\u00fcr Phlebologie und Lymphologie e.V (2025, December 03). S2k-Leitlinie Lip\u00f6dem [Registernummer 037-012]. AWMF-Leitlinien-Register. Available online: https:\/\/register.awmf.org\/de\/leitlinien\/detail\/037-012."},{"key":"ref_127","first-page":"106","article-title":"A Family-Based Study of Inherited Genetic Risk in Lipedema","volume":"22","author":"Morgan","year":"2024","journal-title":"Lymphat. Res. Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1055\/a-2090-0877","article-title":"Lipohyperplasia dolorosa\u2014Neu betrachtet","volume":"52","author":"Brenner","year":"2023","journal-title":"Phlebologie"},{"key":"ref_129","first-page":"1179","article-title":"Body mass index vs. waist-to-height-ratio in patients with lipohyperplasia dolorosa (vulgo lipedema)","volume":"21","author":"Brenner","year":"2023","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Cornely, M.E., Marsch, W., and Brenner, E. (2025). Applied Lymphology\u2014Basics|Daily Practice|Perspectives, Springer Nature. [1st ed.]. eBook.","DOI":"10.1007\/978-3-031-77734-9"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/lrb.2010.0005","article-title":"Indocyanine green and lymphatic imaging: Current problems","volume":"8","author":"Gashev","year":"2010","journal-title":"Lymphat. Res. Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/lrb.2015.0040","article-title":"Near-Infrared Fluorescence Lymphatic Imaging to Reconsider Occlusion Pressure of Superficial Lymphatic Collectors in Upper Extremities of Healthy Volunteers","volume":"14","author":"Belgrado","year":"2016","journal-title":"Lymphat. Res. Biol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/lrb.2018.0042","article-title":"Edema Fluid Can Be Successfully Evacuated from the Lymphedematous Limbs by Implantation of Silicone Tubings Bypassing the Site of Flow Obstruction Long-Term Observations","volume":"17","author":"Olszewski","year":"2019","journal-title":"Lymphat. Res. Biol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejim.2025.01.027","article-title":"Advancing women\u2019s health with a pioneering implant to treat breast cancer related lymphedema","volume":"135","author":"Mazzolai","year":"2025","journal-title":"Eur. J. Intern. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"14308","DOI":"10.1074\/jbc.RA119.007674","article-title":"A hierarchical network of hypoxia-inducible factor and SMAD proteins governs procollagen lysyl hydroxylase 2 induction by hypoxia and transforming growth factor beta1","volume":"294","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1093\/nar\/gkp425","article-title":"An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia","volume":"37","author":"Benita","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"51473","DOI":"10.18632\/oncotarget.10444","article-title":"Long non-coding RNA-H19 antagonism protects against renal fibrosis","volume":"7","author":"Xie","year":"2016","journal-title":"Oncotarget"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Ambele, M.A., Dhanraj, P., Giles, R., and Pepper, M.S. (2020). Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124283"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1194\/jlr.C200010-JLR200","article-title":"Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase","volume":"43","author":"Yoshida","year":"2002","journal-title":"J. Lipid Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"19817","DOI":"10.1038\/srep19817","article-title":"Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity","volume":"6","author":"Torrisi","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Sevick-Muraca, E.M., Fife, C.E., and Rasmussen, J.C. (2023). Imaging peripheral lymphatic dysfunction in chronic conditions. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1132097"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Davis, M.J., and Zawieja, S.D. (2024). Pacemaking in the lymphatic system. J. Physiol.","DOI":"10.1113\/JP284752"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"256e","DOI":"10.1097\/PRS.0000000000011675","article-title":"Phase II Study Shows the Effect of Adenoviral Vascular Endothelial Growth Factor C and Lymph Node Transfer in Lymphedema","volume":"155","author":"Rannikko","year":"2025","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nature09229","article-title":"Nuclear reprogramming to a pluripotent state by three approaches","volume":"465","author":"Yamanaka","year":"2010","journal-title":"Nature"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"11019","DOI":"10.1038\/srep11019","article-title":"Generation of pure lymphatic endothelial cells from human pluripotent stem cells and their therapeutic effects on wound repair","volume":"5","author":"Lee","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_146","first-page":"464","article-title":"Robust Differentiation of Human Pluripotent Stem Cells into Lymphatic Endothelial Cells Using Transcription Factors","volume":"213","author":"Saha","year":"2024","journal-title":"Cells Tissues Organs"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/24\/1955\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T05:12:14Z","timestamp":1765429934000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/24\/1955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":146,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["cells14241955"],"URL":"https:\/\/doi.org\/10.3390\/cells14241955","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]}}}