{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:32:50Z","timestamp":1789410770493,"version":"build-2803163510"},"reference-count":103,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["PR 241\/5-1"],"award-info":[{"award-number":["PR 241\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["5-2 (JCP)"],"award-info":[{"award-number":["5-2 (JCP)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"LMU-China Scholarship Council Program Scholarship","award":["201706160167"],"award-info":[{"award-number":["201706160167"]}]},{"name":"Japanese Dermatological Association Grant-In-Aid for Study Abroad"},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K16234"],"award-info":[{"award-number":["21K16234"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Psoriasis vulgaris is a T-cell-mediated skin disease that may involve an autoimmune response against melanocytes. It develops through still unexplained pathomechanisms. Streptococcal tonsillopharyngitis is a major trigger of psoriasis onset and relapses. HLA-C*06:02 is the main psoriasis risk gene. Here we find that B cells isolated from streptococci-infected tonsils or peripheral blood of HLA-C*06:02+ psoriasis patients stimulate an HLA-C*06:02-restricted melanocyte-reactive V\u03b13S1\/V\u03b213S1 T-cell receptor (TCR) from a lesional psoriatic CD8+ T cell clone in an IFN-\u03b3-enhanced manner. Patients\u2019 B cells furthermore induce proliferation of autologous blood CD8+ T cells. We identify several HLA-C*06:02-presented self-peptides in the immunopeptidomes we had isolated from four HLA-C*06:02 homozygous B-cell lines that stimulate the V\u03b13S1\/V\u03b213S1 TCR and differ from the melanocyte autoantigen recognized by this TCR. These data suggest that the proinflammatory environment of streptococcal tonsillopharyngitis may enable B cells to activate autoreactive CD8+ T cells that, owing to the polyspecificity of T-cell receptors, recognize several B-cell self-peptides presented by HLA-C*06:02 and subsequently cross-react against melanocytes in the skin, thereby triggering psoriasis. The capacity of B cells to stimulate a cross-reactive autoimmune response through HLA class I-presented B-cell peptides is a previously unknown mechanism in the induction of autoimmunity that could explain psoriasis onset and persistence.<\/jats:p>","DOI":"10.3390\/cells14242002","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:47:26Z","timestamp":1765889246000},"page":"2002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["B Cells Can Trigger the T-Cell-Mediated Autoimmune Response Against Melanocytes in Psoriasis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1891-6506","authenticated-orcid":false,"given":"Mengwen","family":"He","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2078-1454","authenticated-orcid":false,"given":"Melissa","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Rudolf Virchow Center, Center for Integrative and Translational Bioimaging, University W\u00fcrzburg, D-97078 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6679-3029","authenticated-orcid":false,"given":"Akiko","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Vollmer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8136-7335","authenticated-orcid":false,"given":"Burkard","family":"Summer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-6393","authenticated-orcid":false,"given":"Yukiyasu","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0105-572X","authenticated-orcid":false,"given":"Tatsushi","family":"Ishimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0612-9932","authenticated-orcid":false,"given":"Andreas","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Rudolf Virchow Center, Center for Integrative and Translational Bioimaging, University W\u00fcrzburg, D-97078 W\u00fcrzburg, Germany"},{"name":"Department for Dermatology, Venereology and Allergology, Frankfurt University Hospital, D-60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8857-5495","authenticated-orcid":false,"given":"J\u00f6rg Christoph","family":"Prinz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University of Munich, D-80337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1038\/s41467-025-56719-8","article-title":"GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets","volume":"16","author":"Dand","year":"2025","journal-title":"Nat. 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