{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T06:32:45Z","timestamp":1766212365549,"version":"3.48.0"},"reference-count":51,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Louisiana State University Health Sciences Center-Shreveport, National Heart, Lung, and Blood Institute","award":["5K01HL144882-04"],"award-info":[{"award-number":["5K01HL144882-04"]}]},{"name":"COBRE","award":["3P20GM121307-03S1"],"award-info":[{"award-number":["3P20GM121307-03S1"]}]},{"name":"CCDS Malcolm Feist Fellowship"},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["1R01NS117906"],"award-info":[{"award-number":["1R01NS117906"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Intramural Research Program of the NIH, NIEHS","award":["ZIAES090057"],"award-info":[{"award-number":["ZIAES090057"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>An increase in mental stress is a recognized risk factor for cardiovascular disease (CVD). The present study investigated the relationships between stress, glucocorticoid receptors (GR), and ischemia\/reperfusion (I\/R) injury. We subjected male and female mice lacking cardiomyocyte GR (CardioGRKO) and their respective controls to a murine model of mental stress (restraint stress). Following stress exposure, mice from both experimental and control groups underwent I\/R injury via surgical ligation of the left anterior descending coronary artery. Our findings suggest that the absence of cardiomyocyte GR mitigates the detrimental effects of restraint stress on infarct size and improves post-I\/R survival rates in female mice. We found that cardiomyocyte GR deficiency protects the female heart from stress-induced damage by reducing oxidative stress (superoxide and lipid peroxide production). This study is the first to test the impact of systemic stress on cardiomyocyte GR activation, linking it to redox stress in the heart during I\/R injury. Our findings provide proof of concept that stress exacerbates cardiomyocyte GR-mediated responses to myocardial infarction (MI) in the female heart. These insights may contribute to the development of sex-specific treatments and therapies tailored for women.<\/jats:p>","DOI":"10.3390\/cells14242017","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:08:28Z","timestamp":1766056108000},"page":"2017","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiomyocyte Glucocorticoid Receptors Exacerbate Stress Effects in Myocardial Ischemia Injury in Mice"],"prefix":"10.3390","volume":"14","author":[{"given":"Analilia","family":"Cardenas-Garza","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Center of Excellence for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilly A.","family":"Kamberov","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Center of Excellence for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemangini A.","family":"Dhaibar","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Center of Excellence for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Dudenbostel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Huntsville Regional Medical Campus, University of Alabama at Birmingham, Huntsville, AL 35801, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopi Krishna","family":"Kolluru","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Center of Excellence for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Kevil","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Center of Excellence for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Oakley","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences\u2014NIH, Research Triangle Park, Durham, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Cidlowski","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences\u2014NIH, Research Triangle Park, Durham, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2827-7162","authenticated-orcid":false,"given":"Luca","family":"Cucullo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA"},{"name":"Department of Foundation Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Cruz-Topete","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA"},{"name":"Center of 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