{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:05:00Z","timestamp":1791813900995,"version":"4.3.4"},"reference-count":135,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Platelets are often described in simple terms as small anucleate cells that mediate hemostasis, but studies over more than half a century have shown that circulating platelets are heterogeneous in size, density, age, and functional responses. These subtypes not only contribute to normal hemostasis but also play pivotal roles in the pathogenesis of diverse diseases, including cardiovascular, inflammatory, and malignant disorders. Accumulating evidence indicates that alterations in specific platelet subtypes are closely linked to disease onset, progression, and severity, underscoring their importance as both biomarkers and potential therapeutic targets. Current clinical assessments of platelet status rely primarily on platelet count and mean platelet volume (MPV) as part of routine complete blood count analysis. However, these global measures often fail to capture differences in platelet subtypes, which may remain undetected despite their significant contribution to disease pathology. This gap highlights the necessity of moving beyond conventional metrics toward a more nuanced understanding of platelet heterogeneity and its clinical implications. In this review, we discuss the diversity of platelet subpopulations and their roles in health and disease, emphasizing how specific subsets contribute to divergent pathological mechanisms. We also highlight emerging strategies that target defined platelet subpopulations, illustrating how this knowledge could pave the way for more precise diagnostic and therapeutic approaches.<\/jats:p>","DOI":"10.3390\/cells15010011","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T07:01:33Z","timestamp":1766386893000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Platelet Subpopulations in Health and Disease: Heterogeneity, Clinical Associations, and Therapeutic Targeting"],"prefix":"10.3390","volume":"15","author":[{"given":"Deepa","family":"Gautam","sequence":"first","affiliation":[{"name":"Division of Hematology, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"},{"name":"Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6586-5502","authenticated-orcid":false,"given":"Giovanni","family":"Goggi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth M.","family":"Battinelli","sequence":"additional","affiliation":[{"name":"Division of Hematology, Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"},{"name":"Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1111\/bcp.15221","article-title":"Antiplatelet Therapy in Cardiovascular Disease: Current Status and Future Directions","volume":"88","author":"Passacquale","year":"2022","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"G53","DOI":"10.1093\/eurheartj\/sul056","article-title":"Resistance to Antiplatelet Drugs","volume":"8","author":"Michelson","year":"2006","journal-title":"Eur. Heart J. Suppl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jvs.2020.10.049","article-title":"Clopidogrel Resistance Is Common in Patients Undergoing Vascular and Coronary Interventions","volume":"73","author":"Hawken","year":"2021","journal-title":"J. Vasc. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kang, H.G., Lee, S.J., Heo, S.H., Chang, D.-I., and Kim, B.J. (2021). Clopidogrel Resistance in Patients With Stroke Recurrence Under Single or Dual Antiplatelet Treatment. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.652416"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/2051332a0","article-title":"Two Populations of Platelets","volume":"205","author":"Webber","year":"1965","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1172\/JCI106063","article-title":"Heterogeneity of Human Platelets. I. Metabolic and Kinetic Evidence Suggestive of Young and Old Platelets","volume":"48","author":"Karpatkin","year":"1969","journal-title":"J. Clin. Investig."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1172\/JCI106064","article-title":"Heterogeneity of Human Platelets. II. Functional Evidence Suggestive of Young and Old Platelets","volume":"48","author":"Karpatkin","year":"1969","journal-title":"J. Clin. Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2141.1982.tb01947.x","article-title":"Size Dependent Platelet Subpopulations: Relationship of Platelet Volume to Ultrastructure, Enzymatic Activity, and Function","volume":"50","author":"Thompson","year":"1982","journal-title":"Br. J. Haematol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2141.1969.tb01366.x","article-title":"Reticulated Platelets Following Acute Blood Loss","volume":"17","author":"Ingram","year":"1969","journal-title":"Br. J. Haematol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1182\/blood.V49.1.71.71","article-title":"Heterogeneity of Human Whole Blood Platelet Subpopulations. I. Relationship between Buoyant Density, Cell Volume, and Ultrastructure","volume":"49","author":"Corash","year":"1977","journal-title":"Blood"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1182\/blood.V85.7.1822.bloodjournal8571822","article-title":"Demonstration That Thiazole-Orange-Positive Platelets in the Dog Are Less than 24 Hours Old","volume":"85","author":"Dale","year":"1995","journal-title":"Blood"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1365-2141.1976.tb03611.x","article-title":"Megakaryocytes and the Heterogeneity of Circulating Platelets","volume":"34","author":"Penington","year":"1976","journal-title":"Br. J. Haematol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1182\/blood.V61.2.362.362","article-title":"Survival of Density Subpopulations of Rabbit Platelets: Use of 51Cr-or 111In-Labeled Platelets to Measure Survival of Least Dense and Most Dense Platelets Concurrently","volume":"61","author":"Rand","year":"1983","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2141.1976.tb03583.x","article-title":"Platelet Density and Size: The Interpretation of Heterogeneity","volume":"34","author":"Penington","year":"1976","journal-title":"Br. J. Haematol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1182\/blood.V64.1.185.185","article-title":"Heterogeneity of Human Whole Blood Platelet Subpopulations. III. Density-Dependent Differences in Subcellular Constituents","volume":"64","author":"Corash","year":"1984","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1365-2141.1992.tb06949.x","article-title":"Adhesion Efficiency, Platelet Density and Size","volume":"82","author":"Raha","year":"1992","journal-title":"Br. J. Haematol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1365-2141.1993.tb03147.x","article-title":"Blood Platelet Heterogeneity: Evidence for Two Classes of Platelets in Man and Rat","volume":"84","author":"Behnke","year":"1993","journal-title":"Br. J. Haematol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0049-3848(73)90009-1","article-title":"Kinetics of Platelet \u00abpopulations\u00e5 in the Stationary State","volume":"3","author":"Boneu","year":"1973","journal-title":"Thromb. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1161\/ATVBAHA.119.313280","article-title":"Megakaryocyte and Platelet Transcriptomics for Discoveries in Human Health and Disease","volume":"40","author":"Rowley","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1182\/blood.2021010697","article-title":"Single-Cell Analysis of Ploidy and the Transcriptome Reveals Functional and Spatial Divergency in Murine Megakaryopoiesis","volume":"138","author":"Sun","year":"2021","journal-title":"Blood"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1182\/bloodadvances.2018020834","article-title":"Megakaryocytes Package Contents into Separate \u03b1-Granules That Are Differentially Distributed in Platelets","volume":"3","author":"Battinelli","year":"2019","journal-title":"Blood Adv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s40364-025-00830-x","article-title":"Age- and Sex-Specific Transcriptomic Changes Drive the Prothrombotic Potential of Megakaryocytes","volume":"13","author":"Lee","year":"2025","journal-title":"Biomark. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1182\/blood.2019000200","article-title":"TNF-\u03b1\u2013Driven Inflammation and Mitochondrial Dysfunction Define the Platelet Hyperreactivity of Aging","volume":"134","author":"McMahon","year":"2019","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/ATVBAHA.120.316772","article-title":"Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists With Platelet PAR (Protease-Activated Receptor)-1 and PAR-4\u2013Mediated Thrombin Resistance","volume":"42","author":"Gnanenthiran","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/s41598-017-19126-8","article-title":"Platelet Subpopulations Remain despite Strong Dual Agonist Stimulation and Can Be Characterised Using a Novel Six-Colour Flow Cytometry Protocol","volume":"8","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"10300","DOI":"10.1038\/s41598-018-28211-5","article-title":"Mass Cytometry Reveals Distinct Platelet Subtypes in Healthy Subjects and Novel Alterations in Surface Glycoproteins in Glanzmann Thrombasthenia","volume":"8","author":"Blair","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1111\/jth.15330","article-title":"Multidimensional Flow Cytometry Reveals Novel Platelet Subpopulations in Response to Prostacyclin","volume":"19","author":"Hindle","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/s41598-023-28352-2","article-title":"Identification of Platelet Subpopulations in Cryopreserved Platelet Components Using Multi-Colour Imaging Flow Cytometry","volume":"13","author":"Johnson","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"102523","DOI":"10.1016\/j.rpth.2024.102523","article-title":"Multiparameter Phenotyping of Platelets and Characterization of the Effects of Agonists Using Machine Learning","volume":"8","author":"Vadgama","year":"2024","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Qiu, X., Nair, M.G., Jaroszewski, L., and Godzik, A. (2023). Deciphering Abnormal Platelet Subpopulations in Inflammatory Diseases through Machine Learning and Single-Cell Transcriptomics. bioRxiv.","DOI":"10.1101\/2023.12.20.572680"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Qiu, X., Nair, M.G., Jaroszewski, L., and Godzik, A. (2024). Deciphering Abnormal Platelet Subpopulations in COVID-19, Sepsis and Systemic Lupus Erythematosus through Machine Learning and Single-Cell Transcriptomics. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115941"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.201304054","article-title":"The Incredible Journey: From Megakaryocyte Development to Platelet Formation","volume":"201","author":"Machlus","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.thromres.2022.12.004","article-title":"Platelet Ageing: A Review","volume":"231","author":"Allan","year":"2023","journal-title":"Thromb. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exphem.2017.10.001","article-title":"Megakaryocyte and Polyploidization","volume":"57","author":"Mazzi","year":"2018","journal-title":"Exp. Hematol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.5858\/arpa.2012-0624-OA","article-title":"Reference Intervals of Reticulated Platelets and Other Platelet Parameters and Their Associations","volume":"137","author":"Hoffmann","year":"2013","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ajh.2830110108","article-title":"Evidence That Platelet Buoyant Density, but Not Size, Correlates with Platelet Age in Man","volume":"11","author":"Mezzano","year":"1981","journal-title":"Am. J. Hematol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1111\/jth.14895","article-title":"Ultrastructural, Transcriptional, and Functional Differences between Human Reticulated and Non-reticulated Platelets","volume":"18","author":"Hille","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1111\/jth.15496","article-title":"Proteome and Functional Decline as Platelets Age in the Circulation","volume":"19","author":"Allan","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1055\/s-0039-1695009","article-title":"Transcriptome Analysis of Reticulated Platelets Reveals a Prothrombotic Profile","volume":"119","author":"Bongiovanni","year":"2019","journal-title":"Thromb. Haemost."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1432-1033.1987.tb11010.x","article-title":"Biosynthesis of Major Platelet Proteins in Human Blood Platelets","volume":"164","author":"Kieffer","year":"1987","journal-title":"Eur. J. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1111\/jth.14537","article-title":"Cell Surface Expression of HLA I Molecules as a Marker of Young Platelets","volume":"17","author":"Dupuis","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chen, H.-L., Wang, Q.-Y., Qi, R.-M., and Cai, J.-P. (2024). Identification of the Changes in the Platelet Proteomic Profile of Elderly Individuals. Front. Cardiovasc. Med., 11.","DOI":"10.3389\/fcvm.2024.1384679"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1182\/bloodadvances.2022007099","article-title":"Temporal In Vivo Platelet Labeling in Mice Reveals Age-Dependent Receptor Expression and Conservation of Specific MRNAs","volume":"6","author":"Armstrong","year":"2022","journal-title":"Blood Adv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"120600","DOI":"10.1016\/j.cca.2025.120600","article-title":"Immature Platelet Fraction in Cardiology","volume":"579","author":"Cao","year":"2026","journal-title":"Clin. Chim. Acta"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3343\/kjlm.2010.30.5.451","article-title":"Immature Platelet Fraction: Establishment of a Reference Interval and Diagnostic Measure for Thrombocytopenia","volume":"30","author":"Jung","year":"2010","journal-title":"Ann. Lab. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s11239-013-0932-x","article-title":"Propensity for Young Reticulated Platelet Recruitment into Arterial Thrombi","volume":"37","author":"McBane","year":"2014","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.jacc.2004.05.033","article-title":"Reticulated Platelets in Acute Coronary Syndrome: A Marker of Platelet Activity","volume":"44","author":"Lakkis","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Larsen, S.B., Grove, E.L., Hvas, A.-M., and Kristensen, S.D. (2014). Platelet Turnover in Stable Coronary Artery Disease\u2014Influence of Thrombopoietin and Low-Grade Inflammation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0085566"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1136\/bmj.287.6390.456","article-title":"Changes in Volume and Density of Platelets in Myocardial Infarction","volume":"287","author":"Martin","year":"1983","journal-title":"BMJ"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1365-2362.1990.tb01850.x","article-title":"Accelerated Atherogenesis Occurs Following Platelet Destruction and Increases in Megakaryocyte Size and DNA Content","volume":"20","author":"Kristensen","year":"1990","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/0953710042000267707","article-title":"Mean Platelet Volume in Patients with Type 2 Diabetes Mellitus","volume":"15","author":"Papanas","year":"2004","journal-title":"Platelets"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1172\/JCI94494","article-title":"Sugar Makes Neutrophils RAGE: Linking Diabetes-Associated Hyperglycemia to Thrombocytosis and Platelet Reactivity","volume":"127","author":"Lee","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1172\/JCI92450","article-title":"Neutrophil-Derived S100 Calcium-Binding Proteins A8\/A9 Promote Reticulated Thrombocytosis and Atherogenesis in Diabetes","volume":"127","author":"Kraakman","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1161\/01.CIR.0000072771.11429.83","article-title":"Clopidogrel for Coronary Stenting","volume":"107","author":"Gurbel","year":"2003","journal-title":"Circulation"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nrcardio.2012.131","article-title":"The Causal Role of Megakaryocyte\u2013Platelet Hyperactivity in Acute Coronary Syndromes","volume":"9","author":"Martin","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jcin.2010.05.014","article-title":"Patients With Previous Definite Stent Thrombosis Have a Reduced Antiplatelet Effect of Aspirin and a Larger Fraction of Immature Platelets","volume":"3","author":"Grove","year":"2010","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1161\/CIRCULATIONAHA.105.542696","article-title":"Contribution of Cyclooxygenase-2 to Elevated Biosynthesis of Thromboxane A 2 and Prostacyclin in Cigarette Smokers","volume":"112","author":"McAdam","year":"2005","journal-title":"Circulation"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/01.CIR.0000081770.51929.5A","article-title":"Functional and Biochemical Evaluation of Platelet Aspirin Resistance After Coronary Artery Bypass Surgery","volume":"108","author":"Zimmermann","year":"2003","journal-title":"Circulation"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1182\/blood-2009-08-236679","article-title":"The Contribution of Cyclooxygenase-1 and -2 to Persistent Thromboxane Biosynthesis in Aspirin-Treated Essential Thrombocythemia: Implications for Antiplatelet Therapy","volume":"115","author":"Dragani","year":"2010","journal-title":"Blood"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1538-7836.2007.02387.x","article-title":"Reticulated Platelets and Uninhibited COX-1 and COX-2 Decrease the Antiplatelet Effects of Aspirin","volume":"5","author":"Guthikonda","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e010193","DOI":"10.1136\/jitc-2024-010193","article-title":"Enhanced Thrombopoiesis Supplies PD-L1 to Circulating Immune Cells via the Generation of PD-L1-Expressing Platelets in Patients with Lung Cancer","volume":"13","author":"Lee","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"eadp3971","DOI":"10.1126\/science.adp3971","article-title":"Platelets Sequester Extracellular DNA, Capturing Tumor-Derived and Free Fetal DNA","volume":"389","author":"Murphy","year":"2025","journal-title":"Science"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.dld.2024.03.007","article-title":"Reticulated Platelets Are Increased and Hyper-Activated in Patients with Cirrhosis, Especially Those with Poor Outcome","volume":"56","author":"Zanetto","year":"2024","journal-title":"Dig. Liver Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1751-553X.2009.01184.x","article-title":"Immature Platelet Fraction Measurement in Patients with Chronic Liver Disease: A Convenient Marker for Evaluating Cirrhotic Change","volume":"32","author":"Nomura","year":"2010","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/bjc.2012.439","article-title":"Levels of a Subpopulation of Platelets, but Not Circulating Endothelial Cells, Predict Early Treatment Failure in Prostate Cancer Patients after Prostatectomy","volume":"107","author":"Wong","year":"2012","journal-title":"Br. J. Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s11239-020-02290-6","article-title":"Immature Platelets in Patients Hospitalized with Covid-19","volume":"51","author":"Cohen","year":"2021","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e9424","DOI":"10.1097\/MD.0000000000009424","article-title":"Clinical Significance of Measuring Reticulated Platelets in Infectious Diseases","volume":"96","author":"Liu","year":"2017","journal-title":"Medicine"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1007\/s00134-012-2725-7","article-title":"Immature Platelet Fraction in Predicting Sepsis in Critically Ill Patients","volume":"39","author":"Cardelli","year":"2013","journal-title":"Intensive Care Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1179\/1607845413Y.0000000143","article-title":"Immature Platelet Fraction Levels in a Variety of Bone Marrow Pathologies in South African HIV-Positive Patients with Thrombocytopenia","volume":"19","author":"Vaughan","year":"2014","journal-title":"Hematology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1182\/blood-2012-09-457739","article-title":"Hierarchical Organization in the Hemostatic Response and Its Relationship to the Platelet-Signaling Network","volume":"121","author":"Stalker","year":"2013","journal-title":"Blood"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1161\/ATVBAHA.107.151100","article-title":"Segregation of Platelet Aggregatory and Procoagulant Microdomains in Thrombus Formation","volume":"27","author":"Munnix","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Lesyk, G., and Jurasz, P. (2019). Advances in Platelet Subpopulation Research. Front. Cardiovasc. Med., 6.","DOI":"10.3389\/fcvm.2019.00138"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1182\/blood-2006-12-027698","article-title":"The Growing Complexity of Platelet Aggregation","volume":"109","author":"Jackson","year":"2007","journal-title":"Blood"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1182\/blood.V94.1.172.413k17_172_178","article-title":"Contribution of Distinct Adhesive Interactions to Platelet Aggregation in Flowing Blood","volume":"94","author":"Ruggeri","year":"1999","journal-title":"Blood"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1161\/01.CIR.102.16.1931","article-title":"P-Selectin Expression on Platelets Determines Size and Stability of Platelet Aggregates","volume":"102","author":"Merten","year":"2000","journal-title":"Circulation"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1016\/j.bpj.2012.04.004","article-title":"Identification of Different Proaggregatory Abilities of Activated Platelet Subpopulations","volume":"102","author":"Yakimenko","year":"2012","journal-title":"Biophys. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/09537109909169171","article-title":"Differences in the Platelet Proaggregatory Activity of Immune Complexes Isolated from Patients with Myocardial Infarction or Pulmonary Cancer","volume":"10","author":"Das","year":"1999","journal-title":"Platelets"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1182\/blood-2006-08-040980","article-title":"Conversion of Platelets from a Proaggregatory to a Proinflammatory Adhesive Phenotype: Role of PAF in Spatially Regulating Neutrophil Adhesion and Spreading","volume":"110","author":"Kulkarni","year":"2007","journal-title":"Blood"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1182\/blood-2005-03-1223","article-title":"Role of FcRgamma and Factor XIIIA in Coated Platelet Formation","volume":"106","author":"Jobe","year":"2005","journal-title":"Blood"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3324\/haematol.2015.131441","article-title":"Coated Platelets Function in Platelet-Dependent Fibrin Formation via Integrin AIIb\u03b23 and Transglutaminase Factor XIII","volume":"101","author":"Mattheij","year":"2016","journal-title":"Haematologica"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1182\/blood-2006-07-037283","article-title":"Active Tissue Factor Pathway Inhibitor Is Expressed on the Surface of Coated Platelets","volume":"109","author":"Maroney","year":"2007","journal-title":"Blood"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1182\/blood.V95.5.1694.005k24_1694_1702","article-title":"Surface Expression and Functional Characterization of Alpha-Granule Factor V in Human Platelets: Effects of Ionophore A23187, Thrombin, Collagen, and Convulxin","volume":"95","author":"Alberio","year":"2000","journal-title":"Blood"},{"key":"ref_83","first-page":"338","article-title":"All Platelets Are Not Equal: COAT Platelets","volume":"3","author":"Alberio","year":"2004","journal-title":"Curr. Hematol. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"102970","DOI":"10.1016\/j.rpth.2025.102970","article-title":"Serotonin Transporter Deficiency, but Not Absence of Platelet Serotonin, Impairs Thrombus Formation in a Model of Deep Vein Thrombosis","volume":"9","author":"Naber","year":"2025","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.lab.2004.02.001","article-title":"Glycoprotein IIb\/IIIa Inhibitors Increase COAT-Platelet Production In Vitro","volume":"143","author":"Hamilton","year":"2004","journal-title":"J. Lab. Clin. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/415175a","article-title":"Stimulated Platelets Use Serotonin to Enhance Their Retention of Procoagulant Proteins on the Cell Surface","volume":"415","author":"Dale","year":"2002","journal-title":"Nature"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1538-7836.2008.02890.x","article-title":"Coated-Platelets in Ischemic Stroke: Differences between Lacunar and Cortical Stroke","volume":"6","author":"Prodan","year":"2008","journal-title":"J. Thromb. Haemost."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/jcbfm.2012.168","article-title":"Higher Coated-Platelet Levels Are Associated with Stroke Recurrence Following Nonlacunar Brain Infarction","volume":"33","author":"Prodan","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.06.033","article-title":"Higher Coated-Platelet Levels in Acute Stroke Are Associated with Lower Cognitive Scores at Three Months Post Infarction","volume":"28","author":"Kirkpatrick","year":"2019","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/jth.14714","article-title":"Increased Platelet Procoagulant Potential Predicts Recurrent Stroke and TIA after Lacunar Infarction","volume":"18","author":"Kirkpatrick","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1212\/WNL.0000000000206008","article-title":"Lower Coated-Platelet Potential Is Associated with Major Hemorrhagic Complications After Discharge in Patients with Non-Lacunar Brain Infarction (P2-5.030)","volume":"102","author":"Ribeiro","year":"2024","journal-title":"Neurology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1161\/STROKEAHA.109.549014","article-title":"Coated-Platelet Levels Are Low in Patients With Spontaneous Intracerebral Hemorrhage","volume":"40","author":"Prodan","year":"2009","journal-title":"Stroke"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1161\/STROKEAHA.110.581447","article-title":"Coated Platelet Levels Correlate With Bleed Volume in Patients With Spontaneous Intracerebral Hemorrhage","volume":"41","author":"Prodan","year":"2010","journal-title":"Stroke"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/HTR.0000000000000010","article-title":"Coated-Platelet Levels Are Persistently Elevated in Patients with Mild Traumatic Brain Injury","volume":"29","author":"Prodan","year":"2014","journal-title":"J. Head. Trauma. Rehabil."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrneurol.2011.11","article-title":"Coated-Platelets Can Predict Risk of Alzheimer Disease","volume":"7","author":"McSharry","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1212\/WNL.0b013e3182074bd2","article-title":"Coated-Platelet Levels and Progression from Mild Cognitive Impairment to Alzheimer Disease","volume":"76","author":"Prodan","year":"2011","journal-title":"Neurology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/jth.15687","article-title":"Low COAT Platelets Are Frequent in Patients with Bleeding Disorders of Unknown Cause (BDUC) and Can Be Enhanced by DDAVP","volume":"20","author":"Segot","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/cyto.b.22026","article-title":"Diagnostic Utility of Flow Cytometry Based Coated-platelets Assay as a Biomarker to Predict Thrombotic or Hemorrhagic Phenotype in Acute Stroke","volume":"102","author":"Dave","year":"2022","journal-title":"Cytometry B Clin. Cytom."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Reddy, E.C., and Rand, M.L. (2020). Procoagulant Phosphatidylserine-Exposing Platelets In Vitro and In Vivo. Front. Cardiovasc. Med., 7.","DOI":"10.3389\/fcvm.2020.00015"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1182\/blood-2002-02-0354","article-title":"Thrombospondin and Fibrinogen Bind Serotonin-Derivatized Proteins on COAT-Platelets","volume":"100","author":"Szasz","year":"2002","journal-title":"Blood"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1111\/j.1538-7836.2005.01274.x","article-title":"REVIEW ARTICLE: Coated-Platelets: An Emerging Component of the Procoagulant Response","volume":"3","author":"Dale","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"ref_102","unstructured":"Wolfs, J.L.N. (2009). Generation of Procoagulant Activity in Blood Cells: Studies on the Process of Lipid Scrambling. [Doctoral Thesis, Maastricht University]."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1182\/bloodadvances.2019000182","article-title":"Supramaximal Calcium Signaling Triggers Procoagulant Platelet Formation","volume":"4","author":"Abbasian","year":"2020","journal-title":"Blood Adv."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1161\/ATVBAHA.117.309473","article-title":"Inner Mitochondrial Membrane Disruption Links Apoptotic and Agonist-Initiated Phosphatidylserine Externalization in Platelets","volume":"37","author":"Choo","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"13325","DOI":"10.1074\/jbc.M112.428359","article-title":"Dual Mechanism of Integrin AIIb\u03b23 Closure in Procoagulant Platelets","volume":"288","author":"Mattheij","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1538-7836.2009.03366.x","article-title":"The Role of the Intrinsic Apoptosis Pathway in Platelet Life and Death","volume":"7","author":"Kile","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1182\/blood-2009-01-200345","article-title":"Two Distinct Pathways Regulate Platelet Phosphatidylserine Exposure and Procoagulant Function","volume":"114","author":"Schoenwaelder","year":"2009","journal-title":"Blood"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1182\/blood-2015-08-663005","article-title":"Necrotic Platelets Provide a Procoagulant Surface during Thrombosis","volume":"126","author":"Hua","year":"2015","journal-title":"Blood"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1161\/ATVBAHA.112.300433","article-title":"Mitochondrial Calcium and Reactive Oxygen Species Regulate Agonist-Initiated Platelet Phosphatidylserine Exposure","volume":"32","author":"Choo","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/jth.14008","article-title":"Novel Assay Demonstrates That Coronary Artery Disease Patients Have Heightened Procoagulant Platelet Response","volume":"16","author":"Pasalic","year":"2018","journal-title":"J. Thromb. Haemost."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/jth.15650","article-title":"Measurement of Procoagulant Platelets Provides Mechanistic Insight and Diagnostic Potential in Heparin-Induced Thrombocytopenia","volume":"20","author":"Lee","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13046-016-0328-9","article-title":"Phosphatidylserine Exposing-Platelets and Microparticles Promote Procoagulant Activity in Colon Cancer Patients","volume":"35","author":"Zhao","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1182\/blood.2024025476","article-title":"Procoagulant Platelet Activation Promotes Venous Thrombosis","volume":"144","author":"Kaiser","year":"2024","journal-title":"Blood"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"17444","DOI":"10.1073\/pnas.1904978116","article-title":"Histone H4 Induces Platelet Ballooning and Microparticle Release during Trauma Hemorrhage","volume":"116","author":"Vulliamy","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0889-8529(05)70225-5","article-title":"Treatment for the Procoagulant State in Type 2 Diabetes","volume":"30","author":"Colwell","year":"2001","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1111\/j.1538-7836.2008.03185.x","article-title":"Platelet Hyperprocoagulant Activity in Type 2 Diabetes Mellitus: Attenuation by Glycoprotein IIb\/IIIa Inhibition","volume":"6","author":"RAZMARA","year":"2008","journal-title":"J. Thromb. Haemost."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.thromres.2020.06.033","article-title":"Small Procoagulant Platelets in Diabetes Type 2","volume":"195","author":"Edvardsson","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1111\/jth.15107","article-title":"COVID-19 Patients Exhibit Reduced Procoagulant Platelet Responses","volume":"18","author":"Denorme","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.3324\/haematol.2021.279000","article-title":"Antibody-Mediated Procoagulant Platelets in SARS-CoV-2-Vaccination Associated Immune Thrombotic Thrombocytopenia","volume":"106","author":"Althaus","year":"2021","journal-title":"Haematologica"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/jth.15587","article-title":"Antibody-mediated Procoagulant Platelet Formation in COVID-19 Is AKT Dependent","volume":"20","author":"Pelzl","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1161\/ATVBAHA.121.316244","article-title":"Role of Reticulated Platelets in Cardiovascular Disease","volume":"42","author":"Bongiovanni","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1160\/TH17-07-0466","article-title":"Impact of Reticulated Platelets on the Antiplatelet Effect of the Intravenous P2Y12-Receptor Inhibitor Cangrelor","volume":"118","author":"Stratz","year":"2018","journal-title":"Thromb. Haemost."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11239-011-0665-7","article-title":"Immature Platelet Fraction (IPF) Determined with an Automated Method Predicts Clopidogrel Hyporesponsiveness","volume":"33","author":"Ibrahim","year":"2012","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1093\/eurheartj\/ehaf694","article-title":"Reticulated Platelets in Coronary Artery Disease: A Multidimensional Approach Unveils Prothrombotic Signalling and Novel Therapeutic Targets","volume":"46","author":"Kirmes","year":"2025","journal-title":"Eur. Heart J."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"10937","DOI":"10.1073\/pnas.1933204100","article-title":"Interaction of a Selective Cyclooxygenase-2 Inhibitor with Aspirin and NO-Releasing Aspirin in the Human Gastric Mucosa","volume":"100","author":"Fiorucci","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1111\/jth.15478","article-title":"Platelets Stimulate Programmed Death-ligand 1 Expression by Cancer Cells: Inhibition by Anti-platelet Drugs","volume":"19","author":"Asgari","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Tornyos, D., Meuer, M., Luk\u00e1cs, R., El Alaoui El Abdallaoui, O., Kup\u00f3, P., Faludi, R., and Kom\u00f3csi, A. (2022). Cardiovascular Outcomes in Patients Treated with Sodium-Glucose Transport Protein 2 Inhibitors, a Network Meta-Analysis of Randomized Trials. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.1041200"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/art.33493","article-title":"Pharmacokinetics, Tolerability, and Preliminary Efficacy of Paquinimod (ABR-215757), a New Quinoline-3-carboxamide Derivative: Studies in Lupus-prone Mice and a Multicenter, Randomized, Double-blind, Placebo-controlled, Repeat-dose, Dose-ranging Study in Patients with Systemic Lupus Erythematosus","volume":"64","author":"Bengtsson","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1056\/NEJMoa0904327","article-title":"Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes","volume":"361","author":"Wallentin","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/jamacardio.2021.0475","article-title":"Efficacy and Safety of Revacept, a Novel Lesion-Directed Competitive Antagonist to Platelet Glycoprotein VI, in Patients Undergoing Elective Percutaneous Coronary Intervention for Stable Ischemic Heart Disease","volume":"6","author":"Mayer","year":"2021","journal-title":"JAMA Cardiol."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Nichetti, F., Ligorio, F., Zattarin, E., Signorelli, D., Prelaj, A., Proto, C., Galli, G., Marra, A., Apollonio, G., and Porcu, L. (2019). Is There an Interplay between Immune Checkpoint Inhibitors, Thromboprophylactic Treatments and Thromboembolic Events? Mechanisms and Impact in Non-Small Cell Lung Cancer Patients. Cancers, 12.","DOI":"10.3390\/cancers12010067"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1111\/j.1538-7836.2007.02691.x","article-title":"Coated-platelet Levels Are Influenced by Smoking, Aspirin, and Selective Serotonin Reuptake Inhibitors","volume":"5","author":"Prodan","year":"2007","journal-title":"J. Thromb. Haemost."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1161\/01.CIR.0000151355.07568.B4","article-title":"Diabetes, Coronary Intervention, and Platelet Glycoprotein IIb\/IIIa Blockade","volume":"110","author":"Tang","year":"2004","journal-title":"Circulation"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/01.CIR.103.2.201","article-title":"Increased Mortality With Oral Platelet Glycoprotein IIb\/IIIa Antagonists","volume":"103","author":"Chew","year":"2001","journal-title":"Circulation"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/annrheumdis-2018-213523","article-title":"Humanised Effector-Null Fc\u03b3RIIA Antibody Inhibits Immune Complex-Mediated Proinflammatory Responses","volume":"78","author":"Chen","year":"2019","journal-title":"Ann. Rheum. Dis."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/1\/11\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T07:07:59Z","timestamp":1766387279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/1\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,20]]},"references-count":135,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["cells15010011"],"URL":"https:\/\/doi.org\/10.3390\/cells15010011","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,20]]}}}