{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:09:13Z","timestamp":1792480153012,"version":"4.5.0"},"reference-count":266,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>(1) Background: Wound healing is a highly coordinated process encompassing hemostasis, inflammation, angiogenesis, keratinocyte migration, collagen deposition, and extracellular matrix remodeling. Successful repair also requires adequate nutrient and oxygen delivery through a well-developed vascular supply. Disruption of these processes can occur through aberrations in diverse biological pathways, including extracellular matrix organization, cellular adhesions, angiogenesis, and immune regulation. (2) Methods: We reviewed mechanisms of impaired tissue repair in monogenic disorders by focusing on three categories\u2014connective tissue, hematological\/immunological, and aging-related disorders\u2014to illustrate how single-gene defects disrupt inflammation, cellular proliferation, and matrix remodeling. Additionally, we reviewed various polygenic disorders\u2014chronic kidney disease, diabetes mellitus, hypertension, and obesity\u2014to contrast complex multifactorial pathologies with single-gene defects. (3) Results: This review establishes that genetic impediments, despite their distinct etiologies, monogenic and polygenic disorders share critical downstream failures in the wound healing cascade. While monogenic diseases illustrate direct causal links between specific protein deficits and repair failure, polygenic diseases demonstrate how multifactorial stressors overwhelm the body\u2019s regenerative capacity. (4) Conclusions: This review synthesizes current evidence on both monogenic diseases and polygenic contributions to impaired wound healing. These findings highlight that genetic susceptibility is a decisive factor in the ability to restore tissue homeostasis. This underscores the profound impact of genetic background on the efficacy of hemostasis, inflammation, and remodeling.<\/jats:p>","DOI":"10.3390\/cells15010074","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T12:23:44Z","timestamp":1767356624000},"page":"74","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Genetic Determinants of Wound Healing: Monogenic Disorders and Polygenic Influence"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1130-2004","authenticated-orcid":false,"given":"Stephanie M.","family":"Mueller","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"},{"name":"Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8059-8763","authenticated-orcid":false,"given":"Nalani","family":"Miller","sequence":"additional","affiliation":[{"name":"John A. Burns School of Medicine, University of Hawai\u02bbi at M\u0101noa, 651 Ilalo Street, Honolulu, HI 96813, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3091-3102","authenticated-orcid":false,"given":"Jasleen","family":"Gill","sequence":"additional","affiliation":[{"name":"Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7849-0844","authenticated-orcid":false,"given":"LaYow C.","family":"Yu","sequence":"additional","affiliation":[{"name":"Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5382-6027","authenticated-orcid":false,"given":"Michael Drake","family":"Pike","sequence":"additional","affiliation":[{"name":"Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-7310","authenticated-orcid":false,"given":"Dennis P.","family":"Orgill","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Brigham and Women\u2019s Hospital, 75 Francis Street, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jss.2011.07.007","article-title":"A review of the role of mechanical forces in cutaneous wound healing","volume":"171","author":"Agha","year":"2011","journal-title":"J. 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