{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:18:39Z","timestamp":1787620719923,"version":"build-2736575974"},"reference-count":167,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["RO1HL161205"],"award-info":[{"award-number":["RO1HL161205"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Asthma is a heterogeneous disease that varies in clinical presentation, severity, and underlying biology but consistently involves airway remodeling (AR) and airway hyperresponsiveness (AHR), which is characterized by excessive airway narrowing in response to various stimuli. Airway smooth muscle (ASM) cells are primary contributors to airway hyperresponsiveness and bronchoconstriction. This review focuses on ASM cells and their role in asthma. We discuss the mechanisms by which ASM mediates AHR, increases airway thickness, and contributes to AR. Signaling through G protein-coupled receptors (GPCRs) regulates many ASM functions, including contraction, growth, and the synthetic activities that drive airway inflammation and remodeling. GPCR-dependent calcium flux serves as a key signaling axis controlling the contractile responses of ASM. Here we provide a comprehensive summary of the major GPCRs as well as other non-GPCRs identified in ASM cells. GPCR-induced calcium mobilization, downstream signaling and how it has been linked to specific ASM functions are also discussed. Furthermore, we highlight the clinical significance of targeting GPCRs in asthma therapy as well as recent development of novel therapeutics in the management of asthma. Thus, this review provides a comprehensive overview of airway smooth muscle in the context of asthma pathophysiology.<\/jats:p>","DOI":"10.3390\/cells15020203","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:31:46Z","timestamp":1769009506000},"page":"203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Integrating GPCR Regulation and Calcium Dynamics in Airway Smooth Muscle Function: A Comprehensive Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4649-0741","authenticated-orcid":false,"given":"Saptarshi","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Kumar","family":"Gangipangi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Hancock","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2904-2306","authenticated-orcid":false,"given":"Pawan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"},{"name":"Thoracic Medicine and Surgery, Center for Inflammation and Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"},{"name":"Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15025","DOI":"10.1038\/nrdp.2015.25","article-title":"Asthma","volume":"1","author":"Holgate","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0140-6736(22)02125-0","article-title":"Asthma","volume":"401","author":"Porsbjerg","year":"2023","journal-title":"Lancet"},{"key":"ref_3","unstructured":"GBD 2019 Diseases and Injuries Collaborators (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet, 396, 1204\u20131222."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Xie, C., Yang, J., Gul, A., Li, Y., Zhang, R., Yalikun, M., Lv, X., Lin, Y., Luo, Q., and Gao, H. (2024). Immunologic aspects of asthma: From molecular mechanisms to disease pathophysiology and clinical translation. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1478624"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1016\/j.cell.2021.04.019","article-title":"The basic immunology of asthma","volume":"184","author":"Hammad","year":"2021","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"L382","DOI":"10.1152\/ajplung.00121.2024","article-title":"T cell and airway smooth muscle interaction: A key driver of asthmatic airway inflammation and remodeling","volume":"327","author":"Zhou","year":"2024","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1164\/rccm.200907-1101OC","article-title":"Beyond atopy: Multiple patterns of sensitization in relation to asthma in a birth cohort study","volume":"181","author":"Simpson","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/cea.12450","article-title":"To what extent is allergen exposure a risk factor for the development of allergic disease?","volume":"45","author":"Custovic","year":"2015","journal-title":"Clin. Exp. Allergy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"190096","DOI":"10.1183\/16000617.0096-2019","article-title":"Cellular mechanisms underlying steroid-resistant asthma","volume":"28","author":"Wadhwa","year":"2019","journal-title":"Eur. Respir. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"680","DOI":"10.12688\/f1000research.14581.1","article-title":"New targets for resolution of airway remodeling in obstructive lung diseases","volume":"7","author":"Nayak","year":"2018","journal-title":"F1000Research"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/j.jaci.2021.03.035","article-title":"Airway smooth muscle pathophysiology in asthma","volume":"147","author":"Lockey","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Xiong, D.J.P., Martin, J.G., and Lauzon, A.M. (2022). Airway smooth muscle function in asthma. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.993406"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1152\/jappl.1993.74.6.2771","article-title":"Functional significance of increased airway smooth muscle in asthma and COPD","volume":"74","author":"Lambert","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"O\u2019Sullivan, M.J., Jang, J.H., Panariti, A., Bedrat, A., Ijpma, G., Lemos, B., Park, J.A., Lauzon, A.M., and Martin, J.G. (2021). Airway Epithelial Cells Drive Airway Smooth Muscle Cell Phenotype Switching to the Proliferative and Pro-inflammatory Phenotype. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.687654"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.cellsig.2006.04.008","article-title":"Targeting G protein-coupled receptor signaling in asthma","volume":"18","author":"Deshpande","year":"2006","journal-title":"Cell. Signal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/rr195","article-title":"Signaling and regulation of G protein-coupled receptors in airway smooth muscle","volume":"4","author":"Billington","year":"2003","journal-title":"Respir. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00210-008-0263-1","article-title":"Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma","volume":"378","author":"Penn","year":"2008","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S1357-2725(02)00259-5","article-title":"Airway smooth muscle: Contraction and beyond","volume":"35","author":"Amrani","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"C798","DOI":"10.1152\/ajpcell.00337.2024","article-title":"Factors influencing airway smooth muscle tone: A comprehensive review with a special emphasis on pulmonary surfactant","volume":"327","author":"Hanusrichterova","year":"2024","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-201X.1998.00441.x","article-title":"The cytoskeleton of the vertebrate smooth muscle cell","volume":"164","author":"Small","year":"1998","journal-title":"Acta Physiol. Scand."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1034\/j.1399-3003.2000.15.29.x","article-title":"The contractile apparatus and mechanical properties of airway smooth muscle","volume":"15","author":"Gunst","year":"2000","journal-title":"Eur. Respir. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1152\/jappl.1987.62.3.1324","article-title":"Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans","volume":"62","author":"Ding","year":"1987","journal-title":"J. Appl. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1569-9048(03)00148-4","article-title":"Mechanisms of inflammation-mediated airway smooth muscle plasticity and airways remodeling in asthma","volume":"137","author":"Halayko","year":"2003","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1183\/09031936.00051407","article-title":"Treating asthma means treating airway smooth muscle cells","volume":"32","author":"Zuyderduyn","year":"2008","journal-title":"Eur. Respir. J."},{"key":"ref_26","first-page":"L197","article-title":"Divergent differentiation paths in airway smooth muscle culture: Induction of functionally contractile myocytes","volume":"276","author":"Halayko","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pupt.2012.08.005","article-title":"Phenotype modulation of airway smooth muscle in asthma","volume":"26","author":"Wright","year":"2013","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1164\/rccm.2108069","article-title":"The relationship of reticular basement membrane thickness to airway wall remodeling in asthma","volume":"166","author":"James","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2147\/JAA.S267222","article-title":"Pathobiology of Airway Remodeling in Asthma: The Emerging Role of Integrins","volume":"15","author":"Joseph","year":"2022","journal-title":"J. Asthma Allergy"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1001\/archinte.1922.00110120002001","article-title":"The Pathology of Bronchial Asthma","volume":"30","author":"Huber","year":"1922","journal-title":"Arch. Intern. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1111\/all.15473","article-title":"Biologics and airway remodeling in severe asthma","volume":"77","author":"Varricchi","year":"2022","journal-title":"Allergy"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Bazan-Socha, S., Jakiela, B., Zuk, J., Zarychta, J., Soja, J., Okon, K., Dziedzina, S., Zareba, L., Dropinski, J., and Wojcik, K. (2021). Interactions via \u03b12\u03b21 Cell Integrin May Protect against the Progression of Airway Structural Changes in Asthma. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126315"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S1569-9048(03)00157-5","article-title":"Airway smooth muscle\u2014Its relationship to the extracellular matrix","volume":"137","author":"Black","year":"2003","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.chest.2017.03.020","article-title":"Mitochondrial Dysfunction in Airway Disease","volume":"152","author":"Prakash","year":"2017","journal-title":"Chest"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1183\/13993003.01196-2014","article-title":"Novel concepts in airway inflammation and remodelling in asthma","volume":"46","author":"Saglani","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hough, K.P., Curtiss, M.L., Blain, T.J., Liu, R.M., Trevor, J., Deshane, J.S., and Thannickal, V.J. (2020). Airway Remodeling in Asthma. Front. Med., 7.","DOI":"10.3389\/fmed.2020.00191"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1080\/17476348.2023.2262920","article-title":"Epithelial alarmins: A new target to treat chronic respiratory diseases","volume":"17","author":"Nedeva","year":"2023","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1183\/09031936.00181608","article-title":"Airway smooth muscle thickness in asthma is related to severity but not duration of asthma","volume":"34","author":"James","year":"2009","journal-title":"Eur. Respir. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/all.13323","article-title":"Airway pathology in severe asthma is related to airflow obstruction but not symptom control","volume":"73","author":"Ferreira","year":"2018","journal-title":"Allergy"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"L545","DOI":"10.1152\/ajplung.2000.278.3.L545","article-title":"IGFBP-3 mediates TGF-beta1-induced cell growth in human airway smooth muscle cells","volume":"278","author":"Cohen","year":"2000","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_41","first-page":"L415","article-title":"PDGF isoform-induced proliferation and receptor expression in human cultured airway smooth muscle cells","volume":"270","author":"Hirst","year":"1996","journal-title":"Am. J. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1164\/ajrccm.156.2.9605065","article-title":"Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid","volume":"156","author":"Redington","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1056\/NEJMoa021660","article-title":"Dysfunctional interaction of C\/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells","volume":"351","author":"Roth","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1165\/rcmb.2004-0411OC","article-title":"4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy","volume":"33","author":"Zhou","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1165\/rcmb.2009-0037OC","article-title":"p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression","volume":"42","author":"Deng","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_46","first-page":"1171","article-title":"Mechanics of airway narrowing","volume":"133","author":"Moreno","year":"1986","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1152\/japplphysiol.00950.2012","article-title":"Airway smooth muscle in the pathophysiology and treatment of asthma","volume":"114","author":"Doeing","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1080\/17476348.2024.2419543","article-title":"Bronchomotor tone imbalance evokes airway hyperresponsiveness","volume":"18","author":"Jude","year":"2024","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/14728222.2023.2177533","article-title":"Airway smooth muscle in contractility and remodeling of asthma: Potential drug target mechanisms","volume":"27","author":"Khalfaoui","year":"2023","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0034-5687(00)00208-5","article-title":"Neural regulation of airway smooth muscle tone","volume":"125","author":"Canning","year":"2001","journal-title":"Respir. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12931-015-0296-1","article-title":"Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling","volume":"16","author":"Tang","year":"2015","journal-title":"Respir. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"C576","DOI":"10.1152\/ajpcell.00253.2008","article-title":"Actin cytoskeletal dynamics in smooth muscle: A new paradigm for the regulation of smooth muscle contraction","volume":"295","author":"Gunst","year":"2008","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"\u00c1lvarez-Santos, M.D., \u00c1lvarez-Gonz\u00e1lez, M., Estrada-Soto, S., and Baz\u00e1n-Perkins, B. (2020). Regulation of Myosin Light-Chain Phosphatase Activity to Generate Airway Smooth Muscle Hypercontractility. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00701"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"L994","DOI":"10.1152\/ajplung.00550.2016","article-title":"TNF\u03b1 enhances force generation in airway smooth muscle","volume":"312","author":"Dogan","year":"2017","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0091-6749(75)90107-4","article-title":"Standardization of bronchial inhalation challenge procedures","volume":"56","author":"Chai","year":"1975","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"S269","DOI":"10.1067\/mai.2002.129429","article-title":"Airway smooth muscle: An immunomodulatory cell","volume":"110","author":"Panettieri","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev.physiol.010908.163227","article-title":"Noncontractile functions of airway smooth muscle cells in asthma","volume":"71","author":"Tliba","year":"2009","journal-title":"Annu. Rev. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pupt.2012.05.006","article-title":"Pro-inflammatory and immunomodulatory functions of airway smooth muscle: Emerging concepts","volume":"26","author":"Xia","year":"2013","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1164\/rccm.200409-1220OC","article-title":"The CXCL10\/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle","volume":"171","author":"Brightling","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.4049\/jimmunol.176.3.1860","article-title":"Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma","volume":"176","author":"Berger","year":"2006","journal-title":"J. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/thx.2006.062141","article-title":"Inflammation of bronchial smooth muscle in allergic asthma","volume":"62","author":"Begueret","year":"2007","journal-title":"Thorax"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1378\/chest.12-3073","article-title":"Mechanisms of airway remodeling","volume":"144","author":"Hirota","year":"2013","journal-title":"Chest"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrd.2018.135","article-title":"Targeting G protein-coupled receptor signalling by blocking G proteins","volume":"17","author":"Campbell","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Tiwari, D., and Gupta, P. (2020). Nuclear Receptors in Asthma: Empowering Classical Molecules Against a Contemporary Ailment. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.594433"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0091-6749(95)70209-1","article-title":"Muscarinic receptors in human airways","volume":"95","author":"White","year":"1995","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_66","unstructured":"Kudlak, M., and Tadi, P. (2025). Physiology, Muscarinic Receptor. StatPearls, StatPearls Publishing LLC."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0024-3205(93)90310-Y","article-title":"Muscarinic receptor subtypes in airways","volume":"52","author":"Barnes","year":"1993","journal-title":"Life Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0165-6147(94)90047-7","article-title":"Muscarinic acetylcholine receptor subtypes in smooth muscle","volume":"15","author":"Eglen","year":"1994","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"409580","DOI":"10.1155\/2012\/409580","article-title":"Muscarinic receptors and their antagonists in COPD: Anti-inflammatory and antiremodeling effects","volume":"2012","author":"Karakiulakis","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1165\/ajrcmb.26.3.f232","article-title":"m3 muscarinic acetylcholine receptor regulation in the airway","volume":"26","author":"Billington","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1465-9921-7-73","article-title":"Muscarinic receptor signaling in the pathophysiology of asthma and COPD","volume":"7","author":"Gosens","year":"2006","journal-title":"Respir. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1096\/fj.201700186R","article-title":"Targeting acetylcholine receptor M3 prevents the progression of airway hyperreactivity in a mouse model of childhood asthma","volume":"31","author":"Patel","year":"2017","journal-title":"FASEB J."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Buels, K.S., and Fryer, A.D. (2012). Muscarinic receptor antagonists: Effects on pulmonary function. Handbook of Experimental Pharmacology, Springer.","DOI":"10.1007\/978-3-642-23274-9_14"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pupt.2012.07.003","article-title":"Muscarinic receptors on airway mesenchymal cells: Novel findings for an ancient target","volume":"26","author":"Meurs","year":"2013","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"805627","DOI":"10.1155\/2013\/805627","article-title":"Role of m2 muscarinic receptor in the airway response to methacholine of mice selected for minimal or maximal acute inflammatory response","volume":"2013","author":"Castro","year":"2013","journal-title":"BioMed. Res. Int."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1164\/ajrccm.158.supplement_2.13tac120","article-title":"Muscarinic receptors and control of airway smooth muscle","volume":"158","author":"Fryer","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000358740","article-title":"Histamine receptors and antihistamines: From discovery to clinical applications","volume":"100","author":"Cataldi","year":"2014","journal-title":"Chem. Immunol. Allergy"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejphar.2005.12.044","article-title":"Histamine receptors are hot in immunopharmacology","volume":"533","author":"Akdis","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Thangam, E.B., Jemima, E.A., Singh, H., Baig, M.S., Khan, M., Mathias, C.B., Church, M.K., and Saluja, R. (2018). The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01873"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jaci.2011.09.005","article-title":"Histamine and H1-antihistamines: Celebrating a century of progress","volume":"128","author":"Simons","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Yamauchi, K., and Ogasawara, M. (2019). The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071733"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2006.09.032","article-title":"Inverse agonism or neutral antagonism at G-protein coupled receptors: A medicinal chemistry challenge worth pursuing?","volume":"553","author":"Greasley","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1042\/cs0870151","article-title":"Functional relationship between mast cells and C-sensitive nerve fibres evidenced by histamine H3-receptor modulation in rat lung and spleen","volume":"87","author":"Dimitriadou","year":"1994","journal-title":"Clin. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1124\/mol.62.2.389","article-title":"Behavioral characterization of mice lacking histamine H3 receptors","volume":"62","author":"Toyota","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"ref_85","first-page":"462","article-title":"The histamine H4 receptor as a new therapeutic target for inflammation","volume":"26","author":"Thurmond","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"793505","DOI":"10.1155\/2013\/793505","article-title":"The involvement of phospholipases A2 in asthma and chronic obstructive pulmonary disease","volume":"2013","author":"Pniewska","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/jlb.65.3.330","article-title":"Regulation of arachidonic acid release and cytosolic phospholipase A2 activation","volume":"65","author":"Leslie","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"12989","DOI":"10.1038\/s41598-017-13154-0","article-title":"Novel mechanism of regulation of the 5-lipoxygenase\/leukotriene B4 pathway by high-density lipoprotein in macrophages","volume":"7","author":"Tsuda","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1021\/cr200246d","article-title":"Lipoxygenase and leukotriene pathways: Biochemistry, biology, and roles in disease","volume":"111","author":"Funk","year":"2011","journal-title":"Chem. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-pathol-012513-104640","article-title":"Leukocyte chemoattractant receptors in human disease pathogenesis","volume":"10","author":"Zabel","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"105247","DOI":"10.1016\/j.jbc.2023.105247","article-title":"Structural diversity of leukotriene G-protein coupled receptors","volume":"299","author":"Luginina","year":"2023","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1073\/pnas.0601223103","article-title":"Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells","volume":"103","author":"Uzonyi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1100\/tsw.2007.185","article-title":"Cysteinyl-leukotriene receptors and cellular signals","volume":"7","author":"Rovati","year":"2007","journal-title":"Sci. World J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1067\/mai.2003.1491","article-title":"Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma","volume":"111","author":"Pierzchalska","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Lee, K., Lee, S.H., and Kim, T.H. (2020). The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051851"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"30647","DOI":"10.1039\/D4RA04686B","article-title":"NSAIDs between past and present; a long journey towards an ideal COX-2 inhibitor lead","volume":"14","author":"Khalil","year":"2024","journal-title":"RSC Adv."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1096\/fj.201801959R","article-title":"Cooperativity of E-prostanoid receptor subtypes in regulating signaling and growth inhibition in human airway smooth muscle","volume":"33","author":"Michael","year":"2019","journal-title":"FASEB J."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"645383","DOI":"10.1155\/2012\/645383","article-title":"Role of PGE2 in asthma and nonasthmatic eosinophilic bronchitis","volume":"2012","author":"Sastre","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2222.2011.03813.x","article-title":"A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma","volume":"42","author":"Barnes","year":"2012","journal-title":"Clin. Exp. Allergy"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1124\/pr.110.003517","article-title":"International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of prostanoid receptors, updating 15 years of progress","volume":"63","author":"Woodward","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1159\/000313836","article-title":"CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases","volume":"85","author":"Schuligoi","year":"2010","journal-title":"Pharmacology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.anai.2024.04.007","article-title":"8-Iso-prostaglandin F2\u03b1 as a biomarker of type 2 low airway inflammation and remodeling in adult asthma","volume":"133","author":"Woo","year":"2024","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1038\/s41467-023-38411-x","article-title":"Ligand-induced activation and G protein coupling of prostaglandin F2\u03b1 receptor","volume":"14","author":"Wu","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1083\/jcb.201003144","article-title":"The cell biology of taste","volume":"190","author":"Chaudhari","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0092-8674(03)00071-0","article-title":"Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways","volume":"112","author":"Zhang","year":"2003","journal-title":"Cell"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nm.2237","article-title":"Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction","volume":"16","author":"Deshpande","year":"2010","journal-title":"Nat. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1165\/rcmb.2013-0439RC","article-title":"Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells","volume":"50","author":"Robinett","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1183\/09031936.00077712","article-title":"Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics","volume":"42","author":"James","year":"2013","journal-title":"Eur. Respir. J."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jaci.2014.02.029","article-title":"Bitter taste receptor (TAS2R) agonists inhibit IgE-dependent mast cell activation","volume":"134","author":"Ekoff","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Figueiredo, I.A.D., Ferreira, S.R.D., Fernandes, J.M., Silva, B.A.D., Vasconcelos, L.H.C., and Cavalcante, F.A. (2023). A review of the pathophysiology and the role of ion channels on bronchial asthma. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1236550"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2174\/1570159X13666150331223118","article-title":"TRP Channels in Respiratory Pathophysiology: The Role of Oxidative, Chemical Irritant and Temperature Stimuli","volume":"13","author":"Zholos","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"M\u00fcller, I., Alt, P., Rajan, S., Schaller, L., Geiger, F., and Dietrich, A. (2022). Transient Receptor Potential (TRP) Channels in Airway Toxicity and Disease: An Update. Cells, 11.","DOI":"10.3390\/cells11182907"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11882-021-01022-x","article-title":"The Role of PPAR-\u03b3 in Allergic Disease","volume":"21","author":"Stark","year":"2021","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1165\/rcmb.2015-0002OC","article-title":"Peroxisome Proliferator-Activated Receptor \u03b3-Mediated Inhibition on Hypoxia-Triggered Store-Operated Calcium Entry. A Caveolin-1-Dependent Mechanism","volume":"53","author":"Yang","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1124\/mol.114.092163","article-title":"Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells","volume":"86","author":"Lehman","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"809164","DOI":"10.1155\/2012\/809164","article-title":"PPAR\u03b3 Ligands Regulate Noncontractile and Contractile Functions of Airway Smooth Muscle: Implications for Asthma Therapy","volume":"2012","author":"Donovan","year":"2012","journal-title":"PPAR Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e23842","DOI":"10.1096\/fj.202400452R","article-title":"Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway smooth muscle","volume":"38","author":"Conaway","year":"2024","journal-title":"FASEB J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12931-024-02920-0","article-title":"G12\/13 signaling in asthma","volume":"25","author":"McDuffie","year":"2024","journal-title":"Respir. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"eaao6451","DOI":"10.1126\/scitranslmed.aao6451","article-title":"DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment","volume":"11","author":"Saunders","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4161\/psb.4.10.9530","article-title":"Signaling through G protein coupled receptors","volume":"4","author":"Tuteja","year":"2009","journal-title":"Plant Signal. Behav."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1111\/bph.12538","article-title":"Transient receptor potential (TRP) channels in the airway: Role in airway disease","volume":"171","author":"Grace","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.4049\/jimmunol.1300104","article-title":"Functional KCa3.1 channels regulate steroid insensitivity in bronchial smooth muscle cells","volume":"191","author":"Chachi","year":"2013","journal-title":"J. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1165\/rcmb.2012-0103OC","article-title":"Ca2+-activated K+ channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model","volume":"48","author":"Girodet","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/361315a0","article-title":"Inositol trisphosphate and calcium signalling","volume":"361","author":"Berridge","year":"1993","journal-title":"Nature"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"L114","DOI":"10.1152\/ajplung.00322.2002","article-title":"Methacholine-induced airway hyperresponsiveness is dependent on Galphaq signaling","volume":"285","author":"Borchers","year":"2003","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1124\/mol.64.6.1444","article-title":"Role of muscarinic receptor subtypes in the constriction of peripheral airways: Studies on receptor-deficient mice","volume":"64","author":"Struckmann","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1093\/oxfordjournals.jbchem.a124993","article-title":"A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization","volume":"118","author":"Eto","year":"1995","journal-title":"J. Biochem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1164\/ajrccm.158.supplement_2.13tac700","article-title":"Regulation of second messengers associated with airway smooth muscle contraction and relaxation","volume":"158","author":"Hakonarson","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1007\/s00018-008-8086-2","article-title":"Ca2+\/calmodulin-dependent protein kinases","volume":"65","author":"Swulius","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.118.016899","article-title":"G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action","volume":"72","author":"Wendell","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0092-8674(02)00682-7","article-title":"Calmodulin in action: Diversity in target recognition and activation mechanisms","volume":"108","author":"Hoeflich","year":"2002","journal-title":"Cell"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"C358","DOI":"10.1152\/ajpcell.90645.2007","article-title":"Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo","volume":"295","author":"Mizuno","year":"2008","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1165\/rcmb.2021-0106OC","article-title":"Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling","volume":"65","author":"Sharma","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1183\/09031936.00090511","article-title":"Caveolin-1 regulation of store-operated Ca2+ influx in human airway smooth muscle","volume":"40","author":"Sathish","year":"2012","journal-title":"Eur. Respir. J."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"L1118","DOI":"10.1152\/ajplung.00136.2007","article-title":"Caveolins and intracellular calcium regulation in human airway smooth muscle","volume":"293","author":"Prakash","year":"2007","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"L347","DOI":"10.1152\/ajplung.90559.2008","article-title":"The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca2+ signaling of airway smooth muscle cells","volume":"297","author":"Bai","year":"2009","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1074\/jbc.M109.067546","article-title":"Ca2+ sparks act as potent regulators of excitation-contraction coupling in airway smooth muscle","volume":"285","author":"Zhuge","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Sancho, M., and Kyle, B.D. (2021). The Large-Conductance, Calcium-Activated Potassium Channel: A Big Key Regulator of Cell Physiology. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.750615"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"C966","DOI":"10.1152\/ajpcell.1997.272.3.C966","article-title":"Regulation of intracellular calcium oscillations in porcine tracheal smooth muscle cells","volume":"272","author":"Prakash","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1152\/jappl.2001.91.5.2266","article-title":"Temporal aspects of excitation-contraction coupling in airway smooth muscle","volume":"91","author":"Sieck","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"L70","DOI":"10.1152\/ajplung.00058.2025","article-title":"Spatiotemporal calcium signaling patterns underlying opposing effects of histamine and TAS2R agonists in airway smooth muscle","volume":"329","author":"Conaway","year":"2025","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1080\/17476348.2023.2276732","article-title":"Interactions between calcium regulatory pathways and mechanosensitive channels in airways","volume":"17","author":"Yao","year":"2023","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1165\/rcmb.2021-0320OC","article-title":"PD 102807 Induces M3 mAChR-Dependent GRK-\/Arrestin-Biased Signaling in Airway Smooth Muscle Cells","volume":"67","author":"Tompkins","year":"2022","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"185971","DOI":"10.1155\/2013\/185971","article-title":"Airway smooth muscle hypercontractility in asthma","volume":"2013","author":"Berair","year":"2013","journal-title":"J. Allergy"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1465-9921-6-48","article-title":"Activation of the SPHK\/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways","volume":"6","author":"Pfaff","year":"2005","journal-title":"Respir. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1165\/rcmb.2024-0536OC","article-title":"Piezo1 Agonist Yoda1 Induces Rapid Relaxation in Cultured Airway Smooth Muscle Cells and Bronchodilation in Mouse Models","volume":"73","author":"Luo","year":"2025","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"284ra60","DOI":"10.1126\/scitranslmed.aaa0282","article-title":"Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma","volume":"7","author":"Yarova","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1124\/jpet.120.000281","article-title":"Characterization of Negative Allosteric Modulators of the Calcium-Sensing Receptor for Repurposing as a Treatment of Asthma","volume":"376","author":"Yarova","year":"2021","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"105189","DOI":"10.1016\/j.phrs.2020.105189","article-title":"Why do some asthma patients respond poorly to glucocorticoid therapy?","volume":"160","author":"Henderson","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_150","first-page":"101157","article-title":"Long-acting muscarinic antagonists (LAMA) in asthma: What is the best strategy?","volume":"87","author":"Mahay","year":"2025","journal-title":"Respir. Med. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"100062","DOI":"10.1016\/j.pharmr.2025.100062","article-title":"Asthma therapeutics: Past, present, and future","volume":"77","author":"Rhoads","year":"2025","journal-title":"Pharmacol. Rev."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1701247","DOI":"10.1183\/13993003.01247-2017","article-title":"The mode of action of anticholinergics in asthma","volume":"52","author":"Gosens","year":"2018","journal-title":"Eur. Respir. J."},{"key":"ref_153","first-page":"S77","article-title":"A comparison of the cardiorespiratory effects of isoprenaline and salbutamol in patients with bronchial asthma","volume":"47","author":"Conolly","year":"1971","journal-title":"Postgrad. Med. J."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4168\/aair.2010.2.3.165","article-title":"A brief history of asthma and its mechanisms to modern concepts of disease pathogenesis","volume":"2","author":"Holgate","year":"2010","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/1817-1737.140120","article-title":"Corticosteroids in the treatment of acute asthma","volume":"9","author":"Alangari","year":"2014","journal-title":"Ann. Thorac. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","article-title":"The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights","volume":"335","author":"Coutinho","year":"2011","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1080\/21655979.2022.2044278","article-title":"The role of human mast cells in allergy and asthma","volume":"13","author":"Banafea","year":"2022","journal-title":"Bioengineered"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.rmed.2006.12.004","article-title":"Summing up 100 years of asthma","volume":"101","author":"Diamant","year":"2007","journal-title":"Respir. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1753466618810192","DOI":"10.1177\/1753466618810192","article-title":"Omalizumab, the first available antibody for biological treatment of severe asthma: More than a decade of real-life effectiveness","volume":"12","author":"Pelaia","year":"2018","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jaip.2014.03.010","article-title":"Omalizumab in asthma: An update on recent developments","volume":"2","author":"Humbert","year":"2014","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jaci.2019.10.037","article-title":"IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways","volume":"145","author":"Manson","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(16)30307-5","article-title":"Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting \u03b22 agonist: A randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial","volume":"388","author":"Wenzel","year":"2016","journal-title":"Lancet"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1056\/NEJMoa2034975","article-title":"Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma","volume":"384","author":"Corren","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1164\/rccm.201103-0396OC","article-title":"Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study","volume":"184","author":"Castro","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1056\/NEJMoa0805435","article-title":"Mepolizumab for prednisone-dependent asthma with sputum eosinophilia","volume":"360","author":"Nair","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1183\/09059180.00005114","article-title":"Bronchial thermoplasty: A new therapeutic option for the treatment of severe, uncontrolled asthma in adults","volume":"23","author":"Dombret","year":"2014","journal-title":"Eur. Respir. Rev."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1164\/rccm.200507-1162OC","article-title":"Bronchial thermoplasty for asthma","volume":"173","author":"Cox","year":"2006","journal-title":"Am. J. Respir. Crit. 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