{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:38:53Z","timestamp":1792697933178,"version":"4.5.0"},"reference-count":81,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2024YFA1107401"],"award-info":[{"award-number":["2024YFA1107401"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China NSFC","doi-asserted-by":"publisher","award":["32450812"],"award-info":[{"award-number":["32450812"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China NSFC","doi-asserted-by":"publisher","award":["32595480"],"award-info":[{"award-number":["32595480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China NSFC","doi-asserted-by":"publisher","award":["32170803"],"award-info":[{"award-number":["32170803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SMART Investigator Program","award":["40113-13011301225"],"award-info":[{"award-number":["40113-13011301225"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Taurine metabolism is emerging as an important player in cancer progression, yet its precise roles remain incompletely understood. Our study revealed that elevated serum Taurine levels and concomitant upregulation of its transporter, Slc6a6, are associated with enhanced tumor growth. Functionally, Slc6a6 overexpression drives tumor progression in vivo and accelerates cancer cell proliferation in vitro. Mechanistically, we identified a dual pro-oncogenic function for Slc6a6. First, Slc6a6 possesses intrinsic antioxidant regulatory capacity and further enhances cellular redox homeostasis by mediating the uptake of the antioxidant molecule Taurine. Second, beyond its metabolic role, Slc6a6 directly interacts with the cell cycle regulator Rprd1b to promote the G1\/S phase transition, leading to uncontrolled proliferation. Clinically, bioinformatics analyses correlate high SLC6A6 expression with poor prognosis in breast cancer patients, underscoring its potential as a therapeutic target.<\/jats:p>","DOI":"10.3390\/cells15020207","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T13:55:34Z","timestamp":1769176534000},"page":"207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Taurine-Slc6a6 Axis Promotes Breast Cancer Progression by Alleviating Oxidative Stress and Accelerating Cell Cycle Progression"],"prefix":"10.3390","volume":"15","author":[{"given":"Pei","family":"Cai","sequence":"first","affiliation":[{"name":"Westlake Institute for Advanced Study, Fudan University, Shanghai 310018, China"},{"name":"School of Life Sciences, Westlake University, Hangzhou 310024, China"},{"name":"Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou 310024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Westlake University, Hangzhou 310024, China"},{"name":"Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou 310024, China"},{"name":"College of Life Sciences, Zhejiang University, Hangzhou 310024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhen","family":"Lin","sequence":"additional","affiliation":[{"name":"Westlake Institute for Advanced Study, Fudan University, Shanghai 310018, China"},{"name":"School of Life Sciences, Westlake University, Hangzhou 310024, China"},{"name":"Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou 310024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofang","family":"Xie","sequence":"additional","affiliation":[{"name":"Westlake Institute for Advanced Study, Fudan University, Shanghai 310018, China"},{"name":"School of Life Sciences, Westlake University, Hangzhou 310024, China"},{"name":"Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou 310024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Westlake Institute for Advanced Study, Fudan University, Shanghai 310018, China"},{"name":"School of Life Sciences, Westlake University, Hangzhou 310024, China"},{"name":"Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou 310024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuobao","family":"Lin","sequence":"additional","affiliation":[{"name":"Westlake Institute for Advanced Study, Fudan University, Shanghai 310018, China"},{"name":"School of Life Sciences, Westlake University, Hangzhou 310024, China"},{"name":"Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou 310024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Westlake Institute for Advanced Study, Fudan University, Shanghai 310018, China"},{"name":"School of Life Sciences, Westlake University, Hangzhou 310024, China"},{"name":"Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou 310024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-7719","authenticated-orcid":false,"given":"Shang","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Westlake University, Hangzhou 310024, China"},{"name":"Westlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou 310024, China"},{"name":"Westlake Disease Modeling Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00726-013-1524-y","article-title":"Taurine prevented cell cycle arrest and restored neurotrophic gene expression in arsenite-treated SH-SY5Y cells","volume":"45","author":"Chou","year":"2013","journal-title":"Amino Acids"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3101(24)00213-5","article-title":"Taurine: Its biological role and clinical implications","volume":"32","author":"Chesney","year":"1985","journal-title":"Adv. Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1248\/bpb.27.1792","article-title":"Effect of taurine on biliary excretion and metabolism of acetaminophen in male hamsters","volume":"27","author":"Lee","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/physrev.1992.72.1.101","article-title":"Physiological actions of taurine","volume":"72","author":"Huxtable","year":"1992","journal-title":"Physiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4062\/biomolther.2017.251","article-title":"Effects and Mechanisms of Taurine as a Therapeutic Agent","volume":"26","author":"Schaffer","year":"2018","journal-title":"Biomol. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0091-7435(89)90056-X","article-title":"Taurine: An overview of its role in preventive medicine","volume":"18","author":"Kendler","year":"1986","journal-title":"Prev. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0899-9007(98)00097-5","article-title":"Immunonutrition: The role of taurine","volume":"14","author":"Redmond","year":"1998","journal-title":"Nutrition"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3892\/mmr.2021.12242","article-title":"Protective role of taurine against oxidative stress (Review)","volume":"24","author":"Baliou","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"eabn9257","DOI":"10.1126\/science.abn9257","article-title":"Taurine deficiency as a driver of aging","volume":"380","author":"Singh","year":"2023","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"skaa311","DOI":"10.1093\/jas\/skaa311","article-title":"Dietary taurine supplementation attenuates lipopolysaccharide-induced inflammatory responses and oxidative stress of broiler chickens at an early age","volume":"98","author":"Han","year":"2020","journal-title":"J. Anim. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Santulli, G., Kansakar, U., Varzideh, F., Mone, P., Jankauskas, S.S., and Lombardi, A. (2023). Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview. Nutrients, 15.","DOI":"10.3390\/nu15194236"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"114705","DOI":"10.1016\/j.ecoenv.2023.114705","article-title":"Dietary taurine supplementation counteracts deoxynivalenol-induced liver injury via alleviating oxidative stress, mitochondrial dysfunction, apoptosis, and inflammation in piglets","volume":"253","author":"Ji","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e2303894","DOI":"10.1002\/advs.202303894","article-title":"Taurine Inhibits Ferroptosis Mediated by the Crosstalk between Tumor Cells and Tumor-Associated Macrophages in Prostate Cancer","volume":"11","author":"Xiao","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-3-030-93337-1_11","article-title":"Taurine and Its Anticancer Functions: In Vivo and In Vitro Study","volume":"1370","author":"Ma","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41586-025-09018-7","article-title":"Taurine from tumour niche drives glycolysis to promote leukaemogenesis","volume":"644","author":"Sharma","year":"2025","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1038\/s41467-023-40243-8","article-title":"TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation","volume":"14","author":"Suzuki","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jare.2024.09.005","article-title":"Serum taurine affects lung cancer progression by regulating tumor immune escape mediated by the immune microenvironment","volume":"73","author":"Liang","year":"2025","journal-title":"J. Adv. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Tao, Q., Qiao, X., Yang, Y., Peng, C., Han, M., Dong, K., Zhang, W., Xu, M., and Wang, D. (2025). Targeting amino acid metabolism to inhibit gastric cancer progression and promote anti-tumor immunity: A review. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1508730"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.tem.2025.08.001","article-title":"The dual role of taurine in cancer and immune metabolism","volume":"36","author":"Xu","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"189403","DOI":"10.1016\/j.bbcan.2025.189403","article-title":"Taurine and cancer: Biological properties and multifaceted roles in cancer progression","volume":"1880","author":"Liu","year":"2025","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Rev. Cancer"},{"key":"ref_21","first-page":"306","article-title":"Tumour cell consumption of taurine exhausts CD8+ T cells","volume":"24","author":"Flemming","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1152\/physrev.00056.2006","article-title":"Cellular Response to Hyperosmotic Stresses","volume":"87","author":"Burg","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"C1113","DOI":"10.1152\/ajpcell.00485.2001","article-title":"Beneficial effect of taurine depletion on osmotic sodium and calcium loading during chemical hypoxia","volume":"282","author":"Schaffer","year":"2002","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41698-025-00872-2","article-title":"Taurine and proline promote lung tumour growth by co-regulating Azgp1\/mTOR signalling pathway","volume":"9","author":"Liang","year":"2025","journal-title":"npj Precis. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/01.cad.0000176502.40810.b0","article-title":"Taurolidine-a new drug with anti-tumor and anti-angiogenic effects","volume":"16","author":"Jacobi","year":"2005","journal-title":"Anti-Cancer Drugs"},{"key":"ref_26","first-page":"5473","article-title":"Effect of taurine on cell proliferation and apoptosis human lung cancer A549 cells","volume":"15","author":"Tu","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/abbs\/gmu004","article-title":"Mechanism of taurine-induced apoptosis in human colon cancer cells","volume":"46","author":"Zhang","year":"2014","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.21037\/tcr-22-1297","article-title":"Effect of taurine on the proliferation, apoptosis and MST1\/Hippo signaling in prostate cancer cells","volume":"11","author":"Song","year":"2022","journal-title":"Transl. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3892\/ijmm.2014.2002","article-title":"Taurine induces the apoptosis of breast cancer cells by regulating apoptosis-related proteins of mitochondria","volume":"35","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.3892\/mmr.2020.11321","article-title":"Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review)","volume":"22","author":"Baliou","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.cell.2024.03.011","article-title":"Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells","volume":"187","author":"Cao","year":"2024","journal-title":"Cell"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Stary, D., and Bajda, M. (2023). Taurine and Creatine Transporters as Potential Drug Targets in Cancer Therapy. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043788"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2217\/bmm-2018-0256","article-title":"Elevated SLC6A6 expression drives tumorigenesis and affects clinical outcomes in gastric cancer","volume":"13","author":"Dazhi","year":"2019","journal-title":"Biomark. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1038\/srep04852","article-title":"Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer","volume":"4","author":"Yasunaga","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1038\/s41592-023-02039-y","article-title":"Reconstruction of dynamic mammary mini gland in vitro for normal physiology and oncogenesis","volume":"20","author":"Yuan","year":"2023","journal-title":"Nat. Methods"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.cell.2022.02.027","article-title":"Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer","volume":"185","author":"Fu","year":"2022","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5154","DOI":"10.1038\/s41467-024-49106-2","article-title":"Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer","volume":"15","author":"Bai","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s44319-023-00012-6","article-title":"NME4 mediates metabolic reprogramming and promotes nonalcoholic fatty liver disease progression","volume":"25","author":"Xie","year":"2024","journal-title":"EMBO Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"101569","DOI":"10.1016\/j.xpro.2022.101569","article-title":"Protocol for establishing a protein-protein interaction network using tandem affinity purification followed by mass spectrometry in mammalian cells","volume":"3","author":"Bian","year":"2022","journal-title":"STAR Protoc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/prot.25234","article-title":"Addressing recent docking challenges: A hybrid strategy to integrate template-based and free protein-protein docking","volume":"85","author":"Yan","year":"2017","journal-title":"Proteins"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","article-title":"Ligand docking and binding site analysis with PyMOL and Autodock\/Vina","volume":"24","author":"Seeliger","year":"2010","journal-title":"J. Comput. Aided Mol. Des."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1021\/ci200227u","article-title":"LigPlot+: Multiple ligand-protein interaction diagrams for drug discovery","volume":"51","author":"Laskowski","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13045-024-01527-8","article-title":"Metabolic reprogramming in the tumor microenvironment of liver cancer","volume":"17","author":"Lin","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"eaaw5473","DOI":"10.1126\/science.aaw5473","article-title":"Metabolic reprogramming and cancer progression","volume":"368","author":"Faubert","year":"2020","journal-title":"Science"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.7150\/thno.82920","article-title":"The role of lipid metabolic reprogramming in tumor microenvironment","volume":"13","author":"Yang","year":"2023","journal-title":"Theranostics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Fagerberg","year":"2015","journal-title":"Science"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"UALCAN: An update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","article-title":"UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses","volume":"19","author":"Chandrashekar","year":"2017","journal-title":"Neoplasia"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41421-025-00794-0","article-title":"Distinct mammary stem cells orchestrate long-term homeostasis of adult mammary gland","volume":"11","author":"Lin","year":"2025","journal-title":"Cell Discov."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1158\/0008-5472.CAN-09-4380","article-title":"The immunosuppressive surface ligand CD200 augments the metastatic capacity of squamous cell carcinoma","volume":"70","author":"Stumpfova","year":"2010","journal-title":"Cancer Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1007\/s00405-013-2510-4","article-title":"Expression of selected regulatory molecules on the CD83+ monocyte-derived dendritic cells generated from patients with laryngeal cancer and their clinical significance","volume":"270","author":"Klatka","year":"2013","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.0022-202X.2004.23461.x","article-title":"Expression of CD200 on epithelial cells of the murine hair follicle: A role in tissue-specific immune tolerance?","volume":"123","author":"Rosenblum","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1073\/pnas.1211655110","article-title":"CD200-expressing human basal cell carcinoma cells initiate tumor growth","volume":"110","author":"Colmont","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1182\/bloodadvances.2020001802","article-title":"CD200 expression marks leukemia stem cells in human AML","volume":"4","author":"Ho","year":"2020","journal-title":"Blood Adv."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/hed.23608","article-title":"CD200: Association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma","volume":"37","author":"Jung","year":"2015","journal-title":"Head Neck"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1007\/s00726-018-2651-2","article-title":"Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN\/Akt pathways in vitro","volume":"50","author":"He","year":"2018","journal-title":"Amino Acids"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1097\/CM9.0000000000000162","article-title":"Impact of Taurine on the proliferation and apoptosis of human cervical carcinoma cells and its mechanism","volume":"132","author":"Li","year":"2019","journal-title":"China Med. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/0-306-46838-7_17","article-title":"Hypotaurine and superoxide dismutase: Protection of the enzyme against inactivation by hydrogen peroxide and peroxidation to taurine","volume":"483","author":"Pecci","year":"2000","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Bhat, M.A., Ahmad, K., Khan, M.S.A., Bhat, M.A., Almatroudi, A., Rahman, S., and Jan, A.T. (2020). Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases. Biomolecules, 10.","DOI":"10.3390\/biom10060863"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/978-0-387-75681-3_51","article-title":"Effect of taurine on antioxidant enzyme system in B16F10 melanoma cells","volume":"643","author":"Yu","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: An enhanced web server for large-scale expression profiling and interactive analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1152\/physrev.1968.48.2.424","article-title":"Biochemistry and physiology of taurine and taurine derivatives","volume":"48","author":"Jacobsen","year":"1968","journal-title":"Physiol. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1111\/j.1432-1033.2004.04420.x","article-title":"Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 fibroblasts","volume":"271","author":"Voss","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ccr.2011.12.016","article-title":"CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes","volume":"21","author":"Lu","year":"2012","journal-title":"Cancer Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1038\/s41388-018-0161-z","article-title":"CREPT facilitates colorectal cancer growth through inducing Wnt\/\u03b2-catenin pathway by enhancing p300-mediated \u03b2-catenin acetylation","volume":"37","author":"Zhang","year":"2018","journal-title":"Oncogene"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1158\/1541-7786.MCR-22-0259","article-title":"Regulation of Cyclin D1 Degradation by Ubiquitin-Specific Protease 27X Is Critical for Cancer Cell Proliferation and Tumor Growth","volume":"20","author":"Alam","year":"2022","journal-title":"Mol. Cancer Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"22589","DOI":"10.1074\/jbc.M114.560979","article-title":"CREPT\/RPRD1B, a Recently Identified Novel Protein Highly Expressed in Tumors, Enhances the \u03b2-Catenin TCF4 Transcriptional Activity in Response to Wnt Signaling","volume":"289","author":"Zhang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41392-024-02080-z","article-title":"Cyclin-dependent protein kinases and cell cycle regulation in biology and disease","volume":"10","author":"Pellarin","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/s41419-018-1211-8","article-title":"CREPT\/RPRD1B associates with Aurora B to regulate Cyclin B1 expression for accelerating the G2\/M transition in gastric cancer","volume":"9","author":"Ding","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wang, M., Wu, B., Tang, K., Wang, X., Liu, X., Duan, Y., Wang, J., Wang, X., Wang, Y., and Li, J. (2024). Cell-Cycle-Related and Expression Elevated Protein in Tumor Upregulates the Antioxidant Genes via Activation of NF-\u03baB\/Nrf2 in Acute Liver Injury. Toxics, 12.","DOI":"10.3390\/toxics12120893"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1002\/ijc.32369","article-title":"ROCplot.org: Validating predictive biomarkers of chemotherapy\/hormonal therapy\/anti-HER2 therapy using transcriptomic data of 3,104 breast cancer patients","volume":"145","author":"Fekete","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Wang, T., Gao, Y., Liu, Z., Du, P., Tang, S., Lai, Z., and Li, G. (2025). Serum metabolomics-based diagnostic biomarkers for colorectal cancer: Insights and multi-omics validation. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1663938"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Zhuang, J., Yang, X., Zheng, Q., Li, K., Cai, L., Yu, H., Lv, J., Bai, K., Cao, Q., and Li, P. (2022). Metabolic Profiling of Bladder Cancer Patients\u2019Serum Reveals Their Sensitivity to Neoadjuvant Chemotherapy. Metabolites, 12.","DOI":"10.3390\/metabo12060558"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.tins.2023.01.003","article-title":"How cancer hijacks the body\u2019s homeostasis through the neuroendocrine system","volume":"46","author":"Slominski","year":"2023","journal-title":"Trends Neurosci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1021\/pr500494u","article-title":"Colorectal cancer detection using targeted serum metabolic profiling","volume":"13","author":"Zhu","year":"2014","journal-title":"J. Proteome Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e002968","DOI":"10.1136\/jitc-2021-002968","article-title":"Overexpression of CD200 is a Stem Cell-Specific Mechanism of Immune Evasion in AML","volume":"9","author":"Herbrich","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1146\/annurev.bi.55.070186.002235","article-title":"Taurine: Biological update","volume":"55","author":"Wright","year":"1986","journal-title":"Annu. Rev. Biochem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"102460","DOI":"10.1016\/j.arr.2024.102460","article-title":"Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise","volume":"101","author":"Batitucci","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative Stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1042\/BST0351151","article-title":"Redox regulation of lung inflammation: Role of NADPH oxidase and NF-\u03baB signalling","volume":"35","author":"Yao","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.redox.2016.01.010","article-title":"Redox homeostasis: The Golden Mean of healthy living","volume":"8","author":"Ursini","year":"2016","journal-title":"Redox Biol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/2\/207\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T05:21:07Z","timestamp":1769232067000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/2\/207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":81,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["cells15020207"],"URL":"https:\/\/doi.org\/10.3390\/cells15020207","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]}}}