{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:34:24Z","timestamp":1772548464551,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"National Council of Humanities, Science and Technology","doi-asserted-by":"publisher","award":["FORDECYT-PRONACES 302994"],"award-info":[{"award-number":["FORDECYT-PRONACES 302994"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"National Council of Humanities, Science and Technology","doi-asserted-by":"publisher","award":["IMSS R-2023-785-047"],"award-info":[{"award-number":["IMSS R-2023-785-047"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Temas Prioritarios de Salud, Poblaci\u00f3n Vulnerable y Temas Emergentes","award":["IMSS R-2023-785-047"],"award-info":[{"award-number":["IMSS R-2023-785-047"]}]},{"DOI":"10.13039\/501100003141","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Investigadoras e Investigadores por M\u00e9xico Secihti"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Background\/Objectives: B-cell precursor acute lymphoblastic leukemia (B-ALL), the most common pediatric acute leukemia (AL), is frequently characterized by aberrant antigen expression, which aids diagnosis and prognosis. The myeloid antigen CD66c is notably frequent in B-ALL and has been proposed as a marker of disease aggressiveness and treatment response. Evaluating CD66c in Mexican pediatric patients may provide insights into disease biology. Methods: A cohort of 128 pediatric patients was referred to the Laboratory of Oncoimmunology and Cytomics of Childhood Cancer (OCL) at Instituto Mexicano del Seguro Social (IMSS) for immunophenotyping tests between March 2022 and November 2023. Additionally, control bone marrow (BM) samples were assessed. Aberrant antigen expression in hematopoietic populations and BM microenvironment stroma phenotyping were performed. Results: In total, 84.38% of B-ALL patients exhibited aberrant expression of \u22651 myeloid antigen. Among CD66c-positive patients, 13.79% had detectable measurable residual disease (MRD) during follow-up and 20.69% died. Mesenchymal stromal cells (MSCs) from patients with positive or low CD66c expression displayed inflammatory profiles. ProB leukemias with low CD66c expression were more likely to exhibit detectable MRD, increased mortality, and reduced survival. Conclusions: Low CD66c expression induces molecular stealth that could favor immune evasion and niche persistence, thereby increasing the risk of relapse and therapeutic failure.<\/jats:p>","DOI":"10.3390\/cells15050437","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T16:06:59Z","timestamp":1772467619000},"page":"437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low-Intensity CD66c Expression Orchestrates an Immunosuppressive Niche Promoting Residual Disease in Pediatric ProB Acute Lymphoblastic Leukemia"],"prefix":"10.3390","volume":"15","author":[{"given":"Gabriela","family":"Zamora-Herrera","sequence":"first","affiliation":[{"name":"Laboratory of Oncoimmunology and Cytomics of Childhood Cancer, Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente, Instituto Mexicano del Seguro Social, Puebla 74360, Mexico"},{"name":"Instituto de Fisiolog\u00eda, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla 72570, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-2337","authenticated-orcid":false,"given":"Rub\u00ed","family":"Romo-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratory of Oncoimmunology and Cytomics of Childhood Cancer, Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente, Instituto Mexicano del Seguro Social, Puebla 74360, Mexico"},{"name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n (Secihti), Mexico City 03940, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-8289","authenticated-orcid":false,"given":"Jebea A.","family":"L\u00f3pez-Blanco","sequence":"additional","affiliation":[{"name":"Laboratory of Oncoimmunology and Cytomics of Childhood Cancer, Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente, Instituto Mexicano del Seguro Social, Puebla 74360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Alfaro-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Oncoimmunology and Cytomics of Childhood Cancer, Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente, Instituto Mexicano del Seguro Social, Puebla 74360, Mexico"},{"name":"Facultad de Ciencias Qu\u00edmicas, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla 72570, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5580-2551","authenticated-orcid":false,"given":"Diana","family":"Casique-Aguirre","sequence":"additional","affiliation":[{"name":"Laboratory of Oncoimmunology and Cytomics of Childhood Cancer, Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente, Instituto Mexicano del Seguro Social, Puebla 74360, Mexico"},{"name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n (Secihti), Mexico City 03940, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-9727","authenticated-orcid":false,"given":"Juan Carlos","family":"N\u00fa\u00f1ez-Enriquez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n en Salud, Unidad M\u00e9dica de Alta Especialidad (UMAE) Hospital de Pediatr\u00eda \u201cSilvestre Frenk Freund\u201d Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-5884","authenticated-orcid":false,"given":"Michael","family":"Schnoor","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedicine, Cinvestav-IPN, Mexico City 07360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2740-0317","authenticated-orcid":false,"given":"Dalia","family":"Ram\u00edrez-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Laboratory of Oncoimmunology and Cytomics of Childhood Cancer, Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente, Instituto Mexicano del Seguro Social, Puebla 74360, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-9757","authenticated-orcid":false,"given":"Rosana","family":"Pelayo","sequence":"additional","affiliation":[{"name":"Laboratory of Oncoimmunology and Cytomics of Childhood Cancer, Centro de Investigaci\u00f3n Biom\u00e9dica de Oriente, Instituto Mexicano del Seguro Social, Puebla 74360, Mexico"},{"name":"Unidad de Educaci\u00f3n e Investigaci\u00f3n, Instituto Mexicano del Seguro Social, Mexico City 06725, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"N\u00fa\u00f1ez-Enr\u00edquez, J.C., Romo-Rodr\u00edguez, R., Gaspar-Mendoza, P., Zamora-Herrera, G., Torres-Pineda, L., Amador-Cardoso, J., L\u00f3pez-Blanco, J.A., Alfaro-Hern\u00e1ndez, L., L\u00f3pez-Garc\u00eda, L., and Rosas-Cruz, A. 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