{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:18:19Z","timestamp":1784841499305,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Stem cell therapy represents an intrinsic part of regenerative medicine, with expanding applications in orthopedic and musculoskeletal research. Although studies span from small-animal models to early-phase clinical trials, the field remains fragmented, with wide variation in stem cell types, delivery methods, and target tissues. A consolidated overview is needed to inform future directions and bridge the gap between preclinical promise and clinical application. This scoping review synthesized evidence from 500 preclinical and clinical studies, identified through systematic searches and screened in accordance with PRISMA-ScR guidelines. Data were extracted on stem cell type and source, delivery approach, targeted tissue and organ, and disease indication. We found that autologous bone marrow-derived mesenchymal stem cells were the most used, with adipose- and perinatal-derived cells gaining prominence in recent years. Small-animal models such as rats and rabbits predominated, while large-animal and human studies focused mainly on knee osteoarthritis. Intra-articular injection was the principal delivery method across both preclinical and clinical settings. By mapping prevailing practices and emerging trends, this review provides a comprehensive reference for researchers, clinicians, and regulatory stakeholders. It highlights translational pathways, identifies critical gaps, and offers evidence to guide the design of safe, effective, and scalable regenerative therapies in orthopedics.<\/jats:p>","DOI":"10.3390\/cells15050456","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:51:33Z","timestamp":1772614293000},"page":"456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research Landscape of Stem Cell Applications in Musculoskeletal Tissue: A Scoping Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2807-5274","authenticated-orcid":false,"given":"Aiyarin","family":"Kittilukkana","sequence":"first","affiliation":[{"name":"Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Clinical Research Center for Food and Herbal Product Trials and Development (CR-FAH), Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puwapong","family":"Nimkingratana","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dumnoensun","family":"Pruksakorn","sequence":"additional","affiliation":[{"name":"Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-5367","authenticated-orcid":false,"given":"Mingkwan","family":"Na Takuathung","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Food and Herbal Product Trials and Development (CR-FAH), Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-597X","authenticated-orcid":false,"given":"Nut","family":"Koonrungsesomboon","sequence":"additional","affiliation":[{"name":"Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Clinical Research Center for Food and Herbal Product Trials and Development (CR-FAH), Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"To, K., Zhang, B., Romain, K., Mak, C., and Khan, W. (2019). Synovium-Derived Mesenchymal Stem Cell Transplantation in Cartilage Regeneration: A PRISMA Review of in vivo Studies. Front. Bioeng. Biotechnol., 7.","DOI":"10.3389\/fbioe.2019.00314"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Liang, W., Zhou, C., Bai, J., Zhang, H., Jiang, B., Wang, J., Fu, L., Long, H., Huang, X., and Zhao, J. (2024). Current advancements in therapeutic approaches in orthopedic surgery: A review of recent trends. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1328997"},{"key":"ref_3","first-page":"83","article-title":"The use of molecular cues to regenerate musculoskeletal tissues","volume":"11","author":"Joris","year":"2026","journal-title":"Innov. Surg. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrrheum.2014.157","article-title":"Repair and tissue engineering techniques for articular cartilage","volume":"11","author":"Makris","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1053\/joca.2002.0801","article-title":"Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects","volume":"10","author":"Hunziker","year":"2002","journal-title":"Osteoarthr. Cartil."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/physrev.00019.2003","article-title":"Cellular and Molecular Regulation of Muscle Regeneration","volume":"84","author":"Rudnicki","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"628767","DOI":"10.1155\/2015\/628767","article-title":"Adult Mesenchymal Stem Cells: When, Where, and How","volume":"2015","author":"Caplan","year":"2015","journal-title":"Stem Cells Int."},{"key":"ref_9","first-page":"2638305","article-title":"The Holy Grail of Orthopedic Surgery: Mesenchymal Stem Cells-Their Current Uses and Potential Applications","volume":"2017","author":"Granados","year":"2017","journal-title":"Stem Cells Int."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Costela-Ruiz, V.J., Melguizo-Rodr\u00edguez, L., Bellotti, C., Illescas-Montes, R., Stanco, D., Arciola, C.R., and Lucarelli, E. (2022). Different Sources of Mesenchymal Stem Cells for Tissue Regeneration: A Guide to Identifying the Most Favorable One in Orthopedics and Dentistry Applications. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116356"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12951-023-01778-6","article-title":"Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon-bone healing","volume":"21","author":"Zou","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"ref_12","first-page":"1","article-title":"Vascular endothelial growth factor mediates the therapeutic efficacy of mesenchymal stem cell-derived extracellular vesicles against neonatal hyperoxic lung injury","volume":"50","author":"Ahn","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4252\/wjsc.v6.i2.144","article-title":"Adipose mesenchymal stem cells in the field of bone tissue engineering","volume":"6","author":"Romagnoli","year":"2014","journal-title":"World J. Stem Cells"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3187491","DOI":"10.1155\/2016\/3187491","article-title":"Mesenchymal Stem Cells Subpopulations: Application for Orthopedic Regenerative Medicine","volume":"2016","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Shang, Z., Wang, M., Zhang, B., Wang, X., and Wanyan, P. (2022). Clinical translation of stem cell therapy for spinal cord injury still premature: Results from a single-arm meta-analysis based on 62 clinical trials. BMC Med., 20.","DOI":"10.1186\/s12916-022-02482-2"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/jlb\/lsy025","article-title":"The stem cell market and policy options: A call for clarity","volume":"5","author":"Zarzeczny","year":"2018","journal-title":"J. Law Biosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nbt.2960","article-title":"Overcoming immunological barriers in regenerative medicine","volume":"32","author":"Zakrzewski","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/neu.2014.3562","article-title":"Immunosuppression of allogenic mesenchymal stem cells transplantation after spinal cord injury improves graft survival and beneficial outcomes","volume":"32","author":"Hernandez","year":"2015","journal-title":"J. Neurotrauma"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.12998\/wjcc.v9.i16.3826","article-title":"Xenogeneic stem cell transplantation: Research progress and clinical prospects","volume":"9","author":"Jiang","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/1947603514534681","article-title":"Cartilage Repair with Autologous Bone Marrow Mesenchymal Stem Cell Transplantation: Review of Preclinical and Clinical Studies","volume":"5","author":"Yamasaki","year":"2014","journal-title":"Cartilage"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.21037\/sci-2020-036","article-title":"Safety and therapeutic potential of human bone marrow-derived mesenchymal stromal cells in regenerative medicine","volume":"8","author":"Aithal","year":"2021","journal-title":"Stem Cell Investig."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s12016-016-8552-9","article-title":"Adipose-Derived Mesenchymal Stem Cells in Autoimmune Disorders: State of the Art and Perspectives for Systemic Sclerosis","volume":"52","author":"Maria","year":"2017","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1186\/s13287-021-02477-5","article-title":"A focus on allogeneic mesenchymal stromal cells as a versatile therapeutic tool for treating multiple sclerosis","volume":"12","author":"Shokati","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"11692","DOI":"10.3390\/ijms140611692","article-title":"Wharton\u2019s jelly-derived mesenchymal stem cells: Phenotypic characterization and optimizing their therapeutic potential for clinical applications","volume":"14","author":"Kim","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Bruno, A., Milillo, C., Anaclerio, F., Buccolini, C., Dell\u2019Elice, A., Angilletta, I., Gatta, M., Ballerini, P., and Antonucci, I. (2024). Perinatal Tissue-Derived Stem Cells: An Emerging Therapeutic Strategy for Challenging Neurodegenerative Diseases. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25020976"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.21315\/mjms2023.30.2.5","article-title":"Human Mesenchymal Stromal Cells Derived from Perinatal Tissues: Sources, Characteristics and Isolation Methods","volume":"30","author":"Teoh","year":"2023","journal-title":"Malays. J. Med. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s13287-019-1450-3","article-title":"Osteogenic commitment of Wharton\u2019s jelly mesenchymal stromal cells: Mechanisms and implications for bioprocess development and clinical application","volume":"10","author":"Roura","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4252\/wjsc.v6.i2.195","article-title":"Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility","volume":"6","author":"He","year":"2014","journal-title":"World J. Stem Cells"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"23544","DOI":"10.1038\/srep23544","article-title":"Tissue-specific Differentiation Potency of Mesenchymal Stromal Cells from Perinatal Tissues","volume":"6","author":"Kwon","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050: A systematic analysis for the Global Burden of Disease Study 2021","volume":"5","author":"Steinmetz","year":"2023","journal-title":"Lancet Rheumatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s13287-024-03870-6","article-title":"Human adipose and synovial-derived MSCs synergistically attenuate osteoarthritis by promoting chondrocyte autophagy through FoxO1 signaling","volume":"15","author":"Wu","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1002\/art.34626","article-title":"Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis","volume":"64","author":"Schelbergen","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4103\/ijp.ijp_860_22","article-title":"Translational research: Bridging the gap between preclinical and clinical research","volume":"54","author":"Mahalmani","year":"2022","journal-title":"Indian J. Pharmacol."},{"key":"ref_35","first-page":"207","article-title":"The Mighty Mouse: The impact of rodents on advances in biomedical research","volume":"110","author":"Bryda","year":"2013","journal-title":"Mo. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/ten.teb.2009.0452","article-title":"Animal models for cartilage regeneration and repair","volume":"16","author":"Chu","year":"2010","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Zhou, L., Ho, K.-W.K., Zheng, L., Xu, J., Chen, Z., Ye, X., Zou, L., Li, Y., Chang, L., and Shao, H. (2024). A rabbit osteochondral defect (OCD) model for evaluation of tissue engineered implants on their biosafety and efficacy in osteochondral repair. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1352023"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"dmm029462","DOI":"10.1242\/dmm.029462","article-title":"Generating mouse models for biomedical research: Technological advances","volume":"12","author":"Gurumurthy","year":"2019","journal-title":"Dis. Model Mech."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Park-Sarge, O.-K., and Curry, T.E. (2009). Transgenic Mouse Technology: Principles and Methods. Molecular Endocrinology: Methods and Protocols, Humana Press.","DOI":"10.1007\/978-1-60327-378-7"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"D981","DOI":"10.1093\/nar\/gkaa1083","article-title":"Mouse Genome Database (MGD): Knowledgebase for mouse\u2013human comparative biology","volume":"49","author":"Blake","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41584-019-0202-1","article-title":"Spontaneous dog osteoarthritis\u2014A One Medicine vision","volume":"15","author":"Meeson","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2217\/rme.14.42","article-title":"The Current \u2018State of Play\u2019 of Regenerative Medicine in Horses: What the Horse Can Tell the Human","volume":"9","author":"Smith","year":"2014","journal-title":"Regen. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.21037\/sci-2020-013","article-title":"Human bone marrow-derived mesenchymal stem cells from different bone sources: A panorama","volume":"7","author":"Vasiliadis","year":"2020","journal-title":"Stem Cell Investig."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e264","DOI":"10.18295\/squmj.2018.18.03.002","article-title":"Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review","volume":"18","year":"2018","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"ref_45","first-page":"448","article-title":"Mesenchymal stem cells in osteoarthritis therapy: A review","volume":"13","author":"Zhu","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1002\/jor.22370","article-title":"Intraarticular injection of synovial stem cells promotes meniscal regeneration in a rabbit massive meniscal defect model","volume":"31","author":"Hatsushika","year":"2013","journal-title":"J. Orthop. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.joca.2014.04.028","article-title":"Repetitive allogeneic intraarticular injections of synovial mesenchymal stem cells promote meniscus regeneration in a porcine massive meniscus defect model","volume":"22","author":"Hatsushika","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/jor.23211","article-title":"Transplantation of autologous synovial mesenchymal stem cells promotes meniscus regeneration in aged primates","volume":"35","author":"Kondo","year":"2017","journal-title":"J. Orthop. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/jor.22614","article-title":"Meniscus regeneration by syngeneic, minor mismatched, and major mismatched transplantation of synovial mesenchymal stem cells in a rat model","volume":"32","author":"Okuno","year":"2014","journal-title":"J. Orthop. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3892\/etm.2015.2944","article-title":"Targeted transplantation of iron oxide-labeled, adipose-derived mesenchymal stem cells in promoting meniscus regeneration following a rabbit massive meniscal defect","volume":"11","author":"Qi","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jcyt.2012.10.002","article-title":"The mesenchymal stromal cells dilemma\u2014Does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?","volume":"15","author":"Galipeau","year":"2013","journal-title":"Cytotherapy"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s13578-021-00698-y","article-title":"Allogeneic vs. autologous mesenchymal stem\/stromal cells in their medication practice","volume":"11","author":"Li","year":"2021","journal-title":"Cell Biosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jcyt.2020.01.006","article-title":"A Monte Carlo framework for managing biological variability in manufacture of autologous cell therapy from mesenchymal stromal cells therapies","volume":"22","author":"Picken","year":"2020","journal-title":"Cytotherapy"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Pozzobon, M., D\u2019Agostino, S., Roubelakis, M.G., Cargnoni, A., Gramignoli, R., Wolbank, S., Gindraux, F., Bollini, S., Kerdjoudj, H., and Fenelon, M. (2022). General consensus on multimodal functions and validation analysis of perinatal derivatives for regenerative medicine applications. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.961987"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Gindraux, F., Hofmann, N., Agudo-Barriuso, M., Antica, M., Couto, P.S., Dubus, M., Forostyak, S., Girandon, L., Gramignoli, R., and Jurga, M. (2022). Perinatal derivatives application: Identifying possibilities for clinical use. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.977590"},{"key":"ref_56","first-page":"CD013342","article-title":"Stem cell injections for osteoarthritis of the knee","volume":"2019","author":"Whittle","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Torre, P., and Flores, A.I. (2020). Current Status and Future Prospects of Perinatal Stem Cells. Genes, 12.","DOI":"10.3390\/genes12010006"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4055\/cios.2016.8.1.1","article-title":"Stem Cell Therapy for the Treatment of Hip Osteonecrosis: A 30-Year Review of Progress","volume":"8","author":"Hernigou","year":"2016","journal-title":"Clin. Orthop. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nrrheum.2015.13","article-title":"Stem cell therapy for intervertebral disc regeneration: Obstacles and solutions","volume":"11","author":"Sakai","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"100608","DOI":"10.1016\/j.ocarto.2025.100608","article-title":"Stromal cell-based injection therapies for the treatment of knee osteoarthritis: A systematic review of level I randomized controlled trials","volume":"7","author":"Dhillon","year":"2025","journal-title":"Osteoarthr. Cartil. Open"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/5\/456\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T09:08:55Z","timestamp":1772615335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/5\/456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":60,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["cells15050456"],"URL":"https:\/\/doi.org\/10.3390\/cells15050456","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,4]]}}}