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These USP10 substrates contain both tumor suppressors and oncogenic proteins, thus conferring both inhibitory and promoting effects of USP10 on tumorigenesis and progression. This review focuses on the dual roles of USP10 in various cancer types and addresses the association of aberrant USP10 expression with the development of various types of cancers, including hepatocellular carcinoma, lung cancer, breast cancer, prostate cancer, gastric cancer, and acute and chronic myelogenous leukemia. In addition, this review discusses the potential applications of USP10 inhibitors as targeted drugs for cancer therapy.<\/jats:p>","DOI":"10.3390\/cells15060518","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:36:48Z","timestamp":1773423408000},"page":"518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual Roles of Ubiquitin-Specific Peptidase 10 (USP10) in Cancer"],"prefix":"10.3390","volume":"15","author":[{"given":"Yifei","family":"Zhai","sequence":"first","affiliation":[{"name":"School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manhan","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/s41419-020-03246-7","article-title":"When the Chains Do Not Break: The Role of USP10 in Physiology and Pathology","volume":"11","author":"Bhattacharya","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Jee, S.-C., and Cheong, H. 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