{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:14:02Z","timestamp":1785420842297,"version":"3.56.0"},"reference-count":37,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008095","name":"Yanshan University","doi-asserted-by":"publisher","award":["x2020271"],"award-info":[{"award-number":["x2020271"]}],"id":[{"id":"10.13039\/501100008095","id-type":"DOI","asserted-by":"publisher"}]},{"award":["x2020271"],"award-info":[{"award-number":["x2020271"]}],"id":[{"id":"https:\/\/ror.org\/02txfnf15","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Photothermal therapy is a highly promising non-invasive treatment strategy, but its clinical application is still limited by issues such as insufficient light-to-heat conversion efficiency and potential biological toxicity. To address these challenges, this study employed a biomineralization strategy to synthesize gold nanoflowers (Van@Au4 NFs) using vancomycin as a template. The synthesized Van@Au4 NFs exhibited a uniform flower-like morphology with a hydrodynamic diameter of approximately 122 nm. Under 808 nm laser irradiation, this material demonstrated excellent photothermal properties, with a photothermal conversion efficiency of 34.94%, and remained stable after four cold-hot cycles. The introduction of vancomycin effectively enhanced the colloidal stability and photothermal conversion ability of the nanoflowers. In vitro experiments showed that Van@Au4 NFs had an inhibition rate of 90.8% against Staphylococcus aureus and 95.18% against A549 tumor cells under near-infrared light irradiation. This study constructed an efficient photothermal agent, providing important experimental evidence for in vitro synergistic photothermal treatment of bacterial infections and tumors.<\/jats:p>","DOI":"10.3390\/cells15080680","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:38:26Z","timestamp":1776080306000},"page":"680","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vancomycin-Biomineralized Gold Nanoflowers for In Vitro Photothermal Antibacterial and Antitumor Applications"],"prefix":"10.3390","volume":"15","author":[{"given":"Hongying","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingtao","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1294-2164","authenticated-orcid":false,"given":"Zhiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longgang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"ref_1","first-page":"488","article-title":"Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward","volume":"71","author":"Nanayakkara","year":"2021","journal-title":"CA A Cancer J. 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