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Carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family receptors play a crucial role in regulating innate responses of both leukocytes and epithelia. Human CEACAM3, CEACAM5 and CEACAM6 receptors recognize Candida albicans and are expressed in transgenic CEABAC10 mice. In a murine C. albicans infection model, CEABAC10 mice exhibited a shortened survival period attributed to an early cytokine storm, an exacerbated acute phase response, and heightened systemic inflammation compared to their wild-type littermates. The livers and kidneys of CEABAC10 mice displayed intensified purulent necrotizing inflammation, accompanied by increased infiltration of neutrophils and macrophages. Our in vivo and in vitro data indicated that the expression of CEACAM6 on monocytes of CEABAC10 mice caused the elevated cytokine levels and the subsequent exacerbation of the acute phase response upon C. albicans infection, resulting in decreased survival.<\/jats:p>","DOI":"10.3390\/cells15080707","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:35:42Z","timestamp":1776339342000},"page":"707","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression of Human CEACAM Receptors Promotes Inflammation and Organ Damage During Systemic Candida albicans Infection in Mice"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7389-6862","authenticated-orcid":false,"given":"Esther","family":"Klaile","sequence":"first","affiliation":[{"name":"Center for Clinical Studies, Jena University Hospital, 07747 Jena, Germany"},{"name":"Host Septomics Group, 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-9993","authenticated-orcid":false,"given":"Olivia","family":"Kershaw","sequence":"additional","affiliation":[{"name":"Institut F\u00fcr Tierpathologie, Freie Universit\u00e4t Berlin, 14163 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1828-8351","authenticated-orcid":false,"given":"Jan-Philipp","family":"Praetorius","sequence":"additional","affiliation":[{"name":"Department of Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute (HKI), 07745 Jena, Germany"},{"name":"Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4044-9166","authenticated-orcid":false,"given":"Marc 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortense","family":"Slevogt","sequence":"additional","affiliation":[{"name":"Respiratory Infection Dynamics, Helmholtz Centre for Infection Research-HZI Braunschweig, 38124 Braunschweig, Germany"},{"name":"Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1007\/s00134-014-3355-z","article-title":"Candida colonization index and subsequent infection in critically ill surgical patients: 20 years later","volume":"40","author":"Eggimann","year":"2014","journal-title":"Intensive Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/21505594.2021.2019950","article-title":"Pathogenesis and virulence of Candida 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