{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:41:24Z","timestamp":1784547684100,"version":"3.55.0"},"reference-count":100,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Depression is one of the most prevalent psychiatric disorders worldwide, with a steadily increasing incidence and complex, multifactorial pathophysiology. Beyond classical neurochemical mechanisms, growing evidence points to the role of systemic low-grade inflammation and immuno-metabolic disturbances in its development. Gut microbiota dysbiosis has emerged as a key factor linking metabolic, immune, and neuroendocrine pathways, potentially exacerbating neuroinflammation and contributing to the onset and progression of depressive symptoms. Immune activation, which is a result of gut dysbiosis, may play a crucial role in the pathogenesis of immuno-metabolic depression. Thyroid dysfunction appears to be an important, yet insufficiently understood component of this network. Thyroid hormones play a crucial role in regulating metabolism, immune responses, and central nervous system function. Alterations in thyroid function, even within subclinical ranges, have been associated with mood disturbances and may share common inflammatory and metabolic pathways with depression. Furthermore, emerging data suggest that gut microbiota may influence thyroid hormone metabolism, including deiodinase activity, linking dysbiosis with thyroid axis dysregulation. Despite these insights, the integrated interactions between thyroid function, gut microbiota, metabolic syndrome, and inflammation in depression remain largely unexplored. This review explores current evidence to highlight gaps in existing research and synthesizes current knowledge, aiming to clarify mechanisms underlying immuno-metabolic depression. Understanding these relationships may provide a rationale for redefining depression as an immuno-metabolic disorder and support the development of more integrative therapeutic strategies targeting not only the brain, but also the gut-thyroid axis.<\/jats:p>","DOI":"10.3390\/cells15080723","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:01:22Z","timestamp":1776686482000},"page":"723","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thyroid Dysfunction as a Component of an Immuno-Metabolic Depression\u2014A Possible Role of Gut Microbiota and a Rationale for Future Studies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1279-9835","authenticated-orcid":false,"given":"Karolina","family":"Michno","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9891-6067","authenticated-orcid":false,"given":"Mateusz","family":"Kapela","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8559-1078","authenticated-orcid":false,"given":"Dominik","family":"Strzelecki","sequence":"additional","affiliation":[{"name":"Department of Affective and Psychotic Disorders, Medical University of Lodz, 92-216 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1398-3117","authenticated-orcid":false,"given":"Oliwia","family":"Gawlik-Kotelnicka","sequence":"additional","affiliation":[{"name":"Department of Affective and Psychotic Disorders, Medical University of Lodz, 92-216 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"ref_1","unstructured":"(2025, May 06). Depressive Disorder (Depression). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jad.2024.03.074","article-title":"Global burden of depression or depressive symptoms in children and adolescents: A systematic review and meta-analysis","volume":"354","author":"Lu","year":"2024","journal-title":"J. Affect. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1192\/bjp.184.5.386","article-title":"Global burden of depressive disorders in the year 2000","volume":"184","author":"Chatterji","year":"2004","journal-title":"Br. J. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/eurheartj\/eht462","article-title":"Depression and cardiovascular disease: A clinical review","volume":"35","author":"Hare","year":"2014","journal-title":"Eur. Hear. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ajp.2017.01.025","article-title":"The neurobiology of depression: An integrated view","volume":"27","author":"Dean","year":"2017","journal-title":"Asian J. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0893-133X(00)00159-7","article-title":"The Corticosteroid Receptor Hypothesis of Depression Clinical Evidence","volume":"23","author":"Holsboer","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbi.2020.04.002","article-title":"Depression profilers and immuno-metabolic dysregulation: Longitudinal results from the NESDA study","volume":"88","author":"Lamers","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.31887\/DCNS.2018.20.1\/bpenninx","article-title":"Metabolic syndrome in psychiatric patients: Overview, mechanisms, and implications","volume":"20","author":"Penninx","year":"2018","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"102063","DOI":"10.1016\/j.eclinm.2023.102063","article-title":"Psychiatric disorders and subsequent risk of cardiovascular disease: A longitudinal matched cohort study across three countries","volume":"61","author":"Shen","year":"2023","journal-title":"eClinicalMedicine"},{"key":"ref_10","first-page":"e28201","article-title":"Hypothyroidism and Depression: A Narrative Review","volume":"14","author":"Nuguru","year":"2022","journal-title":"Cureus"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"590648","DOI":"10.1155\/2012\/590648","article-title":"The Link between Thyroid Function and Depression","volume":"2012","author":"Hage","year":"2012","journal-title":"J. Thyroid. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2010.2","article-title":"Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies","volume":"67","author":"Luppino","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8000359","DOI":"10.1155\/2024\/8000359","article-title":"The Association between Depression, Anxiety, and Thyroid Disease: A UK Biobank Prospective Cohort Study","volume":"2024","author":"Fan","year":"2024","journal-title":"Depress. Anxiety"},{"key":"ref_14","first-page":"101571","article-title":"A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation","volume":"36","author":"Mehdi","year":"2023","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.biopsych.2020.01.014","article-title":"Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression","volume":"88","author":"Milaneschi","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.euroneuro.2015.06.007","article-title":"Inflammation and clinical response to treatment in depression: A meta-analysis","volume":"25","author":"Strawbridge","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"732","DOI":"10.2174\/1570159X14666151208113700","article-title":"Inflammation in Depression and the Potential for Anti-Inflammatory Treatment","volume":"14","author":"Kohler","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gawlik-Kotelnicka, O., Margulska, A., P\u0142eska, K., Skowro\u0144ska, A., and Strzelecki, D. (2024). Metabolic Status Influences Probiotic Efficacy for Depression\u2014PRO-DEMET Randomized Clinical Trial Results. Nutrients, 16.","DOI":"10.3390\/nu16091389"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/dmm.001180","article-title":"A comprehensive definition for metabolic syndrome","volume":"2","author":"Huang","year":"2009","journal-title":"Dis. Model. Mech."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5603\/AH.a2022.0012","article-title":"Metabolic syndrome\u2014A new definition and management guidelines","volume":"26","author":"Dobrowolski","year":"2022","journal-title":"Arter. Hypertens."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1177\/2047487314525529","article-title":"Metabolic syndrome across Europe: Different clusters of risk factors","volume":"22","author":"Scuteri","year":"2015","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(23)02750-2","article-title":"Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults","volume":"403","author":"Phelps","year":"2024","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/1753944717711379","article-title":"Metabolic syndrome: Pathophysiology, management, and modulation by natural compounds","volume":"11","author":"Rochlani","year":"2017","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Walczak, K., and Sieminska, L. (2021). Obesity and Thyroid Axis. Int. J. Env. Res. Public Health, 18.","DOI":"10.3390\/ijerph18189434"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gutjnl-2014-308778","article-title":"Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: Relationship with gut microbiome richness and ecology","volume":"65","author":"Dao","year":"2016","journal-title":"Gut"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: Human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Koliada, A., Syzenko, G., Moseiko, V., Budovska, L., Puchkov, K., Perederiy, V., Gavalko, Y., Dorofeyev, A., Romanenko, M., and Tkach, S. (2017). Association between body mass index and Firmicutes\/Bacteroidetes ratio in an adult Ukrainian population. BMC Microbiol., 17.","DOI":"10.1186\/s12866-017-1027-1"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrmicro3089","article-title":"The gut microbiota and obesity: From correlation to causality","volume":"11","author":"Zhao","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Magne, F., Gotteland, M., Gauthier, L., Zazueta, A., Pesoa, S., Navarrete, P., and Balamurugan, R. (2020). The firmicutes\/bacteroidetes ratio: A relevant marker of gut dysbiosis in obese patients?. Nutrients, 12.","DOI":"10.3390\/nu12051474"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1177\/0300060519851624","article-title":"Effects of thyroid hormone and depression on common components of central obesity","volume":"47","author":"Du","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/wps.20252","article-title":"Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: A systematic review and meta-analysis","volume":"14","author":"Vancampfort","year":"2015","journal-title":"World Psychiatry"},{"key":"ref_33","first-page":"427","article-title":"Medications that cause weight gain and alternatives in Canada: A narrative review","volume":"11","author":"Wharton","year":"2018","journal-title":"Diabetes Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1161\/HYPERTENSIONAHA.108.126698","article-title":"Depression is associated with decreased blood pressure, but antidepressant use increases the risk for hypertension","volume":"53","author":"Licht","year":"2009","journal-title":"Hypertension"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6613827","DOI":"10.1155\/2021\/6613827","article-title":"NAFLD, Insulin Resistance, and Diabetes Mellitus Type 2","volume":"2021","author":"Knobloch","year":"2021","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40842-021-00117-8","article-title":"The relationship between depression and risk of metabolic syndrome: A meta-analysis of observational studies","volume":"7","author":"Moradi","year":"2021","journal-title":"Clin. Diabetes Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/dc11-2055","article-title":"Bidirectional association between depression and metabolic syndrome: A systematic review and meta-analysis of epidemiological studies","volume":"35","author":"Pan","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_38","first-page":"41","article-title":"Changes in health-related quality of life, motivation for physical activity, and the levels of anxiety and depression after individualized aerobic training in subjects with metabolic syndrome","volume":"66","author":"Zupkauskiene","year":"2022","journal-title":"Hell. J. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.bbi.2024.10.033","article-title":"Running therapy or antidepressants as treatments for immunometabolic depression in patients with depressive and anxiety disorders: A secondary analysis of the MOTAR study","volume":"123","author":"Vreijling","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Suneson, K., Lindahl, J., H\u00e5rsmar, S.C., S\u00f6derberg, G., and Lindqvist, D. (2021). Inflammatory depression\u2014Mechanisms and non-pharmacological interventions. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041640"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.tics.2019.03.003","article-title":"Can\u2019t or Won\u2019t? Immunometabolic Constraints on Dopaminergic Drive","volume":"23","author":"Treadway","year":"2019","journal-title":"Trends Cogn. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1210\/jc.2013-2409","article-title":"The Incidence and Prevalence of Thyroid. Dysfunction in Europe: A Meta-Analysis","volume":"99","author":"Madariaga","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrendo.2018.18","article-title":"Global epidemiology of hyperthyroidism and hypothyroidism","volume":"14","author":"Taylor","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1210\/er.2018-00163","article-title":"Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders","volume":"40","author":"Biondi","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Biondi, B. (2024). Subclinical Hypothyroidism in Patients with Obesity and Metabolic Syndrome: A Narrative Review. Nutrients, 16.","DOI":"10.3390\/nu16010087"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/MED.0000000000000089","article-title":"Psychiatric and cognitive manifestations of hypothyroidism","volume":"21","author":"Samuels","year":"2014","journal-title":"Curr. Opin. Endocrinol. Diabetes"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"110754","DOI":"10.1016\/j.brainresbull.2023.110754","article-title":"Altered resting-state brain activity in major depressive disorder comorbid with subclinical hypothyroidism: A regional homogeneity analysis","volume":"202","author":"Zhao","year":"2023","journal-title":"Brain Res. Bull."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1089\/thy.2013.0555","article-title":"Increased psychiatric morbidity before and after the diagnosis of hypothyroidism: A nationwide register study","volume":"24","author":"Thvilum","year":"2014","journal-title":"Thyroid"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1089\/thy.2020.0884","article-title":"Thyroid Function and Mood Disorders: A Mendelian Randomization Study","volume":"31","author":"Kjaergaard","year":"2021","journal-title":"Thyroid"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.psyneuen.2015.04.016","article-title":"Relationship between thyroid-stimulating hormone levels and risk of depression among the general population with normal free T4 levels","volume":"58","author":"Kim","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3109\/08039488.2014.972454","article-title":"Is suppressed thyroid-stimulating hormone (TSH) associated with subclinical depression in the Danish General Suburban Population Study?","volume":"69","author":"Kvetny","year":"2015","journal-title":"Nord. J. Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e28160","DOI":"10.1097\/MD.0000000000028160","article-title":"Comparison of thyroid-stimulating hormone levels in adolescents with schizophrenia, bipolar disorder, unipolar depression, conduct disorders, and hyperkinetic disorders","volume":"100","author":"Margulska","year":"2021","journal-title":"Medicine"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Ma, Y., Wu, Q., Wang, Q., Yang, W.F.Z., Wang, Y., Yang, D., Luo, Y., Tang, K., and Liu, T. (2021). Comparison of Thyroid Hormone Levels Between Patients With Major Depressive Disorder and Healthy Individuals in China. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.750749"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.soard.2015.02.021","article-title":"Subclinical hypothyroidism and its relation to obesity in patients before and after Roux-en-Y gastric bypass","volume":"11","author":"Janssen","year":"2015","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Loh, H.H., Lim, L.L., Yee, A., and Loh, H.S. (2019). Association between subclinical hypothyroidism and depression: An updated systematic review and meta-analysis. BMC Psychiatry, 19.","DOI":"10.1186\/s12888-018-2006-2"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"105219","DOI":"10.1016\/j.psyneuen.2021.105219","article-title":"Thyroid axis activity and dopamine function in depression","volume":"128","author":"Duval","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(72)92407-5","article-title":"Effects of Thyrotropin-Releasing Hormone in Depression","volume":"300","author":"Prange","year":"1972","journal-title":"Lancet"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1210\/me.2007-0048","article-title":"Thyrotropin-Releasing Hormone Receptor 1-Deficient Mice Display Increased Depression and Anxiety-Like Behavior","volume":"21","author":"Zeng","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1196\/annals.1314.040","article-title":"Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism?","volume":"1032","author":"Joffe","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/cen.14742","article-title":"Combined T4 + T3 therapy versus T4 monotherapy effect on psychological health in hypothyroidism: A systematic review and meta-analysis","volume":"97","author":"Lan","year":"2022","journal-title":"Clin. Endocrinol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e7502","DOI":"10.7717\/peerj.7502","article-title":"Factors affecting the composition of the gut microbiota, and its modulation","volume":"7","author":"Hasan","year":"2019","journal-title":"PeerJ"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Sublette, M.G., Cross, T.L., Korcarz, C.E., Hansen, K.M., Murga-Garrido, S.M., Hazen, S.L., Wang, Z., Oguss, M.K., Rey, F.E., and Stein, J.H. (2020). Effects of smoking and smoking cessation on the intestinal microbiota. J. Clin. Med., 9.","DOI":"10.1101\/2020.07.11.20151480"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Aleman, R.S., Moncada, M., and Aryana, K.J. (2023). Leaky Gut and the Ingredients That Help Treat It: A Review. Molecules, 28.","DOI":"10.3390\/molecules28020619"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jad.2012.02.023","article-title":"Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut","volume":"141","author":"Maes","year":"2012","journal-title":"J. Affect. Disord."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/BF03346542","article-title":"Regulation of sodium\/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines","volume":"33","author":"Sponziello","year":"2010","journal-title":"J. Endocrinol. Investig."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1210\/en.2005-0789","article-title":"Bacterial lipopolysaccharide stimulates the thyrotropin-dependent thyroglobulin gene expression at the transcriptional level by involving the transcription factors thyroid transcription factor-1 and paired box domain transcription factor 8","volume":"147","author":"Costamagna","year":"2006","journal-title":"Endocrinology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"114459","DOI":"10.1016\/j.bbr.2023.114459","article-title":"Intestinal permeability and its significance in psychiatric disorders\u2014A narrative review and future perspectives","volume":"448","author":"Wasiak","year":"2023","journal-title":"Behav. Brain Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3109\/00365529609094568","article-title":"Short-chain fatty acids in the human colon: Relation to gastrointestinal health and disease","volume":"31","author":"Mortensen","year":"1996","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Silva, Y.P., Bernardi, A., and Frozza, R.L. (2020). The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00025"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1038\/s41467-024-47273-w","article-title":"Immunoregulatory role of the gut microbiota in inflammatory depression","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic T reg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Mendoza-Le\u00f3n, M.J., Mangalam, A.K., Regaldiz, A., Gonz\u00e1lez-Madrid, E., Rangel-Ram\u00edrez, M.A., \u00c1lvarez-Mardonez, O., Vallejos, O.P., M\u00e9ndez, C., Bueno, S.M., and Melo-Gonz\u00e1lez, F. (2023). Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1192216"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/oby.2005.117","article-title":"Oligofructose promotes satiety in rats fed a high-fat diet: Involvement of glucagon-like peptide","volume":"13","author":"Cani","year":"2005","journal-title":"Obes. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1241214","DOI":"10.1126\/science.1241214","article-title":"Gut microbiota from twins discordant for obesity modulate metabolism in mice","volume":"341","author":"Ridaura","year":"2013","journal-title":"Science"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"dos Santos, A., and Gali\u00e8, S. (2024). The Microbiota-Gut-Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review. Nutrients, 16.","DOI":"10.3390\/nu16030390"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41574-022-00747-7","article-title":"The role of insufficient sleep and circadian misalignment in obesity","volume":"19","author":"Chaput","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Knezevic, J., Starchl, C., Berisha, A.T., and Amrein, K. (2020). Thyroid-gut-axis: How does the microbiota influence thyroid function?. Nutrients, 12.","DOI":"10.3390\/nu12061769"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fendo.2021.774362","article-title":"Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis","volume":"12","author":"Gong","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"111661","DOI":"10.1016\/j.biopha.2021.111661","article-title":"Role of microbiota-derived short-chain fatty acids in nervous system disorders","volume":"139","author":"Mirzaei","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Jiang, W., Lu, G., Gao, D., Lv, Z., and Li, D. (2022). The relationships between the gut microbiota and its metabolites with thyroid diseases. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.943408"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3920\/BM2010.0011","article-title":"The role of components of Bifidobacterium and Lactobacillus in pathogenesis and serologic diagnosis of autoimmune thyroid diseases","volume":"2","author":"Kiseleva","year":"2011","journal-title":"Benef. Microbes"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.tem.2019.05.008","article-title":"Microbiota and Thyroid Interaction in Health and Disease","volume":"30","author":"Wahl","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1210\/clinem\/dgad030","article-title":"Gut Microbiome Associated With Graves Disease and Graves Orbitopathy: The INDIGO Multicenter European Study","volume":"108","author":"Biscarini","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"184","DOI":"10.26444\/aaem\/112331","article-title":"The importance of nutritional factors and dietary management of Hashimoto\u2019s thyroiditis","volume":"27","author":"Ihnatowicz","year":"2020","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.neuropharm.2016.07.002","article-title":"Kynurenine pathway metabolism and the microbiota-gut-brain axis","volume":"112","author":"Kennedy","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The Microbiota-Gut-Brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Cao, Y.Y., Cheng, Y.R., Pan, W.C., Diao, J.W., Sun, L.Z., and Meng, M.M. (2025). Gut microbiota variations in depression and anxiety: A systematic review. BMC Psychiatry, 25.","DOI":"10.1186\/s12888-025-06871-8"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota\u2013gut\u2013brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.biopsych.2016.12.031","article-title":"Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice","volume":"82","author":"Burokas","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Chen, B., Zhang, J., Dong, J., Ma, J., Zhang, Y., Jin, K., and Lu, J. (2023). Effect of prebiotics, probiotics, synbiotics on depression: Results from a meta-analysis. BMC Psychiatry, 23.","DOI":"10.1186\/s12888-023-04963-x"},{"key":"ref_92","first-page":"1","article-title":"Probiotics Decrease C-Reactive Protein Levels in Depression Depending on Metabolic Syndrome Presence or Antidepressant Treatment\u2014Secondary Results of a Randomized Clinical Trial","volume":"23","author":"Gajewska","year":"2025","journal-title":"Curr. Neuropharmacol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Wang, L., Zhang, S., Liu, Y., Li, D., Tian, G., Li, X., and Li, Y. (2026). A study on the efficacy and safety of fecal microbiota transplantation as an adjunctive therapy for treating depressive episodes. Sci. Rep.","DOI":"10.1038\/s41598-026-41801-y"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Chen, Y., Xu, J., and Chen, Y. (2021). Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders. Nutrients, 13.","DOI":"10.3390\/nu13062099"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s44337-024-00114-7","article-title":"Unravelling the neuroinflammatory links in depression: The potential of a lipopolysaccharide preclinical model","volume":"1","author":"Pienaar","year":"2024","journal-title":"Discov. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.brainres.2014.06.032","article-title":"Inflammatory cytokine-associated depression","volume":"1617","author":"Lotrich","year":"2015","journal-title":"Brain Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.coph.2007.10.010","article-title":"The leptin hypothesis of depression: A potential link between mood disorders and obesity?","volume":"7","author":"Lu","year":"2007","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_98","first-page":"40","article-title":"Thyroid function and obesity","volume":"5","author":"Longhi","year":"2013","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"605","DOI":"10.55730\/1300-0144.5352","article-title":"The relationship between elevated plasma zonulin levels and Hashimoto\u2019s thyroiditis","volume":"52","author":"Demir","year":"2022","journal-title":"Turk. J. Med. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6757154","DOI":"10.1155\/2016\/6757154","article-title":"Thyroid Hormones, Oxidative Stress, and Inflammation","volume":"2016","author":"Mancini","year":"2016","journal-title":"Mediat. Inflamm."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/8\/723\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:13:29Z","timestamp":1776687209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/15\/8\/723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,19]]},"references-count":100,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["cells15080723"],"URL":"https:\/\/doi.org\/10.3390\/cells15080723","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,19]]}}}